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Neglected tropical diseases:an effective global response to local poverty-related disease priorities

Infectious Diseases of Poverty 2020年第1期9卷 9-17页

作者： Dirk Engels Xiao-Nong Zhou Uniting to Combat NTDs Support Centre GenevaSwitzerland National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention Chinese Center for Tropical Diseases ResearchShanghai 200025People’s Republic of China World Health Organization Collaborative Centre for Tropical Diseases Key Laboratory of Parasite and Vector BiologyMinistry of Health of ChinaShanghai 200025People’s Republic of China School of Global Health Chinese Center for Tropical Diseases ResearchJiatong University School of MedicineShanghai 200025People’s Republic of China

Background:Neglected tropical diseases(NTDs)have long been overlooked in the global health agenda.They are intimately related to poverty,cause important local burdens of disease,but individually do not represent global priorities.Yet,NTDs were estimated to affect close to 2 billion people at the turn of the millennium,with a collective burden equivalent to HIV/AIDS,tuberculosis,or malaria.A global response was therefore warranted.Main text:The World Health Organization(WHO)conceived an innovative strategy in the early 2000s to combat NTDs as a group of diseases,based on a combination of five public health interventions.Access to essential NTD medicines has hugely improved thanks to strong public-private partnership involving the pharmaceutical sector.The combination of a WHO NTD roadmap with clear targets to be achieved by 2020 and game-changing partner commitments endorsed in the London Declaration on Neglected Tropical Diseases,have led to unprecedented progress in the implementation of large-scale preventive treatment,case management and care of NTDs.The coming decade will see as challenges the mainstreaming of these NTD interventions into Universal Health Coverage and the coordination with other sectors to get to the roots of poverty and scale up transmissionbreaking interventions.Chinese expertise with the elimination of multiple NTDs,together with poverty reduction and intersectoral action piloted by municipalities and local governments,can serve as a model for the latter.The international community will also need to keep a specific focus on NTDs in order to further steer this global response,manage the scaling up and sustainment of NTD interventions globally,and develop novel products and implementation strategies for NTDs that are still lagging behind.Conclusions:The year 2020 will be crucial for the future of the global response to NTDs.Progress against the 2020 roadmap targets will be assessed,a new 2021–2030 NTD roadmap will be launched,and the London Declaration commitments will need to be renewed.It

关键词： Neglected tropical diseases Diseases of poverty Global health priorities Integrated control

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Time to Integrate Malaria and Neglected Tropical Diseases Control and Elimination

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China CDC weekly 2021年第17期3卷 372-374页

作者： Dirk Engels Fang Huang Xiao-nong Zhou Secretariat Uniting Forum To Combate NTDsGenevaSwitzerland NHC Key Laboratory for Parasite and Vector Biology National Institute of Parasitic DiseasesChinese Center for Disease Control and PreventionShanghaiChina Chinese Center for Tropical Diseases Research WHO Collaborating Centre for Tropical Diseases School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiChina.

Traditionally,malaria has always been considered one of the tropical diseases.This only has changed in the late 1990s,with the World Health Organization(WHO)profiling HIV,tuberculosis(TB),and malaria as priority“poverty-related”killing diseases(1).This has led to the creation of the Global Fund to Fight AIDS,Tuberculosis,and Malaria(2),that has mobilized substantial resources to advance the control of all three diseases,even if mostly in a siloed manner.

关键词： Malaria diseases malaria

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World NTD Day 2022 and a new Kigali Declaration to galvanise commitment to end neglected tropical diseases

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Infectious Diseases of Poverty 2022年第1期11卷 5-7页

作者： Thoko Elphick-Pooley Dirk Engels on behalf of Uniting to Combat NTDs Hove EnglandUK Commugny VaudSwitzerland 不详

The World Health Organization’s first roadmap and the London Declaration on neglected tropical diseases(NTDs)have allowed an unprecedented expansion of interventions to control and eliminate this group of infectious diseases that primarily affects vulnerable or marginalised communities.The 2021-2030 NTD roadmap sustains a further acceleration of interventions but also introduces a broader and more ambitious agenda,calling to be accompanied by a new political declaration.Sponsored by the Government of Rwanda,the Kigali Declaration on neglected tropical diseases will be launched in 2022 to renew and reinvigorate commitments to end NTDs,also in the wake of the current setback caused by the COVID-19 pandemic.Starting on World NTD Day 2022,a global campaign"100%Committed"will call on a broad range of stakeholders to sign the declaration and make bold financial and political commitments towards achieving the 2030 roadmap and Sustainable Development Goals'targets for NTDs.

关键词： Neglected tropical diseases Kigali Declaration World Health Organization NTD roadmap World NTD Day 100 Committed

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The cross-cutting contribution of the end of neglected tropical diseases to the sustainable development goals

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Infectious Diseases of Poverty 2017年第1期6卷 634-653页

作者： Mathieu Bangert David H.Molyneux Steve W.Lindsay Christopher Fitzpatrick Dirk Engels Department of Control of Neglected Tropical Diseases World Health Organization20 Avenue Appia1211 GenevaSwitzerland Department of Parasitology Liverpool School of Tropical MedicineLiverpoolUK Department of Biosciences Durham UniversityDurhamUK

The Sustainable Development Goals(SDGs)call for an integrated response,the kind that has defined Neglected Tropical Diseases(NTDs)efforts in the past decade.NTD interventions have the greatest relevance for SDG3,the health goal,where the focus on equity,and its commitment to reaching people in need of health services,wherever they may live and whatever their circumstances,is fundamentally aligned with the target of Universal Health Coverage.NTD interventions,however,also affect and are affected by many of the other development areas covered under the 2030 Agenda.Strategies such as mass drug administration or the programmatic integration of NTD and WASH activities(SDG6)are driven by effective global partnerships(SDG17).Intervention against the NTDs can also have an impact on poverty(SDG1)and hunger(SDG2),can improve education(SDG4),work and economic growth(SDG8),thereby reducing inequalities(SDG10).The community-led distribution of donated medicines to more than 1 billion people reinforces women’s empowerment(SDG5),logistics infrastructure(SDG9)and non-discrimination against disability(SDG16).Interventions to curb mosquito-borne NTDs contribute to the goals of urban sustainability(SDG11)and resilience to climate change(SDG13),while the safe use of insecticides supports the goal of sustainable ecosystems(SDG15).Although indirectly,interventions to control waterand animal-related NTDs can facilitate the goals of small-scale fishing(SDG14)and sustainable hydroelectricity and biofuels(SDG7).NTDs proliferate in less developed areas in countries across the income spectrum,areas where large numbers of people have little or no access to adequate health care,clean water,sanitation,housing,education,transport and information.This scoping review assesses how in this context,ending the epidemic of the NTDs can impact and improve our prospects of attaining the SDGs.

关键词： Neglected tropical diseases Sustainable development goals

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A decade of innovation to deepen the understanding of infectious diseases of poverty and foster their control and elimination

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Infectious Diseases of Poverty 2022年第6期11卷 1-4页

作者： Dirk Engels Sheng‑lan Tang Colin DButler Ayoade MJOduola Tania Cde Araujo‑Jorge George FGao Jürg Utzinger Xiao‑Nong Zhou World Health Organization(Retired) GenevaSwitzerland Duke University DurhamUSA Australia National University CanberraAustralia University of Ibadan Research Foundation University of IbadanIbadanNigeria Institute Oswaldo Cruz Oswaldo Cruz FoundationRio de JaneiroBrazil Chinese Acad‑emy of Sciences BeijingPeople’s Republic of China Swiss Tropical and Public Health Institute AllschwilSwitzerland University of Basel BaselSwitzerland National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention Chinese Center for Tropical Diseases ResearchShanghaiPeo‑ple’s Republic of China One Health Center Shanghai Jiao Tong University The University of EdinburghShanghaiPeople’s Republic of China

Exactly 10 years ago,on 25 October 2012,a group of scientists,policy-makers,and practitioners undertook an ambitious project to launch a new open-access journal,named Infectious Diseases of Poverty[1].The idea had originated from a think-tank put forth by the Special Programme for Research and Training in Tropical Diseases(TDR),an organisation co-sponsored by the United Nations Children’s Fund(UNICEF),the United Nations Development Programme(UNDP),the World Bank,and the World Health Organization(WHO).Indeed,this think-tank published a comprehensive Global Report for Research on Infectious Diseases of Poverty[2]that guided the scope and remit of Infectious Diseases of Poverty.

关键词： UNICEF elimination originated

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On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients

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World Journal of Gastroenterology 2005年第35期11卷 5540-5544页

作者： Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder dirk J de Jong Department of Gastroenterology and Hepatology VU University Medical Centre Amsterdam The Netherlands Department of Clinical Pharmacy Maxima Medical Centre Veldhoven The Netherlands Department of Gastroenterology and Hepatology Academic Hospital Maastricht The Netherlands Department of Gastroenterology and Hepatology Academic Medical Centre Amsterdam The Netherlands Department of Gastroenterology and Hepatology Maasland Hospital Sittard The Netherlands Department of Gastroenterology and Hepatology Rijnstate Hospital Arnhem The Netherlands Department of Clinical Pharmacy Maasland Hospital Sittard The Netherlands Department of Gastroenterology and Hepatology Isala Clinics Location Sophia Zwolle The Netherlands Department of Gastroenterology and Hepatology Radboud University Nijmegen Medical Centre The Netherlands

AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.

关键词：咪唑硫嘌呤免疫抑制剂 6-巯基嘌呤急性白血病肝中毒

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