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Regional lymphadenectomy strongly recommended in T1b gallbladder cancer

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World Journal of Gastroenterology 2011年第38期17卷 4347-4348页

作者： Ulrich Klaus Fetzner Arnulf H Hlscher dirk L Stippel Department of General Visceral and Cancer SurgeryUniversity Hospital of Cologne

This article discusses the adequate treatment of early gallbladder cancer （Tla, Tlb） and is based on published studies extending over nearly 3 decades. Ran- domized studies and meta analyses comparing different surgical treatments do not exist. The literature shows that in up to 20% of patients lymph node metastasis are found in Tlb gallbladder cancer. Due to high malignancy with early angiolymphatic spread and resistance to chemotherapy and radiation on the one hand, and the relative low operative risk of extended cholecystectomy （cholecystectomy and regional lymphadenectomy） on the other hand, we believe that this procedure is mandatory in early gallbladder cancer.

关键词： Gallbladder cancer Long-term survival Lymphadenectomy Surgical treatment

Targeting cell death signaling in colorectal cancer:Current strategies and future perspectives

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World Journal of Gastroenterology 2014年第8期20卷 1923-1934页

作者： Bruno Christian Koehler dirk Jger Henning Schulze-Bergkamen National Center for Tumor Diseases University Hospitals Heidelberg69120 HeidelbergGermany

The evasion from controlled cell death induction has been considered as one of the hallmarks of cancer cells. Defects in cell death signaling are a fundamental phenomenon in colorectal cancer. Nearly any non-invasive cancer treatment finally aims to induce cell death. However, apoptosis resistance is the major cause for insufficient therapeutic success and disease relapse in gastrointestinal oncology. Various compounds have been developed and evaluated with the aim to meet with this obstacle by triggering cell death in cancer cells. The aim of this review is to illustrate current approaches and future directions in targeting cell death signaling in colorectal cancer. The complex signaling network of apoptosis will be demonstrated and the “druggability” of targets will be identified. In detail, proteins regulating mitochondrial cell death in colorectal cancer, such as Bcl-2 and survivin, will be discussed with respect to potential therapeutic exploitation. Death receptor signaling and targeting in colorectal cancer will be outlined. Encouraging clinical trials including cell death based targeted therapies for colorectal cancer are under way and will be demonstrated. Our conceptual understanding of cell death in cancer is rapidly emerging and new types of controlled cellular death have been identified. To meet this progress in cell death research, the implication of autophagy and necroptosis for colorectal carcinogenesis and therapeutic approaches will also be depicted. The main focus of this topic highlight will be on the revelation of the complex cell death concepts in colorectal cancer and the bridging from basic research to clinical use.

关键词： Colorectal cancer Apoptosis Necroptosis Autophagy Clinical trial Bcl-2 proteins BH-3 mimetics Inflammatory bowel disease

Carbonates as Foaming Agent in Chip-based Aluminium Foam Precursor

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Journal of Materials Science & Technology 2010年第9期26卷 845-850页

作者： Marco Haesche dirk Lehmhus Jrg Weise Manfred Wichmann Irene Cristina Magnabosco Mocellin University of Bremen Fraunhofer IFAM Federal University of Santa Catarina Florianópolis

Replacement of TiH2 as foaming agent by CaCO3（lime） and CaMg（CO3）2（dolomite） for AlMg4.5-and AlSi9Cu3-foams was investigated considering inluences on foaming capability and cellular *** materials were produced from alloy chip and powder mixtures by means of the thixocasting ***9Cu3 variants showed expansion levels suffcient for commercial *** in expansion observed when CaCO3 and CaMg（CO3）2 were compared as foaming agent are explained based on the course of *** performance of dolomite-based foams relies on formation of stabilizing MgO phases,which do not develop during decomposition of CaCO3 in Al-Si-Cu alloys

关键词： Aluminium foam Foaming agent Calcium carbonate Dolomite Stabilisation

Quality of life after laparoscopic and open colorectal surgery: A systematic review

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World Journal of Gastroenterology 2010年第40期16卷 5035-5041页

作者： Sanne AL Bartels Malaika S Vlug dirk T Ubbink Willem A Bemelman Department of Surgery Academic Medical Center Department of Quality Assurance and Process Innovation Academic Medical Center

This study was a systematic review of the available evidence on quality of life in patients after laparoscopic or open colorectal surgery. A systematic review was performed of all randomized clinical trials (RCTs) that compared laparoscopic with open colorectal surgery. Study selection, quality assessment and data extraction were carried out independently by two reviewers. Primary endpoint was quality of life after laparoscopic and open colorectal surgery, as assessed by validated questionnaires. The search resulted in nine RCTs that included 2263 patients. Shortand long-term results of these RCTs were described in 13 articles. Postoperative follow-up ranged from 2 d to 6.7 years. Due to clinical heterogeneity, no meta-analysis could be conducted. Four RCTs did not show any difference in quality of life between laparoscopic or open colorectal surgery. The remaining five studies reported a better quality of life in favor of the laparoscopic group on a few quality of life scales at time points ranging from 1 wk to 2 years after surgery. In conclusion, based on presently available high-level evidence, this systematic review showed no clinically relevant differences in postoperative quality of life between laparoscopic and open colorectal surgery.

关键词： Quality of life Colorectal surgery Laparoscopy Colonic neoplasms Colonic diseases Inflammatory bowel diseases

Approximation of NURBS Curves and Surfaces Using Adaptive Equidistant Parameterizations

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Tsinghua Science and Technology 2005年第3期10卷 316-322页

作者：阿孜古丽.吾拉木 GOETTING Marc ZECKZER dirk School of Information Engineering University of Science and Technology Beijing Beijing 100083 China School of Information Science and Engineering University of Xinjiang Urumq 830046 China Department of Computer Science University of Kaiserslautern D-6753 Germany

Non-uniform rational B-spline (NURBS) curves and surfaces are very important tools for model- ling curves and surfaces. Several important details, such as the choice of the sample points, of the parame- terization, and of the termination condition, are however not well described. These details have a great in- fluence on the performance of the approximation algorithm, both in terms of quality as well as time and space usage. This paper described how to sample points, examining two standard parameterizations: equi- distant and chordal. A new and local parameterization, namely an adaptive equidistant model, was pro- posed, which enhances the equidistant model. Localization can also be used to enhance the chordal parameterization. For NURBS surfaces, one must choose which direction will be approximated first and must pay special attention to surfaces of degree 1 which have to be handled as a special case.

关键词： computer graphics computer-aided design (CAD) computer-aided geometric design (CAGD) NURBS curves NURBS surfaces approximation implementation

Characterization and quantification of multi-field coupling in lithium-ion batteries under mechanical constraints

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Journal of Energy Chemistry 2024年第8期95卷 364-379,I0009页

作者： Xue Cai Caiping Zhang Zeping Chen Linjing Zhang dirk Uwe Sauer Weihan Li National Active Distribution Network Technology Research Center Beijing Jiaotong UniversityBeijing 100044China Chair for Electrochemical Energy Conversion and Storage Systems Institute for Power Electronics and Electrical Drives(ISEA)RWTH Aachen UniversityCampus Boulevard 8952074 AachenGermany Center for Ageing Reliability and Lifetime Prediction of Electrochemical and Power Electronic Systems(CARL)Campus-Boulevard 8952074 AachenGermany Juelich Aachen Research Alliance JARA-EnergyAachenGermany Helmholtz Institute Münster(HI MS) IEK-12Forschungszentrum JülichGermany

The safety and durability of lithium-ion batteries under mechanical constraints depend significantly on electrochemical,thermal,and mechanical fields in *** and quantifying the multi-field coupling behaviors requires interdisciplinary ***,we design experiments under mechanical constraints and introduce an in-situ analytical framework to clarify the complex interaction mechanisms and coupling degrees among multi-physics *** proposed analytical framework integrates the parameterization of equivalent models,in-situ mechanical analysis,and quantitative assessment of coupling *** results indicate that the significant impact of pressure on impedance at low temperatures results from the diffusion-controlled step,enhancing kinetics when external pressure,like 180 to 240 k Pa at 10℃,is *** diversity in control steps for the electrochemical reaction accounts for the varying impact of pressure on battery performance across different *** thermal expansion rate suggests that the swelling force varies by less than 1.60%per unit of elevated temperature during the lithiation *** introducing a composite metric,we quantify the coupling correlation and intensity between characteristic parameters and physical fields,uncovering the highest coupling degree in electrochemical-thermal *** results underscore the potential of analytical approaches in revealing the mechanisms of interaction among multi-fields,with the goal of enhancing battery performance and advancing battery management.

关键词： Lithium-ion battery Muti-field coupling Mechanical constraints Interaction mechanisms Quantitative analysis

Reproducible Research Publication Workflow:A Canonical Workflow Framework and FAIR Digital Object Approach to Quality Research Output

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Data Intelligence 2022年第2期4卷 306-319页

作者： Limor Peer Claudia Biniossek dirk Betz Thu-Mai Christian Institution for Social and Policy Studies Yale UniversityConnecticut 06520USA Center for Empirical Research in Economics and Behavioral Sciences(CEREB) University of ErfurtThuringen 99089Germany Odum Institute for Research in Social Science University of North Carolina SystemNorth Carolina 27514-3916USA

In this paper we present the Reproducible Research Publication Workflow(RRPW)as an example of how generic canonical workflows can be applied to a specific *** RRPW includes essential steps between submission and final publication of the manuscript and the research artefacts(i.e.,data,code,etc.)that underlie the scholarly claims in the manuscript.A key aspect of the RRPW is the inclusion of artefact review and metadata creation as part of the publication *** paper discusses a formalized technical structure around a set of canonical steps which helps codify and standardize the process for researchers,curators,and *** proposed application of canonical workflows can help achieve the goals of improved transparency and reproducibility,increase FAIR compliance of all research artefacts at all steps,and facilitate better exchange of annotated and machine-readable metadata.

关键词： FAIR research output FAIR Digital Objects Reproducible research Research compendium Compendium publication workflow Data quality review

Unloading behaviors of the rare-earth magnesium alloy ZE10 sheet

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Journal of Magnesium and Alloys 2021年第3期9卷 927-936页

作者： Weiqin Tang Jeong Yeon Lee Huamiao Wang dirk Steglich Dayong Li Yinghong Peng Peidong Wu State Key Laboratory of Mechanical Systems and Vibration Shanghai Jiao Tong University800 Dongchuan RoadShanghai 200240PR China Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea Institute of Materials Research Materials Mechanics/ACE-CentreHelmholtz-Zentrum GeesthachtMax-Planck-Str.121502 GeesthachtGermany Materials Genome Initiative Center Shanghai Jiao Tong University200240China Department of Mechanical Engineering McMaster UniversityHamiltonOntario L8S 4L7Canada

Due to their low symmetry in crystal structure,low elastic modulus(~45 GPa)and low yielding stress,magnesium(Mg)alloys exhibit strong inelastic behaviors during *** more and more Mg alloys are developed,their unloading behaviors were less investigated,especially for rare-earth(RE)Mg *** the current work,the unloading behaviors of the RE Mg alloy ZE10 sheet is carefully studied by both mechanical tests and crystal plasticity *** terms of the stress-strain curves,the inelastic strain,the chord modulus,and the active deformation mechanisms,the substantial anisotropy and the loading path dependency of the unloading behaviors of ZE10 sheets are *** inelastic strains are generally larger under compressive Loading-Un Loading(L-UL)than under tensile L-UL,along the transverse direction(TD)than along the rolling direction(RD)under tensile L-UL,and along RD than along TD under compressive *** basal slip,twinning and de-twinning are found to be responsible for the unloading behaviors of ZE10 sheets.

关键词： Inelasticity Magnesium alloy Rare-earth Crystal plasticity Twinning Detwinning

Time to Integrate Malaria and Neglected Tropical Diseases Control and Elimination

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China CDC weekly 2021年第17期3卷 372-374页

作者： dirk Engels Fang Huang Xiao-nong Zhou Secretariat Uniting Forum To Combate NTDsGenevaSwitzerland NHC Key Laboratory for Parasite and Vector Biology National Institute of Parasitic DiseasesChinese Center for Disease Control and PreventionShanghaiChina Chinese Center for Tropical Diseases Research WHO Collaborating Centre for Tropical Diseases School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiChina.

Traditionally,malaria has always been considered one of the tropical *** only has changed in the late 1990s,with the World Health Organization(WHO)profiling HIV,tuberculosis(TB),and malaria as priority“poverty-related”killing diseases(1).This has led to the creation of the Global Fund to Fight AIDS,Tuberculosis,and Malaria(2),that has mobilized substantial resources to advance the control of all three diseases,even if mostly in a siloed manner.

关键词： Malaria diseases malaria