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Liver tumor infiltrating lymphocytes: Comparison of hepatocellular and cholangiolar carcinoma

World Journal of Gastroenterology 2009年第40期15卷 5053-5057页

作者： Hans-Udo Kasper Uta Drebber dirk ludger stippel Hans Peter Dienes Anton Gillessen Department of Pathology Medical CenterClemenshospital Münster Department of Pathology University of Cologne Department of Visceral and Vascular Surgery University of Cologne Department of Gastroenterology Herz-Jesu-Hospital Hiltrup

AIM: To investigate the role of tumor inf iltrating lym-phocytes (TIL) in primary hepatocellular and cholangio-lar carcinomas of the ***: Immunohistochemical analysis was per-formed including antibodies to CD3, CD4, CD8, CD20, CD56 and TIA-1 in formalin-f ixed and paraff in-embed-ded tissue of 35 liver resection specimens of hepatocel-lular or cholangiocellular carcinomas. Semiquantitative evaluation was performed with emphasis on the area of the tumor itself and of the tumor/liver ***: All hepatocellular carcinomas showed in-filtration of lymphocytes predominantly around the tumor in the tumor/liver interface consisting mainly of CD3+ CD4+ T lymphocytes [164.3/10 high power f ields (HPF)] and in the tumor itself of CD8+ cells (54.9/10 HPF). Cholangiocarcinomas contained a heterogeneous amount of TIL, composed mainly of CD3+ T cells with a predominance of CD8+ cells in the tumor tissue (52.6/10 HPF) and of CD4+ cells in the interface region (223.1/10 HPF). CD56+ cells of the innate immune system were scarce. There was no significant difference between hepatocellular or cholangiolar carcinoma. No correlation with the clinicopathological data was seen. CONCLUSION: Liver TIL consists of intratumoral CD8+ T cells and peritumoral CD4+ T cells indepen-dent of histogenetic origin. Different functions of lym-phocytes in these regions seem possible.

关键词：原发性肝癌 T淋巴细胞肿瘤浸润高通滤波器胆管肿瘤肿瘤组织半定量评价 CD8

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