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LC-MS Identification and Preliminary Pharmacological Study of the Aqueous and Ethanol Extracts from Combretum glutinosum Perr ex DC.(Combretaceae)

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Clinical Complementary Medicine and Pharmacology 2023年第4期3卷 49-59页

作者： Placide Mahougnan Toklo Mathias Amour Ahomadegbe Durand Dah-nouvlessounon Jean-Bosco Jouda Billy Toussie Tchegnitegni Steven Collins Njonte Wouamba djidénou ahoton Mahoudo Fidèle Assogba Joseph Tchamgoue Bruno Ndjakou Lenta Simeon Fogue Kouam Lamine Baba-Moussa Eléonore Chikani Yayi Ladekan Joachim Djimon Gbenou Laboratoire de Pharmacognosie et des Huiles Essentielles Département de ChimieFacultés des Sciences et TechniquesISBAUniversitéd’Abomey CalaviCotonou 01 BP:918Benin Laboratoire de Biologie et de Typage Moléculaire en Microbiologie Facultédes Sciences et TechniquesUniversitéd’Abomey-CalaviCotonou 01 BP:526Benin Department of Chemical Engineering School of Chemical Engineering and Mineral IndustriesNgaoundéréP.O.Box 454Cameroon Department of Chemistry Faculty of ScienceUniversity of DschangDschangP.O.Box 67Cameroon Department of Chemistry Higher Teacher Training CollegeUniversity of Yaounde I4124 YaoundeP.O.Box 47Cameroon Département de Chimie Facultés des Sciences et TechniquesUniversitéNationale des SciencesTechnologiesIngénierie et MathématiquesGoho Abomey BP:2282Benin

Background:Combretum glutinosum is a plant whose leaves are consumed as a vegetable and used in traditional medicine for the treatment of microbial ***:The present study was designed to identify the compounds in *** leaves extracts,and evaluate its antimicrobial activity,antioxidant ability and its toxicity in Artemia salina larvae in ***:The aqueous and ethanol extracts obtained from the leaves of the plant as well as known compounds previously isolated and characterized from the leaves of *** were tested on eleven different microbial *** antioxidant activity of the extracts was evaluated by the Ferric Reducing Antioxidant Power method and the larval toxicity on Artemia salina larvae was also *** screening and HPLC-DAD-HRESI-MS analysis were performed on the extracts to characterize its chemical ***:When tested at a concentration of 20 mg‧mL^(−1),the extracts of *** leaves strongly inhibited the growth of the bacterial strains with an inhibition diameter ranging from 7.25 mm to 44 mm,superior to those of the positive controls(tetracycline at 30μg‧mL^(−1)and amikacin at 30μg‧mL^(−1)),inhibition diameters from 15 mm to 33 *** evaluated larval toxicity demonstrated that it had no harmful effects on Artemia salina *** extracts present a good antioxidant activity at a concentration of 0.17 and 1.33 mmol ascorbic acid(per gram of extract)for the aqueous and ethanol extracts,***,none of the compounds tested at 500μg‧mL^(−1)were able to show good activity on the 11 reference *** analysis revealed the presence of alkaloids,polyphenols,steroids,triterpenoids,reducing compounds,*** both *** HPLC-DAD-HRESI-MS analyses revealed 18 compounds in the ethanol extract,from which 3 were identified,15 compounds in the aqueous extract from which 5 could be ***:The present work has shown that *** extracts can

关键词： Combretum glutinosum HPLC-DAD-HRESI-MS Antimicrobial activity Antioxidant activity Larval toxicity

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