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Epidemiological and Clinical Profile of Patients Undergoing Primary nephrological Consultation at the Fousseyni DAOU Hospital in Kayes, Mali

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Open Journal of nephrology 2022年第1期12卷 142-153页

作者： Magara Samaké Seydou Sy Aboubacar Sidiki Fofana Hamadoun Yattara Sah Dit baba Coulibaly djénéba Diallo nanko Doumbia Moctar Coulibaly Kodio Atabieme djénéba maiga Aboudou Messoum Dolo nouhoum Coulibaly Saharé Fongoro nephrology Unit Fousseyni DAOU Hospital Kayes Mali national Center for Scientific and Technological Research (CnRST) Bamako Mali nephrology and Hemodialysis Department Point G Teaching Hospital Bamako Mali Faculty of Medicine of bamako University of Bamako Bamako Mali nephrology Unit Somine DOLO Hospital Mopti Mali Department of Medicine Mali Hospital Bamako Mali nephrology Unit Mali GAVARDO Hospital Sebenicoro Bamako Mali nephrology Unit Sikasso Hospital Sikasso Mali

Introduction: The first nephrological consultation is often late, even in developed countries. This delay is related to the insidious nature of renal disease, the lack of qualified personnel and structures for the management of these conditions and the context of chronic insecurity in our country. In Kayes, there is no data related to the first consultations of patients with the nephrologist, hence the interest of this study, which aimed to describe the epidemiological and clinical characteristics of patients undergoing a first nephrological consultation in Kayes hospital. Materials and methods: This was a retrospective, descriptive study conducted from January 1 to December 31, 2020 at the nephrology unit of the Fousseyni DAOU hospital in Kayes. All patients received for nephrological consultation for whom a medical record was made were included. The following data were collected and analyzed: the specialty of the medical referent, the reason for consultation, sociodemographic characteristics and the renal assessment of patients. Patients who consulted for non-nephrological pathologies and those who had no medical record were not included. Results: We collected the records of 346 patients, composed of 180 (52%) women and 166 (48%) men, i.e. a sex ratio of 0.92. The age group [20 - 40 years] was the most represented, 107 cases or 30.9%, with a mean age of 48.84 ± 21.33 years and extremes of 1 and 90 years. Housewives were the most consulted population, 149 cases (41.33%). Patients consulted more between the months of January and February, 116 cases (33.5%), this period was followed by the months of October-December, July-September and April-June with respectively 94 cases (27.2%), 76 cases (22.0%) and 60 cases (17.3%). The patients were referred by the general practitioner in 59.5% (209 cases), specialist doctor, 26.0% (90 cases). The patients came mainly from hospital practitioners, 172 cases (49.7%), private clinic and practice 81 cases (23.4%), community health c

关键词： Primary Consultation nephrology Kayes Mali

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Acute Renal Failure Secondary to Paracetamol Intoxication: A Case Report

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Open Journal of nephrology 2022年第3期12卷 235-240页

作者： Moctar Coulibaly Magara Samaké Konaré Samba Fofana Aboubacar Sidiki Ossil Ampion Marc batcho Jimmy Mansour Janette Seydou Sy Hamadoun Yattara Atabième Kodio djénéba maiga Sah Dit baba Coulibaly djénèba Diallo Aboudou M. Dolo Moustapha Tangara nouhoum Coulibaly Kalilou Coulibaly Ibrahima Koné Saharé Fongoro nephrology Unit of Mali GAVARDO Hospital in Sebénicoro Bamako Mali nephrology Unit of the Fousseyni DAOU Hospital Kayes Mali national Center for Scientific and Technological Research (CnRST) Bamako Mali nephrology Department of the Soissons Hospital Soissons France nephrology and Hemodialysis Department of the UHC du Point G Bamako Mali Faculty of Medicine of bamako Bamako Mali nephrology Unit of Sikasso Hospital Sikasso Mali nephrology Unit of Somino DOLO Hospital Mopti Mali

Renal damage secondary to paracetamol intoxication is rare, estimated between 1% and 2% of intoxication cases. Its pathophysiology is still debated, the clinical involvement consisting in an acute tubular necrosis with a good prognosis if it is rapidly treated. Renal damage can sometimes occur without prior hepatic damage, and the onset of renal manifestations is generally between the 2nd and 7th day after taking paracetamol. If its management remains exclusively symptomatic, its late onset can sometimes lead to serious metabolic complications. It is therefore important to systematically monitor renal function following paracetamol drug intoxication. We report the case of a 60-year-old male subject hospitalized for the management of voluntary drug intoxication (VDI) with paracetamol complicated by acute hepatocellular failure and acute renal failure. His management required extrarenal purification (hemodialysis) and the evolution was favorable with recovery ad integrumof renal function. Conclusion: Although less known and of unelucidated physiopathology, nephrotoxicity secondary to voluntary drug intoxication with paracetamol is a reality and can lead in extreme cases to the use of extrarenal purification technique (hemodialysis).

关键词： Acute Renal Failure Paracetamol Intoxication Hemodialysis

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Comprehensive Evaluation Method for Traffic Flow Data Quality based on Grey Correlation Analysis and Particle Swarm Optimization

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Journal of Systems Science and Systems Engineering 2024年第1期33卷 106-128页

作者： Wei ba baojun Chen Qi Li School of Automation and Electrical Engineering Dalian Jiaotong UniversityDalian116028China Faculty of Electronic Information and Electrical Engineering Dalian University of TechnologyDalian116023China

nowadays,data are more and more used for intelligent modeling and prediction,and the comprehensive evaluation of data quality is getting more and more attention as a necessary means to measure whether the data are usable or ***,the comprehensive evaluation method of data quality mostly contains the subjective factors of the evaluator,so how to comprehensively and objectively evaluate the data has become a bottleneck that needs to be solved in the research of comprehensive evaluation *** order to evaluate the data more comprehensively,objectively and differentially,a novel comprehensive evaluation method based on particle swarm optimization(PSO)and grey correlation analysis(GCA)is presented in this *** first,an improved GCA evaluation model based on the technique for order preference by similarity to an ideal solution(TOPSIS)is ***,an objective function model of maximum difference of the comprehensive evaluation values is built,and the PSO algorithm is used to optimize the weights of the improved GCA evaluation model based on the objective function ***,the performance of the proposed method is investigated through parameter analysis.A performance comparison of traffic flow data is carried out,and the simulation results show that the maximum average difference between the evaluation results and its mean value(MDR)of the proposed comprehensive evaluation method is 33.24%higher than that of TOPSIS-GCA,and 6.86%higher than that of *** proposed method has better differentiation than other methods,which means that it objectively and comprehensively evaluates the data from both the relevance and differentiation of the data,and the results more effectively reflect the differences in data quality,which will provide more effective data support for intelligent modeling,prediction and other applications.

关键词： Data quality comprehensive evaluation particle swarm optimization grey correlation analysis traffic flow data

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Digestive Pathologies during Chronic Renal Failure in the nephrology and Haemodialysis Department at the University Hospital Center of Point G in Mali

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Open Journal of Clinical Diagnostics 2020年第1期10卷 41-48页

作者： Magara Samaké Seydou Sy Hamadoun Yattara Moctar Coulibaly Mamadou badou Sanogo Aboubacar Sidiki Fofana Aboudou Messoum Dolo djénéba maiga djénéba Diallo Atabieme Kodio bakary Diarra Karamoko djiguiba djibril Sy Saharé Fongoro nephrology Unit of the Fousseyni DAOU Hospital Kayes Mali nephrology and Haemodialysis Department of the CHU of Point G Bamako Mali Faculty of Medicine of bamako University of Bamako Bamako Mali nephrology Unit of Mali GAVARDO Hospital Bamako Mali nephrology Unit of the Sikasso Regional Hospital Sikasso Mali nephrology Unit of the Mother and Child Hospital The Luxembourg Bamako Mali Internal Medicine Service of the University Hospital Center of Point G Bamako Mali

Introduction: Chronic kidney disease (CKD) is the progressive and irreversible loss of kidney function. It exposes to many complications, among which, digestive complications. In Mali, we do not have data on the prevalence of digestive pathologies in people with chronic renal failure, hence the interest of this study. Objective: To determine the prevalence of digestive pathologies and to describe their manifestations during chronic renal failure. Patients and Methods: This was a prospective cross-sectional study conducted from September 2016 to August 2017, a period of 12 months. Included were patients hospitalized in our department with CKD who received digestive endoscopy and/or liver serology. Results: Seventy-one patients underwent digestive endoscopy with oesogastroduodenal fibroscopy (60 patients), rectoscopy (6 patients) and anoscopy (5 patients), i.e. 15.9% of those hospitalized. The mean age of the patients was 48 ± 14 years with extremes of 15 and 84 years. The sample consisted of 59.2% men versus 40.8% women, for a sex ratio of 1.5. The functional signs are in order of frequency: vomiting (72.4%), anorexia (51.3%) and epigastralgia (48.7%). Terminal CKD by creatinine clearance accounted for 88.2% of cases, of which 47.4% were monitored by hemodialysis. Hepatitis C virus infection was present in 21.3% of cases, hepatitis B (18%) and HIV (7.5%). Endoscopic examinations were represented by fibroscopy (84.5%), rectoscopy (8.5%) and anuscopy (7%). The fibroscopic lesions were respectively gastric (96.8%), duodenal (14.1%) and esophageal (12.5%). They were dominated by gastritis (40.5%), duodeno-gastric reflux (16.4%), pyloric gap (12.6%). Rectoscopy found 4 cases of hemorrhoids, 2 cases of rectitis and no lesions were observed at anuscopy. Conclusion: The prevalence of these digestive manifestations and the endoscopic lesions encountered indicate the importance of digestive endoscopy and the performance of hepatic serologies in chronic renal failure patients w

关键词： Chronic Renal Failure Digestive Signs Mali

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Interest of Beta-2-Microglobilin Plasma Assay in Iterative Haemodialysis in the nephrology and Haemodialysis Department of University Teaching Hospital of Point G, bamako, Mali

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Open Journal of nephrology 2020年第4期10卷 282-289页

作者： Saharé Fongoro Magara Samaké Seydou Sy Hamadoun Yattara djénèba Diallo Jacques Coulibaly Moctar Coulibaly Aboubacar Sidiki Fofana Atabième Kodio djénéba maiga Aboudou M. Dolo Moustapha Tangara nouhoum Coulibaly Brahima Dégoga Ibrahima Koné nephrology and Haemodialysis Department of the University Teaching Hospital of Point-G Bamako Mali Faculty of Medicine of bamako Bamako Mali nephrology Unit of the Fousseyni DAOU Hospital in Kayes Kayes Mali nephrology Unit of Ségou Hospital Ségou Mali nephrology Unit of the Mali GAVARDO Hospital of Sébénicoro Bamako Mali nephrology Unit of Sikasso Hospital Sikasso Mali nephrology Unit of Somino DOLO Hospital in Mopti Mopti Mali

Beta-2-microglobulin (B2M) is a low molecular weight polypeptide (11,800 Da) that exists in a free form and a form bound to cell membranes (light chains of HLA class I molecules). Their dosage is used in the exploration and monitoring of renal function in haemodialysis patients, hence the interest of this study, the objective of which is to study the different players involved in the increase of beta-2-microglobulin. ng>Materials and Methods:ng> This was a prospective and descriptive study from January 1st, 2017 to August 31, 2017 (08 months). All patients with chronic hemodialysis for 3 years or more were included. We analyzed sociodemographic, clinical and paraclinical data. ng>Results:ng> We collected 50 patients. The mean age was 50 ± 4.6 years with extremes of 30 and 82 years. The female sex predominated (52%). Chronic end-stage renal failure was hypertensive (86%), diabetic (4%). All patients benefited from intermittent hemodialysis for 8 hours per week using a low permeability membrane (cuprophane). The average duration of hemodialysis was 68 ± 6.4 months with extremes of 36 and 204 months. Twenty percent (20%) and four percent (4%) of chronic dialysis patients had joint pain and sensory deficit. Phalen’s sign was positive in 2% (1 case), Tinel’s sign in 2% (1 case) and carpal tunnel syndrome in 2% (1 case). The mean serum beta-2-microglobulin level was 58.34 ng/l with extremes of 16.99 and 112.24 ng/l. There was a correlation between hypertensive nephropathies and beta-2-microglobulin levels above 50 ng/l (P ng>Conclusion:ng> Our study has objectified factors such as inadequate dialysis (8 hours/week), use of low permeability membrane in the increase of beta-2-microglobulin. The increase in serum beta-2-microglobulin levels in our patients is evidence of poor purification of medium molecules. Its reduction can be established by improving the quality of dialysis, in particular by

关键词： Chronic Hemodialysis Beta-2-Microglobulin Carpal Tunnel Syndrome

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Kidney Damage during Sharp’s Syndrome: About Two Cases

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Open Journal of nephrology 2020年第4期10卷 290-297页

作者： Saharé Fongoro Seydou Sy Magara Samaké Hamadoun Yattara Moctar Coulibaly Aboubacar Sidiki Fofana Brahima Dégoga Atabième Kodio Eyram Yoan Makafui Amekoudi djénèba Diallo djénéba maiga Aboudou M. Dolo Moustapha Tangara nouhoum Coulibaly Kalilou Coulibaly Ibrahima Koné nephrology and Haemodialysis Department of the University Teaching Hospital of Point-G Bamako Mali Faculty of Medicine of bamako Bamako Mali nephrology Unit of the Fousseyni DAOU Hospital in Kayes Kayes Mali nephrology Unit of the Mali GAVARDO Hospital Bamako Mali nephrology Unit of Sikasso Hospital Sikasso Mali nephrology Unit of Somino DOLO Hospital in Mopti Mopti Mali

Context: The coexistence in the same patient of a mixed connectivitis or Sharp’s syndrome is a rare eventuality. Objective: To underline the presence of this mixed connectivitis in our practice, whose prevalence rema... 详细信息

ng>Context:ng> The coexistence in the same patient of a mixed connectivitis or Sharp’s syndrome is a rare eventuality. ng>Objective:ng> To underline the presence of this mixed connectivitis in our practice, whose prevalence remains unknown, particularly in Africa and more precisely in Mali. ng>Case Presentations:ng> We report two cases of Sharp’s syndrome in a 48-year-old man and a 40-year-old woman with impaired renal function. The picture achieved associated massive proteinuria, hypoalbuminemia, moderate renal failure and edematous syndrome in men. In women, the picture was associated with accelerated to malignant hypertension and severe renal failure. There were no osteoarticular manifestations and the diagnosis of Sharp’s syndrome was based on the presence of high levels of antibodies to U1RnP. Therapeutic management has been that of predominantly associated connective tissue disease (systemic lupus erythematosus). ng>Conclusion:ng> Mixed connectivitis or Sharp’s syndrome is increasingly recognized as a separate entity thanks to advances in molecular biology. Its prevalence is low in sub-Saharan African countries with renal disease that manifests itself as proteinuria or nephrotic syndrome associated with microscopic hematuria, renal failure, and hypertension. This renal impairment is more likely to occur in severe forms of the disease.

关键词： Sharp Syndrome/Mixed Connectivitis Renal Failure Mali

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Physics-based seismic analysis of ancient wood structure:fault-to-structure simulation

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 727-740页

作者： ba Zhenning Fu Jisai Wang Fangbo Liang Jianwen Zhang Bin Zhang Long State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation (Tianjin University)Tianjin 300350China School of Civil Engineering Tianjin UniversityTianjin 300350China Administrative Office of the Summer Palace Beijing 100091China School of Architecture Tianjin UniversityTianjin 300072China

based on the domain reduction method,this study employs an SEM-FEM hybrid workflow which integrates the advantages of the spectral element method(SEM)for flexible and highly efficient simulation of seismic wave propagation in a three-dimensional(3D)regional-scale geophysics model and the finite element method(FEM)for fine simulation of structural response including soil-structure interaction,and performs a physics-based simulation from initial fault rupture on an ancient wood *** verification of the hybrid workflow,a large-scale model of an ancient wood structure in the Beijing area,The Tower of Buddhist Incense,is established and its responses under the 1665 Tongxian earthquake and the 1730 Yiheyuan earthquake are *** results from the simulated ground motion and seismic response of the wood structure under the two earthquakes demonstrate that this hybrid workflow can be employed to efficiently provide insight into the relationships between geophysical parameters and the structural response,and is of great significance toward accurate input for seismic simulation of structures under specific site and fault conditions.

关键词： spectral element method finite element method fault-to-structure simulation physical model domain reduction method

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Force Compensation Control for Electro-Hydraulic Servo System with Pump-Valve Compound Drive via QFT-DTOC

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 228-246页

作者： Kaixian ba Yuan Wang Xiaolong He Chunyu Wang Bin Yu Yaliang Liu Xiangdong Kong Hebei Provincial Key Laboratory of Heavy Machinery Fluid Power Transmission and Control Qinhuangdao 066004China School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004China national Engineering Research Center for Local Joint of Advanced Manufacturing Technology and Equipment Yanshan UniversityQinhuangdao 066004China

Each joint of a hydraulic-driven legged robot adopts a highly integrated hydraulic drive unit(HDU),which features a high power-weight ***,most HDUs are throttling-valve-controlled cylinder systems,which exhibit high energy *** contrast,pump control systems offer a high ***,their response ability is *** fully utilize the advantages of pump and valve control systems,in this study,a new type of pump-valve compound drive system(PCDS)is designed,which can not only effectively reduce the energy loss,but can also ensure the response speed and response accuracy of the HDUs in robot joints to satisfy the performance requirements of ***,considering the force control requirements of energy conservation,high precision,and fast response of the robot joint HDU,a nonlinear mathematical model of the PCDS force control system is first *** addition,pressure-flow nonlinearity,friction nonlinearity,load complexity and variability,and other factors affecting the system are considered,and a novel force control method based on quantitative feedback theory(QFT)and a disturbance torque observer(DTO)is designed,which is denoted as QFT-DTOC *** method improves the control accuracy and robustness of the force control system,reduces the effect of the disturbance torque on the control performance of the servo motor,and improves the overall force control performance of the ***,experimental verification is performed using the PCDS performance test *** experimental results and quantitative data show that the QFT-DTOC proposed herein can significantly improve the force control performance of the *** relevant force control method can be used as a bottom-control method for the hydraulic servo system to provide a foundation for implementing the top-level trajectory planning of the robot.

关键词： Legged robot Pump-valve compound drive system(PCDS) Force compensation control Quantitative feedback theory(QFT) Disturbance torque observer(DTO)

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Severe Thromboembolic Complication Revealing a nephrotic Syndrome Due to Segmental and Focal Hyalinosis: A Case Report

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Open Journal of nephrology 2021年第3期11卷 450-457页

作者： Sah Dit baba Coulibaly Magara Samaké Aboubacar Sidiki Fofana Seydou Sy Hamadoun Yattara nanko Doumbia Katilé Drissa Moctar Coulibaly Kodio Atabieme djénéba maiga Aboudou Messoum Dolo nouhoum Coulibaly Hamat Ibrahim Saharé Fongoro Konaté Anselme nephrology Unit of Somino DOLO Hospital Mopti Mali nephrology Unit of the Fousseyni DAOU Hospital Kayes Mali national Center for Scientific and Technological Research (CnRST) Bamako Mali Faculty of Medicine of bamako Bamako Mali Department of nephrology and Haemodialysis University Teaching Hospital of Point-G Bamako Mali Medicine Department of Mali Hospital Bamako Mali Gastrohepato-Enterology Unit of the Fousseyni DAOU Hospital Kayes Mali nephrology Unit of the Mali GAVARDO Hospital of Sebenicoro Bamako Mali nephrology Unit of Sikasso Hospital Sikasso Mali Department of nephrology-Hemodialysis National General Reference Hospital N'Djamena Chad Department of Gastro-Hepato-Enterology Gabriel Touré University Hospital Bamako Mali

Adult nephrotic Syndrome (nS) is defined by proteinuria > 3 g/24h or 50 mg/kg/day, hypoprotidemia < 60 g/24h, hypoalbuminemia < 30 g/L. It is a disease with high thromboembolic risk. Peripheral vein thrombosis is comm... 详细信息

Adult nephrotic Syndrome (nS) is defined by proteinuria > 3 g/24h or 50 mg/kg/day, hypoprotidemia nemia n thrombosis is common, while its association with pulmonary localizations has been more rarely reported. We report a case of nephrotic syndrome revealed by an association of pulmonary embolism, renal vein and inferior vena cava thrombosis. The diagnosis was confirmed by thoracic angioscan. Renal biopsy revealed Focal Segmental Hyalinosis (FSH). An anti-coagulant treatment and an anti-proteinuric treatment were instituted based on a calcium channel blocker (amlodipine) associated with the conversion enzyme inhibitor (perindopril).

关键词： Thromboembolic Complication nephrotic Syndrome Segmental and Focal Hyalinosis bamako/Mali

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The value of toxicological analysis in acute poisoning patients with uncertain exposure histories:a retrospective and descriptive study from an institute of poisoning

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World Journal of Emergency Medicine 2024年第2期15卷 98-104页

作者： Qifang Shi Gen ba Zhenyu Xia Zhengsheng Mao Hao Sun Jinsong Zhang Institute of Poisoning Nanjing Medical UniversityNanjing 211100China Department of Emergency Medicine the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Forensic Medicine Nanjing Medical UniversityNanjing 211166China The Key Laboratory of Modern Toxicology of Ministry of Education Nanjing Medical UniversityNanjing 211166China

baCKGROUnD:In clinical practice,some patients might not be able or unwilling to provide a thorough history of medication and poison *** aim of this study was to use toxicological analysis to examine the clinical characteristics of patients with acute poisoning whose exposure history was uncertain from a toxicological analysis ***:This was a retrospective and descriptive study from an institute of *** registration information and test reports spanning the period from April 1,2020 to March 31,2022,were *** with uncertain exposure histories and who underwent toxicological analysis were *** manifestations and categories of toxics were ***:Among the 195 patients with positive toxicological analysis results,the main causes of uncertain exposure history was disturbance of consciousness(62.6%),unawareness(23.6%)and unwillingness or lack of cooperation(13.8%).The predominant clinical manifestations were disturbed consciousness(62.6%),followed by vomiting and nausea(14.4%)and liver function abnormalities(8.7%).A comparison of clinical manifestations between patients with positive and negative(n=99)toxicological analyses results revealed significantly different proportions of disturbances in consciousness(63%vs.21%),dizziness(1.5%vs.5.1%),multi-organ failure(1.5%vs.7.1%),and local pain(0 vs 4%).The main categories of substances involved were psychiatric medications(23.1%),sedatives(20.5%),insecticides(13.8%),and herbicides(12.8%).COnCLUSIOn:The clinical manifestations of acute poisoning in patients with an uncertain exposure history are diverse and nonspecific,and toxicological analysis plays a pivotal role in the diagnosis and differential diagnosis of such patients.

关键词： Acute poisoning Toxic exposure Toxicological analysis Clinical manifestation

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