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Phylogenetic analysis and protective effects of thymol and its chromatographic fractions from a novel wild mushroom in combating oxidative stress

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Food Science and Human Wellness 2021年第4期10卷 452-459页

作者： M.Subbulakshmi Sugapriya Dhanasekaran S.Abirami M.Kannan R.Palaniappan divya venugopal Department of Microbiology K.R.College of Arts and ScienceKovilpattiTamil NaduIndia Department of Medical Laboratory Sciences College of Applied Medical SciencesPrince Sattam Bin Abdulaziz UniversityWadi Al DawaserSaudi Arabia Department of Microbiology Kamaraj CollegeThoothukudiTamil NaduIndia Research Department of Zoology V.H.N.Senthikumara Nadar College(Autonomus)VirudhunagarTamil NaduIndia Research Department of Computer Science V.H.N.Senthikumara Nadar College(Autonomus)VirudhunagarTamil NaduIndia

Mushrooms are good sources of phytochemicals that have antioxidant and anti-proliferative *** study identifi ed a unique isoform of 18S rRNA gene(864 bp)from a novel wild mushroom(SMK-1)(GenBank accession number:SUB3267363).Thin layer chromatographic(TLC)profiling of the methanolic extract of the dried mushroom fruiting bodies of SMK-1 revealed the presence of phenolic and fl avonoid fractions with retention factor(Rf)values of 0.955 and 0.927 *** GC/MS chromatograms of the SMK-1 methanolic extract identifi ed the main bioactive compound was phenol,5-methyl-2-(1-methylethyl)(74.00%)(thymol).The radical scavenging activity for the fl avonoid fraction was greater than the phenolic fractions(Rf–phenolics fractions>Rf–fl avonoid fractions)with the antioxidant activity more than that of standard ascorbic ***,the phenolic and flavonoid fractions of SMK-1 expressed cytotoxic effects in HeLa cells with IC50 values ranging from 5μg/mL to 80μg/mL in a dose-dependent *** present research highlights the presence of high thymol concentration in a novel wild mushroom that has antioxidant and anti-poliferative potential with therapeutic benefi *** application of thymol natural products from novel mushroom SMK-1 as nutrition supplements could inhibit oxidative stress triggered by numerous pathologies that may pave the way to develop a new therapeutic natural drug.

关键词： Antioxidant Anti-proliferation Dietary mushrooms HeLa cells Novel Mushrooms Thymol

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Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance

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Genes & Diseases 2024年第1期11卷 148-175页

作者： divya Ajmeera Rajanna Ajumeera Cell Biology Department ICMR-National Institute of Nutrition(NIN)HyderabadTelangana 500007India

Chemotherapy is an effortless and frequently used approach in cancer ***,in most cases,it can only prolong life expectancy and does not guarantee a complete ***,chemotherapy is associated with severe adverse effects,one of the major complications of effective cancer *** addition,newly published research outputs show that cancer stem cells are involved in cancer disease progression,drug resistance,metastasis,and recurrence and that they are functional in the trans-differentiation capacity of cancer stem cells to cancer cells in response to *** strategies are therefore required for better management of cancer *** prime approach would be to synthesize and develop novel drugs that need extensive resources,time,and endurance to be brought into therapeutic *** subsequent approach would be to screen the anti-cancer activity of avail-able non-cancerous *** concept of repurposing non-cancer drugs as an alternative to current cancer therapy has become popular in recent years because using existing anticancer drugs has several adverse *** have also been investigated for cancer ther-apy due to their significant anti-cancer effects with negligible or no side effects and availabil-ity in food *** this paper,we discuss an ideal hypothesis for screening available non-cancerous drugs with anticancer activity,with a focus on cancer stem cells and their clinical application for cancer ***,drug repurposing and the combination of micronu-trients that can target both cancers and cancer stem cells may result in a better therapeutic approach leading to maximum tumor growth control.

关键词： Cancerstem cells Chemotherapy Combination therapy micronutrients Non-cancer drugs Novel strategies

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Deep Learning-Based Classification of Rotten Fruits and Identification of Shelf Life

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Computers, Materials & Continua 2024年第1期78卷 781-794页

作者： S.Sofana Reka Ankita Bagelikar Prakash venugopal V.Ravi Harimurugan Devarajan Centre for Smart Grid Technologies School of Electronics EngineeringVellore Institute of TechnologyChennai600127India School of Electronics Engineering Vellore Institute of TechnologyChennai600127India Department of Electrical Engineering Dr.B R Ambedkar National Institute of TechnologyJalandharPunjab144008India

The freshness of fruits is considered to be one of the essential characteristics for consumers in determining their quality,flavor and nutritional *** primary need for identifying rotten fruits is to ensure that only fresh and high-quality fruits are sold to *** impact of rotten fruits can foster harmful bacteria,molds and other microorganisms that can cause food poisoning and other illnesses to the *** overall purpose of the study is to classify rotten fruits,which can affect the taste,texture,and appearance of other fresh fruits,thereby reducing their shelf *** agriculture and food industries are increasingly adopting computer vision technology to detect rotten fruits and forecast their shelf ***,this research work mainly focuses on the Convolutional Neural Network’s(CNN)deep learning model,which helps in the classification of rotten *** proposed methodology involves real-time analysis of a dataset of various types of fruits,including apples,bananas,oranges,papayas and ***,machine learningmodels such as GaussianNaïve Bayes(GNB)and random forest are used to predict the fruit’s shelf *** results obtained from the various pre-trained models for rotten fruit detection are analysed based on an accuracy score to determine the best *** comparison to other pre-trained models,the visual geometry group16(VGG16)obtained a higher accuracy score of 95%.Likewise,the random forest model delivers a better accuracy score of 88% when compared with GNB in forecasting the fruit’s shelf *** developing an accurate classification model,only fresh and safe fruits reach consumers,reducing the risks associated with contaminated ***,the proposed approach will have a significant impact on the food industry for efficient fruit distribution and also benefit customers to purchase fresh fruits.

关键词： Rotten fruit detection shelf life deep learning convolutional neural network machine learning gaussian naïve bayes random forest visual geometry group16

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Conformally symmetric wormhole solutions supported by non-commutative geometry in f(Q,T)gravity

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Communications in Theoretical Physics 2024年第2期76卷 111-124页

作者： Chaitra Chooda Chalavadi V Venkatesha N S Kavya S V divya Rashmi Department of P.G.Studies and Research in Mathematics Kuvempu UniversityShankaraghattaShivamogga 577451KarnatakaIndia Department of Mathematics Vidyavardhaka College of EngineeringMysuru—570002India

This paper investigates wormhole solutions within the framework of extended symmetric teleparallel gravity,incorporating non-commutative geometry,and conformal *** achieve this,we examine the linear wormhole model with anisotropic fluid under Gaussian and Lorentzian *** primary objective is to derive wormhole solutions while considering the influence of the shape function on model parameters under Gaussian and Lorentzian *** resulting shape function satisfies all the necessary conditions for a traversable ***,we analyze the characteristics of the energy conditions and provide a detailed graphical discussion of the matter contents via energy ***,we explore the effect of anisotropy under Gaussian and Lorentzian ***,we present our conclusions based on the obtained results.

关键词： traversable wormhole f(Q T)gravity energy conditions non-commutative geometry conformal motion

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A Hybrid Model for Improving Software Cost Estimation in Global Software Development

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Computers, Materials & Continua 2024年第1期78卷 1399-1422页

作者： Mehmood Ahmed Noraini B.Ibrahim Wasif Nisar Adeel Ahmed Muhammad Junaid Emmanuel Soriano Flores divya Anand Faculty of Computer Science and Information Technology Universiti Tun Hussein Onn Malaysia Parit RajaBatu Pahat86400Malaysia Department of Computer Science COMSATS University Wah Cantt CampusIslamabad47010Pakistan Department of Information Technology The University of HaripurKhyber Pakhtunkhwa22620Pakistan Engineering Research Innovation Group Universidad Europea del AtlanticoSantander39011Spain

Accurate software cost estimation in Global Software Development(GSD)remains challenging due to reliance on historical data and expert *** models,such as the Constructive Cost Model(COCOMO II),rely heavily on historical and accurate *** addition,expert judgment is required to set many input parameters,which can introduce subjectivity and variability in the estimation ***,there is a need to improve the current GSD models to mitigate reliance on historical data,subjectivity in expert judgment,inadequate consideration of GSD-based cost drivers and limited integration of modern technologies with cost *** study introduces a novel hybrid model that synergizes the COCOMO II with Artificial Neural Networks(ANN)to address these *** proposed hybrid model integrates additional GSD-based cost drivers identified through a systematic literature review and further vetted by industry *** article compares the effectiveness of the proposedmodelwith state-of-the-artmachine learning-basedmodels for software cost *** the NASA 93 dataset by adopting twenty-six GSD-based cost drivers reveals that our hybrid model achieves superior accuracy,outperforming existing *** findings indicate the potential of combining COCOMO II,ANN,and additional GSD-based cost drivers to transform cost estimation in GSD.

关键词： Artificial neural networks COCOMO II cost drivers global software development linear regression software cost estimation

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Mechanism of microbial spore inactivation through electromagnetic radiations:a review

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Journal of Future Foods 2024年第4期4卷 324-334页

作者： Piyush Sharma Arun Prasath venugopal Parag Prakash Sutar Hong-wei Xiao Qi Zhang Deparment of Food Process Engineering.National Institute of Techmology Rourkela Odisha 769008India College of Engineering China Agriculural UniversityBeijing 100083China School of Mechanical Engineering Yangzhou UTniversiny Yangzhou 225002China

Spores are the biological structures formed out of sporulation from vegetative cells in adverse *** tolerant to many extreme environment and conditions,they escape and survives critical processing steps in the food industry that poses food and health safety problems,as is evident from the increase in reports of food-bome outbreaks due to *** radiation(EM)is used for rapid decontamination and sterilization purposes in the food *** studies have reported a greater reduction in spore population upon irradiation with EM rays due to its impact on genomic material and other components of spores that destabilises overall structue and brings clonogenic death However,there is scattered literature regarding the mechanism of its inactivation and resistance against such *** review attempts to concisely evaluate the potential of electromagnetic radiations in spore inactivation and details its mechanism through a collective study of scientific results and *** also briefs about the process of sporulation,the structure of spores and the role of its components in the resistance of spores to *** studies,which demonstrated that combining various EM treatments might be an effective way for inactivation of spores,were discussed in detail.

关键词： Spore structure Electromagnetic radiations Mechanism of inactivation Damage resistance

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Advancements in nanotechnology for the delivery of phytochemicals

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Journal of Integrative Medicine 2024年第4期22卷 385-398页

作者： divya Chauhan Pavan K.Yadav Nazneen Sultana Arun Agarwal Saurabh Verma Manish K.Chourasia Jiaur R.Gayen Division of Pharmaceutics and Pharmacokinetics Central Drug Research InstituteCouncil of Scientific and Industrial ResearchLucknow 226031Uttar PradeshIndia Academy of Scientific and Innovative Research Ghaziabad 201002Uttar PradeshIndia

Phytosomes(phytophospholipid complex) are dosage forms that have recently been introduced to increase the stability and therapeutic effect of herbal medicine. Currently, bioactive herbs and the phytochemicals they contain are considered to be the best remedies for chronic diseases. One promising approach to increase the efficacy of plant-based therapies is to improve the stability and bioavailability of their bio-active ingredients. Phytosomes employ phospholipids as their active ingredients, and use their amphiphilic properties to solubilize and protect herbal extracts. The unique properties of phospholipids in drug delivery and their use in herbal medicines to improve bioavailability results in significantly enhanced health benefits. The introduction of phytosome nanotechnology can alter and revolutionize the current state of drug delivery. The goal of this review is to explain the application of phytosomes, their future prospects in drug delivery, and their advantages over conventional formulations.

关键词： Phytochemical Bioavailability Drug delivery system Phytosome Plant extracts

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Malignant pleural mesothelioma:The disdained member of thoracic oncology!

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World Journal of Experimental Medicine 2024年第3期14卷 1-10页

作者： divya Khosla Pawan Kumar Singh Bharath A Chhabria Vaishali Kataria Navneet Singh Rakesh Kapoor Department of Radiotherapy and Oncology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Pulmonary and Critical Care Medicine Pandit Bhagwat Dayal Sharma Postgraduate Institute of Medical SciencesRohtak 124001India Department of Pulmonary and Critical Care Medicine Ramaiah Memorial HospitalBengaluru 560054India Department of Pulmonary Medicine Postgraduate Institute of Medical Education and ResearchChandigarh 160012India

Pleural mesothelioma is a very aggressive malignancy that arises from the pleural mesothelial cell lining and is linked strongly to prior asbestos *** ban on asbestos has helped to lower the incidence,but in developing countries like India,it is expected to *** has an extended latency period usually progressing over decades and presents with nonspecific *** has a median survival ranging between 10-22 *** diagnosis of malignant pleural mesothelioma is challenging and is done using computed tomography(CT),magnetic resonance imaging,or positron emission tomography-CT,with the last two predicting the resectability of the tumor better than CT alone.A pleural biopsy along with an array of immunohistochemical markers,such as p16,BRCA1 associated protein 1,and claudin-4,are required for a definitive *** genetic alterations have prognostic significance as *** current histological subtype identification is indispensable for decision making because of the new therapeutic avenues being *** combination of nivolumab and ipilimumab-based immunotherapy outperformed platinum and pemetrexed-based chemotherapy in terms of survival benefit and improved quality of life especially for non-epithelioid ***,the latter continues to be a robust treatment option for patients with the epithelioid *** is recommended for resectable cases with radiotherapy being indicated in neoadjuvant,adjuvant,and palliative settings along with systemic *** review article provides an overview of epidemiology,etiology,clinical manifestations,diagnostic approaches(including immunohistochemical and genetic markers),staging,and multidisciplinary approaches to current treatment for malignant pleural mesothelioma using surgery,chemotherapy,immunotherapy,and *** also sheds light on some recent studies(EMPHACIS,CALGB30901,Checkmate-743,etc.)that have led to significant developments in recent years with clinically mean

关键词： Chemotherapy Diagnosis Immunotherapy Malignant pleural mesothelioma Radiotherapy

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Comparative utility of vestibular function tests in patients with peripheral and central vestibular dysfunction

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Journal of Otology 2024年第1期19卷 5-9页

作者： Cameron B.Fattahi Christopher Zaro Janice J.Chung Richard F.Lewis divya A.Chari Department of Otolaryngology-Head and Neck Surgery UMASS Memorial Medical CenterUniversity of Massachusetts Chan Medical SchoolWorcesterMAUSA Jenks Vestibular Physiology Laboratory Massachusetts Eye and EarBostonMAUSA Department of Otolaryngology-Head and Neck Surgery Massachusetts Eye and EarHarvard Medical SchoolBostonMAUSA Department of Neurology Harvard Medical SchoolBostonMAUSA

Background: Bithermal caloric irrigation, video head impulse test(vHIT), and rotational testing are commonly used to assess peripheral vestibular function, but the relative clinical utility of each test in differentiating patients with peripheral vestibulopathy is ***: To determine whether(1) the combination of two or more vestibular tests enhances diagnostic utility over a single test;(2) abnormal test results on vestibular tests correlate with one ***: Retrospective analysis of data collected from multidisciplinary vestibular clinics at two academic medical centers from 2016 to ***: 150 patients(54.10 ± 15.09 years, 88 females) were included. No individual test was significantly better at predicting the presence of peripheral vestibular damage(p > 0.05). vHIT test results improved significantly when combined with either the caloric test(p = 0.007) or rotary chair test(p = 0.039). Caloric and rotational testing had high sensitivity(74.65% and 76.06%, respectively) and specificity(83.54% and 78.48%, respectively). vHIT demonstrated excellent specificity(89.87%) but poor sensitivity(47.89%). Caloric, vHIT, and rotary chair tests results did not correlate with one another(p > 0.05).Conclusions: Vestibular function tests have comparable diagnostic utility, yet each offers unique advantages. Caloric and rotational testing may be best suited for screening peripheral damage and vHIT may function ideally as a confirmatory test.

关键词： vestibular patients specificity

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Exploring the Reasons for Selfie-Taking and Selfie-Posting on Social Media with Its Effect on Psychological and Social Lives:A Study among Indian Youths

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International Journal of Mental Health Promotion 2024年第5期26卷 389-398页

作者： divya P.Vijayan Tokani Ghuhato Eslavath Rajkumar Allen Joshua George Romate John John Abraham Department of Psychology Central University of KarnatakaKalaburagi585367India Department of Liberal Arts Indian Institute of Technology BhilaiChhattisgarh491002India Liberal Arts&Sciences Indian Institute of Management RanchiJharkhand834001India Department of Family Medicine/Geriatrics St.John’s National Academy of Health SciencesBangalore560034India

‘Selfie’taking was introduced to the common people by smartphones and has become a common practice across the globe in no *** technological advancement and the popularity of smartphones,selfie-taking has grown rapidly within a short *** light of the new trend set by the generation,this study aimed to explore reasons for selfie-taking and selfie-posting on social media and their effects on the social and psychological lives of young adults.A purposive sampling method was adopted to select 20 Indian citizens,between 18 and 24 *** data were collected through semi-structured interviews and analysed using thematic ***-taking and posting on social media give positive feelings,and it acts as a mood modifier dependent mostly on the favourability and feedback about the post which in turn affects emotions and self-satisfaction.

关键词： Selfie social media social networking sites obsessive selfie-taking Indian youth

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