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Geochemical,mineralogical and sedimentological analyses of reworked sediments(new)in the syn-to post-rift Middle Cretaceous-Quaternary detrital deposits from western Atlantic margin of Cameroon:evidence from sedimentation-erosion alternation in the cont

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Acta Geochimica 2021年第5期40卷 676-701页

作者： Milan Stafford Tchouatcha Arnaud patrice Kouske Amr Said Deaf Arthur Paterne Mioumnde Department of Earth Sciences University of DschangP.O.Box 67DschangCameroon Higher Institute of Chemistry and Management P.O.Box 4789YaoundeCameroon University Institute of Technology University of DoualaP.O.Box 8698DoualaCameroon Department of Geology Faculty of ScienceAssiut UniversityAsyut 71516Egypt Institute for Geological and Mining Research B.P.4110Yaounde´Cameroon

Reworked detrital sediments were discovered in the syn-rift to post-rift Cretaceous to Quaternary(Pleistocene)detrital deposits of the Douala coastal sub-basin in the eastern margin of the South Atlantic Ocean at West *** contribution presents the geochemical,mineralogical,and sedimentological data to constrain the origin of these reworked *** investigated samples are characterized by the high values of Plagioclase Index of Alteration(PIA,97.83–99.90),Chemical Index of Alteration(CIA,71.9–99.08),and Chemical Index of Weathering(CIW,98.67–99.90).Data gleaned from these indices suggest that the reworked sediments and their potential source rocks experienced severe *** A-CN-K plot along with the mineralogical indicates a probably post-depositional *** high light rare earth elements(LREE)/heavy rare earth elements(HREE)ratios(15.82–79.13)suggest that the reworked were mainly derived from felsic igneous *** interpretation is further confirmed by the Zr versus TiO2,TiO2/Al2O3,Th/Co versus La/Sc,and La/Th versus Th/Yb plots,which indicate felsic igneous and silicic source ***,the high variability of LREE/HREE ratios(15.82–79.13)and the positive Eu anomalies(1.10–1.32)of studied samples could indicate a little contribution of mafic source *** of the distribution of the heavy minerals(***,aluminum silicate,and rutile)revealed that these felsic and silicic source rocks are mainly granite and gneiss,probably belonging to the Nyong Group and the Western part of the Neoproterozoic Yaounde *** morphoscopic analyses of the host rocks(very angular to angular shapes)have revealed that the reworked sediments have proximal to subproximal onshore origins,probably from former sedimentary deposits,as is indicated by variation of their *** tectonic discriminant diagram indicates the Oceanic Island Arc and Active Continental Margin which are inconsistent with the geological history of the Doual

关键词： Reworked sediments Geochemistry Mineralogy Sedimentology Nyong and yaoundégroups Douala coastal sub-basin Cameroon

A comparative analysis of spontaneous fertility after myomectomy by laparotomy associated or not with a“second look”laparoscopy

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Laparoscopic, Endoscopic and Robotic Surgery 2019年第2期2卷 27-30页

作者： Etienne Belinga Daniel Antony Bikak djima Bruno Ela Ondo Esther Juliette Ngo Um Meka Emile Telesphore Mboudou Pascal Foumane Department of Obstetrics and Gynecology Faculty of Medicine and Biomedical Sciencesthe University of Yaounde ICameroon Higher Institute of Health Sciences University of the MountainsCameroon Department of Epidemiology Higher Institute of Health SciencesUniversity of the MountainsCameroon

Objective:The importance of a“second look”laparoscopy for adhesion formation after myomectomy by laparotomy in improving fertility is not clearly defined in our *** aim of this study was to compare spontaneous fertility after myomectomy by laparotomy between women who underwent a“second look”laparoscopy and those who did ***:We conducted an analytical cross-sectional study with retrospective data collection from January 1,2008 to December 31,2015,comparing spontaneous fertility between patients who underwent“second-look”laparoscopy after myomectomy by laparotomy to those who did ***,data was collected from the records of patients included in the ***,through phone calls,informed consent for each participant was obtained after which inquiries were made regarding their fertility ***:After a period of 24 months,23 patients(47.9%)with“second look”laparoscopy conceived,compared to 37 patients(35.2%)without“second look”laparoscopy(p=0.136);and 24 patients(50.0%)with“second look”had term pregnancies compared to 39 patients(37.1%)without“second look”laparoscopy(p=0.134).Conclusion:Spontaneous fertility rates seemed to be improved after a“second look”laparoscopy,however,there was no statistically significant difference between spontaneous fertility rates obtained after myomectomy by laparotomy,irrespective of the fact that the patient had undergone a“second look”laparoscopy or not at Yaounde Gyneco-Obstetric and Pediatric Hospital.

关键词： Myomectomy Laparotomy Infertility Adhesions “Second look”laparoscopy

银铜双金属/组氨酸功能化石墨烯量子点/石墨烯杂化物的制备及其在电化学法测定黄瓜中毒死蜱、克百威和多菌灵上的应用

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理化检验（化学分册） 2022年第9期58卷 1063-1070页

作者：徐丹 djima Hassan Ali 李瑞怡李在均江南大学化学与材料工程学院无锡214122 南京中医药大学翰林学院泰州225300 江南大学生命科学与健康工程学院无锡214122

为了提高金属纳米粒子在石墨烯片上的分散度,通过组氨酸功能化石墨烯量子点(His-GQD)作为桥梁,设计合成银铜双金属/His-GQD/石墨烯杂化物(AgCu/His-GQD/G)。His-GQD通过π-π堆积作用固定到氧化石墨烯上,然后与银离子和铜离子结合形成... 详细信息

为了提高金属纳米粒子在石墨烯片上的分散度,通过组氨酸功能化石墨烯量子点(His-GQD)作为桥梁,设计合成银铜双金属/His-GQD/石墨烯杂化物(AgCu/His-GQD/G)。His-GQD通过π-π堆积作用固定到氧化石墨烯上,然后与银离子和铜离子结合形成复合物,最后在氮气保护下热还原获得AgCu/His-GQD/G。形成的杂化物表现出独特的三维结构,且银、铜纳米粒子均匀分散在石墨烯片上。基于该杂化物构建了电化学适配体传感器,适配体与杂化物上的银、铜纳米粒子通过Ag-N和Cu-N键连接而修饰到电极表面上,用于毒死蜱、克百威和多菌灵的测定,表现出高的灵敏度和选择性。毒死蜱、克百威和多菌灵标准曲线的线性范围分别为1.00×10^(-2)~1.00×10^(3)pmol·L^(-1)、1.00×10^(-1)~1.00×10^(4)pmol·L^(-1)和1.00~1.00×10^(6)pmol·L^(-1),检出限(3S/N)分别为3.2×10^(-3)pmol·L^(-1)、2.3×10^(-2)pmol·L^(-1)和2.9×10^(-1)pmol·L^(-1)。该适配体传感器用于黄瓜样品中克百威、毒死蜱和多菌灵的测定,仅检出多菌灵,检出量为1.21 pmol·L^(-1)和1.25 pmol·L^(-1);并按标准加入法进行回收试验,回收率为99.3%~100%。

关键词：银铜双金属/组氨酸功能化石墨烯量子点/石墨烯杂化物电化学适配体传感器农药残留黄瓜

Have some landscapes in the eastern Canadian boreal forest moved beyond their natural range of variability?

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Forest Ecosystems 2018年第4期5卷 412-428页

作者： Pierre Grondin Sylvie Gauthier Veronique Poirier patrice Tardif Yan Boucher Yves Bergeron Direction de la Recherche Forestiere Ministere des Foretsde la Faune et des Pares (MFFP)2700rue EinsteinQuebecQC GIP 3W8Canada Ressources Naturelles Canada/Natural Resources Canada Service Canadien des forets/Canadian Forest ServiceCentre de foresterie des Laurentides/Laurentian Forestry Center1055 rue du P.E.P.SQuebecQC G1V 4C7 Canada Institut de Recherche sur les Forets Universite du Quebec en Abitibi-Temiscamingue445boul.de I'UniversiteRouyn-NorandaQC J9X 5E4Canada Centre d'etude de la Foret Universite du QuebecMontreal CP 8888succ AMontrealQC H3C 3P8Canada

Background: In the contxt of ecosystem management, the present study aims to compare the natural and the present-day forested landscapes of a large territory in Quebec(Canada). Using contemporary and long-term fire cycles, each natural forst landscape is defined according to the variability of its structure and composition, and compared to the present-day landscape. This analysis was conducted to address the question of whether human activities have moved these ecosystems outside the range of natural landscape ***: The study encompassed a forested area of 175 000 km2 divided into 14 landscapes. Using a framework that integrates fire cycles, age structure and forest dynamics, we characterized the forest composition and age structures that resulted from three historical fire cycles(110,140, and 180 years) representative of the boreal forest of eastern Canada. The modeled natural landscapes were compared with present-day landscapes in regard to the proportion of old-growth forests(landscape level) and the proportion of late-successional forest stands(landscape level and potential vegetation type).Results: Four landscapes(39%) remain within their natural range of variability. In contrast, nine landscapes(54%)show a large gap between natural and present-day landscapes. These nine are located in the southern portion of the study area, and are mainly associated with Abies-Betula vegetation where human activities have contributed to a strong increase in the proportion of Populus tremuloides stands(early-successional stages) and a decrease of oldgrowth forest stands(more than 100 years old). A single landscape(7%), substantially changed from its potential natural state, is a candidate for adaptive-based ***: Comparison of corresponding natural(reference conditions) and present-day landscapes showed that ten landscapes reflecting an important shift in forest composition and age structure could be considered beyond the range of their natural v

关键词： Ecosystem management Reference conditions Natural variability Resilience Fire cycle Age structure Forest dynamics Potential vegetation type Landscape ecology Theoretical natural landscape Present-day landscape

Non-linear optimal control for multi-DOF electro-hydraulic robotic manipulators

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IET Cyber-Systems and Robotics 2020年第2期2卷 96-106页

作者： Gerasimos Rigatos Nikolaos Zervos Masoud Abbaszadeh Jorge Pomares patrice Wira Unit of Industrial Automation Industrial Systems Institute26504Rion PatrasGreece Unit of Digital Communications Industrial Systems Institute26504Rion PatrasGreece GE Global Research General Electric12309 New YorkUSA Department of Systems Engineering University of Alicante03690 AlicanteSpain IRIMAS Universitéd’Haute Alsace68093MulhouseFrance

A non-linear optimal(H-infinity)control approach is proposed for the dynamic model of multi-degree-of-freedom(DOF)electro-hydraulic robotic *** of electro-hydraulic manipulators is a non-trivial problem because of their non-linear and multi-variable *** this study,the considered robotic system consists of a multi-link robotic manipulator that receives actuation from rotary electro-hydraulic *** article's approach relies first on approximate linearisation of the state-space model of the electro-hydraulic manipulator,according to first-order Taylor series expansion and the computation of the related Jacobian *** the approximately linearised model of the manipulator,a stabilising H-infinity feedback controller is *** compute the controller's gains,an algebraic Riccati equation is solved at each time-step of the control *** global stability properties of the control scheme are proven through Lyapunov *** proposed control method retains the advantages of typical optimal control,*** and accurate tracking of the reference setpoints under moderate variations of the control inputs.

关键词： manipulators robotic optimal

Relationships between soil seed banks and above-ground vegetation along a disturbance gradient in the W National Park trans-boundary biosphere reserve,West Africa

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Journal of Plant Ecology 2017年第2期10卷 349-363页

作者： patrice Savadogo Lassina Sanou SDjibril Dayamba Fidele Bognounou Adjima Thiombiano World Agroforestry Centre and International Crop Research Institute for the Semi-Arid Tropics(ICRAF-ICRISAT) West and Central Africa Region-Sahel NodeBP 12404 NiameyNiger Centre National de la Recherche Scientifique et Technologique INERADépartement Productions Forestières03 BP 7047Ouagadougou 03BurkinaFaso Unitéde Formation et de Recherche en Sciences de la Vie et de la Terre/Laboratoire de Biologie et Ecologie Végétales(UFR/SVT) Universitéde Ouagadougou03 BP 7047Ouagadougou 03BurkinaFaso World Agroforestry Centre(ICRAF) West and Central Africa Regional Office-Sahel NodeBP E5118 BamakoMali Département des Sciences Biologiques Université´du QuébecàMontréal2080 rue Saint Urbain8888Montréal QC H3C 3P8Canada

Aims Vegetation succession depends on the availability of suitable prop-agules in the soils,thus knowledge of soil seed banks is essential for formulating effective strategies for restoring the vegetation of degraded *** W National Park,the only trans-boundary bio-sphere reserve in West Africa,is being extensively fragmented and degraded in recent *** aims of this study were to assess the reserve’s soil seed banks,their relationships with standing veg-etation and bundle of disturbances and their potential significance for vegetation *** The size and composition of the above-ground species vegetation were assessed in nine plots of 1 ha each representing a range of habitats with differing disturbance severity(low,intermediate and high).A total of 702 soil samples were taken from three layers(0-3,3-6 and 6-9 cm)and soil seed bank was analyzed using the seed-ling emergence *** Findings Generally,seeds of non-woody taxa dominated in samples from all soil depths and habitats of all disturbance *** mean soil seed density was 17.8,24.4 and 26.3 seeds/dm^(3) in samples from the least,intermediate and most disturbed sites,respectively,and highest in the upper soil layers in all *** results indi-cate that there is limited potential for restoring woody vegetation solely from soil seed banks,and that woody species in the region rely more on recently shed seeds trapped in the standing dead biomass and litter on the ground than soil seed banks for ***,human intervention is needed to accelerate forest recovery,mainly through alleviating anthropogenic impacts on the ecosystem(for instance,avoiding destruction of new seeds by intense fire),and site manipulation to improve environmen-tal conditions for seedling establishment and *** ways of restoring forests than through the soil seed bank(*** seeds collected elsewhere,and planting tree seedlings)could also be relevant.

关键词： disturbance savanna-woodland restoration regeneration seed bank vegetation degradation West Africa

Immune precision medicine for cancer:a novel insight based on the efficiency of immune effector cells

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Cancer Communications 2019年第1期39卷 318-333页

作者： Jean-François Rossi patrice Céballos Zhao-Yang Lu Institut Sainte Catherine 84918 AvignonFrance UniversitéMontpellier 1 UFR Médecine34396 MontpellierFrance Département d’Hématologie CHU de Montpellier34295 MontpellierFrance Unitéde Thérapie Cellulaire CHU Saint-Eloi34295 MontpellierFrance

Cancer cell growth is associated with immune surveillance ***,restoring the desired immune response against cancer cells remains a major therapeutic *** to the recent advances in biological knowledge,efficient therapeutic tools have been developed to support the best bio-clinical approaches for immune precision *** of the most important successes in immune therapy is represented by the applicational use of monoclonal antibodies,particularly the use of rituximab for B-cell lymphoproliferative *** recently,other monoclonal antibodies have been developed,to inhibit immune checkpoints within the tumor microenvironment that limit immune suppression,or to enhance some immune functions with immune adjuvants through different targets such as Toll-receptor *** aim is to inhibit cancer proliferation by the diminishing/elimination of cancer residual cells and clinically improving the response duration with no or few adverse *** effect is supported by enhancing the number,functions,and activity of the immune effector cells,including the natural killer(NK)lymphocytes,NKT-lymphocytes,γδT-lymphocytes,cytotoxic T-lymphocytes,directly or indirectly through vaccines particularly with neoantigens,and by lowering the functions of the immune suppressive *** these new therapeutics and their personalized usage,new considerations have to be taken into account,such as epigenetic regulation particularly from microbiota,evaluation of transversal functions,particularly cellular metabolism,and consideration to the clinical consequences at the body *** aim of this review is to discuss some practical aspects of immune therapy,giving to clinicians the concept of immune effector cells balancing between control and *** precision medicine is a combination of modern biological knowledge and clinical therapeutic decisions in a global vision of the patient.

关键词： Precision therapy Immunotherapy NK lymphocytes T-lymphocytes Dendritic cells Vaccination Cancer

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The sisters Mederos

The sisters Mederos

Endothelin increases the proliferation of rat olfactory mucosa cells

作者： patrice Sarath.

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Neural Regeneration Research 2020年第2期15卷 352-360页

作者： Bertrand Bryche Audrey Saint-Albin Claire Le Poupon Schlegel Christine Baly patrice Congar Nicolas Meunier Neurobiologie de l'olfaction Institut National de Recherche Agronomique (INRA)Université Paris-SaclayJouy-en-JosasFrance Université de Versailles Saint-Quentin en Yvelines Département de BiologieVersaillesFrance

The olfactory mucosa holds olfactory sensory neurons directly in contact with an aggressive environment. In order to maintain its integrity, it is one of the few neural zones which are continuously renewed during the whole animal life. Among several factors regulating this renewal, endothelin acts as an anti-apoptotic factor in the rat olfactory epithelium. In the present study, we explored whether endothelin could also act as a proliferative factor. Using primary culture of the olfactory mucosa, we found that an early treatment with endothelin increased its growth. Consistently, a treatment with a mixture of BQ123 and BQ788(endothelin receptor antagonists) decreased the primary culture growth without affecting the cellular death level. We then used combined approaches of calcium imaging, reverse transcriptase-quantitative polymerase chain reaction and protein level measurements to show that endothelin was locally synthetized by the primary culture until it reached confluency. Furthermore, in vivo intranasal instillation of endothelin receptor antagonists led to a decrease of olfactory mucosa cell expressing proliferating cell nuclear antigen(PCNA), a marker of proliferation. Only short-term treatment reduced the PCNA level in the olfactory mucosa cells. When the treatment was prolonged, the PCNA level was not statistically affected but the expression level of endothelin was increased. Overall, our results show that endothelin plays a proliferative role in the olfactory mucosa and that its level is dynamically regulated. This study was approved by the Comité d’éthique en expérimentation animale COMETHEA(COMETHEA C2 EA-45;protocol approval #12-058) on November 28, 2012.

关键词： autocrine factor cell culture cellular dynamics endothelin olfaction olfactory basal cells olfactory epithelium olfactory mucosa primary culture