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Virologica Sinica 2023年第2期38卷 309-312页

作者： Rui Huang Wenbo Chen Xueya zhao Yuefei Ma Qiong Zhou Junsen Chen Muyi Zhang dingran zhao Yu Hou Chunjiang He Ying Wu State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology Institute of Medical VirologyTaiKang Medical SchoolWuhan UniversityWuhan430072China TaiKang Medical School Wuhan UniversityWuhan430071China Institute of Life Sciences Chongqing Medical UniversityChongqing400016China Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Clinical Laboratory The First Affiliated HospitalFujian Medical UniversityFuzhou350005China Public Health Institute of Kunming Medical University Kunming650500China

Dear Editor,Alternative splicing of eukaryotic transcripts refers to the posttranscriptional process in which the coding regions(exons)of a precursor transcript are joined in different combinations through the removal or retention of non-coding intervening sequences(introns)to produce distinct mature messenger RNA(mRNA)transcripts and further generate one or more mature mRNAs(Lee and Rio,2015).Alternative splicing is revealed dysregulation in infectious *** pathogens hijack the splicing mechanism of host cells to complete their replications,accompanied by dysregulated innate immune response or cell damage,leading to the changes of alternative splicing landscape in host cells(Ashraf et al.,2019;Tomezsko et al.,2020;Kremsdorf et al.,2021).The regulation mechanism of alternative splicing by viral pathogens,such as hepatitis B virus(Duriez et al.,2017),human immunodeficiency virus 1(Tomezsko et al.,2020),Zika virus(Bonenfant et al.,2020)and enterovirus 71(Li et al.,2020),have been explored.

关键词： landscape retention

数字经济发展对我国省际贸易的影响:理论逻辑与实证检验

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北京师范大学学报（社会科学版） 2022年第5期 102-113页

作者：李宏兵赵丁然赵春明北京邮电大学经济管理学院北京100876 北京师范大学经济与工商管理学院北京100875

贸易成本和技术创新是影响贸易行为的核心要素。从数字经济影响省际贸易的理论机制看,数字经济依托互联网、人工智能、大数据等信息技术,打破了时间和空间上的限制,增强了信息的有效性和要素的匹配效率,有助于降低贸易成本和推动知识溢... 详细信息

贸易成本和技术创新是影响贸易行为的核心要素。从数字经济影响省际贸易的理论机制看,数字经济依托互联网、人工智能、大数据等信息技术,打破了时间和空间上的限制,增强了信息的有效性和要素的匹配效率,有助于降低贸易成本和推动知识溢出进而促进地区间的贸易往来。实证检验结果表明:数字经济发展能够显著促进本省省际贸易流出;数字经济对省际贸易的促进作用存在明显的结构异质性:省际贸易流出的增加主要是由本省数字经济发展带来的贸易成本下降和知识溢出引致的,且降低贸易成本的机制更为明显;而数字经济发展会对邻近省份贸易流出产生负向空间溢出效应。

关键词：数字经济省际贸易贸易成本知识溢出空间溢出效应

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工业蛭石吸附甲苯的性能及机理研究

非金属矿 2023年第2期46卷 1-4页

作者：卿越彭同江张曦月赵丁冉西南科技大学环境与资源学院四川绵阳621010 西南科技大学分析测试中心四川绵阳621010 西南科技大学矿物材料及应用研究所四川绵阳621010

基于工业蛭石具有阳离子交换容量高、内比表面积大、吸附性强等特性,考察了新疆尉犁和河北灵寿蛭石矿山不同阳离子交换容量的工业蛭石对甲苯的吸附量及变化规律。结果表明,工业蛭石对甲苯的吸附能力与阳离子交换容量成正相关,阳离子交... 详细信息

基于工业蛭石具有阳离子交换容量高、内比表面积大、吸附性强等特性,考察了新疆尉犁和河北灵寿蛭石矿山不同阳离子交换容量的工业蛭石对甲苯的吸附量及变化规律。结果表明,工业蛭石对甲苯的吸附能力与阳离子交换容量成正相关,阳离子交换容量为120 mmol/100g的样品对甲苯吸附量达到76.93 mg/g。本研究为工业蛭石用作甲苯吸附材料提供了试验依据和理论支撑。

关键词：工业蛭石阳离子交换容量甲苯吸附量

辅助试剂强化电动修复矿区周边土壤中放射性钍污染

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有色金属（冶炼部分） 2021年第3期 36-42,50页

作者：陈敏洁刘雪峰李博文李亚飞赵丁冉郑春丽内蒙古科技大学生命科学与技术学院内蒙古包头014010 内蒙古科技大学能源与环境学院内蒙古包头014010

为探究矿区周边土壤最佳的电动修复电解液修复参数,实现最优化的试验方案,采用一种新型辅助试剂(柠檬酸和皂素),通过设计7组电动力修复装置,对比研究了0.2mol/L的柠檬酸和0.2mol/L柠檬酸与不同浓度皂素的混合溶液作为阴极、阳极电解液,... 详细信息

为探究矿区周边土壤最佳的电动修复电解液修复参数,实现最优化的试验方案,采用一种新型辅助试剂(柠檬酸和皂素),通过设计7组电动力修复装置,对比研究了0.2mol/L的柠檬酸和0.2mol/L柠檬酸与不同浓度皂素的混合溶液作为阴极、阳极电解液,进行电动修复钍污染的土壤,并与去离子水对照,讨论了在辅助试剂下强化电动修复过程,分析了柠檬酸和皂素作为电动修复添加剂的可行性。在电压梯度为1V/cm,持续通电7d,随着皂素浓度的增加修复矿区周边土壤中钍的修复效果明显增加,当0.2mol/L柠檬酸与0.1mol/L的皂素作为电解液进行修复时效果最佳,钍去除率达到59.94%。

关键词：柠檬酸皂素钍污染土壤电动修复

Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia zhao Taixi Feng Guimin Lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

High-temperature-tolerant flexible supercapacitors: Gel polymer electrolytes and electrode materials

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Journal of Energy Chemistry 2025年第1期100卷 426-457页

作者： Chong Peng Xinyi Huang Mingwei zhao Shuling Liao Quanhong Yang Nianjun Yang Siyu Yu School of Chemistry & Chemical Engineering Southwest University Nanoyang Group Tianjin Key Laboratory of Advanced Carbon and Electrochemical Energy Storage School of Chemical Engineering and Technology and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin University Department of Chemistry & IMO-IMOMEC Hasselt University

The development of flexible supercapacitors(FSCs) capable of operating at high temperatures is crucial for expanding the application areas and operating conditions of supercapacitors. Gel polymer electrolytes and electrode materials stand as two key components that significantly impact the efficacy of hightemperature-tolerant FSCs(HT-FSCs). They should not only exhibit high electrochemical performance and excellent flexibility, but also withstand intense thermal stress. Considerable efforts have been devoted to enhancing their thermal stability while maintaining high electrochemical and mechanical performance. In this review, the fundamentals of HT-FSCs are outlined. A comprehensive overview of state-of-the-art progress and achievements in HT-FSCs, with a focus on thermally stable gel polymer electrolytes and electrode materials is provided. Finally, challenges and future perspectives regarding HT-FSCs are discussed, alongside strategies for elevating operational temperatures and *** review offers both theoretical foundations and practical guidelines for designing and manufacturing HT-FSCs, further promoting their widespread adoption across diverse fields.

关键词： Flexible supercapacitors High-temperature tolerance Gel polymer electrolytes Electrode materials

Decision making module based on stochastic magnetic tunnel junctions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 202-209页

作者： Yifan Miao Li zhao Yajun Zhang Zhe Yuan Center for Advanced Quantum Studies and Department of Physics Beijing Normal University Institute for Nanoelectric Devices and Quantum Computing Fudan University Interdisciplinary Center for Theoretical Physics and Information Sciences Fudan University

In biological neural systems, noise is ubiquitous but does not affect the correct decisions made in the complex cognitive ***-making in biological neural system is typically achieved by accumulating input information over a period of *** by recent developments in neurosciences, we design a decision-making module based on spintronic devices, utilizing superparamagnetic tunnel junctions as artificial neurons. The feasibility of this decision-making module is verified through circuit simulations. Taking a multi-layer perceptron as an example, the module significantly improves the accuracy of the perceptron in the handwritten digit recognition task. Furthermore, the spintronic decision-making module offers advantages over the conventional pooling methods, such as adaptive decision time, high performance and the absence of analog-to-digital conversion. The decision-making module is flexible to be integrated into artificial neural networks and provides a general yet effective solution to enhance performance against device noise.

关键词： neuromorphic computing spintronics magnetic tunnel junction neural networks

Resolving the developmental mechanisms of cardiac microthrombosis of SARS-CoV-2 based on single-cell transcriptome analysis

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Science China Life Sciences 2025年第1期 103-115页

作者： Xizi Luo Nan Zhang Yuntao Liu Beibei Du Xuan Wang Tianxu zhao Bingqiang Liu Shishun zhao Jiazhang Qiu Guoqing Wang State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Basic MedicineJilin University State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Veterinary MedicineJilin University College of Mathematics Jilin University Bioinformatic Lab School of MathematicsShandong University Department of Cardiology China-Japan Union HospitalJilin University

The coronavirus disease 2019（COVID-19） outbreak caused by the severe acute respiratory syndrome coronavirus-2（SARS-CoV-2） developed into a global health emergency. Systemic microthrombus caused by SARS-CoV-2 infection is a common complication in patients with COVID-19. Cardiac microthrombosis as a complication of SARS-CoV-2 infection is the primary cause of cardiac injury and death in patietns with severe COVID-19. In this study, we performed single-cell sequencing analysis of the right ventricular free wall tissue from healthy donors,patients who died during the hypercoagulable period of characteristic coagulation abnormality（CAC）, and patients who died during the fibrinolytic period of CAC. We collected 61,187 cells enriched in 24 immune cell subsets and 13 cardiac-resident cell subsets. We found that in the course of SARS-CoV-2 infected heart microthrombus, MYO1EhighRASGEF1Bhighmonocyte-derived macrophages promoted hyperactivation of the immune system and initiated the extrinsic coagulation pathway by activating chemokines CCL3, CCL5. This series of events is the main cause of cardiac microthrombi following SARS-CoV-2 infection. In a SARS-CoV-2 infected heart microthrombus, excessive immune activation is accompanied by an increase in cellular iron content, which in turn promotes oxidative stress and intensifies intercellular competition. This induces cells to alter their metabolic environment, resulting in increased sugar uptake via the glycosaminoglycan synthesis pathway. In addition, high levels of reactive oxygen species generated by elevated iron levels promote increased endogenous malondialdehyde synthesis in a subpopulation of cardiac endothelial cells. This exacerbates endothelial cell dysfunction and exacerbates the coagulopathy process.

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Low-cost and fluoride-free synthesis of MFI zeolite nanosheets with enhanced stability for benzene alkylation with ethanol

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Journal of Energy Chemistry 2025年第1期100卷 458-468页

作者： Peng Zhu Cun Liu Yiren Yu Guoshu Gao Yumeng zhao Xiongfu Zhang Guodong Liu Guohui Yang State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences

Zeolite nanosheets with a short b-axis thickness are highly desirable in lots of catalytic reactions due to their reduced diffusion resistance. Nevertheless, conventional synthesis methods usually require expensive structure-directing agents(SDAs), pricey raw materials, and eco-unfriendly fluorine-containing additives. Here, we contributed a cost-effective and fluoride-free synthesis method for synthesizing high-quality MFI zeolite nanosheets through a Silicalite-1(Sil-1) seed suspension and urea cooperative strategy, only with inexpensive colloidal silica as the Si source. Our approach was effective for synthesizing both Sil-1 and aluminum-containing ZSM-5 nanosheets. By optimizing key synthesis parameters,including seed aging time, seed quantity, and urea concentration, we achieved precise control over the crystal face aspect ratio and b-axis thickness. We also revealed a non-classical oriented nanosheet growth mechanism, where Sil-1 seeds induced the formation of quasi-ordered precursor particles, and the(010)crystal planes of these particles facilitated urea adsorption, thereby promoting c-axis-oriented *** obtained ZSM-5 nanosheets exhibited exceptional catalytic performance in the benzene alkylation with ethanol, maintaining stability for over 500 h, which is 5 times longer than traditional ZSM-5 catalysts. Furthermore, large-scale production of ZSM-5 nanosheets was successfully carried out in a 3 L highpressure autoclave, yielding samples consistent with those from laboratory-scale synthesis. This work marks a significant step forward in the sustainable and efficient production of MFI nanosheets using inexpensive and environmentally friendly raw materials, offering the broad applicability in catalysis.

关键词： MFI zeolite ZSM-5 Nanosheets Scale-up synthesis Aromatic alkylation

A new horizon for neuroscience:terahertz biotechnology in brain research

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Neural Regeneration Research 2025年第2期20卷 309-325页

作者： Zhengping Pu Yu Wu Zhongjie Zhu Hongwei zhao Donghong Cui Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Kangci Hospital of JiaxingTongxiangZhejiang ProvinceChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghaiChina National Facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain *** this article,we review the development of terahertz biotechnology and its applications in the field of *** evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin *** vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric *** the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic ***,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical *** review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关键词： biological effect brain neuron neuropsychiatry neuroscience non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology