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COmbination of Targeted temperature management and Thrombectomy after acute Ischemic Stroke(COTTIS):a pilot study

Stroke & Vascular Neurology 2024年第3期9卷 258-267页

作者： Jürgen Bardutzky Rainer Kollmar Forat Al-Rawi Johann Lambeck Mohammad Fazel Christian Taschner Wolf-dirk Niesen Department of Neurology and Neurophysiology Medical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburgGermany Neurology and Neurointensive Care Darmstadt HospitalDarmstadtGermany BrainCool AB LundSweden Department of Neuroradiology Medical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburgGermany

Background To evaluate the feasibility and safety of a fast initiation of cooling to a target temperature of 35℃by means of transnasal cooling in patients with anterior circulation large vessel occlusion(LVO)undergoing endovascular thrombectomy(EVT).Methods Patients with an LVO onset of<24hour who had an indication for EVT were included in the *** cooling(RhinoChill)was initiated immediately after the patient was intubated for EVT and continued until an oesophageal target temperature of 35℃was *** was maintained with surface cooling for 6-hour postrecanalisation,followed by active rewarming(+0.2℃/hour).The primary outcome was defined as the time required to reach 35℃,while secondary outcomes comprised clinical,radiological and safety *** Twenty-two patients(median age,77 years)were included in the study(14 received additional thrombolysis,4 additional stenting of the proximal internal carotid artery).The median time intervals were 309min for last-seen-normal-to-groin,58min for door-to-cooling-initiation,65min for door-to-groin and 123min for *** target temperature of 35℃was reached within 30min(range 13–78min),corresponding to a cooling rate of 2.6℃/*** recanalisation,86%of the patients had a body temperature of≤35℃.The median National Institutes of Health Stroke Scale at admission was 15 and improved to 2 by day 7,and 68%of patients had a good outcome(modified Rankin Scale 0–2)at 3 *** complications included asymptomatic bradycardia(32%),pneumonia(18%)and asymptomatic haemorrhagic transformation(18%).Conclusion The combined application of hypothermia and thrombectomy was found to be feasible in sedated and ventilated *** events were comparable to those previously described for EVT in the absence of *** effect of this procedure will next be evaluated in the randomised COmbination of Targeted temperature management and Thrombectomy after acute Ischemic Stro

关键词： maintained continued initiated

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Gene complementation analysis indicates that parasitic dodder plants do not depend on the host FT protein for flowering

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Plant Communications 2024年第5期5卷 104-108页

作者： Sina Mackelmann Andrea Kanel Lara M.Kosters Peter Lyko dirk Prufer Gundula A.Noll Susann Wicke Institute of Plant Biology and Biotechnology University of MuensterSchlossplatz 848143 MuensterGermany Institute for Biology Humboldt-University of BerlinHaus 22Philippstr.1310115 BerlinGermany Fraunhofer Institute for Molecular Biology and Applied Ecology IME Schlossplatz 848143 MuensterGermany

Dear Editor,Cuscuta,a genus of parasitic plants,poses a significant threat to global agriculture due to its broad host range that encompasses numerous cultivated *** plants form specialized feeding organs(haustoria)that connect to the host vascular tissue and import water,nutrients,secondary metabolites,small RNAs,mRNAs,and *** such protein is FT,a peptide hormone and florigen that was recently proposed to cause the synchronization of flowering in the parasite–host system(Shen et al.,2020).

关键词： specialized organs analysis

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Fresnel Equations Derived Using a Non-Local Hidden-Variable Particle Theory

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Journal of Modern Physics 2024年第6期15卷 950-984页

作者： dirk J. Pons Department of Mechanical Engineering University of Canterbury Christchurch New Zealand

Problem: The Fresnel equations describe the proportions of reflected and transmitted light from a surface, and are conventionally derived from wave theory continuum mechanics. Particle-based derivations of the Fresnel equations appear not to exist. Approach: The objective of this work was to derive the basic optical laws from first principles from a particle basis. The particle model used was the Cordus theory, a type of non-local hidden-variable (NLHV) theory that predicts specific substructures to the photon and other particles. Findings: The theory explains the origin of the orthogonal electrostatic and magnetic fields, and re-derives the refraction and reflection laws including Snell’s law and critical angle, and the Fresnel equations for s and p-polarisation. These formulations are identical to those produced by electromagnetic wave theory. Contribution: The work provides a comprehensive derivation and physical explanation of the basic optical laws, which appears not to have previously been shown from a particle basis. Implications: The primary implications are for suggesting routes for the theoretical advancement of fundamental physics. The Cordus NLHV particle theory explains optical phenomena, yet it also explains other physical phenomena including some otherwise only accessible through quantum mechanics (such as the electron spin g-factor) and general relativity (including the Lorentz and relativistic Doppler). It also provides solutions for phenomena of unknown causation, such as asymmetrical baryogenesis, unification of the interactions, and reasons for nuclide stability/instability. Consequently, the implication is that NLHV theories have the potential to represent a deeper physics that may underpin and unify quantum mechanics, general relativity, and wave theory.

关键词： Wave-Particle Duality Optical Law Fresnel Equation Non-Local Hidden-Variable

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Knock-out of BnHva22c reduces the susceptibility of Brassica napus to infection with the fungal pathogen Verticillium longisporum

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The Crop Journal 2024年第2期12卷 503-514页

作者： Wanzhi Ye Roxana Hossain Michael Prbsting Abdallah Abdelmegid Mohamed Ali Lingyue Han Ying Miao Steffen Rietz Daguang Cai dirk Schenke Department of Molecular Phytopathology and Biotechnology Institute of PhytopathologyChristian-Albrechts-University of KielKielGermany Institut für Zuckerrübenforschung GöttingenGermany Plant Pathology Department Faculty of Agriculture and Natural ResourcesAswan UniversityAswanEgypt Fujian Provincial Key Laboratory of Plant Functional Biology College of Life SciencesFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Hohenlieth-Hof NPZ Innovation GmbHHoltseeGermany

Verticillium longisporum(Vl43)is a soilborne hemibiotrophic fungal pathogen causing stem striping on oilseed rape(OSR)and severe yield *** for resistant varieties is the most promising approach to control this ***,we report the identification of Hva22c as a novel susceptibility factor and its potential for improving OSR ***22c is a member of the Hva22 gene family,originally described for barley(Hordeum vulgare).Several Hva22 members have been located at the endoplasmic ***22c is up-regulated in response to Vl43 in both Arabidopsis and *** demonstrate that knock-out of Hva22c in OSR by CRISPR/Cas9 and its homolog in Arabidopsis by T-DNA insertion reduced plants’susceptibility to Vl43 infection and impaired the development of disease *** understand the underlying mechanism,we analysed transcriptomic data from infected and non-infected roots of hva22c knock-out and wild type *** identified a homozygous mutant with frame-shifts in all four BnHva22c loci displaying a vastly altered transcriptional landscape at 6 ***,a large set of genes was suppressed under mock conditions including genes related to the endomembrane *** the up-regulated genes we found several defense-related and phytohormone-responsive genes when comparing mutant to the wild *** results demonstrate that Hva22c is functionally required for a fully compatible plant-fungus *** loss of function reduces plant susceptibility,most likely due to endoplasmatic reticulum and Golgi dysfunction accompanied by additionally activated defense *** findings can help improve OSR resistance to *** infection.

关键词： Hva22c Susceptibility factor CRISPR/Cas9 Brassica napus Arabidopsis Verticillium longisporum Resistance breeding

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Monogenic features of urolithiasis: A comprehensive review

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Asian Journal of Urology 2024年第2期11卷 169-179页

作者： Kyo Chul Koo Abdulghafour Halawani Victor K.F.Wong dirk Lange Ben H.Chew Department of Urology Yonsei University College of MedicineSeoulRepublic of Korea Department of Urology King Abdulaziz UniversityJeddahSaudi Arabia Department of Urological Sciences University of British ColumbiaStone Centre at Vancouver General HospitalVancouverBritish ColumbiaCanada

Objective: Urolithiasis formation has been attributed to environmental and dietary factors. However, evidence is accumulating that genetic background can contribute to urolithiasis formation. Advancements in the identification of monogenic causes using high-throughput sequencing technologies have shown that urolithiasis has a strong heritable ***: This review describes monogenic factors implicated in a genetic predisposition to urolithiasis. Peer-reviewed journals were evaluated by a PubMed search until July 2023 to summarize disorders associated with monogenic traits, and discuss clinical implications of identification of patients genetically susceptible to urolithiasis ***: Given that more than 80% of urolithiases cases are associated with calcium accumulation, studies have focused mainly on monogenetic contributors to hypercalciuric urolithiases, leading to the identification of receptors, channels, and transporters involved in the regulation of calcium renal tubular reabsorption. Nevertheless, available candidate genes and linkage methods have a low resolution for evaluation of the effects of genetic components versus those of environmental, dietary, and hormonal factors, and genotypes remain undetermined in the majority of urolithiasis ***: The pathophysiology underlying urolithiasis formation is complex and multifactorial, but evidence strongly suggests the existence of numerous monogenic causes of urolithiasis in humans.

关键词： Gene Genetic expression Inheritance pattern Urolithiasis

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Development of a two-dimensional bipolar electrochemistry technique for high throughput corrosion screening

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Materials Genome Engineering Advances 2024年第3期2卷 71-82页

作者： Yiqi Zhou dirk Lars Engelberg Metallurgy and Corrosion Department of MaterialsThe University of ManchesterManchesterUK

Bipolar electrochemistry allows testing and analysing the crevice corrosion,pitting corrosion,passivation,general corrosion,and cathodic deposition reactions on one sample after a single experiment.A novel two-dimensional bipolar electrochemistry setup is designed using two orthogonal feeder electrode arrangements,allowing corrosion screening tests across a far wider potential range with a smooth potential gradient to be *** two-dimensional bipolar electrochemistry setup was applied here to simultaneously measure for the simultaneous measurement of the nucleation and propagation of pitting and crevice corrosion under a broad range of applied potential on type 420 stainless steel,which has a very short localised corrosion induction *** reduces the error from corrosion induction to corrosion competition,and all pits and crevice corrosion have no lacy *** show crevice corrosion can gain current density and easier to support its nucleation and propagation at different potential regions more easily than pitting corrosion.

关键词： 2D bipolar electrochemistry corrosion competition crevice corrosion high throughput corrosion test pitting corrosion

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Prevention and control strategies for antibiotic resistance:from species to community level

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Soil Ecology Letters 2024年第3期6卷 17-34页

作者： Yan-Zi Wang Hu Li Qing-Lin Chen Ting Pan Yong-Guan Zhu dirk Springael Jian-Qiang Su Key Laboratory of Urban Environment and Health Ningbo Observation and Research StationInstitute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Division of Soil and Water Management KU LeuvenKasteelpark Arenberg 20 Box 24593001 HeverleeBelgium

Antibiotic resistance genes(ARGs)and antibiotic resistant bacteria(ARB)in the environment pose serious threats to environmental security and public *** is an urgent need for methods to specifically and effectively control environmental pollution or pathogen infection associated with ARGs and *** review aims to provide an overview of methods abating the prevalence and spread of ARGs and ARB from species to community *** the species level,species-specific technologies,such as nanoparticle-,photosensitizer-,CRISPR-Cas-,and phage-related technology can be utilized to clear a particular class of ARGs or ARB,and in combination with low-dose antibiotics,a higher removal efficiency can be ***,the combination of antibiotics can be used to reverse microbial resistance and treat recurrent antibiotic resistant pathogen *** the community level,community-specific strategies,such as biochar,hyperthermophilic compost,and fecal microbiota transplantation can eradicate most types of ARGs or ARB in one shot,reducing the probability of resistance *** some progress has been made to eliminate ARGs and ARB in disease treatment or decontamination scenarios,further research is still needed to elucidate their mechanisms of action and scopes of application,and efforts should be made to explore novel strategies to counter the prevalence of antibiotic resistance.

关键词： antibiotic resistance genes antibiotic resistant bacteria treatment strategy disinfection

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Detection of a reassortant swine H1N2 influenza A virus from pigs in Hong Kong

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Virologica Sinica 2024年第2期39卷 343-346页

作者： Guoqian Gu Congnuan Liu Song Hao Lee Lewis Sze Chun Choi Michael T.Wilson dirk U.Pfeiffer Yun Young Go Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life SciencesCity University of Hong KongHong Kong SARChina Center for Applied One Health Research and Policy Advice Jockey Club College of Veterinary Medicine and Life SciencesCity University of Hong KongHong Kong SARChina College of Veterinary Medicine Konkuk UniversitySeoul143-701Republic of Korea

Dear Editor,Influenza A viruses(IAVs)are responsible for significant respiratory illnesses in humans and a broad range of animal *** outbreaks and the rapid spread of genetically and antigenically distinct IAVs represent a considerable challenge for swine *** are susceptible to avian and human IAV infections and are considered“mixing vessels”where human,avian,and swine IAVs can recombine and generate novel reassortant influenza viruses with pandemic potential(Vincent et al.,2014).

关键词： swine influenza mixing

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高等教育国际化视域下EMI课程建设的实践与思考——以浙江中医药大学《智慧康复基础》课程为例

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中国康复医学杂志 2024年第10期39卷 1527-1529页

作者：曹缦婷曾甦 dirk Vissers 解光尧陈静马睿杰浙江中医药大学第三临床医学院杭州市310053 比利时安特卫普大学

高等教育国际化(internationalization of higher education)是指将国际合作、跨文化交流或全球维度融入高等教育的过程中~([1])。在经济全球化、社会信息化和教育现代化的的时代要求下,推动高等教育的国际化是一个必然的趋势~([2])。... 详细信息

高等教育国际化(internationalization of higher education)是指将国际合作、跨文化交流或全球维度融入高等教育的过程中~([1])。在经济全球化、社会信息化和教育现代化的的时代要求下,推动高等教育的国际化是一个必然的趋势~([2])。国际化教育的根本目的是培育出既能继承和发扬本国优秀文化,又能理解和包容世界先进文化的,有知识、有思想、有技能、有创新精神和有国际竞争力的高水平人才~([3])。在这样的国际化背景的影响下,世界许多国家纷纷建立起了英语作为教授媒介的专业课程,简称EMI(English Medium Instruction)课程。

关键词：高等教育国际化世界先进文化国际化教育社会信息化高水平人才国际化视域浙江中医药大学 EMI

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Rethinking neurodegenerative diseases:neurometabolic concept linking lipid oxidation to diseases in the central nervous system

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Neural Regeneration Research 2024年第7期19卷 1437-1445页

作者： Steinunn Sara Helgudóttir Anne Skøttrup Mørkholt Jacek Lichota Preben Bruun-Nyzell Mads Christian Andersen Nanna Marie Juhl Kristensen Amanda Krøger Johansen Mikela Reinholdt Zinn Hulda Maria Jensdóttir John dirk Vestergaard Nieland 2N Pharma ApS NOVI Science ParkAalborgDenmark Molecular Pharmacology Group Department of Health Science and TechnologyAalborg UniversityAalborgDenmark

Currently,there is a lack of effective medicines capable of halting or reve rsing the progression of neurodegenerative disorde rs,including amyotrophic lateral sclerosis,Parkinson s disease,multiple sclerosis,or Alzheimer s *** the unmet medical need,it is necessary to reevaluate the existing para digms of how to to rget these *** considering neurodegenerative diseases from a systemic neurometabolic perspective,it becomes possible to explain the shared pathological *** innovative approach presented in this paper draws upon exte nsive research conducted by the authors and researchers *** this review,we highlight the importance of metabolic mitochondrial dysfunction in the context of neurodegenerative *** provide an overview of the risk factors associated with developing neurodegenerative disorders,including genetic,epigenetic,and environmental fa ***,we examine pathological mechanisms implicated in these diseases such as oxidative stress,accumulation of misfolded proteins,inflammation,demyelination,death of neurons,insulin resistance,dysbiosis,and neurotransmitter ***,we outline a proposal for the restoration of mitochondrial metabolism,a crucial aspect that may hold the key to facilitating curative therapeutic interventions for neurodegenerative disorders in forthcoming advancements.

关键词： brain disease carnitine palmitoyl transferase 1 epigenetics metabolism gut microbiome mitochondrial dysfunction neurodegeneration oxidative stress

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