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Evaluation of functional capacity, body composicion and pulmonary function after bariatric surgery

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Health 2013年第8期5卷 47-53页

作者： Flavia Sales Leite Marcela Cangussu Barbalho-Moulim Kadma Karenina Damaceno Soares Fernanda Dultra Dias Fabiana Sobral Peixoto-Souza dirceu costa Uninove—Nove de Julho University Sao PauloBrazil UFSCar—Federal University of Sao Carlos Sao CarlosBrazil

Introduction: Obesity has been considered a global epidemic and a serious public health problem closely related to other diseases. Moreover, obese individuals have limitations in physical capacity and pulmonary function. Weight loss induced by bariatric surgery appears to help reverse this situation. However, questions about physical capacity and lung function, and its relationship with body composition remain to be clarified. Objective: To evaluate the physical capacity, body composition and lung function in women undergoing bariatric surgery. Methods: Twenty five women who underwent bariatric surgery between 6 and 24 months ago, and 10 non-obese women were evaluated for exercise capacity by the six minutes walk test (6 MWT), body composition by bio-electrical impedance analysis and lung function by spirometry and measurement of maximal static respiratory pressures. Results: Subjects with BMI 2 were found to have better physical performance, demonstrated by increased 6 MWT distance, not differing from non-obese women. When compared with non-obese women, there were no significant differences in body composition and lung function. Higher BMI was correlated with shorter distances in 6 MWT. Conclusion: 6 to 24 months after surgery, when the weight loss of patients who underwent bariatric surgery reaches levels considered non-obese, it provides improvement in physical performance to a level similar to that of non-obese patients.

关键词： Obesity Bariatric Surgery Exercise Spirometry Muscle Strength

King's College criteria and the Clichy-Villejuif criteria require adjustments for assessing acute liver failure due to yellow fever

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World Journal of Transplantation 2025年第1期15卷 124-134页

作者： Bruno da Silva Athanasio Antonio Marcio de Faria Andrade Vivian Vasconcelos costa Juliano Felix Castro Silverio Leonardo Macedo Garcia Mauro Martins Teixeira Daniele da Gloria Souza Paula Vieira Teixeira Vidigal Cristiano Xavier Lima Department of Surgery Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Liver Transplantation Unit Felicio Rocho HospitalBelo Horizonte 30110-934Minas GeraisBrazil Department of Morphology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Biochemistry and Immunology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Pathology Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Acute liver failure(ALF)is a severe condition characterized by rapid deterioration of liver function in individuals without preexisting liver *** transplantation(LT)is the most impactful *** fever(YF)is an infectious disease that primarily affects the liver and has a high mortality ***,LT can be a viable option for treating rare cases with extensive liver ***,the criteria for assessing the severity of ALF and determining the indications for transplantation have not been specifically validated for cases caused by *** To present necessary adjustments to established scoring systems for ALF secondary to *** This was an observational,retrospective,single-center *** consecutive patients with confirmed ALF due to YF were monitored in the intensive care unit by a specialized liver transplant team during a three-month epidemic outbreak in *** hospitalization,general supportive therapeutic measures were implemented,and the patients were regularly assessed using the King's College criteria and the Clichy-Villejuif criteria to determine the severity of liver *** is considered a viable measure for patients with signs of end-stage liver *** Eight of 14(57%)patients developed severe neurological alterations within the first 96 hours after hospital *** patients underwent emergency LT,and despite a moderate viral infection of the graft after transplantation,the 5-year survival rate was 50%.Although the King's College criteria and the Clichy-Villejuif criteria are the main scoring systems for ALF,they are insufficient for predicting the risk of mortality in this context,primarily because of low serum bilirubin levels in the final stage of the disease and significant disparities between coagulation abnormalities and patient *** To ensure good applicability in cases of YF-induced ALF,the authors suggest adaptations to the King's College and Clichy-Vill

关键词： Yellow fever Acute liver failure Liver transplantation King's College criteria Clichy-Villejuif criteria

EFFECTIVE NETWORKS FOR REAL-TIME DISTRIBUTED PROCESSING

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Journal of Systems Science & Complexity 2011年第1期24卷 39-50页

作者： Gonzalo TRAVIESO Luciando da Fontoura costa Instituto de Fisica de Sao Carlos Universidade de Sao Paulo Av. do Trabalhador SSo-Carlensc 400 13566 - 590 Sao Carlos SP Brazil.

This paper applies the concepts and methods of complex networks to the development of models and simulations of master-slave distributed real-time systems by introducing an upper bound in the allowable delivery time of the packets with computation results. Two representative intercom nection models are taken into account： Uniformly random and scale free （Barabasi-Albert）, including the presence of background traffic of packets. The obtained results include the identification of the uniformly random interconnectivity scheme as being largely more efficient than the scale-free counterpart. Also, increased latency tolerance of the application provides no help under congestion.

关键词： Complex networks distributed computing real-time.

Pathogenesis and clinical management of arboviral diseases

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World Journal of Virology 2025年第1期14卷 9-50页

作者： Victoria Cenci Dietrich Juan Marcos Caram costa Marina Maria Gomes Leite Oliveira Carlos Eduardo Oliveira Aguiar Luis Guilherme de Oliveira Silva Marcel Silva Luz Fabian Fellipe Bueno Lemos Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Arboviral diseases are viral infections transmitted to humans through the bites of arthropods,such as mosquitoes,often causing a variety of pathologies associated with high levels of morbidity and *** the past decades,these infections have proven to be a significant challenge to health systems worldwide,particularly following the considerable geographic expansion of the dengue virus(DENV)and its most recent outbreak in Latin America as well as the difficult-tocontrol outbreaks of yellow fever virus(YFV),chikungunya virus(CHIKV),and Zika virus(ZIKV),leaving behind a substantial portion of the population with complications related to these ***,the world is experiencing a period of intense globalization,which,combined with global warming,directly contributes to wider dissemination of arbovirus vectors across the ***,all continents remain on high alert for potential new ***,this review aims to provide a comprehensive understanding of the pathogenesis of the four main arboviruses today(DENV,ZIKV,YFV,and CHIKV)discussing their viral characteristics,immune responses,and mechanisms of viral evasion,as well as important clinical aspects for patient *** includes associated symptoms,laboratory tests,treatments,existing or developing vaccines and the main associated complications,thus integrating a broad historical,scientific and clinical approach.

关键词： Arboviruses Arbovirus infections Dengue Zika virus Yellow fever Chikungunya virus Clinical diagnosis Pathogenesis Flavivirus Togaviridae infections

Oxidative stress in N88S seipinopathy:novel insights into the mechanisms of neurodegeneration and therapeutic avenues

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Neural Regeneration Research 2023年第8期18卷 1719-1720页

作者： Vítor costa Vitor Teixeira i3S-Instituto de Investigação e Inovação em Saúde Universidade do PortoPortoPortugal Yeast Signalling Networks IBMC-Instituto de Biologia Molecular e CelularUniversidade do PortoPortoPortugal ICBAS Instituto de Ciências Biomédicas Abel SalazarUniversidade do PortoPortoPortugal

Lipid droplets (LDs) are ubiquitous cellular orga nelles that perform functions mostly dedicated to energy homeostasis and lipid *** neutral lipid depots (triacylglycerol,sterol esters),they can be rapidly mobilized through lipase-mediated hydrolysis (lipolysis) or via lipophagy,a specific form of autophagy devoted to consumption of LDs inside the lysosome.

关键词： hydrolysis insight devoted

Prenatal and postnatal drug exposure:focus on persistent central effects

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Neural Regeneration Research 2023年第8期18卷 1697-1702页

作者： Giulia costa Alexia E.Pollack Department of Biomedical Sciences Section of NeuroscienceUniversity of CagliariCagliariItaly Department of Biology University of Massachusetts-BostonBostonMAUSA

Clinical studies indicate significant use of prescription,nonprescription and social/recreational drugs by women during pregnancy;however,limited knowledge exists about the detrimental effects that this practice may have on the developing central nervous system of the ***,few experimental and clinical data are available on how gestational exposure could exacerbate the effects of the same or a different drug consumed by the offspring later in *** present review summarizes recent findings on the central toxicity elicited by several classes of drugs,administered prenatally and postnatally in experimental animals and humans,focusing on prescription and nonprescription analgesics,anti-inflammatory agents,alcohol and nicotine.

关键词： 3 4-methylenedioxymethamphetamine acetaminophen alcohol chlorpyrifos dexamethasone ibuprofen methadone neuroinflammation neurotoxicity nicotine

Automorphism Groups of Pseudo-real Riemann Surfaces of Low Genus

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Acta Mathematica Sinica,English Series 2014年第1期30卷 11-22页

作者： Emilio BUJALANCE Antonio F.costa Departamento de Matemáticas Fundamentales Facultad de CienciasUNEDSenda del rey928040 MadridSpain

A pseudo-real Riemann surface admits anticonformal automorphisms but no anticonformal *** obtain the classifcation of actions and groups of automorphisms of pseudo-real Riemann surfaces of genera 2,3 and *** instance the automorphism group of a pseudo-real Riemann surface of genus 4 is eitherC4orC8or the Fro¨benius group of order 20,and in the case ofC4there are exactly two possible topological *** MK P R,g be the set of surfaces in the moduli space MK g corresponding to pseudo-real Riemann *** obtain the equisymmetric stratifcation of MK P R,g for generag=2,3,4,and as a consequence we have that MK P R,gis connected forg=2,3 but MK P R,4has three connected components.

关键词： Riemann surface automorphism anticonformal automorphism moduli space

Structure,stability,catalytic activity,and polarizabilities of small iridium clusters

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Chinese Physics B 2018年第6期27卷 225-230页

作者： Francisco E Jorge José R da costa Venaancio Unidade Academica dc Ffsica Universidade Federal de Campina Grande 58429-900 Campina Grande Brazil Departamento de Ffsica Universidade Federal do Espfrito Santo 29060-900 Vitoria Brazil

At the second order Douglas–Kroll–Hess（DKH2） level, the B3 PW91 functional in conjunction with the relativistic all-electron basis set of valence triple zeta quality plus polarization functions are employed to compute bond lengths, dissociation energies, vertical ionization potentials, and the highest occupied molecular orbital-lowest unoccupied molecular orbital energy gaps of the small iridium clusters（Irn, n≤8）. These results are compared with the experimental and theoretical data available in the literature. Our results confirm the theoretical predictions made by Feng et al. about the catalytic activities of the Ir4 and Ir6 clusters. From the optimized geometries, DKH2 calculations of static electric mean dipole polarizabilities and polarizability anisotropies are also carried out. It is the first time that the polarizabilities of small iridium clusters have been studied. For n≤4, the mean dipole polarizabilities per atom present an odd–even oscillatory behavior,whereas from Ir5 to Ir8, they decrease with the cluster size increasing. The dependence of the polarizability anisotropy on the structure symmetry of the iridium cluster is verified.

关键词： B3PW91 functional all-electron basis sets DKH2 calculations iridium clusters polarizabilities

Novel experimental techniques to assess the time-dependent deformations of geosynthetics under soil confinement

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第2期13卷 410-419页

作者： Carina Maia Lins costa Jorge Gabriel Zornberg Department of Civil Engineering Federal University of Rio Grande do NorteAv.Senador Salgado Filho 3000NatalRio Grande do Norte59078-970Brazil Department of Civil Architectural and Environmental Engineering The University of Texas at Austin301 E.Dean KeetonAustinTX78712-0280USA

A new experimental approach to assess the impact of soil confinement on the long-term behavior of geosynthetics is presented in this *** experimental technique described herein includes a novel laboratory apparatus and the use of different types of tests that allow generation of experimental data suitable for evaluation of the time-dependent behavior of geosynthetics under soil *** soil-geosynthetic interaction equipment involves a rigid box capable of accommodating a cubic soil mass under plane strain conditions.A geosynthetic specimen placed horizontally at the mid-height of the soil mass is subjected to sustained vertical pressures that,in turn,induce reinforcement axial loads applied from the soil to the *** previously reported studies on geosynthetic behavior under soil confinement,the equipment was found to be particularly *** minor setup modifications,not only interaction tests but also in-isolation geosynthetic stress relaxation tests and soil-only tests under a constant strain rate can be conducted using the same ***,the time histories of the reinforcement loads and corresponding strains are generated throughout the *** from typical tests conducted using sand and a polypropylene woven geotextile are presented to illustrate the proposed experimental *** testing procedure was found to provide adequate measurements during tests,including good repeatability of test *** soilegeosynthetic interaction tests were found to lead to increasing geotextile strains with time and decreasing reinforcement tension with *** test results highlighted the importance of measuring not only the time history of displacements but also that of reinforcement loads during *** approach of using different types of tests to analyze the soilegeosynthetic interaction behavior is an innovation that provides relevant insight into the impact of soil confinement on the time-dependent deformations of geos

关键词： Geosynthetics Geotextile Creep Stress relaxation Reinforced soil Long-term deformation