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环状RNA CHACR调控压力超负荷诱导心肌肥大和氧化应激损伤

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中国组织工程研究 2025年第25期29卷 5362-5373页

作者：王霜韩瑜袁敏曹济民孙腾山西医科大学细胞生理学教育部重点实验室山西省细胞生理学重点实验室山西医科大学基础医学院生理学系山西省太原市030001

背景:病理性心肌肥大是多种心脏疾病的危险促进因素,但其发病机制仍未阐明。环状RNA与心肌肥大密切相关,然而环状RNA CHACR在心肌肥大中的作用及调控机制尚未见报道。目的:探究环状RNA CHACR在压力超负荷诱导心肌肥大中的作用及机制。方... 详细信息

背景:病理性心肌肥大是多种心脏疾病的危险促进因素,但其发病机制仍未阐明。环状RNA与心肌肥大密切相关,然而环状RNA CHACR在心肌肥大中的作用及调控机制尚未见报道。目的:探究环状RNA CHACR在压力超负荷诱导心肌肥大中的作用及机制。方法:①心脏原位注射环状RNA CHACR过表达慢病毒1周后进行横向主动脉缩窄手术诱导小鼠心肌肥大。术后8周,计算心脏质量/胫骨长比值和肺质量/胫骨长比值,测量心肌细胞表面积,检测肥大标志基因表达水平和心肌纤维化程度,评估心功能。②H9c2心肌细胞给予环状RNA CHACR过表达慢病毒处理72 h,然后加入1μmol/L血管紧张素Ⅱ处理24 h诱导心肌细胞肥大。通过检测心肌细胞表面积、肥大标志基因表达水平、蛋白质/DNA比值评估细胞肥大情况,通过检测活性氧水平和线粒体膜电位评估氧化应激损伤情况。结果与结论:①在体内和体外心肌肥大模型中,环状RNA CHACR的表达水平均显著降低(P<0.01);②过表达环状RNA CHACR显著抑制了横向主动脉缩窄手术诱导的小鼠心肌肥大表型,主要表现为心脏体积减小、心脏质量/胫骨长比值显著降低(P<0.05),肺质量/胫骨长比值显著降低(P<0.05),心肌细胞表面积显著减小(P<0.05),以及心肌肥大相关标志基因心房利钠肽(P<0.05)、脑钠肽(P<0.05)表达水平降低;③过表达环状RNA CHACR显著抑制了横向主动脉缩窄手术诱导的小鼠心脏纤维化,表现为纤维化面积减小(P<0.01)和纤维化标志基因Acta1的表达水平降低(P<0.05);④过表达环状RNA CHACR显著改善了小鼠心功能,主要表现为射血分数(P<0.05)和短轴缩短率(P<0.01)显著升高;(5)过表达环状RNA CHACR显著抑制了血管紧张素Ⅱ诱导的心肌细胞肥大,主要表现为心肌细胞表面积显著减小(P<0.05),心房利钠肽(P<0.05)和脑钠肽(P<0.05)表达水平显著下调,以及蛋白质/DNA比值显著减小(P<0.05);(6)过表达环状RNA CHACR显著抑制了血管紧张素Ⅱ诱导的活性氧水平升高(P<0.001)和线粒体膜电位降低(P<0.05)。结果表明,环状RNA CHACR在体内和体外心肌肥大模型中表达水平显著降低,过表达环状RNA CHACR显著抑制心肌肥大,减轻心肌纤维化,改善心功能,并且显著减轻了血管紧张素Ⅱ诱导的心肌细胞氧化应激损伤。

关键词：心肌肥大环状RNA CHACR 血管紧张素Ⅱ 横向主动脉缩窄手术氧化应激损伤

Liouville Type Theorem About p-Harmonic Function and p-Harmonic Map with Finite L^q-Energy

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Chinese Annals of Mathematics,Series B 2017年第5期38卷 1071-1076页

作者： Xiangzhi cao School of Mathematics and Statistics Wuhan University Wuhan 430072 China

This paper deals with the p-harmonic function on a complete non-compact submanifold M isometrically immersed in an(n + k)-dimensional complete Riemannian manifold M of non-negative(n-1)-th Ricci curvature. The Liouville type theorem about the p-harmonic map with finite L^q-energy from complete submanifold in a partially nonnegatively curved manifold to non-positively curved manifold is also obtained.

关键词： p-Harmonic map p-Harmonic map Kato inequality Index Liouvilletheorem

Dynamics of Wetland Landscape Pattern in Kaifeng City from 1987 to 2002

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Chinese Geographical Science 2008年第2期18卷 146-154页

作者： cao Xinxiang College of History and Culture Henan University Kaifeng 475001 China Key Research Institution of Yellow River Civilization and Sustainable Development Henan University Kaifeng 475001 China

It is very significant for urban development and urban wetland protection and utilization to probe into the process and reasons of urban wetland landscape dynamics. Taking the information of remote sensing and detailed land survey data as the basic information sources, with the help of RS and GIS, according to the principles and methods of landscape ecology, this paper analyzed wetland landscape pattern dynamics and its reasons in Kaifeng City, Henan Province of China, from 1987 to 2002. The results show that the total wetland area in Kaifeng City firstly reduced by 20.1% from 1987 to 1990 and then increased from 1990 to 2002, with an average annual growth rate of 3.3%. At the same time, landscape fragment degree and landscape dominance degree increased, respectively from 0.64 to 0.72 and from 0.3754 to 0.5563, but mean patch area, maximum patch area, patch fractal dimension reduced. As far as single landscape element concerned, fi＇om 1987 to 2002, patch area, patch number, patch density, patch shape and patch location changed in varying degrees in all wetland types in Kaifeng City, among which rice field changed most and others relatively less. In the recent 20 years, rice fields, lake wetlands, puddles and ponds had a higher stability, but river and bottomland wetlands were mostly transformed to land use types. The change of wetland landscape pattern was the result of the combined action of the Huanghe （Yellow） River, urban expansion, wide cultivation of rice, and rapid development of fishery. Among them human activities were the main driving factors for wetland landscape changes.

关键词： wetland landscape pattern landscape dynamics Kaifeng City

Controlling synthesis and host sensitized Eu^(3+) emissions of K_5Gd_9F_(32) and GdF_3

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Science China(Technological Sciences) 2015年第5期58卷 899-906页

作者： XIE An cao ChunYan cao RenPing NOH HyeonMi JEONG JungHyun School of Materials Science and Engineering Xiamen University of Technology College of Mathematics and Physics Jinggangshan University Department of Physics Pukyong National University

By controlling the reactant ratios, hydrothermal time, hydrothermal temperatures, p H values of the prepared solutions, and the concentrations of K3C6H5O7·2H2O, 1 mol% Eu3+ doped cubic phase of K5Gd9F32 and/or orthorhombic phase of Gd F3 micro/nanocrystals have been synthesized based on a hydrothermal method. For comparison, the sample was also synthesized by a co-precipitation method. The samples were characterized by X-ray diffraction(XRD) patterns, field emission scanning electron microscopy(FE-SEM) images, energy-dispersive spectroscopy(EDS) spectra, and photoluminescence(PL) excitation and emission spectra. By host Gd3+ sensitizing, the Eu3+ presents relatively strong emissions. The energy transfers from host Gd3+ to doping Eu3+ are observed in all the samples and the energy transfer plays an important role in the emission of Eu3+. Acting as a probe, the Eu3+ presents its distinct optical properties in the samples.

关键词： hydrothermal sensitized reactant cubic crystalline emissions dispersive doping excitation orthorhombic

Encapsulating metal organic framework into hollow mesoporous carbon sphere as efficient oxygen bifunctional electrocatalyst

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National Science Review 2020年第3期7卷 609-619页

作者： Wanfeng Xiong Hongfang Li Hanhui You Minna cao Rong cao State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences College of Chemistry and Materials Science Fujian Normal University

Applying metal organic frameworks(MOFs) in electrochemical systems is a currently emerging field owing to the rich metal nodes and highly specific surface area of MOFs. However, the problems for MOFs that need to be solved urgently are poor electrical conductivity and low ion transport. Here we present a facile in situ growth method for the rational synthesis of MOFs@hollow mesoporous carbon spheres(HMCS)yolk–shell-structured hybrid material for the first time. The size of the encapsulated Zeolitic Imidazolate Framework-67(ZIF-67) is well controlled to 100 nm due to the spatial confinement effect of HMCS, and the electrical conductivity of ZIF-67 is also increased significantly. The ZIF@HMCS-25% hybrid material obtained exhibits a highly efficient oxygen reduction reaction activity with 0.823 V(vs. reversible hydrogen electrode) half-wave potential and an even higher kinetic current density(JK= 13.8 m A cm-2) than commercial Pt/C. ZIF@HMCS-25% also displays excellent oxygen evolution reaction performance and the overpotential of ZIF@HMCS-25% at 10 m A cm-2 is 407 m V. In addition, ZIF@HMCS-25% is further employed as an air electrode for a rechargeable Zn–air battery, exhibiting a high power density(120.2 m W cm-2 at 171.4 m A cm-2) and long-term charge/discharge stability(80 h at 5 m A cm-2). This MOFs@HMCS yolk–shell design provides a versatile method for the application of MOFs as electrocatalysts directly.

关键词： metal organic frameworks yolk–shell structure bifunctional electrocatalyst Zn–air battery

Synergetic effects of gold-doped copper nanowires with low Au content for enhanced electrocatalytic CO_(2)reduction to multicarbon products

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Nano Research 2023年第5期16卷 7777-7783页

作者： Zongnan Wei Shuai Yue Shuiying Gao Minna cao Rong cao Department of Chemistry University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China

As efficient catalysts of electrochemical CO_(2)reduction reaction(CO_(2)RR)towards multicarbon(C_(2+))products,Cu-based catalysts have faced the challenges of increasing the reactive activity and ***,we decorated the surface of Cu nanowires(Cu NWs)with a small amount of Au nanoparticles(Au NPs)by the homo-nucleation *** the Au to Cu mass ratio is as little as 0.7 to 99.3,the gold-doped copper nanowires(Cu-Au NWs)could effectively improve the selectivity and activity of CO_(2)RR to C_(2+)resultants,with the Faradaic efficiency(FE)from 39.7%(Cu NWs)to 65.3%,the partial current density from 7.0(Cu NWs)to 12.1 mA/cm^(2) under−1.25 V *** hydrogen electrode(RHE).The enhanced electrocatalytic performance could be attributed to the following three synergetic *** addition of Au nanoparticles caused a rougher surface of the catalyst,which allowed for more active sites ***,Au sites generated*CO intermediates spilling over into Cu sites with the calculated efficiency of 87.2%,which are necessary for multicarbon ***,the interphase electron transferred from Cu to Au induced the electron-deficient Cu,which favored the adsorption of*CO to further generate multicarbon *** results uncovered the morphology,tandem,electronic effect between Cu NWs and Au NPs facilitated the activity and selectivity of CO_(2)RR to multicarbons.

关键词： electrochemical CO_(2)reduction multicarbon production bimetallic catalyst Cu nanowires Au nanoparticles

Structural and electronic properties of bastnaesite and implications for surface reactions in flotation

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Journal of Rare Earths 2020年第3期38卷 332-338页

作者： Shiming cao Yijun cao Zilong Ma Yinfei Liao Xiaolin Zhang School of Resources and Environmental Engineering Shandong University of TechnologyZibo 255000China National Engineering Research Center of Coal Preparation and Purification China University of Mining and TechnologyXuzhau 221116China Henan Province Industrial Technology Research Institute of Resources and Materials Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Complex Nonferrous Meal Resources Clean Utilization Kunming University of Science and TechnologyKunming 650093China

The structural and electronic properties of bastnaesite were studied by using the first-principles method based on the density functional theory(DFT).The geometry structure of bastnaesite was first optimized,and then the Mulliken populations,electron density and density of states were calculated and further analyzed in *** calculation results reveal that it mainly ruptures along the ionic Ce-O and Ce-F bonds during the cleavage of bastnaesite,leaving≡Ce^+,≡F^-and≡CO3^-dangling bonds exposed on the cleavage surface of *** with contact angle measurement,surface complexation theory and XPS analysis,the implications of structural and electronic properties on bastnaesite flotation reactions were *** hydration of exposed strong ionic bond on cleavage surface results in hydrophilic *** to surface complexation theory,the formed surface groups are≡CeOH^0,≡CO3 H^0 and≡FH^0 *** investigated metal ions and flotation reagents complex with surface≡CeOH^0 groups,while≡CO3H^0 and≡FH^0 groups are not involved in the *** high activity of Ce atoms facilitates these surface reactions.

关键词： Bastnaesite Density functional theory calculation Electronic property Flotation Rare earths

Developing MXenes from Wireless Communication to Electromagnetic Attenuation

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Nano-Micro Letters 2021年第7期13卷 188-221页

作者： Peng He Mao-Sheng cao Wen-Qiang cao Jie Yuan School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China School of Information Engineering Minzu University of ChinaBeijing 100081People’s Republic of China

There is an urgent global need for wireless communication utilizing materials that can provide simultaneous flexibility and high *** the harmful effects of electromagnetic(EM)radiation from wireless communication is a persistent research hot ***-dimensional(2D)materials are the preferred choice as wireless communication and EM attenuation materials as they are lightweight with high aspect ratios and possess distinguished electronic ***,as a novel family of 2D materials,have shown excellent properties in various fields,owing to their excellent electrical conductivity,mechanical stability,high flexibility,and ease of *** date,research on the utility of MXenes for wireless communication has been actively ***,MXenes have become the leading materials for EM ***,we systematically review the recent advances in MXene-based materials with different structural designs for wireless communication,electromagnetic interference(EMI)shielding,and EM wave *** relationship governing the structural design and the effectiveness for wireless communication,EMI shielding,and EM wave absorption is clearly ***,our review mainly focuses on future challenges and guidelines for designing MXene-based materials for industrial application and foundational research.

关键词： MXene Wireless communication Electromagnetic wave absorption Electromagnetic interference shielding

Influence of Al^(3+) on Hydrothermally Synthesized Xonotlite Whiskers in cao-SiO_2-H_2O System

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稀有金属材料与工程 2011年第S3期40卷 99-101页

作者： Li Jing, Liu Fei, cao Jianxin Guizhou University, Guiyang 550003, China Guizhou Univ Sch Chem & Chem Engn Guiyang 550003 Peoples R China

Influences of Al3+ concentration on hydrothermally synthesized xonotlite whiskers were researched in this paper. The crystal phase composition and morphology of the products were analyzed and characterized using XRD and SEM techniques. The results indicate that Al3+ concentration have great impact on the crystal phase composition and morphology of the xonotlite whiskers in cao-SiO2-H2O system under the condition of initial cao/SiO2 mol ratio of 1.0, reactant concentration of 0.05 mol·L-1 , at 225 ℃ for 15 h. The main crystal phase of hydrothermally synthesized products had a phase transition from xonotlite to tobermorite, and the morphology changed from fibrous to tabular with increasing the concentration of Al3+ ion. At last, in order to prepare the pure xonotlite whiskers via hydrothermal synthesis in cao-SiO2-H2O system, the Al2O3 contents in raw materials should be less than 1%.

关键词： xonotlite whisker Al3+ ion hydrothermal synthesis