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Symbolic Control of Hybrid Systems from Signal Temporal Logic Specifications

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Guidance, Navigation and Control 2021年第2期1卷 60-84页

作者： Rafael rodrigues da silva Vince Kurtz Hai Lin Department of Electrical Engineering University of Notre DameNotre DameIN 46556USA

In safety-critical systems,it is desirable to automatically synthesize controllers for complex tasks with guaranteed safety and *** much progress has been made through controller synthesis from temporal logic speci-cations,existing approaches generally require conservative assumptions and do not scale well with system *** propose a scalable,provably complete algorithm that synthesizes continuous trajectories for hybrid systems to satisfy temporal logic ***-cally,we harness highly e±cient Boolean satis-ability(SAT)and Linear Programming(LP)solvers to-nd trajectories that satisfy nonconvex Signal Temporal Logic(STL)speci-cations for a class of high dimensional hybrid *** proposed design algorithms are proven sound and complete,and are validated in simulation experiments.

关键词： Signal temporal logic motion planning hybrid systems trajectory synthesis symbolic control

Metabolomics in chronic hepatitis C:Decoding fibrosis grading and underlying pathways

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World Journal of Hepatology 2023年第11期15卷 1237-1249页

作者： Adriana Camargo Ferrasi Samara Vitória Granja Lima Aline Faria Galvani Jeany Delafiori Flavia Luísa Dias-Audibert Rodrigo Ramos Catharino Giovanni Faria silva Roberta rodrigues Praxedes Driele Bretones Santos dayane Trevisan de Macedo Almeida Estela Oliveira Lima Department of Internal Medicine Sao Paulo State UniversityBotucatu 18618-686Brazil Innovare Biomarkers Laboratory University of CampinasCampinas 13083-877Brazil

BACKGROUND Chronic Hepatitis C(CHC)affects 71 million people globally and leads to liver issues such as fibrosis,cirrhosis,cancer,and death.A better understanding and prognosis of liver involvement are vital to reduce morbidity and *** accurate identification of the fibrosis stage is crucial for making treatment decisions and predicting *** used to grade fibrosis include histological analysis and imaging but have *** markers such as molecular biomarkers can offer valuable insights into *** To identify potential biomarkers that might stratify these lesions and add information about the molecular mechanisms involved in the *** Plasma samples were collected from 46 patients with hepatitis C and classified into fibrosis grades F1(n=13),F2(n=12),F3(n=6),and F4(n=15).To ensure that the identified biomarkers were exclusive to liver lesions(CHC fibrosis),healthy volunteer participants(n=50)were also *** untargeted metabolomic technique was used to analyze the plasma metabolites using mass spectrometry and database *** analyses were performed to identify differential biomarkers among *** Six differential metabolites were identified in each grade of *** six-metabolite profile was able to establish a clustering tendency in patients with the same grade of fibrosis;thus,they showed greater efficiency in discriminating *** This study suggests that some of the observed biomarkers,once validated,have the potential to be applied as prognostic ***,it suggests that liquid biopsy analyses of plasma metabolites are a good source of molecular biomarkers capable of stratifying patients with CHC according to fibrosis grade.

关键词： Chronic Hepatitis C Fibrosis Metabolome Biomarkers Plasma Liquid biopsy

Prognostic Factors, Incidence and Management for Acute Variceal Bleeding in the Liver Transplantation Era

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Surgical Science 2011年第4期2卷 198-203页

作者： élio rodrigues da silva Ilka de Fátima Santana Ferreira Boin Eurípedes Soares Filho Patrícia Alexsandra Nunes Barros Rodrgiues Benedito Borges da silva 不详

Background: Gastroesophageal varices are the most common and clinically important part of the portosys-temic collaterals due to their tendency to rupture and cause massive gastrointestinal bleeding. Objective The aim of this work was to evaluate retrospectively the incidence and the factors of prediction for the treatment of bleeding by gastroesophageal varices in the patients attended in the Emergency Room of the Hospital State University of Campinas (Brazil) from the last ten years. Methods: The method used here consisted of a descriptive and retrospective study carried out from the analyses of the medical records of 769 patients with upper gastrointestinal bleeding of which 220 were admitted because of upper gastrointestinal bleeding caused by gastroesophageal varices during this same period. Results: The results showed that the gastroe-sophageal varices appeared in 28.6% of the patients and they were the second most common cause of upper gastrointestinal bleeding. While evaluating factors such as age, sex and the common individual records, it was proved that this disease occurs mainly among people between the third and the fifth decade of life, with the great majority of cases occurring in the fourth decade (29.2%), of which 76.8% were male. There was an association of hematemesis and melena in the admission of 57.7% of the patients and even ascites was a common diagnosis in 48.2% of them. Most of these patients (40%) were classified as Child class B at admis-sion. The early endoscopic exam was used for 96.8% of them and showed the presence of F3 varices in 38.5%, CB varices in 25.1% and RCS varices in 12.6%. Most of these varices (41.5%) were situated in the distal third of the esophagus. The most used pharmacological treatment was based on octreotide in 45.9% of the patients. They received 0.05 mg of intravenous octreotide and a maintenance dose of 1 mg per day in 98.6% of the cases, with efficacy in 74.2% of the patients. The tamponade with Sengstaken-Blakemo

关键词： Liver Transplantation Portal Vein Thrombosis Surgical Technique

The Difference of the Impact of Elective Cholecystectomy Surgery in the Immune Response

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Surgical Science 2018年第8期9卷 243-247页

作者： Rosamaria rodrigues Gomes Manoel Messias Lima Neto Ayrton silva Alves Cristiane Monteiro da Cruz Medical School Centro Universitário Cesmac Maceió Brazil

Introduction: The inflammatory response is essential to initiate the healing process, and in this response there is an increase in white blood cells and pro-inflammatory compounds. Creactive proteins (CRP), together with the blood leukocyte count, have been used to study the immune response. Due to the risk of infection and exacerbated inflammatory response of the patients undergoing surgical procedure, it is relevant to investigate the pre and postoperative inflammatory response of those individuals. Objective: To determine the difference in the impact of elective cholecystectomy surgery on the patient’s immune response. Methods: The present study was cross-sectional, where a group included patients who underwent elective cholecystectomy procedure. Patients who were pregnant, under 18 years, of indigenous communities or with other conditions that depress the immune system, as well as those on immunosuppressive medications, were excluded. Results: CRP and leukocyte counts indicated a mean increase of 5.97-fold (95% CI 3.76 to 8.34, SD 6.98) and 1.97-fold (95% CI 1.71 to 2.24, SD 1.97) respectively, both being evaluated before and after surgery. Discussion: In the present study, to avoid a possible methodological bias, it was chosen to evaluate the patients submitted to videolaparoscopic cholecystectomy only and the hypothesis was confirmed that there is an increase in CRP and leukocyte count as a response to surgical trauma. Conclusion: There was an elevation of the inflammatory markers in patients submitted to surgical trauma when comparing the exams collected in the preoperative period and after the surgical aggression.

关键词： Cholecystectomy Inflammation Leukocytes C-Reactive Protein

Challenges of the Global COVID-19 Pandemic and Invasive Fungal Pathogens in SARS-COV-2 Associations: A dangerous Relationship

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Advances in Microbiology 2023年第1期13卷 1-23页

作者： Alessandra Gomes Mariscal Beatriz Fernanda Siqueira Matias Cíntia Batista de Almeida Nadir Cléia Alves de Santana Simone Matos de Campos Roseli de Souza Klaucia rodrigues Vasconcelos Margareth Léa da silva Maia Cristiane Coimbra de Paula Diniz Pereira Leite Júnior Faculdade EducareMT Cuiab&aacute Brazil Centro Universitá rio de Vá rzea Grande (UNIVAG) V&aacute rzea Grande Brazil Laborató rio Central de Saú de Pú blica do Estado de Mato Grosso (LACEN) Cuiab&aacute Brazil Instituto Ciê ncias Biomé dicas (ICB) Universidade de Sã o Paulo (USP) S&atilde o Paulo Brazil Laboratory Carlos Chagas Sabin Group Cuiab&aacute Brazil Instituto Adolfo Lutz Center of Parasitology and Micology Micology Nucleus S&atilde o Paulo Brazil Research Laboratory Medical School Universidade Federal de Mato Grosso (UFMT) Cuiab&aacute Brazil

Background: COVID-19 is a rapidly transmissible pneumonia-like illness caused by SARS-CoV-2 that out broke in China in 2019 and is currently circulating worldwide. In the current context of the SARS-CoV-2 pandemic, complications are observed in clinical settings for the treatment of severe COVID-19 disease in nosocomial settings, due to cases of fungal co-infections. Objective: To carry out a review on fungal infections associated with respiratory infections caused by COVID-19 (Sars-Cov-2) and their aggravation. Methodology: The purpose of this study is to inform the reader about the characteristics of SARS-CoV-2 and the main fungal species that are affecting patients undergoing treatment for severe COVID-19, provoking discussion of the importance of the proposed topic, in relation to co-infections by different fungal microorganisms. Result: 80 scientific studies were selected, resulting from patients with COVID-19 and most commonly observed in patients with a history of comorbidities such as diabetes mellitus, hypertension, kidney disease, severe liver disease, oncological diseases, obesity and with severe COVID-19. These data do not represent the total number of records of the disease in the world, but cases reported by researchers in their series, showing the overlapping of fungal co-infection through the compromised immune status due to the use of therapeutic drugs, dysregulation of the microbiota, age of patients and the severity itself of the severe inflammation caused by COVID-19. Conclusion: The immunosuppression caused by the infection of COVID-19 concomitant with its therapy through corticosteroid therapy and comorbidities of the patients made fungal infections more susceptible, and these interfere in the evolution of the case and in the treatment of COVID-19, being relevant to distinguish secondary infections to therapy and the best possible reconstitution of the clinical picture.

关键词： Fungal Coinfections COVID-19 Coronavirus Systematic Review

Effect of the Addiction of Metal Oxide Nanoparticles on the Physical, Chemical and Thermal Properties of PVA Based Nanocomposites

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Materials Sciences and Applications 2018年第5期9卷 473-488页

作者： Raquel Couto de Azevedo Gonç alves Mota Emerson Oliveira da silva Lí via rodrigues de Menezes Instituto de Macromolé culas Professora Eloisa Mano Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil

In this study, poly(vinyl alcohol) (PVA)-based nanocomposites consisting of metallic oxide nanoparticles (TiO2, ZnO, ZrO2) were obtained from an aqueous solution of 7% PVA, in order to compare the microstructural, and physical properties of bionanocomposite films reinforced with various loading contents (0.1%, 0.2% and 0.3% w/w). They were evaluated regarding their molecular toughness through Nuclear Magnetic Resonance (NMR), regarding their chemical structural through Fourier Transform Infrared Spectroscopy (FTIR), regarding their crystallinity throught X-ray Diffraction (XRD), and regarding termal properties through Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetry (DSC). The NMR results showed that the smallest concentrations of these oxides have a tendency to disperse better in the polymeric matrix, improving the structural toughness. Besides, changes in the termal resistance of the material were found with the use of TGA and DSC.

关键词： Poly(vinyl alcohol) Nanocomposites Metallic Oxides Titanium Oxide Zirconium Oxide Zinc Oxide

Nutritional,rheological and sensory properties of butter processed with different mixtures of cow and sheep milk cream

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Food Bioscience 2022年第2期46卷 487-497页

作者： Renata S Dias Celso F.Balthazar Rodrigo N.Cavalcanti Louise A.Sobral Jessica F.rodrigues Roberto P.CNeto Maria Inˆes B.Tavares Ana Paula B.Ribeiro Renato Grimaldi Celso Sant’Anna Erick A.Esmerino Tatiana C.Pimentel Marcia Cristina silva Adriano G.Cruz Instituto Federal de Educaç˜ao Ciˆencia e Tecnologia do Rio de Janeiro(IFRJ)Departamento de AlimentosRJBrazil Universidade Estadual de Campinas(UNICAMP) Faculdade de Engenharia de AlimentosCampinasSPBrazil Universidade Federal do Rio de Janeiro(UFRJ) Escola de QuimicaRJBrazil Instituto Federal of Minas Gerais(IFMG) Departamento de Ciˆencias Agr´ariasBambuíMGBrazil Universidade Federal do Rio de Janeiro(UFRJ) Instituto de Macromol´eculas Professora Eloisa Mano(IMA)Rio de JaneiroBrazil Instituto Federal do Paran´a(IFPR) ParanavaíPRBrazil g Instituto Nacional de MetrologiaNormalizaç˜ao Qualidade Industrial(affnInmetro) Duque de Caxias25250-020Rio de JaneiroBrazil Universidade Federal Fluminense(UFF) Faculdade de Medicina VeterinariaNiter´oiRJBrazil

This study assessed the quality parameters and consumer perception and behavior of butter processed with different ratios of cow and sheep milk *** milk cream butter(CMCB)showed lower moisture content and higher fat content,smaller fat globules,and higher concentrations of long-chain saturated fatty acids and monounsaturated fatty acids,resulting in improved potential health *** addition,CMCB showed yellow color,little salt,and butter taste as the main sensory characteristics,resulting in grateful and good digestibility *** milk cream addition improved the rheological properties of the products(lower viscosity,consistency index,and rigidity(J0),and higher fluidity and viscoelastic behavior(J1)),mainly due to the increased concentrations of short-chain and medium-chain saturated fatty acids and polyunsaturated fatty ***,sheep milk cream butter(SMCB)was characterized by a greasy and striking aroma,with a lower perception of good digestibility and good appearance,and a higher bitter *** association of cow and sheep milk cream could be an exciting option to obtain products with improved fatty acid profiles,health indices,and yet maintain desired rheological and sensory *** formulation with 60%sheep milk cream and 40%cow milk cream would be the suggested combination.

关键词： Sheep milk Bovine milk Quality parameters Butter

Autoimmune hepatitis in childhood: The role of genetic and immune factors

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World Journal of Gastroenterology 2013年第28期19卷 4455-4463页

作者： Priscila Menezes Ferri Liu Débora Marques de Miranda Eleonora Druve Tavares Fagundes Alexandre rodrigues Ferreira Ana Cristina Simoes e silva Department of Pediatrics Interdisciplinary Laboratory of Medical Investigation Federal University of Minas Gerais Belo Horizonte Minas Gerais 30130-100 Brazil National Institute of Science and Technology of Molecular Medicine (INCT-MM) CNPq-FAPEMIG Federal University of Minas Gerais Belo Horizonte Minas Gerais 30130-100 Brazil

Autoimmune hepatitis (AIH) is a rare chronic inflammatory disease of the liver, which affects a group of patients who lost their immunological tolerance to antigens of the liver. It is clinically characterized by hypergammaglobulinemia, elevated liver enzymes, presence of autoantibodies and histological changes. Although being rare in children, it represents a serious cause of chronic hepatic disease that can lead to cirrhosis and hepatic failure. Clinical findings, exclusion of more common liver disorders and the detection of antibodies antinuclear antibodies, smooth muscle antibodies and anti-LKM1 are usually enough for diagnosis on clinical practice. The pathogenic mechanisms that lead to AIH remain obscure, but some research findings suggest the participation of immunologic and genetic factors. It is not yet knew the triggering factor or factors that stimulate inflammatory response. Several mechanisms proposed partially explain the immunologic findings of AIH. The knowledge of immune factors evolved might result in better markers of prognosis and response to treatment. In this review, we aim to evaluate the findings of research about genetic and immune markers and their perspectives of application in clinical practice especially in pediatric population.

关键词： Autoimmune hepatitis Genetics Clinical practice Immunophenotype

Yield, Water Use Efficiency and Physiological Characteristic of “Tommy Atkins” Mango under Partial Rootzone Drying Irrigation System

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Journal of Water Resource and Protection 2015年第13期7卷 1029-1037页

作者： Marcelo Rocha dos Santos Breno Rosa Neves Bismarc Lopes da silva Sérgio Luiz rodrigues Donato Instituto Federal de Educa ç o Ciência e Tecnologia Baiano Campus Guanambi Bahia Brazil

This study was conducted to evaluate the yield, water use efficiency and physiologic characteristics of “Tommy Atkins” mango under partial rootzone drying. The experiment was carried out in an orchard of mango in the irrigated perimeter of Ceraíma, BA. Five treatments and six repetitions were used with one tree per experimental plot: 01—Full Irrigation, 100% of ETc, 02—100% of ETc with frequency of alternance (FA) of 15 days, 03—80% ETc with FA of 15 days, 04—60% of ETc with FA of 15 days, 05—40% ETc with FA of 15 days. The treatments were conductedfrom the beginning of flowering to the harvest of mango in an orchard irrigated by drip. There was no significant reduction in productivity of “Tommy Atkins” mango under PRD up to 40% of ETc and PRD with 40% ETc resulted in greater water use efficiency. There was no significant difference among the averages of photosynthetically active radiation, Qleaf;leaf temperature, Tl;internal CO2 concentration, Ci;transpiration, E;stomatal conductance, gs;photosynthesis, A;carboxylation efficiency, A/Ci;quantum efficiency of photosynthesis, A/Qleaf and instantaneous water use efficiency, A/E between full irrigation and PRD with different water depth. The increase in leaf temperature causes reduction in A/Qleaf and A/E, however, it increases the transpiration. Increased gs results in higher rates of E, A and A/Ci. The use of the PRD with 40% of ETc causes no interference in gas exchange, maintains the yield and increases water use efficiency in “Tommy Atkins” mango tree.

关键词： Irrigation Strategy Mangifera Regulated Deficit Irrigation