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Acta Pharmaceutica Sinica B 2016年第4期6卷 287-296页

作者： dinh ha Ningning Yang Venkatareddy Nadithe Manchester University College of Pharmacy Natural & Health Sciences

Exosomes are small intracellular membrane-based vesicles with different compositions that are involved in several biological and pathological processes. The exploitation of exosomes as drug delivery vehicles offers important advantages compared to other nanoparticulate drug delivery systems such as liposomes and polymeric nanoparticles; exosomes are non-immunogenic in nature due to similar composition as body's own cells. In this article, the origin and structure of exosomes as well as their biological functions are outlined. We will then focus on specific applications of exosomes as drug delivery systems in pharmaceutical drug development. An overview of the advantages and challenges faced when using exosomes as a pharmaceutical drug delivery vehicles will also be discussed.

关键词： Exosomes Nanocarrier Extracellular vesicles Drug delivery systems

Improving Indigenous Technologies for Sustainable Land Use in Northern Mountainous Areas of Vietnam

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Journal of Mountain Science 2004年第3期1卷 270-275页

作者： Le Quoc Doanh ha dinh Tuan Vietnam Agricultural Science Institute (VASI) D7 Phoung Mai Dong Da Hanoi VietnamVietnam Agricultural Science Institute (VASI) D7 Phoung Mai Dong Da Hanoi Vietnam

More than 30 ethnic groups are now living in northern mountainous regions, Vietnam, mainly relying on shifting cultivation with the fallow period being shortened from time to time. Naturally, soil fertility reduces from cycle to cycle, entailing the reduction of productivity. Large areas of moderately sloping lands suitable for upland agriculture have become bare after many cultivation-fallow cycles. The soils there have been severely degraded with more toxicity, low porosity, low water retention capacity and poor floral diversity. Normally, these lands cannot be used for food crop cultivation. So farmers in uplands have to rely on slash-and-burn practices for their livelihood. As there is no more forest with good soil in medium slopes, farmers go to cut forests in watershed, high slope lands and old forests up to the mountains’ top. There are ecologically and environmentally very sensitive areas, so their destruction will inevitably cause hazardous consequences in the whole basin. Meanwhile, cultivation in these areas has low economic efficiency and sustainability because the crop yield may decrease very fast due to severe erosion as the higher the slope, the more serious erosion. Consequently living standards of highland farmers remain low and unstable. Sustainable farming on these lands in the perspective of a seriously deteriorated ecology and environmental is not an easy task. There have been many projects trying to help mountainous farmers get out of their vicious circle. However, due to different reasons, the results gained are low, and in some cases, things ceased to move after the projects phased out. During past few years, based on the farmer experiences, the Vietnam Agricultural Science Institute has cooperated with local and international partners to implement different projects in order to solve the problems by developing simple, easy and cheap cultivation technologies, which can be accepted and applied by local poor farmers for sustainable agricultural

关键词： Indigenous technologies sustainable agriculture upland eco-regions northern vietnam

The Role of Occipitotemporal Network for Speed-Reading:An fMRI Study

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Neuroscience Bulletin 2024年第9期40卷 1261-1273页

作者： Dexin Sun Zhilin Zhang Naoya Oishi Qi Dai dinh ha Duy Thuy Nobuhito Abe Jun Tachibana Shintaro Funahashi Jinglong Wu Toshiya Murai Hidenao Fukuyama Research Center for Medical Artificial Intelligence Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055China University of Chinese Academy of Sciences Beijing100049China Department of Psychiatry Graduate School of MedicineKyoto UniversityKyoto606-8501Japan Medial Innovation Center Graduate School of MedicineKyoto UniversityKyoto606-8501Japan Human Brain Research Center Graduate School of MedicineKyoto UniversityKyoto606-8501Japan Kokoro Research Center Kyoto UniversityKyoto606-8501Japan Speed Reading Academy Kyoto600-8439Japan

The activity of occipitotemporal regions involved in linguistic reading processes,such as the ventral occipitotemporal cortex(vOT),is believed to exhibit strong interactions during higher-order language processing,specifically in the connectivity between the occipital gyrus and the temporal *** this study,we utilized functional magnetic resonance imaging(fMRI)with psychophysiological interaction(PPI)and dynamic causal modeling(DCM)to investigate the functional and effective connectivity in the occipitotemporal network during speed *** conducted the experiment with native Japanese speakers who underwent and without speed-reading training and subsequently performed established reading tasks at different speeds(slow,medium,and fast)while undergoing 3-Tesla Siemens *** activation analyses revealed significant changes in occipital and temporal regions as reading speed increased,indicating functional connectivity within the occipitotemporal *** results further demonstrated more intricate effective connections and high involvement within the occipitotemporal pathway:(1)reading signals originated from the inferior occipital gyrus(iO),distributed to the vOT and the posterior superior temporal sulcus(pSTS),and then gathered in the anterior superior temporal sulcus(aSTS);(2)reading speed loads had modulation effects on the pathways from the aSTS to vOT and from the iO to *** findings highlight the complex connectivity and dynamic interactions within the occipitotemporal network during speed-reading processes.

关键词： Speed reading fMRI The occipitotemporal network Functional connectivity Effective connectivity

Eye Strain Detection During Online Learning

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Intelligent Automation & Soft Computing 2023年第3期35卷 3517-3530页

作者： Le Quang Thao Duong Duc Cuong Vu Manh Hung Le Thanh Vinh Doan Trong Nghia dinh ha hai Nguyen Nhan Nhi Faculty of Physics VNU University of ScienceHanoi100000Vietnam University of Science Vietnam National UniversityHanoi100000Vietnam VNU-HUS High School for Gifted StudentsHanoi100000Vietnam hanoi-Amsterdam High School for the Gifted Hanoi100000Vietnam

The recent outbreak of the coronavirus disease of 2019(Covid-19)has been causing many disruptions among the education systems worldwide,most of them due to the abrupt transition to online *** sudden upsurge in digital electronic devices usage,namely personal computers,laptops,tablets and smart-phones is unprecedented,which leads to a new wave of both mental and physical health problems among students,for example eye-related *** overexpo-sure to electronic devices,extended screen time usage and lack of outdoor sun-light have put a consequential strain on the student’s ophthalmic health because of their young age and a relative lack of responsibility on their own *** to take appropriate external measures to mitigate the negative effects of this pro-cess could lead to common ophthalmic illnesses such as myopia or more serious *** remedy this situation,we propose a software solution that is able to track and capture images of its users’eyes to detect symptoms of eye illnesses while simultaneously giving them warnings and even offering *** meet the requirements of a small and light model that is operable on low-end devices without information loss,we optimized the original MobileNetV2 model with depth-wise separable convolutions by altering the parameters in the last layers with an aim to minimize the resizing of the input image and obtained a new model which we call *** with applying the knowledge distillation tech-nique and ResNet-18 as a teacher model to train the student model,we have suc-cessfully increased the accuracy of the EyeNet model up to 87.16%and support the development of a model compatible with embedded systems with limited computing power,accessible to all students.

关键词： Digital eye strain Covid-19 online study knowledge distillation eye care EyeNet

Long-Term Improvement in Precautions for Flood Risk Mitigation:A Case Study in the Low-Lying Area of Central Vietnam

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International Journal of Disaster Risk Science 2021年第2期12卷 250-266页

作者： Cong dinh Nguyen Funiikazu Ubukata Quang Tan Nguyen Hoang ha Vo Graduate School of Environmental and Life Science Okayama UniversityOkayama 700-8530Japan Faculty of Economics and Development Studies University of EconomicsHue UniversityHue City 49000Vietnam International School Hue UniversityHue City 49000Vietnam

Local actors appear as inseparable components of the integrated flood risk mitigation strategy in *** this fact,this study examined the long-term improvement in precautions taken by commune authorities and households between two major floods in 1999 and 2017 by applying both quantitative and qualitative *** flood-prone villages were selected for a survey;one in a rural area and the other in a suburban area of Thua Thien Hue Province,central *** findings indicate that most villagers doubted the structural works’efficacy and were dissatisfied with the current efforts of local ***’self-preparation thus became the decisive factor in mitigating *** most households have paid greater attention to flood precautions in 2017,others seem to be ***-related barriers were the root causes restraining households in both rural and suburban *** suburban riverine residents were further identified as vulnerable by their limitations in upgrading structural measures,which was ascribed to the inconsistency in the ancient town’s preservation *** multidimensional comparison,in terms of vulnerability,emphasized the importance of space-function links in the suburb and the contradictions of different policy initiatives,such as landscape rehabilitation,disaster prevention,and livelihood maintenance.

关键词： Central Vietnam Flood risk mitigation Long-term improvement Natural hazards Precautionary measures

Biological methane production coupled with sulfur oxidation in a microbial electrosynthesis system without organic substrates

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Journal of Environmental Sciences 2022年第6期34卷 68-78页

作者： ha T.T.dinh Hiromi Kambara Shuji Matsushita Yoshiteru Aoi Tomonori Kindaichi Noriatsu Ozaki Akiyoshi Ohashi Department of Civil and Environmental Engineering Graduate School of Advanced Science and EngineeringHiroshima University1-4-1KagamiyamaHigashihiroshimaHiroshima 739-8527Japan Faculty of Environment Ho Chi Minh City University of Natural Resources and Environment236 Le Van Sy1 WardTan Binh DistrictHo Chi Minh CityViet Nam Agricultural Technology Research Center Hiroshima Prefectural Technology Research Institute6869HaraHachihonmatsuHigashihiroshimaHiroshima 739-0151Japan Program of Biotechnology Graduate School of Integrated Sciences for LifeHiroshima University1-3-1KagamiyamaHigashihiroshimaHiroshima 739-8530Japan

Methane is produced in a microbial electrosynthesis system(MES) without organic substrates. However, a relatively high applied voltage is required for the bioelectrical *** this study, we demonstrated that electrotrophic methane production at the biocathode was achieved even at a very low voltage of 0.1 V in an MES, in which abiotic HS-oxidized to SO_(4)^(2-) at the anodic carbon-cloth surface coated with platinum powder. In addition, microbial community analysis revealed the most probable pathway for methane production from electrons. First, electrotrophic H_(2) was produced by syntrophic bacteria, such as Syntrophorhabdus, Syntrophobacter, Syntrophus, Leptolinea, and Aminicenantales, with the direct acceptance of electrons at the biocathode. Subsequently, most of the produced H_(2) was converted to acetate by homoacetogens, such as Clostridium and Spirochaeta 2. In conclusion,the majority of the methane was indirectly produced by a large population of acetoclastic methanogens, namely Methanosaeta, via acetate. Further, hydrogenotrophic methanogens,including Methanobacterium and Methanolinea, produced methane via H_(2).

关键词： Bioelectricity Homoacetogens Methane production Microbial electrosynthesis system Sulfur oxidation

New microbial electrosynthesis system for methane production from carbon dioxide coupled with oxidation of sulfide to sulfate

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Journal of Environmental Sciences 2023年第3期125卷 786-797页

作者： Hiromi Kambara ha T.T.dinh Shuji Matsushita Yoshiteru Aoi Tomonori Kindaichi Noriatsu Ozaki Akiyoshi Ohashi Department of Civil and Environmental Engineering Graduate School of EngineeringHiroshima University1–4–1KagamiyamaHigashi-HiroshimaHiroshima 739–8527Japan Faculty of Environment Ho Chi Minh City University of Natural Resources and Environment236 Le Van Sy1 WardTan Binh DistrictHo Chi Minh CityVietnam Agricultural Technology Research Center Hiroshima Prefectural Technology Research Institute6869HaraHachihonmatsuHigashihiroshimaHiroshima 739–0151Japan Program of Biotechnology Graduate School of Integrated Sciences for LifeHiroshima University1–3–1KagamiyamaHigashi-HiroshimaHiroshima 739–8530Japan Department of Civil and Environmental Engineering Graduate School of Advanced Science and EngineeringHiroshima University1–4–1KagamiyamaHigashi-HiroshimaHiroshima 739–8527Japan

Microbial electrosynthesis system (MES) is a promising method that can use carbon dioxide,which is a greenhouse gas,to produce methane which acts as an energy source,without using organic ***,this bioelectrical reduction reaction can proceed at a certain high applied voltage when coupled with water oxidation in the anode coated with metallic *** coupled with the oxidation of HS–to SO_(4)^(2-),methane production is thermodynamically more feasible,thus implying its production at a considerably lower applied *** this study,we demonstrated the possibility of electrotrophic methane production coupled with HS–oxidation in a cost-effective bioanode chamber in the MES without organic substrates at a low applied voltage of 0.2 *** addition,microbial community analyses of biomass enriched in the bioanode and biocathode were used to reveal the most probable pathway for methane production from HS–*** the bioanode,electroautotrophic SO_(4)^(2-)production accompanied with electron donation to the electrode is performed mainly by the following two steps:first,incomplete sulfide oxidation to sulfur cycle intermediates (SCI) is performed;then the produced SCI are disproportionated to HS^(–)and SO_(4)^(2-).In the biocathode,methane is produced mainly via H_(2)and acetate by electronaccepting syntrophic bacteria,homoacetogens,and acetoclastic ***,a new ecofriendly MES with biological H_(2)S removal is established.

关键词： Microbial electrosynthesis system Low applied voltage Organic substrates Methane production Sulfur oxidation

Converting textile waste into value-added chemicals:An integrated bio-refinery process

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Environmental Science and Ecotechnology 2023年第3期15卷 66-76页

作者： Eun Jin Cho Yoon Gyo Lee Younho Song ha Yeon Kim dinh-Truong Nguyen Hyeun-Jong Bae Bio-Energy Research Center Chonnam National UniversityGwangju500-757Republic of Korea Department of Bioenergy Science and Technology Chonnam National UniversityGwangju500-757Republic of Korea School of Biotechnology Tan Tao UniversityLong An82000Viet Nam

The rate of textile waste generation worldwide has increased dramatically due to a rise in clothing consumption and ***,conversion of cotton-based,colored cotton-based,and blended cotton-polyethylene terephthalate(PET)textile waste materials into value-added chemicals(bioethanol,sorbitol,lactic acid,terephthalic acid(TPA),and ethylene glycol(EG))via enzymatic hydrolysis and fermentation was *** order to enhance the efficiency of enzymatic saccharification,effective pretreatment methods for each type of textile waste were developed,respectively.A high glucose yield of 99.1%was obtained from white cotton-based textile waste after NaOH ***,the digestibility of the cellulose in colored cotton-based textile wastes was increased 1.38e1.75 times because of the removal of dye materials by HPAC-NaOH *** blended cottonPET samples showed good hydrolysis efficiency following PET removal via NaOHeethanol pretreatment,with a glucose yield of 92.49%.The sugar content produced via enzymatic hydrolysis was then converted into key platform chemicals(bioethanol,sorbitol,and lactic acid)via fermentation or *** maximum ethanol yield was achieved with the white T-shirt sample(537 mL/kg substrate),which was 3.2,2.1,and 2.6 times higher than those obtained with rice straw,pine wood,and oak wood,*** was selectively converted into sorbitol and LA at a yield of 70%and 83.67%,*** and EG were produced from blended cottonPET via NaOHeethanol *** integrated biorefinery process proposed here demonstrates significant potential for valorization of textile waste.

关键词： Textile waste Value-added biochemicals Integrated biorefinery Bioethanol Lactic acid

Effects of low energy (160 keV) X-ray on microbial inactivation,sprouting inhibition and genetic variation in potato

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Food Bioscience 2022年第3期47卷 262-270页

作者： Nguyen An Son Nguyen Thi Nguyet ha Nguyen Thi Minh Sang Le Doan dinh Duc Le Ngoc Trieu Faculty of Physic and Nuclear Engineering Da Lat UniversityViet Nam Dalat Vocational Training College Viet Nam Faculty of Biology Da Lat UniversityViet Nam

The effects of low energy X-ray irradiation on microbial inactivation,sprouting inhibition and genetic variation were *** was an inverse correlation between the exposure dose in range of 0 Gy–5000 Gy and the survival rate of *** dose of 1000 Gy seemed to be suitable for inactivation of microorganisms because the respective survival rate is relatively low (0.59%).Dose rate of 13.87 Gy/min was the most appropriate to inactivate the microorganisms,with the survival rate of 0.37%.Applying the irradiation dose of 1000 Gy and dose rate of 13.87 Gy/min,there was a significant sprouting inhibition of irradiated potatoes compared to the control for six months *** effect of irradiation dose (100–1200 Gy) and dose rate (8.63–19.62 Gy/min) on genetic variation of the irradiated samples was assessed by DNA fingerprints induced from using three molecular techniques including Random Amplified Polymorphic DNA (RAPD),Start Codon Targeted Polymorphism (SCoT) and CAAT box – derived polymorphism (CBDP).At the irradiation dose of 1000 Gy and dose rate of 13.87 Gy/min,the level of genetic variation was relatively low (4.85%).Thus,this treatment is a suitable condition of irradiation for potato treatment with the purpose of preservation.

关键词： Dose Dose rate Low energy X-ray Microbial inactivation Potato

Influence of phytochemicals in piper betle linn leaf extract on wound healing

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Burns & Trauma 2015年第3期3卷 143-150页

作者： Le Thi Lien Nguyen Thi Tho Do Minh ha Pham Luong hang Phan Tuan Nghia Nguyen dinh Thang Department of Biochemistry and Plant Physiology VNU University of ScienceVietnam National University334 Nguyen Trai St.Thanh Xuan DistrictHanoiVietnam Key laboratory of Enzyme and Protein Technology(KLEPT) VNU University of ScienceVietnam National UniversityHanoiVietnam

Background:Wound healing has being extensively investigated over the *** impairment is caused by many reasons including increasing of free-radicals-mediated damage,delaying in granulation tissue formation,reducing in angiogenesis and decreasing in collagen *** facts consequently lead to chronic wound *** betle Linn(Betle)leaves have been folklore used as an ingredient of drugs for cutaneous wound ***,the effect of betle leaf on wound healing is not yet well *** this study,we aimed to investigate the healing efficacy of methanol leaf extract of Piper betle Linn on proliferation of fibroblast NIH3T3 cells as well as full-thickness burn and excision wounds in swiss ***:Scratch wound healing assays were conducted to examine the effects of betle leaf extract on healing activity of fibroblast *** and excision wounds on swiss mouse skins were created for investigating the wound healing progress caused by the betle leaf ***(MDA)was also evaluated to examine the products of lipid hydroperoxide(LPO)under conditions of with or without betle leaf extract ***:The results of this study showed that Piper betle Linn leaf extract in methanol increased proliferation of NIH3T3 cells and promoted wound healing in vitro and in vivo with both burn wound and excision wound *** addition,this extract significant decreased level of malondialdehyde(MDA)in liver of treated-mice compared with that in non-treated ***:Our results suggest that Piper betle Linn can be used as an ingredient in developing natural origin drugs for treatment of cutaneous wounds.

关键词： Piper betle Linn Leaf extract Wound healing Malondialdehyde(MDA) Fibroblast(NIH3T3)