检索结果-南通市图书馆

Focusing on the tetra-partite synapse in Parkinson’s disease research using human patient-derived neurons

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第5期19卷 979-981页

作者： diogo Cordeiro Tchelet Stern Shani Stern University of Haifa Sagol Department of NeurobiologyHaifaIsrael

Parkinson’s disease(PD)was first described as a neurological disease by *** Parkinson in 1817 as a“shaking palsy”.Since that time,much more is known about the pathophysiology of PD yet the disease is still *** hallmark of the disease is often considered Lewy body neural inclusions in the substantia nigra pars compacta and other brain areas,although not all patients have these *** patients exhibit massive neuronal cell loss in the substantia nigra pars compacta,which is associated with the motor symptoms of tremor,bradykinesia,rigidity,and postural *** is the second most common neurodegenerative disease after Alzheimer’s disease with a prevalence of around 1%of individuals over the age of 60.

关键词： patients Alzheimer Focus

High-resolution multi-scale air pollution system:Evaluation of modelling performance and emission control strategies

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第3期137卷 65-81页

作者： diogo Lopes Joana Ferreira Sandra Rafael Ka In Hoi Xin Li Yuan Liu Ka-Veng Yuen Kai Meng Mok Ana Isabel Miranda Department of Environment and Planning&CESAM University of AveiroAveiroPortugal Department of Civil&Environmental Engineering Faculty of Science and TechnologyUniversity of MacaoMacao SARChina

A high percentage of the world's population lives in areas where air pollutant concentrations exceed the World Health Organization *** work aims to develop and test,a high-resolution multi-scale air pollution modelling system by integrating a set of adequate *** system is able to provide detailed air pollutant concentrations in urban areas and support air quality management strategies through a better identification of different atmospheric *** also allows furthering the design and assessment of air pollution control measures for a specific *** evaluate its performance and suitability,the system was applied to the Macao Special Administrative Region(SAR),China,one of the most densely populated areas on earth,during a winter period when this area is affected by high levels of Particulate Matter(PM).Although the developed system tends to underestimate the PM concentrations,it revealed a good performance in reproducing the temporal and spatial air pollution *** exceedances of the Chinese air quality standards were calculated and high population exposure to PM pollution was *** tested urban atmospheric emission reduction scenarios have shown air quality improvements,indicating that emission reduction measures at urban level should focus on the domestic ***,it is crucial to implement joint pollution prevention strategies with neighbouring regions to improve the air quality in Macao *** approach developed in this work can support policymakers in defining new strategies to reduce atmospheric pollution in urban areas.

关键词： Urban areas High-resolution emission inventory Particulate matter Population exposure

What is the effect of Tribulus terrestris on testicular morphology and sperm production?An experimental study in the rat model

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2024年第1期26卷 67-70页

作者： Marcello Henrique Araujo Da Silva Gabriela Faria Buys-Goncalves Joao Henrique Duque Reis Estrada Francisco Jose Barcellos Sampaio diogo Benchimol de Souza Urogenital Research Unit Rio de Janeiro State UniversityRio de Janeiro 20551-030RJBrazil

The objective of this study was to investigate whether treatment with Tribulus terrestris(Tt)has any impact on the testicular morphology and function in a rodent *** male rats were divided into a control group and a group receiving 100 mg kg^(-1) body weight of Tt *** 4o days of experiment,the animals were submitted to euthanasia;epididymal tail spermatozoa were collected;and spermatozoa concentration,motility,and viability were *** addition,testicles were collected and processed for histomorphometrical *** were compared using the Student's t-test and considered significant when P<*** concentration,motility,and viability showed no difference between the ***,testicular weight and volume,seminiferous tubule diameter,tunica propria surface density,seminiferous epithelium surface density,and intertubular compartment surface density were statistically similar between the ***,seminiferous epithelium height and tubular lumen surface density were augmented in animals treated with *** with Tt does not cause a major impact on testicular morphology,promoting only subtle *** difference on spermatozoa parameters was observed.

关键词： morphometry testicle Tribulus terrestris

European legal framework related to underground mining and tunnelling concerning commission directive (EU) 2017/164, 31 January establishing a fourth list of indicative occupational exposure limit values

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2020年第4期30卷 541-545页

作者： Miguel Tato diogo Department of Mining Engineering Faculty of EngineeringUniversity of PortoPorto 4200-465Portugal

Directive(EU)2017/164 establishes a fourth list of indicative occupational exposure limit values(IOELVs)to protect workers from risks of exposure to hazardous *** states that in underground mining and tunnelling,Member States may benefit from a transitional period regarding IOELVs for nitrogen monoxide,nitrogen dioxide,and carbon monoxide,during which the existing established IOELVs may be *** European Advisory Committee on Health and Safety at Work questions the technical feasibility of the proposed IOELVs in underground mining(CO,NO and NO2)and tunnelling(NO and NO2).Challenges arise concerning the availability of measurement methodologies for compliance with proposed IOELVs(NO2)in underground mining and tunnelling environments.

关键词： Nitrogen monoxide Nitrogen dioxide Carbon monoxide IOELVs European Directive 2017/164 Underground mining Tunnelling

Intelligent negotiation model for ubiquitous group decision scenarios

在线全文

学校读者我要写书评

暂无评论

Frontiers of Information Technology & Electronic Engineering 2016年第4期17卷 296-308页

作者： Joao CARNEIRO diogo MARTINHO Goreti MARREIROS Paulo NOVAIS GECAD-Knowledge Engineering and Decision Support Group Institute of EngineeringPolytechnic of PortoPorto 4200-072Portugal ALGORITMI Centre University of MinhoGuimaraes 4800-058Portugal

Supporting group decision-making in ubiquitous contexts is a complex task that must deal with a large amount of factors to succeed. Here we propose an approach for an intelligent negotiation model to support the group decision-making process specifically designed for ubiquitous contexts. Our approach can be used by researchers that intend to include arguments, complex algorithms, and agents' modeling in a negotiation model. It uses a social networking logic due to the type of communication employed by the agents and it intends to support the ubiquitous group decision-making process in a similar way to the real process, which simultaneously preserves the amount and quality of intelligence generated in face-to-face meetings. We propose a new look into this problem by considering and defining strategies to deal with important points such as the type of attributes in the multicriterion problems, agents' reasoning, and intelligent dialogues.

关键词： Group decision support systems Ubiquitous computing Automatic negotiation Social networks Multi-agent systems

Impact of hepatitis C oral therapy in portal hypertension

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第26期23卷 4669-4674页

作者： diogo Libanio Rui Tato Marinho Department of Gastroenterology Instituto Português de Oncologia do Porto Department of Gastroenterology and Hepatology Centro Hospitalar de Lisboa Norte/Hospital Santa Maria Faculty of Medicine University of Lisbon

Chronic hepatitis C is a leading cause of morbidity and mortality, mainly related to fibrosis/cirrhosis and portal hypertension. Direct antiviral agents are highly effective and safe and can now cure > 90% of the patients. Sustained viral response (SVR) after interferon-based regimens has been associated with improvement in liver function, fibrosis and portal hypertension in a significant proportion of patients, although a point of no return seems to exist from which viral elimination is no longer capable of preventing portal hypertension progression and liver decompensation. Indeed, although SVR is associated with improvement of hepatic venous pressure gradients and therefore a decreased risk of de novo esophageal varices, several studies show that viral clearance does not eliminate the risk of variceal progression, liver decompensation and death in patients with pre-established portal hypertension. Although evidence about the effects of direct antiviral agents (DAAs) on clinically significant outcomes is still scarce and with short follow-up, DAAs can decrease the burden of the disease if patients are timely treated before significant fibrosis and portal hypertension develops. Studies with longer follow-up are waited to establish the real magnitude of hepatitis C treatment on portal hypertension. Future studies should also focus on predictors of portal hypertension resolution since it can influence management and avoid unnecessary monitoring

关键词： Hepatitis C Portal hypertension Direct antiviral agents Cirrhosis Fibrosis Interferon

In-service performance of emergency shutdown valves and dependent operational relationships in the offshore oil and gas industry

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum 2023年第4期9卷 613-620页

作者： Keith Cameron Andrew Lewis diogo Montalvao Mohammad Reza Herfatmanesh School of Physics Engineering and Computer ScienceUniversity of HertfordshireUnited Kingdom Department of Design and Engineering Faculty of Science and TechnologyBournemouth UniversityUnited Kingdom

Industrial process plants use emergency shutdown valves(ESDVs)as safety barriers to protect against hazardous events,bringing the plant to a safe state when potential danger is *** ESDVs are used extensively in offshore oil and gas processing plants and have been mandated in the design of such systems from national and international standards and *** paper has used actual ESDV operating data from four mid/late life oil and gas production platforms in the North Sea to research operational relationships that are of interest to those responsible for the technical management and operation of *** first of the two relationships is between the closure time(CT)of the ESDV and the time it remains in the open position,prior to the close *** has been hypothesised that the CT of the ESDV is affected by the length of time that it has been open prior to being closed(Time since the last stroke).In addition to the general analysis of the data series,two sub-categories were created to further investigate this possible relationship for CT and these are“above mean”and“below mean”.The correlations(Pearson's based)resulting from this analysis are in the“weak”and“very weak”*** second relationship investigated was the effect of very frequent closures to assess if this improves the *** operational records for six subjects were analysed to find closures that occurred within a 24 h period of each ***,no discriminating trend was apparent where CT was impacted positively or negatively by the frequent closure *** was concluded that the variance of ESDV closure time cannot be influenced by the technical management of the ESDV in terms of scheduling the operation of the ESDV.

关键词： Emergency Shutdown Valve Safety instrumented systems Closure time IEC-61511

Flight initiation distance, color and camouflage

在线全文

学校读者我要写书评

暂无评论

Current Zoology 2019年第5期65卷 535-540页

作者： Anders Pape MOLLER Wei LIANG diogo S.M.SAMiA Laboratoire d'Ecologie Systematique et EvolutionCNRS UMRUniversite Paris-SudBatiment 362Orsay CedexFrance Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering College of Life SciencesBeijing Normal UniversityBeijing 100875China Ministry of Education Key Laboratory for Ecology of Tropical Islands College of Life SciencesHainan Normal UniversityHaikouChina Department of Ecology Federal University of GoiasGoianiaBrazil

Camouflage is widespread throughout the animal kingdom allowing individuals to avoid detection and hence save time and energy rather than escape from an approaching ***,camouflage is likely to have co-evolved with antipredator ***,we propose that camouflage results in dichotomous escape behavior within and among species with classes of individuals and species with cryptic coloration having shorter flight initiation distances(FIDs;the distance at which an individual takes flight when approached by a human).We report the results of 2 tests of this ***,bird species with cryptically colored plumage have consistently shorter FID than closely related species without such *** species with sexually dimorphic plumage,brightly colored adult male common pheasants Phasianus colchicus and golden pheasants Chrysolophus pictus have long and variable FID,whereas cryptically colored juveniles and adult females have short and invariable ***,FID in females was predicted by presence or absence of cryptic color,FID in males and their *** findings are consistent with the hypothesis that risk-taking behavior has been attuned to camouflage,and that species with different levels of camouflage differ consistently in their FID.

关键词： anti-predator behavior birds camouflage crypsis sexual dichromatism

Engineering complex systems applied to risk management in the mining industry

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2017年第4期27卷 611-616页

作者： Domingues Maria S.Q. Baptista Adelina L.F. diogo Miguel Tato CERENA - Centre for Natural Resources and the Environment Faculty of Engineering University of Porto Porto 4200-465 Portugal CLEGI-Centre Lusiada of Research and Development in Engineering and Industrial Management University Lusiada-North Vila Nova de Famalicao 4760-108 Portugal

Related to complexity, there is a wide diversity of concepts, ranging from ‘‘systemic" to ‘‘complex", implying a need for a unified terminology. Per different authors, the main drivers of complexity can be found in human behaviour and uncertainty. This complexity, structural or dynamic can be organizational, technological, or nested in their relationship. ISO international standard 31000:2009 definition of risk management ‘‘coordinated activities to direct and control an organization with regard to risk", when applied to economic sectors, industry, services, project, or activity, it requires the use of models or theories as guidelines. Therefore, as its basic elements comprehend human behaviour and/or uncertainty, risk management to be effective and adapted as much as possible to reality, must be operational within complex systems, as already demonstrated in different R&D environments. Risk management faces demanding challenges when approaching specific and endogenous needs, such as the mining sector. This paper presents a multivariable function analysis methodology approach based on complex system modelling and through real data corresponding to a risk management tool in the mining sector.

关键词： Risk Risk management Complex systems Mining Decision making