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A simple scoring system to predict early recurrence of Bismuth–Corlette type IV perihilar cholangiocarcinoma

Gastroenterology Report 2019年第5期7卷 345-353,I0002页

作者： ding-zhong peng Jiong Lu Bei Li Hai-Jie Hu Xi-Wen Ye Xian-Ze Xiong Nan-Sheng Cheng Department of biliary surgery West China Hospital of Sichuan UniversityChengduSichuanP.R.China

Background:Early recurrence has been reported to be predictive of a poor prognosis for patients with perihilar cholangiocarcinoma(pCCA)after *** objective of our study was to construct a useful scoring system to predict early recurrence for Bismuth–Corlette type IV pCCA patients in clinic and to investigate the value of early recurrence in directing post-operative surveillance and adjuvant ***:In total,244 patients who underwent radical resection for type IV pCCA were *** on clinicopathological characteristics,perioperative details and survival outcomes were *** curves were generated using the Kaplan–Meier *** and multivariate logistic-regression models were used to identify factors associated with early ***:Twenty-one months was defined as the cutoff point to distinguish between early and late *** and multivariate analysis revealed that CA19-9 level>200 U/mL,R1 resection margin,higher N category and positive lymphovascular invasion were independent predictors of early *** scoring system was constructed *** early-recurrence rates of patients with scores of 0,1,2,3,4,and 5 were 23.9%,38.7%,60.0%,78.6%,83.4%,and 100%,*** therapy was significantly associated with higher overall survival rate for patients with early recurrence,but not for those with late *** in the early-recurrence group with scores2 had better prognoses after adjuvant ***:A simple scoring system using CA19-9 level,N category,resection margin and lymphovascular invasion status could predict early recurrence,and thus might direct post-operative surveillance and adjuvant therapy for patients with type IV pCCA.

关键词： early recurrence Bismuth–Corlette classification perihilar cholangiocarcinoma

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Multi boron-doping effects in hard carbon toward enhanced sodium ion storage

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Journal of Energy Chemistry 2025年第1期100卷 730-738页

作者： peng Zheng Wang Zhou Ying Mo Biao Zheng Miaomiao Han Qin zhong Wenwen Yang peng Gao Lezhi Yang Jilei Liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Greater Bay Area Institute for Innovation Hunan University Changsha Research Institute of Mining & Metallurgy Co. LTD.

Hard carbon （HC） has been considered as promising anode material for sodium-ion batteries （SIBs）.The optimization of hard carbon’s microstructure and solid electrolyte interface （SEI） property are demonstrated effective in enhancing the Na+storage capability,however,a one-step regulation strategy to achieve simultaneous multi-scale structures optimization is highly ***,we have systematically investigated the effects of boron doping on hard carbon’s microstructure and interface chemistry.A variety of structure characterizations show that appropriate amount of boron doping can increase the size of closed pores via rearrangement of carbon layers with improved graphitization degree,which provides more Na+storage ***-situ Fourier transform infrared spectroscopy/electrochemical impedance spectroscopy （FTIR/EIS） and X-ray photoelectron spectroscopy （XPS） analysis demonstrate the presence of more BC3and less B–C–O structures that result in enhanced ion diffusion kinetics and the formation of inorganic rich and robust SEI,which leads to facilitated charge transfer and excellent rate *** a result,the hard carbon anode with optimized boron doping content exhibits enhanced rate and cycling *** general,this work unravels the critical role of boron doping in optimizing the pore structure,interface chemistry and diffusion kinetics of hard carbon,which enables rational design of sodium-ion battery anode with enhanced Na+storage performance.

关键词： X ray photoelectron spectroscopy

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以弗洛姆心理学理论解析网络欺凌现象

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黑龙江社会科学 2022年第5期 60-64,136页

作者：丁钟鹏哈尔滨工程大学人文社会科学学院哈尔滨150001

近年来,网络欺凌事件频发,欺凌对象之多样、发生之突然、造成伤害强度烈度之大,是前所未见的。当前,对于网络欺凌问题的研究仍存在诸多不足,需要通过对过往研究进行梳理和相关概念辨析,来认识网络霸凌的新特点,在此基础上重新界定网络... 详细信息

近年来,网络欺凌事件频发,欺凌对象之多样、发生之突然、造成伤害强度烈度之大,是前所未见的。当前,对于网络欺凌问题的研究仍存在诸多不足,需要通过对过往研究进行梳理和相关概念辨析,来认识网络霸凌的新特点,在此基础上重新界定网络欺凌概念,区分网络欺凌类型,并应用弗洛姆的相关心理学理论对网络欺凌进行分析。

关键词：网络欺凌欺凌霸陵弗洛姆

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Plinabulin:A Marine Drug Candidate for Anti-tumor

Plinabulin:A Marine Drug Candidate for Anti-tumor

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第十二届海洋药物学术年会

作者： SUN Tian-wen WANG Shi-xiao ZHAO Jian-chun ding zhong-peng CHENG He-juan LIU Xiao-chun LIU Li CAI Bing GUAN Hua-shi LI Wen-bao School of Medicine and Pharmacy Ocean University of China Marine Biomedical Research Institute of Qingdao

Plinabulin is a synthesized diketopiperazine type tubulin inhibitor discovered based on the structure-activity relationship（SAR）study of Phenylahistin,which was isolated from *** was observed that Plinabulin binds between alpha and beta tubulin subunit which is close to colchicine-binding site of *** study indicated that it has good efficacy,pharmacokinetics and safety properties,current it is in phaseⅢclinical ***,we are working on optimization of its synthesis *** ethyl isocyanoacetate and three methyl acetic anhydride as starting materials,the imidazole aldehyde was obtained through four steps;and then the target molecule was accomplished through two steps of condensation reaction,the total synthesis yield is 12%.The double bond Z,E isomers can be produced in the second condensation reaction,and the Z isomer,which has anti-tumor activity,can be obtained by avoiding *** screening indicated that Plinabulin has strong inhibition the growth of A431 human skin cancer cell,the inhibition rate was91.8%in 12.5 nm concentration *** intracellular fluorescence intensity of the microtubule protein enhanced,and the cell morphology altered were observed with using Alexa488 *** order to obtain a new generation of anti-tumor drugs with better biological activity and to overcome the existing drug resistance,our group has designed and synthesized a series of novel derivatives based on the structure of ***-001,a new marine anti-tumor drug candidate having good druggability,was selected to preclinical study through activity screening,preliminary pharmacokinetics and safety studies.

关键词： Plinabulin Tubulin inhibitor Marine drug Anti-tumor drug candidate

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Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第01期 297-307页

作者： Bin Fang Limin Wang Haoqin Li Jiaxin Zhang Yang ding Pan Pan Li Bo peng Hua Bai Lin Li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

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青年与中老年对医生信任差异及影响机制研究

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广东青年研究 2022年第3期36卷 68-78页

作者：柳建坤丁钟鹏董寅茜哈尔滨工程大学人文社会科学学院黑龙江哈尔滨150001 清华大学社会科学学院北京100084

本文基于“中国社会状况综合调查”多期数据,考察了医生信任的代际差异现象,并从互动论视角分析了就医经历和互联网使用对不同代际群体的影响。研究发现,公众对医生的信任存在明显的代际差异。具体表现为:青年比中老年更不信任医生;就... 详细信息

本文基于“中国社会状况综合调查”多期数据,考察了医生信任的代际差异现象,并从互动论视角分析了就医经历和互联网使用对不同代际群体的影响。研究发现,公众对医生的信任存在明显的代际差异。具体表现为:青年比中老年更不信任医生;就医经历可以增强中老年人对医生的信任;互联网的使用会降低青年对医生的信任。本研究不仅可以加深人们关于医生信任存在的群体性差异的认识,而且有助于相关部门精准施策,以便使不同年龄群体对医生的信任得到同步的提升。

关键词：青年中老年医生信任代际差异就医经历互联网使用

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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology research 2025年第1期33卷 103-121页

作者： Yan Lu Kang Wang Yuanhong peng Meng Chen Lin zhong Luji Huang F U Cheng Xindan Sheng Xin Yang Manzhao Ouyang George A Calin Zhiwei He China-America Cancer Research Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gastrointestinal Surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. The Second School of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors, but the currently used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte antigen-4 (CTLA-4) show limited clinical efficacy in many breast cancers. B7H3 has been widely reported as an immunosuppressive molecule, but its immunological function in breast cancer patients remains unclear.Methods:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program (TCGA) and the Gene Expression Omnibus (GEO) databases. MicroRNAs were selected using the TarBase, miRTarBase, and miRBase databases. The regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays, which identified the specific action sites of interaction. The expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR (qPCR). experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and apoptosis. Additionally, the regulatory impact of hsa-miR-214-3p on B7H3 was examined. Enzyme-linked immunosorbent assays (ELISA) and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells (PBMCs) on immune cells and associated cytokines.Results:In breast cancer tissues, the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p, as well as with the regulatory effects on breast cancercell behavior. Hsa-miR-214-3p was found to inhibit breast cancer cell growth by downregulating B7H3. Importantly, our research identified, for the first time, two binding sites for hsa-miR-214-3p on the 3' UTR of B7H3, both of which exert similar effects independently. Co-culture experime

关键词： B7H3 Breast cancer Hsa-miR-214-3p Immunotherapy

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia peng Wen Qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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含三(2-吡啶甲基)胺识别体的荧光化学敏感器核磁共振谱分析

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分析测试学报 2004年第5期23卷 82-84页

作者：高云玲丁钟彭孝军孙世国孙立成大连理工大学精细化工国家重点实验室辽宁大连116012

采用二维核磁共振谱技术对新型丹磺酰胺和1,8_萘酰亚胺荧光化学敏感器的结构进行了测定。应用 1H - 1HCOSY、HSQC。

关键词：二维核磁共振谱荧光化学敏感器丹磺酰胺 1,8-萘酰亚胺三(2-吡啶甲基)胺

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海洋抗肿瘤候选药物普那布林(Plinabulin)及其类似物的研究进展

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中国海洋药物 2016年第4期35卷 79-86页

作者：孙天文丁忠鹏王世潇赵建春管华诗李文保中国海洋大学海洋药物教育部重点实验室医药学院山东青岛266003 青岛海洋生物医药研究院山东青岛266071

微管蛋白是细胞骨架的重要组成部分,在维持形态、信号传导及有丝分裂等过程中起着重要的作用。普那布林(Plinabulin)是在从海洋焦曲霉菌中分离得到的天然产物Phenylahistin结构基础上,经构效关系研究,合成出的二酮哌嗪类微管蛋白抑制剂... 详细信息

微管蛋白是细胞骨架的重要组成部分,在维持形态、信号传导及有丝分裂等过程中起着重要的作用。普那布林(Plinabulin)是在从海洋焦曲霉菌中分离得到的天然产物Phenylahistin结构基础上,经构效关系研究,合成出的二酮哌嗪类微管蛋白抑制剂。普那布林作为抗肿瘤候选药物,目前已进入临床三期研究。近年来,为了获得高效、低毒和生物利用度更高的普那布林衍生物,本领域研究人员进行了大量的优化研究,获得了一些具有更好活性的衍生物。本文就普那布林及其类似物优化的研究进展进行综述。

关键词：普那布林(Plinabulin) 微管蛋白抑制剂抗肿瘤候选药物衍生物构效关系

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