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NIR-II ?uorescence in vivo confocal microscopy with aggregation-induced emission dots

Science Bulletin 2019年第6期64卷 410-416页

作者： Wenbin Yu Bing Guo Hequn Zhang Jing Zhou Xiaoming Yu Liang Zhu dingwei xue Wen Liu Xianhe Sun Jun Qian State Key Laboratory of Modern Optical Instrumentations Centre for Optical and Electromagnetic Research College of Optical Science and Engineering Zhejiang University Department of Chemical and Biomolecular Engineering National University of Singapore Department of Urology Sir Run-Run Shaw Hospital College of Medicine Innovation Center for Minimally Invasive Technique and Device Zhejiang University Interdisciplinary Institute of Neuroscience and Technology (ZIINT) Zhejiang University Joint Research Laboratory of Optics of Zhejiang Normal University and Zhejiang University Zhejiang Normal University

Significantly reduced tissue scattering of fluorescence signals in the second near-infrared(NIR-Ⅱ,1,000–1,700 nm)spectral region offers opportunities for large-depth in vivo ***,most reported works concerning NIR-II fluorescence in vivo bioimaging are realized by wide-field illumination and 2D-arrayed detection(e.g.,via InGaAs camera),which has high temporal resolution but limited spatial resolution due to out-of-focus *** NIR-II fluorescence imaging with confocal microscopy is a good approach to achieve high-spatial resolution visualization of biosamples even at deep *** this presented work,a NIR-II fluorescence confocal microscopic system was *** using a kind of aggregation-induced emission(AIE)dots as NIR-II fluorescent probes,800 lm-deep 3D in vivo cerebrovascular imaging of a mouse was obtained,and the spatial resolution at 700 lm depth could reach 8.78 ***,the time-correlated single photon counting(TCSPC)technique and femtosecond laser excitation were introduced into NIR-II fluorescence confocal microscopy,and in vivo confocal NIR-II fluorescence lifetime microscopic imaging(FLIM)of mouse cerebral vasculature was successfully realized.

关键词： Confocal microscopy NIR-II fluorescence AIE dots In vivo cerebrovascular imaging TCSPC FLIM imaging

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Hot-band absorption of indocyanine green for advanced anti-stokes fluorescence bioimaging

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Light(Science & Applications) 2021年第10期10卷 1877-1888页

作者： Jing Zhou Xiaoxiao Fan Di Wu Jie Liu Yuhuang Zhang Zikang Ye dingwei xue Mubin He Liang Zhu Zhe Feng Andrey N.Kuzmin Wen Liu Paras N.Prasad Jun Qian State Key Laboratory of Modern Optical Instrumentations Centre for Optical and Electromagnetic ResearchCollege of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZhejiang UniversityHangzhou 310058China Sir Run-Run Shaw Hospital School of MedicineZhejiang UniversityHangzhou 310016China Key Laboratory of Flexible Electronics(KLOFE)Institute of Advanced Materials(IAM) Nanjing Tech University(Nanjing Tech)Nanjing 211800China Department of Chemistry Zhejiang UniversityHangzhou 310058China Interdisciplinary Institute of Neuroscience and Technology(ZIINT) College of Biomedical Engineering and Instrument ScienceZhejiang UniversityHangzhou 310027China Institute for Lasers Photonicsand BiophotonicsDepartment of ChemistryUniversity at BuffaloState University of New YorkBuffaloNY 14260USA Key Laboratory of Optical Information Detection and Display Technology of Zhejiang Zhejiang Normal UniversityJinhua 321004China

Bright anti-Stokes fluorescence(ASF)in the first near-infrared spectral region(NIR-I,800 nm–900 nm)under the excitation of a 915 nm continuous wave(CW)laser,is observed in Indocyanine Green(ICG),a dye approved by the Food and Drug Administration for clinical *** dependence of fluorescence intensity on excitation light power and temperature,together with fluorescence lifetime measurement,establish this ASF to be originated from absorption from a thermally excited vibrational level(hot-band absorption),as shown in our experiments,which is stronger than the upconversion fluorescence from widely-used rare-earth ion doped *** test the utility of this ASF NIR-I probe for advanced bioimaging,we successively apply it for biothermal sensing,cerebral blood vessel tomography and blood stream ***,in combination with L1057 nanoparticles,which absorb the ASF of ICG and emit beyond 1100 nm,these two probes generate multi-mode images in two fluorescent channels under the excitation of a single 915 nm CW *** channel is used to monitor two overlapping organs,urinary system&blood vessel of a live mouse,while the other shows urinary system *** in intraoperative real-time monitoring,such multi-mode imaging method can be beneficial for visual guiding in anatomy of the urinary system to avoid any accidental injury to the surrounding blood vessels during surgery.

关键词： absorption excitation anatomy

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保定西部矿山泥石流特征与防治措施

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山东国土资源 2011年第2期27卷 29-31,34页

作者：李婧薛丁炜河北省保定地质工程勘查院河北保定071051

地质灾害的形成原因有自然的也有人为的,矿山泥石流就是由人为因素为主导,在矿山一带沟谷内形成的。由于物源堆存量和地域短时降水量大小的不同,使灾害发生的规模和对附近居民带来的影响也各不相同。该文以保定西部矿山泥石流特征为例,... 详细信息

地质灾害的形成原因有自然的也有人为的,矿山泥石流就是由人为因素为主导,在矿山一带沟谷内形成的。由于物源堆存量和地域短时降水量大小的不同,使灾害发生的规模和对附近居民带来的影响也各不相同。该文以保定西部矿山泥石流特征为例,弄清地质灾害的发生机制和发展规律,对防灾减灾、环境保护及灾害治理工作有着极其重要而深远的意义。

关键词：矿山泥石流发生机制成因分析防治措施保定西部

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一种基于单光子的多方量子价格谈判协议

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黑龙江大学自然科学学报 2021年第1期38卷 1-8页

作者：薛鼎蔚张龙黑龙江大学数学科学学院哈尔滨100080 黑龙江大学黑龙江省复杂系统理论与计算重点实验室哈尔滨100080

近年来,量子价格谈判(QPN)已成为量子密码中的热点研究问题,在电子商务领域有着广泛的应用前景。本文基于单光子和量子傅里叶变换,利用幺正操作将秘密的价格信息编码到d维单光子态的相位上,提出了一种新型多方量子价格谈判(MQPN)协议。... 详细信息

近年来,量子价格谈判(QPN)已成为量子密码中的热点研究问题,在电子商务领域有着广泛的应用前景。本文基于单光子和量子傅里叶变换,利用幺正操作将秘密的价格信息编码到d维单光子态的相位上,提出了一种新型多方量子价格谈判(MQPN)协议。分析表明,在半诚实第三方(TP)模型下,该协议在保证参与方隐私性的同时,可以有效抵抗外部和不诚实参与者(包括TP)的攻击,且具有更好的实用性。

关键词：量子价格谈判参与者攻击外部攻击半诚实第三方

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Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu Chen xue-Jun Li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

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基于双目定位和同步触发的城市轨道交通工务综合检测车

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城市轨道交通研究 2024年第4期27卷 243-246页

作者：李军樊晓东薛丁维周航高涛陈昌邦张宜霞南宁轨道交通运营公司南宁530029 宽衍(北京)科技发展有限公司北京100089 广西轨交智维科技有限公司南宁530025

[目的]目前城市轨道交通隧道及轨道的工务巡检大多仍采用传统的人工巡检方式,亟需有效提升巡检效率及准确率。[方法]提出了一种基于双目定位和同步触发技术的城市轨道交通工务综合检测车(以下简称“综合检测车”),阐述了该综合检测车的... 详细信息

[目的]目前城市轨道交通隧道及轨道的工务巡检大多仍采用传统的人工巡检方式,亟需有效提升巡检效率及准确率。[方法]提出了一种基于双目定位和同步触发技术的城市轨道交通工务综合检测车(以下简称“综合检测车”),阐述了该综合检测车的系统架构,并介绍了同步定位模块、供电模块及人机交互模块的功能,以及工务病害故障检测所采用的识别算法。介绍了该综合检测车的定位计算和同步控制技术,并对其在城市轨道交通工程中的实际应用效果进行了分析,对其技术优势进行了总结。[结果及结论]该综合检测车可在2 h内完成城市轨道交通线路隧道及轨道的巡检工作,实现对多类病害故障的智能综合检测。与人工检测相比,其准确率提升了60%,巡检成本降低了30%。

关键词：城市轨道交通工务巡检综合检测车双目定位技术同步触发技术

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基于临床可用的亚甲基蓝近红外二区成像用于泌尿系统结构及功能成像的研究

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Engineering 2023年第3期22卷 149-158页

作者：薛丁玮吴迪陆泽毅 Jochen Neuhaus 阿卜杜热合曼·则比布拉冯哲成晟周静钱骏李恭会 Department of Urology Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Department of Urology University of LeipzigLeipzig 04103Germany State Key Laboratory of Modern Optical Instrumentation Centre for Optical and Electromagnetic ResearchCollege of Optical Science and EngineeringZhejiang UniversityHangzhou 310058China

精准的结构和功能成像对于泌尿系统疾病的诊断和预后至关重要。近红外二区(second near-infrared,NIR-Ⅱ;1000~1700 nm)荧光生物成像相较于传统的荧光生物成像具有更高的空间分辨率、更深的穿透力和更好的信噪比,但其临床适用性有限。... 详细信息

精准的结构和功能成像对于泌尿系统疾病的诊断和预后至关重要。近红外二区(second near-infrared,NIR-Ⅱ;1000~1700 nm)荧光生物成像相较于传统的荧光生物成像具有更高的空间分辨率、更深的穿透力和更好的信噪比,但其临床适用性有限。本文首次报道了基于临床可用且经肾脏排泄的荧光染料亚甲蓝(methylene blue,MB)NIR-Ⅱ活体泌尿系统荧光成像,该方法不仅可以实现清晰的有创/无创尿路造影,而且可以有效且无创地检测肾功能。以上研究结果表明MB辅助的NIR-Ⅱ荧光成像在临床及基础研究中的泌尿系统结构和功能成像中具有巨大前景。

关键词： NIR-II fluorescence Methylene blue Renal function Urinary system Real-time imaging

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Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao Yu-Gui Peng Peng Wu Zong-Lin Li xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

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Influence of introducing Zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie Li Wenbo Yu Zhenyu Sun Weichen Zheng Liangwei Zhang Yanling xue Wenning Liu Shoumei Xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing xue Yuejia Ma Ke Ye xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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