检索结果-南通市图书馆

Pharmacological methods for ovarian function and fertility preservation in women with cancer:A literature review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2024年第8期32卷 1309-1322页

作者： ANA s.CVETANOVIC MATTEO LAMBERTINI KEVIN PUNIE GORANA G.MATOVINA BRKO NIKOLA D.ZIVKOVIC MAJA J.popovic MARIJANA M.MILOVIC KOVACEVIC LAZAR s.popovic Department for Oncology Medical Faculty NisUniversity of NisNis18000Serbia Clinic of Oncology University Clinical Centre NisNis18000Serbia Department of Internal Medicine and Medical sciences(DiMI) School of MedicineUniversity of GenovaGenova16100Italy Department of Medical Oncology U.O.C Clinica di Oncologia MedicaIRCCS Ospedale Policlinico San MartinoGenova16100Italy Department of General Medical Oncology and Multidisciplinary Breast Centre Leuven Cancer InstituteUniversity Hospitals LeuvenLeuven3001Belgium Department of Medical Oncology Oncology Institute of VojvodinaSremska Kamenica21208Serbia Department for Pathology Medical Faculty NisUniversity of NisNis18000Serbia Center for Pathology University Clinical Centre NisNis18000Serbia Faculty of Medicine University of Novi SadNovi Sad21000Serbia Department of Medical Oncology Institute of Oncology and Radiology SerbiaBelgrade11000Serbia

Oncofertility is an extremely signiﬁcant topic that is increasingly being discussed owing to increased evidence indicating that fertility preservation does not affect the treatment outcomes of patients with cancer but signiﬁcantly contributes to preserving life *** effect of chemotherapy can range from minimal effects to complete ovarian *** data are available on the effects of monoclonal antibodies and targeted therapies on the ovaries and *** ovarian suppression by administering a gonadotropin-releasing hormone agonist(GnRHa)during chemotherapy decreases the gonadotoxic effect of chemotherapy,thereby diminishing the chance of developing premature ovarian insufﬁciency(POI).At present,the concomitant administration of GnRH analogs during chemotherapy is the only accepted pharmacological method for preserving ovarian ***,most randomized studies on the effectiveness of luteinizing hormone-releasing hormone agonists during chemotherapy in preventing POI have been conducted in women with breast cancer,with a considerably small number of studies on patients with hematological ***,most randomized controlled trials on breast cancer have revealed a decrease in treatment-induced POI risk,regardless of the hormone receptor *** addition,studies on hematological malignancies have yielded negative results;nevertheless,theﬁndings must be interpreted with caution owing to numerous *** guidelines from the American society of Clinical Oncology and EsMO Clinical Practice Guidelines recommend sperm,oocyte,and embryo cryopreservation as a standard practice and only offering GnRHa to patients when proven fertility preservation methods are not *** this manuscript,we present a comprehensive literature overview on the application of ovarian suppression with GnRHa during chemotherapy in patients with cancer by addressing preclinical and clinical data,as well as future perspectives in thisﬁeld

关键词： Gonadotropin-releasing hormone agonists(GnRHa) Fertility preservation Premature ovarian insufficiency(POI) Premenopausal patients

Effect of special types of bread with select herbal components on postprandial glucose levels in diabetic patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第4期15卷 664-674页

作者： Drasko M Gostiljac srdjan s popovic Vesna Dimitrijevic-sreckovic sasa M Ilic Jelena A Jevtovic Dragan M Nikolic Ivan A soldatovic Clinic for Endocrinology Diabetes and Metabolic DiseasesUniversity Clinical Centre of SerbiaBelgrade 11000Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia Clinic for Gastroenterology and Hepatology University Clinical Centre of SerbiaBelgrade 11000Serbia Clinic for Endocrinology Diabetes and Metabolic Diseases-Laboratory for Human Pancreatic Islets CultureUniversity Clinical Centre of SerbiaBelgrade 11000Serbia

BACKGROUND Nutrition recommendations in patients with type 2 diabetes mellitus(T2DM)are to consume rye or integral bread instead of white bread.A positive effect on glucoregulation has been achieved by enriching food with various biologically active substances of herbal origin,so we formulated an herbal mixture that can be used as a supplement for a special type of bread(sTB)to achieve better effects on postprandial glucose and insulin levels in patients with *** To compare organoleptic characteristics and effects of two types of bread on postprandial glucose and insulin levels in T2DM *** This trial included 97 patients with T2DM.A parallel group of 16 healthy subjects was also *** participants were given 50 g of rye bread and the same amount of a sTB with an herbal mixture on 2 consecutive *** blood glucose and insulin levels were compared at the 30^(th),60^(th),90^(th) and 120th min.A questionnaire was used for subjective estimation of the organoleptic and satiety features of the two types of *** Compared to patients who consumed rye bread,significantly lower postprandial blood glucose and insulin concentrations were found in T2DM patients who consumed *** relevant differences were found among the healthy *** estimated organoleptic and satiety characteristics are better for sTB than for rye *** sTB have better effects than rye bread on postprandial glucoregulation in T2DM *** estimated organoleptic and satiety characteristics are better for sTB than for rye ***,sTB can be recommended for nutrition in T2DM patients.

关键词： special types of bread Postprandial glucoregulation Insulin Nutrition Type 2 diabetes mellitus

splenic hamartomas in children

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第11期12卷 1909-1917页

作者： Maja Milickovic Petar Rasic sofija Cvejic Dejana Bozic djordje savic Tanja Mijovic sava Cvetinovic slavisa M Djuricic Department of Abdominal surgery Mother and Child Health Care Institute of Serbia"Dr.Vukan Cupic"Belgrade 11000Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia Department of Radiology The Children’s University HospitalBelgrade 11000Serbia Department of Clinical Pathology Mother and Child Health Care Institute of Serbia"Dr.Vukan Cupic"Belgrade 11000Serbia Faculty of Medicine University of Banja LukaBanja Luka 78000Bosnia and Herzegovina

splenic hamartomas(sHs)are uncommon,benign vascular lesions of unclear etiology and are mostly found incidentally on abdominal images,at surgery,or at *** the first case description,in 1861,less than 50 pediatric sH cases have been reported in the *** this article,we have performed an analysis of all sH cases in children published in the literature to date and presented our case of an 8-year-old male with *** lesions in children were shown to cause symptoms more often than in the adult *** observed sH sizes in children ranged from a few millimeters to 18 cm,and the symptomatic lesions were mostly larger or *** most common clinical finding was *** of hypersplenism were present in children with a single sH larger than 4.5 cm(diameter range:4.5-18.0 cm)and in those with multiple hamartomas,ranging from a few millimeters to 5 *** percent of patients with available laboratory findings had hematological abnormalities such as anemia,thrombocytopenia,or *** symptoms and signs included abdominal pain,recurrent infections,fever,night sweats,lethargy,growth retardation,and weight *** use of multiple imaging modalities may suggest the preoperative diagnosis of a splenic mass in children and determine the therapeutic ***,the final diagnosis of sH relies on histopathological ***,including total or partial splenectomy(Ps),is the mainstay of sH *** M et *** in children WJCC https://*** 1910 April 16,2024 Volume 12 Issue 11 Although total splenectomy carries a greater risk of overwhelming post-splenectomy infection than Ps it has remained the most performed surgical procedure in children with *** the majority of pediatric patients with symptomatic sH,resolution of symptoms and resolution or improvement of cytopenias occurred after surgical treatment.

关键词： splenic hamartoma Pediatric splenoma Clinical features Radiological features Histopathology Treatment

Immunotherapy in the treatment of lymphoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of stem Cells 2021年第6期13卷 503-520页

作者： Lazar s popovic Gorana Matovina-Brko Maja popovic Milica popovic Ana Cvetanovic Ivan Nikolic Biljana Kukic Dragana Petrovic Department for Medical Oncology Oncology Institute of VojvodinaUniversity of Novi SadNovi Sad 21000Serbia Department for Medical Oncology Oncology Institute of VojvodinaNovi Sad 21000Serbia Department for Nephrology and Clinical Immunology Clinical Center of VojvodinaUniversity of Novi SadNovi Sad 21000Serbia Department for Medical Oncology Clinical Center of NisUniversity of NisNis 18000Serbia

Relapsed or refractory non-Hodgkin’s lymphomas,especially diffuse large B-cell lymphoma as well as relapsed or refractory Hodgkin lymphomas are hard-to-treat *** who do not respond to initial therapy or experience relapse are treated with salvage regimens,and if eligible for aggressive therapy,treatment is continued with high-dose chemotherapy and autologous stem cell *** therapy options can cure substantial numbers of patients,however for some it is still an uncurable *** new drugs and cell therapies are being investigated for the treatment of relapsed or refractory *** types of immunotherapy options have shown promising results,and some have already become the standard of ***,we review immunotherapy options for the treatment of lymphoma and discuss the results,positions,practical aspects,and future directions of different drugs and cellular therapies for the treatment of this disease.

关键词： Immunotherapy Receptors Chimeric antigen Antibodies Monoclonal Immunoconjugates Hodgkin disease Lymphoma Large B-cell Diffuse

Targeting triple-negative breast cancer:A clinical perspective

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2023年第3期31卷 221-238页

作者： LAZAR s.popovic GORANA MATOVINA-BRKO MAJA popovic KEVIN PUNIE ANA CVETANOVIC MATTEO LAMBERTINI Department of Medical Oncology Oncology Institute of VojvodinaSremska KamenicaSerbia Faculty of Medicine University of Novi SadNovi SadSerbia Department of General Medical Oncology and Multidisciplinary Breast Centre Leuven Cancer InstituteUniversity Hospitals LeuvenLeuvenBelgium Department for Oncology Medical Faculty NisUniversity of NisNisSerbia Clinic of Oncology Clinical Centre NisNisSerbia Department of Internal Medicine and Medical sciences(DiMI) School of MedicineUniversity of GenovaGenovaItaly Department of Medical Oncology U.O.C Clinica di Oncologia MedicaIRCCS Ospedale Policlinico San MartinoGenovaItaly

Triple-negative breast cancer(TNBC)is a disease with often an aggressive course and a poor prognosis compared to other subtypes of breast *** accounts for approximately 10%–15%of all diagnosed breast cancer cases and represents a high unmet need in the *** to just a few years ago,chemotherapy was the only systemic treatment option for this subtype(1).To date,TNBC is considered a heterogeneous *** of the existing classifications is based on the analysis of mRNA expression in 587 TNBC cases,in which Lehman et *** six subtypes of TNBC as follows:two basal-like(BL1 and BL2)subtypes,a mesenchymal(M)subtype,a mesenchymal stem-like(MsL)subtype,an immunomodulatory(IM)subtype,and a luminal androgen receptor(LAR)subtype(2).Later studies have demonstrated that the IM and MsL subtypes do not correlate with independent subtypes but reflect background expression by dense infiltration of tumor-infiltrating lymphocytes(TILs)or stromal *** to this finding,the classification of TNBC has been revised into the following four subtypes:basal 1,basal 2,LAR,and mesenchymal subtypes(3).Over the last years,several new strategies have been investigated for the treatment of patients with *** them,immunotherapy,antibody drug conjugates,new chemotherapy agents,and targeted therapy have been and are currently being *** present article aims to provide an updated overview on the different treatment options that are now available or are still under investigation for patients with TNBC.

关键词： Triple-negative breast cancer Immunotherapy Antibody-drug conjugates Target therapy

Dielectric and infrared properties of srTiO_3 single crystal doped by 3d (V,Mn,Fe,Ni) and 4f (Nd,sm,Er) ions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2014年第2期23卷 369-374页

作者： s.Maletic D.Maletic I.Petronijevic J.Dojcilovic D.M.popovic Faculty of Physics University of Belgrade Institute of Physics University of Belgrade

In this study, the effects of doping by 3d （V, Mn, Fe, Ni） and 4f （Nd, sm, Er） ions on dielectric and infrared properties of srTiO3 （sTO） single crystals are investigated. It is well known that doping of the srTiO3 can change the dielectric properties of the sTO from an insulator to an n-type semiconductor, and even to a metallic conductor. Dielectric and infrared （IR） properties of the undoped sTO and doped sTO single crystals are analyzed using dielectric spectroscopy （80 kHz-5 MHz）, transmission （200 cm^-1-4000 cm^-1）, and reflection spectroscopy （50 cm^-1-2000 cm^-1）. It is found that doping by the 3d ions reduces the value of dielectric permittivity, but the trend of temperature dependence of the dielectric permittivity remains almost unchanged. On the other hand, dielectric spectroscopy measurements for samples doped by 4f ions show the anomalous behaviors of the dielectric permittivity at temperatures around the temperature of the structural phase transition. There are two fractures of temperature dependences of inverse dielectric permittivity εr^-1 （T）. Transmittance spectroscopy measurements show that there are differences in the shape of the spectrum in the mid-IR region between the undoped sTO and the one doped by 4f ions. The differences in the reflectance spectrum between the sTO：Nd and sTO are analyzed in detail.

关键词： doping dielectric properties phase transitions infrared spectroscopy

Design and science:Content analysis of published peer-reviewed research over the last four decades

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Frontiers of Architectural Research 2023年第4期12卷 613-629页

作者： Milica Vujovic djordje stojanovic Tina selami Michael Hensel Faculty of Architecture and Planning Department of Digital Architecture and PlanningTU WienA-1060 ViennaAustria Faculty of Architecture Buliding and PlanningUniversity of MelbourneMelbourne VIC 3000Australia

The relationship between design and science in architecture continually receives attention from scholars,but to our knowledge,no substantial and systematic literature reviews have been undertaken to generate insights into how the relationship between the two has developed in recent *** most of the related debate remains theoretical,this paper presents evidence acquired through content analysis of selected 782 peer-reviewed papers published in the last four decades,a period in which design requirements continue to grow in complexity and research efforts increasingly concentrate on design *** response,this study departs from the two keywords,architectural science and building science,and develops search strings to support examination of the relationship between science and architectural design since the 1980s,when research that addresses the building environment started to *** analysis employs tools based on machine learning algorithms for text analytics in combination with traditional content analysis *** presented research method is fully replicable and stands as one of the contributions of this *** findings capture the expansion of the research context concerned with the built environment through a careful selection of defining terms,and generate an informed discussion on how the role of science in the architectural design process has changed.

关键词： Architectural science Building science Architectural design Content analysis Literature review

Response of Growth Dynamics of Two spring Geophytes to Light Regime in a Lime-Beech Forest

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2006年第5期48卷 527-535页

作者： Zorica popovic Aleksandar Mijovic Branko Karadzic Miroslava Mijatovic Institute of Biological Research Department of Ecology Despota Stefana Boulevard 142 11060 Belgrade Serbia and Montenegro Environment Protection Agency Ministry for Science and Environmental Protection Republic of Serbia Serbia and Montenegro

Blomaee accumulation, leaf longevity and growth rate of two spring forest geophytes, scllla blfolla L. and Arum maculatum L. were estimated separately for three size groups within each population of these species. Despite the differences in leaf longevity, both species showed a similar pattern of blomass accumulation In relation to their phenologles and reproductive demands. Eco-physlological acclimation to changing light environment was assumed through photosynthetic parameters and dynamics of leaf area Index In the predominant size group of each species. A light response curve was measured under natural light for each species through the continuum of Its phenology to quantify the photosynthetic photon flux density at light saturation, light-saturated photosynthetic rate, light compensation point, and dark respiration. Light-saturated assimilation per leaf area basis, dark respiration rate and light compensation points were significantly higher in s. blfolla relative to A. maculatum. However, the acclimation of photosynthesis that would respond to light changes in environment was not found in s. bifolla. In contrast, In A. maculatum a marked shift In the light dependence of photosynthesis through the season was noticed, which resulted In a strong photosynthetic acclimation to the low-light conditions. Accompanied by significant leaf area Index, this efficient low-light photosynthesis enabled greater leaf longevity, and consequently longer accumulative period to A. maculatum. From the different parameters that we determined （both photosynthetic acclimation and growth strategy） it would appear that these species belong to two distinct subgroups： s. blfolla to the early and A. maculatum to the late vernals.

关键词： biomass accumulation deciduous forests early and late vernals leaf area index (LAI) light response of photosynthesis spring geophytes.

热力学法在泵性能测试中的应用及与传统方法的比较

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

机械工程学报 2015年第10期51卷 189-196页

作者：刘鑫 KARNEY Bryan RADULJ djordje 王正伟清华大学水沙科学与水利水电工程国家重点实验室北京100084 清华大学热能工程系北京100084 多伦多大学土木工程系加拿大多伦多M5S1A4 Hydra Tek&Associates公司加拿大伍德桥L4L8S5

全球范围而言,水泵效率和性能的热力学测试方法大约于十多年前在工业领域开始得到大量应用,但目前在泵站测试中使用还不是很广泛。由于缺少直接的工业应用标准去保证热力学法测试结果的准确可靠,且多数泵站自身又缺乏足够经验来开展独... 详细信息

全球范围而言,水泵效率和性能的热力学测试方法大约于十多年前在工业领域开始得到大量应用,但目前在泵站测试中使用还不是很广泛。由于缺少直接的工业应用标准去保证热力学法测试结果的准确可靠,且多数泵站自身又缺乏足够经验来开展独立研究测试,所以迫切需要一些通用性的指导原则来推动相关领域的进展。通过对多城市多泵站的水泵效率测试和研究,本项目完成了41个泵站的152个城市供水水泵的性能测试。其中57个水泵同时使用了热力学法和传统方法。通过大量的现场测试,并与采用电磁流量计、超声波流量计等传统测试方法的对比,积累了许多关于热力学法和传统方法在水泵性能测试中的经验和技巧;测试研究成果进一步明确了热力学法的适用条件和范围,通过对实测中遇到的各种情况的处理和总结,提出了热力学方法的通用性指导应用原则。

关键词：热力学法水力法水泵效率水泵流量测试