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世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 39-40页

作者： Jordan J.F. Joergens.s. dinslage s. 廖新华 Univers.ty Eye Hos.ital University of Cologne Joseph- Stelzmann- Str. 9 50931 Cologne Germany

Purpos.: The difference in central corneal thicknes. among s.bgroups.of glaucoma patients. as.well as.its.influence on Goldmann applanation tonometry, has.beenwell documented in s.veral clinical trials. In the pres.nt s.udy, pos.ible s.milarities.and differences.between central corneal thicknes. and corneal thicknes. of paracentral quadrants.in patients.with normal tens.on glaucoma (NTG) and ocular hypertens.on (OHT) were inves.igated. Methods. Central and paracentral corneal thicknes. was.meas.red by optical s.it s.an pachymetry (Orbs.an II). Fourteen patients.(28 eyes. with NTG and 11 patients.(22 eyes. with OHT were included in this.s.udy. t-Tes. was.performed for s.atis.ical analys.s. To evaluate overall corneal topography, the mean and s. values.of the differences.between the central corneal thicknes. and each peripheral quadrant were analys.d. Res.lts. The following data was.obtained (μ m): (central, upper, temporal, nas.l, inferior paracentral quadrant): OHT group 617- 695- 663- 687- 660. NTG group 568- 629- 593- 612- 616. Corneal thicknes. of all four paracentral quadrants.differed s.gnificantly between the OHT and NTG groups. There was.a more heterogeneous.intraindividual pattern of overall corneal topography in the OHT group, and a more heterogeneous.pattern of corneal topography among the individuals.of the NTGgroup (interindividual heterogeneity). Conclus.ons. A comparis.n of central corneal thicknes. and paracentral corneal thicknes. revealed clinically relevant differences.between the OHT and NTG groups. The pres.nted data underlines.the importance of correlating the s.te of applanation with the corres.onding corneal thicknes., es.ecially in OHT patients. It further s.bs.antiates.the neces.ity to obtain individual pachymetric data for each NTG patient.

关键词：角膜厚度中央区高眼压角膜地形图角膜中央 Orbs.an 眼压测量临床相关性压平异质性

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维普期刊数据库

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0.005%拉坦前列素对青光眼房水流动及排出的影响:双盲、安慰剂对照临床研究

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 26-27页

作者： dinslage s. Hueber A. Dies.elhors. M. Kriegls.ein G.K. 陈立军 Department of Ophthalmology University of CologneJoseph-Stelzmann-Strasse 9 50924 CologneGermany

Background: Fluorophotometry and pneumotonography were performed to inves.igat e the effect of Latanopros. 0.005%and Placebo on aqueous.humor flow and total o utflow facility in human glaucomatous.eyes. Methods. In a randomis.d doubleblind clinical s.udy patients.with POAG and OHT received either latanopros. 0.005%or placebo once in the evening. Fluorophotometry (Fluorotron Mas.er II, Ocumetrics.) and Pneumatonography (Model 30 Clas.ic Pneumatonometer,Mentor) was.performed i n 20 eyes.of 10 patients.(verum) and 22 eyes.of 11 patients.(placebo). During a 2 week was.-out period all patients.received a s.s.emic antiglaucomatous.therap y (Acetazolamide) up to 3 days.before bas.line meas.rement. Patients.with an IOP higher than 28 mmHg at bas.line were excluded. Fluorophotometry, tonography and IOP were meas.red at bas.line after 1 and 2 weeks.of treatment. Data was.analys.ed by the s.udents.paired tes.. Res.lts. All patients.completed the protocol. The IOP s.gnificantly decreas.d (25%) after 1 and 2 weeks.of treatment with Lat anopros. (P s.rements.s.owed no difference in flow over time in both groups. Although tonographic mean C values.in both groups.did not s.ow any difference over time, the es.imated total outflow facility C (Goldmann) increas.d s.gnificantly (P s.after 2 weeks. A s.gnificant difference of out flow coefficient correlated to normal pres.ure (PO/C) was.found after 2 weeks.of treatment with Latanopros. (P s.ons. In accordance with the lite rature we found a mean 25%decreas. in IOP after 2 weeks.of treatment with Latan opros. 0.005%. The analys.s.of flow values.in both groups.s.owed no increas. or decreas. in aqueous.humor dynamics.as.proved in many previous.s.udies. The know n effect of Latanopros. to increas. uveos.leral outflow by remodeling extracellu lar matrix and widening intermus.ular s.aces.in the ciliary body may not be dete cted by pneumatonography after 2 weeks.of tr

关键词：拉坦眼房水房水流畅系数眼压描记眼压测量基础眼压安慰剂对照气体眼压计高眼压症小梁网

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维普期刊数据库

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青光眼晚期行白内障超声乳化术后的早期眼压(IOP)峰值

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世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 43-43页

作者： Dietlein T. s. Jordan J. dinslage s. 廖新华(译) Zentrum für Augenheilkunde Universitaet Koeln Joseph-Stelzmann-Straβe 9 50931Koeln Germany 不详

Background:Modern cataract s.rgery with us. of vis.oelas.ics.can induce remarkable early s.ikes.of the intraocular pres.ure(IOP)in patients.with *** and Methods.The purpos. of this.pros.ective s.udy was.to inves.igate ris. factors.for an early increas. of the IOP following cataract s.rgery in eyes.with end-s.age *** cornea phacoemuls.fication with implantation of a foldable acrylic lens.was.performed in 25 eyes.with end-s.age glaucoma(primary open-angle glaucoma including normal tens.on glaucoma or exfoliative glaucoma)either under topical anes.hes.a or under general *** eyes.with exfoliative glaucoma,trabecular as.iration was.performed *** meas.rements.were conducted at the day before s.rgery,4 hours.following s.rgery and on the firs. morning following ***:Cataract s.rgery was.performed without *** mean IOP was.18.5± 4.2 mmHg with 2.1± 1.0 topical medications.4 hours.pos.operatively,mean IOP was.31.3± 11.9 *** eyes.with exfoliative glaucoma(n=12)the early pos.operative IOP was.28.5± 12.0 mmHg,but without s.gnificant difference compared to eyes.with POAG(n= 13).The early pos.operative IOP s.owed s.gnificant correlation with the maximum IOP in patient’ s.his.ory(p=0.014).Conclus.ons.Patients.with late-s.age glaucoma can experience cons.derable early IOP s.ikes.following uneventful cataract s.rgery,although preoperatively IOP is.controlled by topical *** IOP monitoring is.recommended at the day of s.rgery,es.ecially if high IOP values.are reported in patient’ s.his.ory.

关键词：白内障超声乳化青光眼患者术后早期早期眼压晚期患者原发性开角型青光眼峰值白内障手术后

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维普期刊数据库

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