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Profile of SARS-CoV-2 Infected Patients Hospitalized at the Epidemic Treatment Center (ETC) in Saint-Louis, Senegal during the First Two Waves

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Advances in Infectious diseases 2024年第2期14卷 322-337页

作者： Alassane dièye Papa Latyr Junior diouf Bourama diémé Moustapha diedhiou diatou dia-Gueye Amadou diop dia Samba Niang Ibrahima Louis Martin dieng Ameth dieng Seynabou Lô Ndéye Méry dia-Badiane Health Sciences Training and Research Unit Gaston Berger University Saint-Louis Senegal Emergency Department of Regional Hospital Center Saint-Louis Senegal Department of Infectious and Tropical diseases of Fann Dakar Senegal

Introduction: The SARS-CoV-2 infection is a major public health emergency. Several risk factors are involved in the occurrence of respiratory distress that can lead to death despite resuscitation measures. Objectives: The aim of this study was to describe the epidemiological, clinical, paraclinical, therapeutic, and evolution profile of patients infected with SARS-CoV-2 hospitalized at the CTE of Saint-Louis (Senegal) during the first two waves. Patients and Methods: We conducted a retrospective, cross-sectional, descriptive, and analytical study that included all patients hospitalized at the ETC of Saint-Louis (Senegal) with SARS-CoV-2 infection from March 2020 to April 2021. Results: A total of 358 cases were collected, 256 (71.5%) during the first wave and 102 (28.5%) during the second wave. The mean age was 49.5 years (19.5). There was a male predominance (58.4%), with a sex ratio of 1.4. Hypertension was the main comorbidity, with 87 cases (24.3%). The most common functional signs were cough in 194 cases (54.2%), dyspnea in 143 cases (40%) and ageusia in 134 cases (37.4%). Thoracic CT scans were performed on 20 patients (5.6%), with severe involvement (50% - 75%) observed in 50% of cases. Hydroxychloroquine-azithromycin was prescribed to 351 patients (98%). Overall, 338 (94.4%) recovered and 17 (4.7%) died. In multivariate analysis, factors associated with death were male sex [OR = 2.645;95% CI: 1.530 - 4.785;p = 0.011], age 60 years [OR = 1.039;95% CI: 0.564 - 1.914;p = 0.002], the presence of comorbidities [OR = 2.171;95% CI: 0.564 - 3.429;p = 0.033], SpO2 (ambient air) 95% [OR = 2.061;95% CI: 0.616 - 3.827;p = 0.03], acute respiratory distress syndrome (ARDS) [OR = 0.635;95% CI: 0.316 - 1.275;p = 0.001], severe form [OR = 1.664;95% CI: 0.298 - 2.478;p = 0.016], occurrence of complications [OR = 0.521;95% CI: 0.287 - 0.944;p = 0.032], high creatinine levels [OR = 2.061;95% CI: 1.616 - 3.827;p = 0.026], and lymphopenia [OR = 0.485;95% CI: 0.370 - 0.636;p = 0.0

关键词： SARS-CoV-2 Saint-Louis Senegal

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Winning Hearts

ChinAfrica 2024年第3期16卷 44-45页

作者： ALY diouf

Sinohydro and Senegal join forces to provide drinking water in ***,a subsidiary of PowerChina,is currently engaged in efforts to substantially enhance the potable water supply in Dakar,Senegal.A diligent group of Chinese and Senegalese workers is engaged in roundthe-clock efforts along the Avenue du Front de Terre prolongée,which marks the starting point of the Route des Pères Maristes,with the objective of improving the distribution network for potable water in the Dakar *** a population density of 7,277 inhabitants per square km and an estimated 1.18 million inhabitants in 2023,there is an evident and increasing need for potable *** need is further compounded by significant water loss caused by the advanced age of the pipelines,with some pipes dating back to the colonial era.

关键词： Avenue starting network

COVID-19/Tuberculosis Co-Infection at the Epidemic Treatment Center (ETC) of Saint-Louis (Senegal): About 9 Cases

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Advances in Infectious diseases 2024年第1期14卷 56-66页

作者： Alassane dièye Moustapha diedhiou Papa Latyr Junior diouf Mba Bambo diakhaby Demba Makalou Samba Niang diatou dia-Gueye Amadou diop dia Ibrahima Louis Martin dieng Seynabou Lô Ndéye Méry dia-Badiane Health Sciences Training and Research Unit Gaston Berger University Saint-Louis Senegal Department of Medicine Saint-Louis Regional Hospital Saint-Louis Senegal Infectious and Tropical diseases Clinic of Fann Dakar Senegal

Introduction: COVID-19 is a global public health emergency that can cause acute respiratory distress syndrome. In countries where tuberculosis (TB) is endemic, coinfection of COVID-19 and TB is often encountered, which increases the risk of developing severe forms of COVID-19. Objectives: The aim of this study was to determine the prevalence of COVID-19/TB coinfection at the Epidemic treatment center (ETC) in Saint-Louis (Senegal) and to describe the epidemiological, clinical, paraclinical, and outcome profile of co-infected patients. Patients and Methods: This is a retrospective, cross-sectional, descriptive cohort study based on the records of COVID-19/ TB co-infected patients who were hospitalized at the ETC in Saint-Louis (Senegal) over an 18-month period from March 2020 to September 2021. Results: Out of a total of 454 hospitalizations, we collected records of 9 patients co-infected with COVID-19/TB, resulting in a prevalence of 2%. The study included patients with a median age of 34 years (range: 10-86 years), with a male predominance (7 cases) and a sex ratio of 3.5. The majority of patients (88.9%) had severe forms of COVID-19. Dyspnea and cough were reported in all patients (100%). Pulmonary TB was the most frequent localization, with 9 cases. The diagnosis of COVID-19 was confirmed by nasopharyngeal PCR in all patients (100%). Bacilloscopy was positive in 3 out of 5 cases. One patient tested positive for GeneXpert? MTB/RIF without rifampicin resistance. All patients were prescribed the hydroxychloroquine-azithromycin combination and anti-tuberculosis treatment. Out of the nine patients, four recovered (44.4%) and five died (55.5%). Conclusion: COVID-19/TB coinfection had a low prevalence in our cohort, but was associated with a high mortality due to the frequent occurrence of severe forms of the disease.

关键词： COVID-19 Tuberculosis Saint-Louis Senegal

Eau les coeurs Sinohydro et le Senegal unissent leurs forces pour l'eau potable a Dakar

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中国与非洲（法文版） 2024年第3期16卷 44-45页

作者： ALY diouf 不详

Au Sénegal,Sinohydro,une filiale de APowerChina,se consacre a I'amelioration significative de I'approvisionnement en eau potable de *** I'avenue du Front de Terre prolongée,a I'origine de la route des Peres Maristes,uneéquipe devouée d'ouvriers sénegalais et chinois s'affaire jour et nuit pour optimiser le reseau de distribution d'eau potable dans le departement de Dakar.

关键词： pour des forces

Corridors écologiques

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中国与非洲（法文版） 2024年第6期16卷 24-26页

作者： GE LIJUN ALY diouf 不详

Fary dieng a nourri une passion pour la conduite depuis son ***,cette《femme d'action》a obtenu son permis il y a quelques anné***ès intéressée par le développement des transports en commun,elle suivait atten tiv... 详细信息

关键词： son des pour

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Paving the Way

ChinAfrica 2024年第10期16卷 24-26页

作者： GE LIJUN ALY diouf 不详

Fary dieng has had a passion for driving since *** an adult,she obtained her driving licence a few years *** a great interest in the development of public transport,she has closely followed the Bus Rapid Transit(BRT)project in Dakar,on which work began on 28 October *** day,while visiting the site,she came across a job advertisement for drivers and immediately *** her confidence and experience,she was able to land the job,becoming the first female BRT driver in *** January,she realised her dream by taking part in the first dry runs.

关键词： Transit BRT driving

Late diagnosis of Turner Syndrome in Adulthood;a Case Study from the Endocrinology-diabetology Nutrition Department of the National Hospital of Pikine Senegal

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Open Journal of Endocrine and Metabolic diseases 2024年第5期14卷 115-122页

作者： Nafy Ndiaye Yakham Mohamed Leye Ngone diaba diack Mamadou Ba Bibatou Abdoulaye Leye Abdou Aziz diouf Alassane diouf Jean Pascal Demba diop Internal Medicine/Endocrinology-diabetology Department Teaching Hospital of Pikine Cheikh Anta Diop University Dakar Senegal Department of Gynaecology-Obstetric Teaching Hospital of Pikine Cheikh Anta Diop University Dakar Senegal Department of Human Genetic Faculty of Medicine Pharmacy and Odontology Cheikh Anta Diop University Dakar Senegal

Introduction: Turner syndrome is a rare genetic disorder characterised by the presence of one X chromosome and the absence of part or all of an X or Y chromosome and patients may experience delayed puberty and infertility. Our study aimed to evaluate the diagnostic delay in our practice and analyze the impact of this diagnostic delay on the effectiveness of patient management. Patients and Methods: Turner syndrome patients were identified from the endocrinology-diabetology nutrition department Database We examined the records of patients in whom the karyotype analysis favoured Turner syndrome. Results: We have selected 5 patients’ records of female patients with Turner syndrome. The mean age was 25, ranging from 19 to 29 years. Primary amenorrhea and characteristic dysmorphic features were observed in all patients. One married patient, who sought consultation for infertility, expressed a desire for pregnancy. Short stature was identified in 3 patients. Primary hypothyroidism and hypertension were respectively found in 1 and 2 patients. Gonadal dysgenesis was noted in 100% of cases. Karyotype analysis revealed monosomy X in 2 patients and mosaic patterns in others. All patients received estrogen-progestin treatment. Antihypertensive therapy was initiated for 2 patients. One patient is on L-thyroxine. In the short term, treatment led to the onset of menstruation after the initial months. Evaluation of treatment efficacy on internal genital organs is yet to be performed. Due to uncertain benefits at this age, growth hormone therapy was not considered for our patients. We provided counseling on assisted reproductive options for couples desiring to conceive. In our study, all patients were placed on estrogen-progestin therapy, and the response appeared favorable. Conclusion: In our practice, the diagnosis of Turner syndrome occurs very late in adulthood, at an age when growth hormone treatment is nearly ineffective. Treatment typically revolves around estrogen-progestin

关键词： Turner Syndrome Primary Amenorrhea Adult Pikine

Pleomorphic Nasopharyngeal Liposarcoma: An Aggressive Tumor

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第1期13卷 11-15页

作者： Mame Sanou diouf Sall Ahmadou Cheikhou Ndiaye Ciré Thiam Amadou Abdoulaye diop Deguenonvo Richard Edouard Alain diom Evelyne Siga Ndiaye Malick diallo Bay Karim diouf Raymond ENT and Cervicofacial Surgery Department Idrissa Pouye General Hospital Grand-Yoff Dakar Senegal ENT Department Diamniadio Children’s Hospital Dakar Senegal ENT clinic Lamine Sine diop Dakar Senegal ENT Department and Cervico-Facial Surgery H&#244pital de la paix Ziguinchor Senegal ENT and Cervicofacial Surgery Department Albert Royer Children’s Hospital Dakar Senegal

Nasopharyngeal liposarcoma is an extremely rare clinical entity. Less than ten cases have been reported in the literature. It mainly occurs in humans. The non-specificity of the clinical and radiological signs explains the difficulty of the diagnosis confirmed by anatomopathological and immunohistochemical examinations. Its pathogenesis remains obscure and often correlates with genetic abnormalities. Pleomorphic liposarcoma is its rarest subtype, remarkable for its aggressiveness and rapidity of growth. Complete surgical excision remains the treatment of choice. We report a case of liposarcoma whose diagnosis was made during histological examination coupled with immunohistochemistry. .

关键词： Liposarcoma Nasopharynx Pathology Immunohistochemistry

Profile of Extra-Pulmonary Tuberculosis in Internal Medicine

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Open Journal of Internal Medicine 2024年第1期14卷 64-73页

作者： Mouhamed dieng Djiby Sow Demba diédhiou Michel Assane Ndour Boundia Djiba Mouhamed Almahy Niang Matar Ndiaye Oumar Boun Khattab diouf Fatou Kiné Gadji Anna Sar Maïmouna Ndour Mbaye Clinique Médicale II H&ocircpital Aristide Abass Ndao Université Cheikh Anta Diop Dakar Sénégal

Introduction: Tuberculosis is an infectious disease that mainly affects the lung. Extrapulmonary localizations are a reason for hospitalization in our health facilities. The objective of this study was to describe the epidemiological, clinical, paraclinical and evolutionary aspects of extra pulmonary tuberculosis (EPT) at the Abass Ndao Hospital Center. Patients and Methods: This was a descriptive cross-sectional study conducted over a period of 11 years (January 1, 2010 to December 30, 2021). All patients with extrapulmonary tuberculosis hospitalized in the department of internal medicine during the recruitment period were included. Results: Fifty-two (52) patients were collected. The year 2019 recorded the most cases 23.08% (n = 20). The mean age of the patients was 40.56 ± 18.24 years. The age group 20 - 34 years 42.31% (n = 22) was the most represented. Females were in the majority 61.54% (n = 32) with a sex ratio (M/F) was 0.63. Housewives were in the majority 40.38% (n = 21). 60.87% of the cases (n = 14) came from a health facility. 38.46% of the cases had been infected. 21.74% (n = 9) were smokers. The reasons for consultation were dominated by fever (67.44%), AEG (62.79%) and cough (41.86%). Eighteen patients (40.91%) had fever. The mean time to consultation was 77.37 ± 90.3 days with extremes of 3 and 365 days. The median was 45 days. More than half of the patients 61.90% (n = 26) had anemia. Positive retroviral serology was noted in 21.43% of cases. All patients had a CRP greater than 6. More than half of the patients 51.92% (n = 27) had multifocal tuberculosis. The peritoneum 44.23% (n = 23) was the main organ affected. The average hospital stay was 9.8 ± 4.9 days with extremes of 1 and 19 days. All patients had received the protocol in force at the national level. Death was noted in 4 patients (9.52%). Conclusion: EPT is characterized in our context by a notorious diagnostic difficulty due to the multiplicity of clinical presentations, the complexity of

关键词： Extrapulmonary Tuberculosis Epidemiology diagnosis Senegal