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Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro D.Almeida iBiMED-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

European legal framework related to underground mining and tunnelling concerning commission directive (EU) 2017/164, 31 January establishing a fourth list of indicative occupational exposure limit values

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International Journal of Mining Science and Technology 2020年第4期30卷 541-545页

作者： miguel tato diogo Department of Mining Engineering Faculty of EngineeringUniversity of PortoPorto 4200-465Portugal

Directive(EU)2017/164 establishes a fourth list of indicative occupational exposure limit values(IOELVs)to protect workers from risks of exposure to hazardous *** states that in underground mining and tunnelling,Member States may benefit from a transitional period regarding IOELVs for nitrogen monoxide,nitrogen dioxide,and carbon monoxide,during which the existing established IOELVs may be *** European Advisory Committee on Health and Safety at Work questions the technical feasibility of the proposed IOELVs in underground mining(CO,NO and NO2)and tunnelling(NO and NO2).Challenges arise concerning the availability of measurement methodologies for compliance with proposed IOELVs(NO2)in underground mining and tunnelling environments.

关键词： Nitrogen monoxide Nitrogen dioxide Carbon monoxide IOELVs European Directive 2017/164 Underground mining Tunnelling

Impact of hepatitis C oral therapy in portal hypertension

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World Journal of Gastroenterology 2017年第26期23卷 4669-4674页

作者： diogo Libanio Rui tato Marinho Department of Gastroenterology Instituto Português de Oncologia do Porto Department of Gastroenterology and Hepatology Centro Hospitalar de Lisboa Norte/Hospital Santa Maria Faculty of Medicine University of Lisbon

Chronic hepatitis C is a leading cause of morbidity and mortality, mainly related to fibrosis/cirrhosis and portal hypertension. Direct antiviral agents are highly effective and safe and can now cure > 90% of the patients. Sustained viral response (SVR) after interferon-based regimens has been associated with improvement in liver function, fibrosis and portal hypertension in a significant proportion of patients, although a point of no return seems to exist from which viral elimination is no longer capable of preventing portal hypertension progression and liver decompensation. Indeed, although SVR is associated with improvement of hepatic venous pressure gradients and therefore a decreased risk of de novo esophageal varices, several studies show that viral clearance does not eliminate the risk of variceal progression, liver decompensation and death in patients with pre-established portal hypertension. Although evidence about the effects of direct antiviral agents (DAAs) on clinically significant outcomes is still scarce and with short follow-up, DAAs can decrease the burden of the disease if patients are timely treated before significant fibrosis and portal hypertension develops. Studies with longer follow-up are waited to establish the real magnitude of hepatitis C treatment on portal hypertension. Future studies should also focus on predictors of portal hypertension resolution since it can influence management and avoid unnecessary monitoring

关键词： Hepatitis C Portal hypertension Direct antiviral agents Cirrhosis Fibrosis Interferon

Intelligent negotiation model for ubiquitous group decision scenarios

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Frontiers of Information Technology & Electronic Engineering 2016年第4期17卷 296-308页

作者： Joao CARNEIRO diogo MARTINHO Goreti MARREIROS Paulo NOVAIS GECAD-Knowledge Engineering and Decision Support Group Institute of EngineeringPolytechnic of PortoPorto 4200-072Portugal ALGORITMI Centre University of MinhoGuimaraes 4800-058Portugal

Supporting group decision-making in ubiquitous contexts is a complex task that must deal with a large amount of factors to succeed. Here we propose an approach for an intelligent negotiation model to support the group decision-making process specifically designed for ubiquitous contexts. Our approach can be used by researchers that intend to include arguments, complex algorithms, and agents' modeling in a negotiation model. It uses a social networking logic due to the type of communication employed by the agents and it intends to support the ubiquitous group decision-making process in a similar way to the real process, which simultaneously preserves the amount and quality of intelligence generated in face-to-face meetings. We propose a new look into this problem by considering and defining strategies to deal with important points such as the type of attributes in the multicriterion problems, agents' reasoning, and intelligent dialogues.

关键词： Group decision support systems Ubiquitous computing Automatic negotiation Social networks Multi-agent systems

Integrated Design Fabrication and Control of a Bioinspired Multimaterial Soft Robotic Hand

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Cyborg and Bionic Systems 2023年第1期4卷 156-165页

作者： Samuel Alves Mihail Babcinschi Afonso Silva diogo Neto diogo Fonseca Pedro Neto University of Coimbra CEMMPREARISEDepartment of Mechanical Engineering3030-788 CoimbraPortugal

Machines that mimic humans have inspired scientists for *** soft robotic hands are a good example of such an endeavor,featuring intrinsic material compliance and continuous motion to deal with uncertainty and adapt to unstructured *** research led to impactful achievements in functional designs,modeling,fabrication,and control of soft ***,the full realization of life-like movements is still challenging to achieve,often based on trial-and-error considerations from design to fabrication,consuming time and *** this study,a soft robotic hand is proposed,composed of soft actuator cores and an exoskeleton,featuring a multimaterial design aided by finite element analysis(FEA)to define the hand geometry and promote finger’s *** actuators are fabricated using molding,and the exoskeleton is 3D-printed in a single *** ON-OFF controller keeps the set fingers’inner pressures related to specific bending angles,even in the presence of *** FEA numerical results were validated by experimental tests,as well as the ability of the hand to grasp objects with different shapes,weights,and *** integrated solution will make soft robotic hands more available to people,at a reduced cost,avoiding the time-consuming design-fabrication trial-and-error processes.

关键词： consuming skeleton realization

Candidates for liver transplantation with alcoholic liver disease: Psychosocial aspects

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World Journal of Gastroenterology 2015年第39期21卷 11027-11033页

作者： diogo Telles-Correia Inês Mega Deparment of Psychiatry Faculty of Medicine University of Lisbon Curry Cabral Liver Transplantation Center

In Europe, 30% to 50% of liver transplantations are currently due to alcoholic liver disease(ALD). In the United States, this percentage is 17.2%. Post-transplantsurvival and other predictors of clinical course do not differ significantly from those in other types of transplanted patients, as long as there is no relapse of drinking. However, 20%-25% of these patients lapse or relapse to heavy drinking post-operatively, which has been associated with an increased risk of liver damage and mortality. It is therefore crucial to design specific selection and follow-up strategies aimed at this particular type of patient. Several good and poor prognosis factors that could help to predict a relapse have been suggested, among them the duration of abstinence, social support, a family history of alcoholism, abuse diagnosis versus alcohol dependence, non-acceptance of diagnosis related to alcohol use, presence of severe mental illness, nonadherence in a broad sense, number of years of alcoholism, and daily quantity of alcohol consumption. In this article, we discuss these and other, more controversial factors in selecting ALD patients for liver transplantation. Abstinence should be the main goal after transplantation in an ALD patient. In this article, we review the several definitions of post-transplant relapse, its monitoring and the psychopharmacological and psychotherapeutic treatment.

关键词： Liver transplantation Alcoholic liver disease Psyc

Focusing on the tetra-partite synapse in Parkinson’s disease research using human patient-derived neurons

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Neural Regeneration Research 2024年第5期19卷 979-981页

作者： diogo Cordeiro Tchelet Stern Shani Stern University of Haifa Sagol Department of NeurobiologyHaifaIsrael

Parkinson’s disease(PD)was first described as a neurological disease by *** Parkinson in 1817 as a“shaking palsy”.Since that time,much more is known about the pathophysiology of PD yet the disease is still *** hallmark of the disease is often considered Lewy body neural inclusions in the substantia nigra pars compacta and other brain areas,although not all patients have these *** patients exhibit massive neuronal cell loss in the substantia nigra pars compacta,which is associated with the motor symptoms of tremor,bradykinesia,rigidity,and postural *** is the second most common neurodegenerative disease after Alzheimer’s disease with a prevalence of around 1%of individuals over the age of 60.

关键词： patients Alzheimer Focus

In-service performance of emergency shutdown valves and dependent operational relationships in the offshore oil and gas industry

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Petroleum 2023年第4期9卷 613-620页

作者： Keith Cameron Andrew Lewis diogo Montalvao Mohammad Reza Herfatmanesh School of Physics Engineering and Computer ScienceUniversity of HertfordshireUnited Kingdom Department of Design and Engineering Faculty of Science and TechnologyBournemouth UniversityUnited Kingdom

Industrial process plants use emergency shutdown valves(ESDVs)as safety barriers to protect against hazardous events,bringing the plant to a safe state when potential danger is *** ESDVs are used extensively in offshore oil and gas processing plants and have been mandated in the design of such systems from national and international standards and *** paper has used actual ESDV operating data from four mid/late life oil and gas production platforms in the North Sea to research operational relationships that are of interest to those responsible for the technical management and operation of *** first of the two relationships is between the closure time(CT)of the ESDV and the time it remains in the open position,prior to the close *** has been hypothesised that the CT of the ESDV is affected by the length of time that it has been open prior to being closed(Time since the last stroke).In addition to the general analysis of the data series,two sub-categories were created to further investigate this possible relationship for CT and these are“above mean”and“below mean”.The correlations(Pearson's based)resulting from this analysis are in the“weak”and“very weak”*** second relationship investigated was the effect of very frequent closures to assess if this improves the *** operational records for six subjects were analysed to find closures that occurred within a 24 h period of each ***,no discriminating trend was apparent where CT was impacted positively or negatively by the frequent closure *** was concluded that the variance of ESDV closure time cannot be influenced by the technical management of the ESDV in terms of scheduling the operation of the ESDV.

关键词： Emergency Shutdown Valve Safety instrumented systems Closure time IEC-61511

Temperature-dependent thermal conductivity and fuel performance of UN-UO_(2) and UN-X-UO_(2)(X=Mo,W)composite nuclear fuels by finite element modeling

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Journal of Materiomics 2024年第4期10卷 937-946页

作者： Faris Sweidan diogo Ribeiro Costa Huan Liu Pär Olsson KTH Royal Institute of Technology Nuclear EngineeringStockholm10691Sweden Westinghouse Electric Sweden AB Västerås72163Sweden

The temperature-dependent effective thermal conductivity of UN-X-UO_(2)(X=Mo,W)nuclear fuel composite was *** the experimental design,the thermal conductivity was calculated using Finite Element Modeling(FEM),and compared with analytical models for 10%,30%,50%,and 70%(in mass)uncoated/coated UN microspheres in a UO_(2) *** FEM results show an increase in the fuel thermal conductivity as the mass fraction of the UN microspheres increases from 1.2 to 4.6 times the UO_(2) reference at 2,000 *** results from analytical models agree with the thermal conductivity estimated by *** results also show that Mo and W coatings have similar thermal behaviors,and the coating thickness influences the thermal conductivity of the *** higher weight fractions,the thermal conductivity of the fuel composite at room temperature is substantially influenced by the high thermal conductivity coatings approaching that of ***,the thermal conductivity from FEM was used in the fuel thermal performance evaluation during LWR normal operation to calculate the maximum centerline *** results show a significant decrease in the fuel maximum centerline temperature ranging from−94 K for 10% UN to−414 K for 70%(in mass)UN compared to UO_(2) under the same operating conditions.

关键词： Accident tolerant fuel UN-X-UO_(2) Composite nuclear fuel Thermal conductivity Finite element modeling Thermal performance