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Cost-Minimization and Budget Impact Analysis of Rituximab SC VS Rituximab IV for Non-Hodgkin’s Lymphoma (NHLs) in Greece

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Journal of Cancer Therapy 2017年第8期8卷 726-734页

作者： dionysis kyriopoulos Vasiliki Tsiantou Labrini Papageorgiou Fani Theodoropoulou Kostas Athanasakis Department of Health Economics National School of Public Health Athens Greece Roche (Hellas) Athens Greece

Background: Non-Hodgkin’s lymphoma (NHLs) is a prevalent type of cancer for which Intravenous (IV) Rituximab is a widely used treatment option. Nevertheless, IV infusions can lead to intense resource use and, subsequently, costs. Given that a subcutaneous (SC) therapeutically equivalent formulation of the drug is currently available, this study aimed to examine the potential clinical and economic value of the introduction of the SC formulation for the Greek healthcare setting. Methods: A cost-minimization and budget-impact analysis contributed to comparing staff, patient time and resource utilization and estimating the clinical effects and associated costs in the IV and SC administration. A questionnaire-based survey was used to provide data regarding the local treatment patterns and the resource use associated with each treatment in the Greek NHS. The analysis followed the third-party payer perspective, and cost data relevant to personnel salaries, pharmaceuticals and resource utilization were obtained from official government sources. Results: SC administration was associated with time savings in activities such as pre-medication administration (3 minutes saved with the SC use), monitoring during infusion (12 minutes for physicians and 3 minutes for nurses) as well as time-savings in the preparation of the drugs, the actual dispensing process and the post-injecting monitoring processes. A significant decrease was observed in the nursing and chair time (57% and 90% per case, respectively) and a higher level of services could be secured in terms of hospital capacity with the SC use. SC administration was found to generate budget savings of 618,708€ per 1000 patients/3 years over the full course of treatment. Conclusions: Switching IV to SC administration, as demonstrated in the case of Rituximab for NHLs in Greece, can reduce staff time and administration costs, improve the capacity of the system and, possibly, improve resource allocation in the healthcare system.

关键词： Non-Hodgkin’s Lymphoma Intravenous Subcutaneous Nursing Time Chair Time Greece

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Feature deformation network with multi-range feature enhancement for agricultural machinery operation mode identification

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International Journal of Agricultural and Biological Engineering 2024年第4期17卷 265-275页

作者： Weixin Zhai Zhi Xu Jinming Liu Xiya Xiong Jiawen Pan Sun-Ok Chung dionysis Bochtis Caicong Wu College of Information and Electrical Engineering China Agricultural UniversityBeijing 100083China Key Laboratory of Agricultural Machinery Monitoring and Big Data Application Ministry of Agriculture and Rural AffairsBeijing 100083China Department of Smart Agricultural Systems Graduate SchoolChungnam National UniversityDaejeon 34134Republic of Korea Institute for Bio-Economy and Agri-Technology(iBO) Centre for Research and Technology-Hellas(CERTH)Thessaloniki 57001Greece

Utilizing the spatiotemporal features contained in extensive trajectory data for identifying operation modes of agricultural machinery is an important basis task for subsequent agricultural machinery trajectory *** the present study,to effectively identify agricultural machinery operation mode,a feature deformation network with multi-range feature enhancement was ***,a multi-range feature enhancement module was developed to fully explore the feature distribution of agricultural machinery trajectory ***,to further enrich the representation of trajectories,a feature deformation module was proposed that can map trajectory points to high-dimensional space to form feature ***,EfficientNet-B0 was used to extract features of different scales and depths from the feature map,select features highly relevant to the results,and finally accurately predict the mode of each trajectory *** validate the effectiveness of the proposed method,experiments were conducted to compare the results with those of other methods on a dataset of real agricultural *** the corn and wheat harvester trajectory datasets,the model achieved accuracies of 96.88%and 96.68%,as well as F1 scores of 93.54%and 94.19%,exhibiting improvements of 8.35%and 9.08%in accuracy and 20.99%and 20.04%in F1 score compared with the current state-of-the-art method.

关键词： road-field trajectory classification efficientNet feature deformation network multi-range feature enhancement agricultural machinery operation mode recognition

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Deep learning framework for multi‐round service bundle recommendation in iterative mashup development

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CAAI Transactions on Intelligence Technology 2023年第3期8卷 914-930页

作者： Yutao Ma Xiao Geng Jian Wang Keqing He dionysis Athanasopoulos School of Computer Science Wuhan UniversityWuhanChina School of Computer Science Central China Normal UniversityWuhanChina School of Electronics Electrical Engineering and Computer ScienceQueen's University BelfastBelfastUK

Recent years have witnessed the rapid development of service‐oriented computing *** boom of Web services increases software developers'selection burden in developing new service‐based systems such as *** recommending appropriate component services for developers to build new mashups has become a fundamental problem in service‐oriented software *** service recom-mendation approaches are mainly designed for mashup development in the single‐round *** is hard for them to effectively update recommendation results according to developers'requirements and behaviours(*** service selection).To address this issue,the authors propose a service bundle recommendation framework based on deep learning,DLISR,which aims to capture the interactions among the target mashup to build,selected(component)services,and the following service to ***,an attention mechanism is employed in DLISR to weigh selected services when rec-ommending a candidate *** authors also design two separate models for learning interactions from the perspectives of content and invocation history,respectively,and a hybrid model called *** on a real‐world dataset indicate that HISR can outperform several state‐of‐the‐art service recommendation methods to develop new mashups iteratively.

关键词： attention deep learning mashup development recommender systems service bundle

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ISTORIA酒店

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现代装饰 2018年第10期 130-137页

作者： Stamos Hondrodimos dionysis Koutsioumaris Giorgos Sfakianakis Breba2 李薇

本项目位于希腊圣托里尼岛附近的海滩,由Laboratorium室内工作室担任建筑改造和室内设计工作。ISTORIA酒店的设计灵感来源于建筑本身以及曾经居住其中的人们的故事。建筑原本是一个废弃的私人住宅,毗邻深蓝色的爱琴海。房子里原有5个马... 详细信息

本项目位于希腊圣托里尼岛附近的海滩,由Laboratorium室内工作室担任建筑改造和室内设计工作。ISTORIA酒店的设计灵感来源于建筑本身以及曾经居住其中的人们的故事。建筑原本是一个废弃的私人住宅,毗邻深蓝色的爱琴海。房子里原有5个马厩,以前的主人用来养她心爱的马,而这个曾被遗忘的故事成为设计师一系列灵感的火花。ISTORIA在希腊语中意为“故事”,正如名字所暗示的那样,设计师希望这个地方更像是一个静居处,一个像家一样的地方,在这里,阳光和海滩共同创造了一种纯粹的轻松与自由,可以让居住在此的旅客自在地创造属于自己的故事与记忆。

关键词：酒店建筑改造设计灵感设计工作私人住宅设计师故事工作室

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