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基质金属蛋白酶在实验性单纯疱疹性角膜炎中的分布表达

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眼科研究 2003年第5期21卷 489-492页

作者：杨燕宁 dirk bauer 邢怡桥 Arnd Heiligenhaus 武汉大学人民医院眼科 Department of Ophthalmology University of Essen45122 EssenGermany

目的明确角膜感染Ⅰ型单纯疱疹病毒(HSV-1)后基质金属蛋白酶(MMPs)及其组织抑制剂(TIMPs)在角膜中的分布。方法 HSV-1(KOS株)接种于BALB/c小鼠角膜上。分别收集正常眼球及感染后第2、7、14及28d的感染眼球行石蜡包埋,并应用抗MMP-2、-8... 详细信息

目的明确角膜感染Ⅰ型单纯疱疹病毒(HSV-1)后基质金属蛋白酶(MMPs)及其组织抑制剂(TIMPs)在角膜中的分布。方法 HSV-1(KOS株)接种于BALB/c小鼠角膜上。分别收集正常眼球及感染后第2、7、14及28d的感染眼球行石蜡包埋,并应用抗MMP-2、-8、-9及TIMP-1、-2的抗体免疫染色角膜切片。结果感染后第2d,MMP-2、-9及TIMP-1、-2的表达比未感染眼增加且表达主要位于浅表基质层及上皮下的炎性细胞中。感染后第14d及28d可见坏死性角膜炎及角膜溃疡形成,角膜基质中及浸润的炎性细胞中尤其是溃疡处可见MMP-2、-9及TIMP-1、-2表达显著增加。溃疡区域可见大量MMP-8阳性染色的中性粒细胞。结论 HSV-1角膜感染后由角膜细胞及浸润的炎性细胞分泌产生的MMPs对于上皮性角膜炎及溃疡形成过程可能起重要作用。

关键词：基质金属蛋白酶实验单纯疱疹性角膜炎 Ⅰ型单纯疱疹病毒基质金属蛋白酶抑制剂

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实验性单纯疱疹性角膜炎的组织病理学研究

华中医学杂志 2002年第5期26卷 261-262页

作者：杨燕宁邢怡桥 dirk bauer Arnd Heiligenhaus 武汉大学人民医院眼科德国埃森大学临床医院眼科

目的　动态观察 1型单纯疱疹病毒 (HSV 1)感染角膜后的组织病理改变。方法　BALB/c小鼠眼角膜接种HSV 1(KOS株 )以诱发单纯疱疹性角膜炎 (HSK)。分别收集正常眼球及感染后第 2、7、14天的感染眼球 ,组织学观察结膜及角膜的病理过程。结... 详细信息

目的　动态观察 1型单纯疱疹病毒 (HSV 1)感染角膜后的组织病理改变。方法　BALB/c小鼠眼角膜接种HSV 1(KOS株 )以诱发单纯疱疹性角膜炎 (HSK)。分别收集正常眼球及感染后第 2、7、14天的感染眼球 ,组织学观察结膜及角膜的病理过程。结果　感染后第 2天 ,中性粒细胞、淋巴细胞及其他单核细胞浸润结膜并在第 7～ 14天间快速向中央角膜扩散。结论　在HSK发展中。

关键词：实验性单纯疱疹性角膜炎组织病理学 HSV-1

Multi-mW,few-cycle mid-infrared continuum spanning from 500 to 2250cm^(−1)

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Light(Science & Applications) 2017年第1期6卷 1-6页

作者： Jinwei Zhang Ka Fai Mak Nathalie Nagl Marcus Seidel Dominik bauer dirk Sutter Vladimir Pervak Ferenc Krausz Oleg Pronin Max-Planck-Institute of Quantum Optics Hans-Kopfermann-Str.1Garching 85748Germany Ludwig-Maximilians-University Munich Am Coulombwall 1Garching 85748Germany TRUMPF Laser GmbH Aichhalder Straße 39Schramberg D-78713Germany

The demand for and usage of broadband coherent mid-infrared sources,such as those provided by synchrotron facilities,are *** most organic molecules exhibit characteristic vibrational modes in the wavelength range between 500 and 4000 cm^(−1),such broadband coherent sources enable micro-or even nano-spectroscopic applications at or below the diffraction limit with a high signal-to-noise ratio1–*** techniques have been applied in diverse fields ranging from life sciences,material analysis,and time-resolved *** we demonstrate a broadband,coherent and intrinsically carrier-envelope-phase-stable source with a spectrum spanning from 500 to 2250 cm^(−1)(−30 dB)at an average power of 24mW and a repetition rate of 77 *** performance is enabled by the first mode-locked thin-disk oscillator operating at 2μm wavelength,providing a tenfold increase in average power over femtosecond oscillators previously demonstrated in this wavelength ***-octave spectral coverage from this compact and power-scalable system opens up a range of time-and frequency-domain spectroscopic applications.

关键词： coherent repetition oscillator

Importance of LV Venting after ECMO Implantation in Post-Cardiotomy Syndrome: A Case Report

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World Journal of Cardiovascular Surgery 2022年第9期12卷 196-199页

作者： Vusal Hajiyev Temirlan Erkenov Elgun Hajiyev Alexander bauer Andreas Smechowski Seymur Musayev dirk Fritzsche Sana-Herzzentrum Cottbus Cottbus Germany

Prolonged cardiorespiratory support can be achieved with ECMO that may provide time for myocardial recovery, prevent multiorgan dysfunction and reduce mortality. Left ventricle (LV) distension can worsen already distended and hypocontractile heart. Early recognition and aggressive management of LV distension are essential for the treatment of patients with low cardiac output. The case report presented intends to show advantages of left ventricular venting on ECMO after post-cardiotomy shock. With direct flow measurements on bypass-grafts before and after the vent implantation, it was possible to clearly demonstrate the importance of venting for myocardial perfusion.

关键词： Extracorporeal Membrane Oxygenation (ECMO) Left Ventricle Vent Cardiac Distension Post-Cardiotomy Syndrome

快速而又精确的测量——生产测量技术中的反射光检测方法

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现代制造 2004年第10期 95-97页

作者： Norbert bauer dirk Berndt

以光学反射原理为基础的反射光检测方法已成功地应用于汽车工业的车轮轮辋检测。三元催化器外壳检测和型材的直线度检测之中。集成在型材加工设备中的光学扫描仪,可以自动地完成三维数字数据的转换,从而可实现加工模具的变形自动校正。

关键词：生产测量技术反射光检测方法光学扫描仪光学反射原理车轮轮辋汽车工业

Studies on Mode of Expression of Apple （Malus x domestica Borkh.） Bud Dormancy under Tropical and Temperate Climatic Conditions

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Journal of Agricultural Science and Technology(B) 2013年第7期3卷 503-516页

作者： Getachew Hruy Julie Tegenbos Renske Petre Tom Deckers Yikunoamlak Teklebirhan Hans bauer Kindeya Gebrehiwot dirk Raes Jozef Deckers Johan Keulemans Department of Dryland Crop and Horticultural Sciences Mekelle University Mekelle Ethiopia Laboratory for Fruit Breeding and Biotechnology KU Leuven W. De Croylaan 42 Heverlee Belgium Pcfruit Fruittuinweg 1 B - 3800 St. Truiden Belgium MU-IUC Research Team Mekelle University Mekelle Ethiopia WildCRU University of Oxford UK Department of Land Resources Management and Environmental Protection Mekelle University P.O. Box 231 Mekelle Ethiopia Department of Environmental and Earth Sciences KU Leuven Celestijnenlaan 200E B - 3001 Heverlee Belgium

A study was conducted to describe the progression of bud dormancy in 1-year-old apple （Malus x domestica Borkh） shoots grown at two contrasting climatic conditions （Belgium, temperate and Ethiopia, tropics）. The experiment was carried out on ＂Golden＂ and ＂Gala＂ cultivars for two consecutive years （2010/2011 and 2011/2012）. Moreover, a validation experiment was conducted on ＂MM106＂ apple rootstock during 2010/2011 only in Ethiopia. Variations in inverse of time to 50% budburst were interpreted in terms of evolution of growth capacity of the buds. Despite differences observed with chilling accumulation later in winter or early in spring, depending on environments, depth of endodormancy intensity during winter can be summarized as follows： buds from pruned shoots were less endodormant than terminal buds of the intact shoots and terminal buds were more endodormant than the dormancy intensity of upper buds of the disbudded shoots, suggesting proximal buds can grow more readily than does terminal ones. Our results provide evidence for the existence of a considerably strong paradormancy inhibition by distal shoot parts and buds, which was more pronounced in Ethiopia than in Belgium, highlighting the importance of designing and applying appropriate pruning and dormancy avoidance strategies in mild-winter climates. Finally, as still there is knowledge gap on bud dormancy progression and its control mechanism especially under mild climates, our study highlights the need for further in-depth research using biological and biochemical tests.

关键词： Bud dormancy, basitony, acrotony, Malus domestica, Ethiopia, Belgium

Importance of LV Venting after ECMO Implantation in Post-Cardiotomy Syndrome:A Case Report

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