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MicroRNA-628-5p Facilitates Enterovirus 71 Infection by Suppressing TRAF3 Signaling

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Cellular & Molecular Immunology 2021年第5期18卷 1320-1322页

作者： Dong Li Shuaiyin Chen Weiguo zhang Chao zhang Tiantian Sun Yue Du Ronghua ding Yanlei Gao Yuefei Jin Guangcai Duan Department of Epidemiology College of Public HealthZhengzhou UniversityZhengzhou450001People’s Republic of China Department of Immunology Duke University Medical CenterDurhamNC27710USA

To date,EV71 infection still poses a great challenge to the health of infants and young children.1 Much established evidence suggests that EV71 infection depends on a wide variety of host factors,including cell surface receptors for EV71 entry,innate immune response,miRNAs,and lncRNAs.2,3 It is thought that diverse signaling pathways are required for EV71 to escape the host immune response.4 Innate immunity serves as the first line of defense against *** necrosis factor receptor-associated factor(TRAF)proteins are essential components of signaling pathways activated by Toll-like receptor(TLR)or RIG-I-like receptor(RLR)family ***3 is widely expressed by many cell types,including all nucleated immune cells,in which it plays many roles in the regulation of immune functions.5 TRAF3 plays a significant role in regulating the functions of B and T ***3 is a highly versatile regulator that positively controls type I interferon and cytokine production through interferon regulatory factors(IRFs)and nuclear factor-κB(NF-κB).6 A recent study indicated that EV71-induced ubiquitin-specific protease 19(USP19)negatively regulates type I IFN signaling by targeting TRAF3.

关键词： interferon TRAF3 EV71

Effect of infiltrating time on interfacial reaction and properties of tungsten particles reinforced Zr-based bulk metallic glass composites

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China Foundry 2020年第4期17卷 253-259页

作者： Qing-chun Xiang Zhi-bo Feng Wei zhang Hong-ding Wang Ying-lei Ren Ke-qiang Qiu School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China

The tungsten particles reinforced Zr41.2Ti13.8Cu12.5Ni10Be22.5 (Vit 1 alloy) bulk metallic glass composites (BMGCs) were prepared by the melt infiltrating casting method with the infiltrating time of 1, 5 and 10 min, respectively. The changes of interfacial reaction and compression properties of the bulk metallic glass composites with different infiltrating times were studied. Results show that with the increase of infiltrating time, tiny nanocrystals are generated at the interfacial boundary of tungsten particles and the amorphous matrix, and the size of tiny crystals increases with the infiltrating time. When the infiltrating time is 10 min, polygonal crystals with a larger size are also generated within the amorphous matrix. The compressive strength of the composites also increases with the infiltrating time. When the infiltrating time is 10 min, the compressive strength of the composite reaches 2,030 MPa and the compression strain is 44%. The fracture morphology of the composite materials is in a vein-like pattern and the melting phenomenon is found on the fracture surface. In addition, the density of the shear bands during the compressive tests of the composite materials increases with the infiltrating time.

关键词： Zr-based metallic glass infiltrating time interfacial reaction shear bands compressive strength

Sex-specific and Dose-response Relationship between the Incidence of Gallstones and Components of the Metabolic Syndrome in Jinchang Cohort:A Prospective Study

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Biomedical and Environmental Sciences 2020年第8期33卷 633-638页

作者： YANG Jing Li HUANG Jun Jun CHENG Ning zhang De Sheng LIU Si Min HUANG Wen Ya LI Na HUANG Pei Yao ding Jiao LIU Nian BAO Kai Fang ding Jie CHEN Xiao Liang ZHENG Tong zhang BAI Ya Na College of Earth and Environmental Sciences Lanzhou UniversityLanzhou 730000GansuChina Department of Epidemiology and Statistics School of Public HealthLanzhou UniversityLanzhou 730000GansuChina Center of Medical Laboratory School of Basic MedicalLanzhou UniversityLanzhou 730000GansuChina Workers’Hospital of Jinchuan Group Co. Ltd.Jinchang 737100GansuChina Department of Epidemiology School of Public HealthBrown UniversityRI02912USA

Gallstones is a very common gastrointestinal disease,involving the formation of masses in the gall bladder or biliary tract,due to abnormally high concentrations of cholesterol or bilirubin in the bile[1].There is a 10%–20%prevalence of gallstones worldwide,and>20%of patients with gallstones show clinical symptoms,implying a substantial disease burden[1].

关键词： bladder cholesterol Gallstone

选择、困境与策略--音乐教师教育专业教学评价的转向

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中国音乐 2021年第3期 106-113页

作者：丁菲菲潍坊学院音乐学院

现代教学评价是有效开展教学活动的核心,是高校教学质量变革的关键。在时代要求与内在需求的共同驱动下,音乐教师教育专业教学评价的改革应主动面对评价目标与学习结果失衡、阶段性评价内容与学生学习需求错位、评价过程与学习活动脱节... 详细信息

现代教学评价是有效开展教学活动的核心,是高校教学质量变革的关键。在时代要求与内在需求的共同驱动下,音乐教师教育专业教学评价的改革应主动面对评价目标与学习结果失衡、阶段性评价内容与学生学习需求错位、评价过程与学习活动脱节、评价标准与达成依据相对模糊的现实困境,应致力于遵循教育生态原则,探索知识与能力统一、理论与实践一致、学习与评价交互、标准与依据匹配的育人型、嵌入式、情境性、精细化的教学评价的转向。

关键词：音乐教师教育专业课程改革教学评价转向

Astronomical Site Monitoring System at Lijiang Observatory

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Research in Astronomy and Astrophysics 2020年第9期20卷 291-308页

作者： Yu-Xin Xin Jin-Ming Bai Bao-Li Lun Yu-Feng Fan Chuan-Jun Wang Xiao-Wei Liu Xiao Guang Yu Kai Ye Teng-fei Song Liang Chang Shou-Sheng He Jji-Rong Mao Liang Xu ding-Rong Xiong Xi-Liang zhang Jian-Guo Wang Xu ding Hai-Cheng Feng Xiang-Kun Liu Yang Huang Bing-Qiu Chen Yunnan Observatories Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China Center for Astronomical Mega-Sciences Chinese Academy of SciencesBeijing 100101China South-Western Institute for Astronomy Research Yunnan UiversityKunming 650500China

We installed two sets of Astronomical Site Monitoring Systems(ASMSs)at Lijiang Observatory(GMG),for the running of the 2.4-meter Lijiang optical telescope(LJT)and the 1.6-meter Multi-channel Photometric Survey Telescope(Mephisto).The Mephisto is under *** ASMS has been running on robotic mode since *** core instruments:Cloud Sensor,All-Sky Camera and AutonomousDIMM that are developed by our group,together with the commercial Meteorological Station and Sky Quality Meter,are combined into the astronomical optical site monitoring *** new Cloud Sensor's Cloud-Clear Relationship is presented for the first time,which is used to calculate the All-Sky cloud *** designed the Autonomous-DIMM located on a tower,with the same height as *** seeing data have been observed for a full ***'s data for the year 2019 are also analysed in detail,which are valuable to observers.

关键词： Astronomical Site Monitoring System Lijiang Observatory Cloud Sensor Autonomous-DIMM

Prevalence and characteristics of extended spectrum β-lactamase-producing Escherichia coli from bovine mastitis cases in China

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Journal of Integrative Agriculture 2018年第6期17卷 1246-1251页

作者： YANG Feng zhang Shi-dong SHANG Xiao-fei WANG Xu-rong WANG Ling YAN Zuo-ting LI Hong-sheng Lanzhou Institute of Husbandry and Pharmaceutical Sciences Chinese Academy of Agricultural Sciences

The aim of the study was to investigate the prevalence and characterization of extended-spectrum β-lactamase （ESBL）- producing Escherichia coli isolated from bovine mastitis cases in China. ChromID ESBL agar was used to confirm ESBL-producing E. coli. PCR and DNA sequencing were employed to characterize the genotype of ESBL-producers. Antimicrobial susceptibility was measured by disc diffusion. Overall, 73 of 318 E. coli isolates （22.96％） were identified as ESBL-producers. Of these ESBL-producing E. coli, the prevalence of blaCTX-M and blaTEM-1 was 97.26 and 71.23％, respectively. The predominant CTX-M-type ESBL was CTX-M-15 （65.75％）, followed by CTX-M-14 （10.96％）, CTX-M-55 （9.59％）, CTX-M-64 （5.48％）, CTX-M-65 （4.11％） and CTX-M-3 （1.37％）. This study is the first report of CTX-M-64 and CTX-M-65 in E. coli isolated from bovine mastitis. Furthermore, 72 ESBL-producing E. coli isolates （98.63％） were found to be multidrug-resistance. This study noted high prevalence and rates of antimicrobial resistance of ESBL-producing E. coli isolates from bovine mastitis cases in China.

关键词： extended spectrum β-lactamase Escherichia coli multidrug-resistance bovine mastitis

Geochemical Characteristics of Granitoids in the Eastern Sector of the Northern Tianshan Mountains in Xinjiang

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Acta Geologica Sinica(English Edition) 1990年第1期64卷 55-67页

作者： Wang Bixiang Li Zhaonai Zhao Guangzan Wang Fubao zhang Shuizhe fei Wenheng Institute of Geology, Chinese Academy of Geological Sciences, Beijing Institute of Geology Chinese Academy of Geological Sciences Beijing

The granitioids in question are located in the geosynclinal fold belt of the Northern Tianshan Mountains.The magmas are intruded into a Carboniferous marine volcanic-sedimentary rock series. forming a contempo-raneous. intermediate-basic to acid. composite intrusion. With a whole-rock Rb-Sr isochron age of 315.7 Ma. itis considered to be of middle Heicynian age. The granitoids have a SiO_2 content of 48-78%, a calc-alkali indexof 60 and silica-alkali indices ρ=2.2-2.4 and σ=1.5-2. From basic to acid compositions, the total REE con-tent increases from 38 to 143 ppm. δEu ranges from 0.47 to 0.86 and the Eu anomalies are negative. Thenormalized curves of REE of various rock types are very similar. These coupled with the characteristics of traceelement geochemistry show that the intrusion is an island arc-continental margin, calc-alkaline one. Theδ^(18)O values range from 5.8 to 8.9‰ and the ^(87)Sr/^(86)Sr initial ratio is 0.705. The materials of the intrusion arecomposed of a mixture of the magmas at the top of the upper mantle and in the lower crust, This indicates thatthe rocks might be consanguineous. differentiated and evolved products and possess the characteristics of Ⅰtype granites.

关键词： Geochemical Characteristics of Granitoids in the Eastern Sector of the Northern Tianshan Mountains in Xinjiang

Morphologies of solid-liquid interface and surface steps during rapid growth of BaB_2O_4 single crystals

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Science China(Physics,Mechanics & Astronomy) 2007年第4期50卷 539-545页

作者： PAN XiuHong, AI fei, JIN WeiQing, LIU Yan & zhang Ying Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China 1. Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China

The evolution of solid-liquid interface during BBO single crystal growth was stud- ied by the differential interference microscopy. And the step morphology on (0001) surface of the as-grown crystal was observed by the atomic force microscopy as well. It was found that the transition from a flat solid-liquid interface to a skeletal shape will occur in case of rapid growth. However, AFM images of surface steps revealed morphology differences correlated with crystallographic directions. The steps advancing along direction form the step flow, whereas those steps propagating along direction shape into step segments. Measurements of step heights by AFM indicated that it is the high anisotropy of the dimension of growth unit and step bunching due to the enlargement of concentration difference along the surface that results in the anisotropy of step morphologies.

关键词： crystal growth morphological instability growth step AFM observation

Synthesis and Biological Activities of Novel Anthranilic Diamides Analogues Containing Benzo[b]thiophene

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Chemical Research in Chinese Universities 2013年第4期29卷 714-720页

作者： zhang Ji-feng LIU Chen LIU Peng-fei YAN Tao WANG Bao-lei XIONG Li-xia LI Zheng-ming State Key Laboratory of Elemento-Organic Chemistry Institute of Elemento-Organic Chemistry Nankai University Tianjin 300071 P.. R. China

A series of novel anthranilic diamides analogues containing benzo[b]thiophenyl ring was designed and synthesized. Their structures were characterized by melting points, 1H nuclear magnetic resonance（IH NMR） and high-resolution mass spectrometry（HRMS）. The bioassay tests indicate that their insecticidal activities were weak to moderate. Antibacterial tests indicate that some of the compounds showed favourable activity in vitro against Physa- lospora piricola, Alternaria solani, Cercospora arachidicola, Gibberella sanbinetti and Phytophthora infestans at a dosage of 50 mg/L.

关键词： Anthranilic diamide Benzo[b]thiophene Insecticidal activity Antibacterial activity