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Fractional flow reserve measured via left internal mammary artery after coronary artery bypass grafting:Two case reports

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World Journal of Clinical Cases 2023年第13期11卷 3045-3051页

作者： Li-Ying Zhang Yi-Rong Gan Yan-Zhen Wang ding-xiong xie Zong-Ke Kou Xiao-Qing Kou Yun-Long Zhang Bing Li Rui Mao Tian-Xiang Liang Jing xie Jian-Jian Jin Jin-Mei Yang Gansu Institute of Cardiovascular Diseases Lanzhou 730050Gansu ProvinceChina Provincial Level Key Laboratory for Molecular Medicine of Major Diseases and Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and Universities Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Department of Functional Lanzhou First People’s HospitalLanzhou 730050Gansu ProvinceChina Department of Cardiology The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND The fractional flow reserve(FFR)has made the treatment of coronary heart disease more ***,there are few reports on the measurement of FFR via the left internal mammary artery(LIMA).Herein,we described the determination of further treatments by measuring FFR via the LIMA in 2 cases after coronary artery bypass grafting(CABG).CASE SUMMARY Case 1 was a 66-year-old male who was admitted due to“chest tightness after CABG.”The patient underwent CABG 7 years prior due to coronary heart *** artery angiography showed complete occlusion of the left anterior descending artery(LAD),and subtotal occlusion of the third segment of the right coronary *** arterial angiography,there was 85%stenosis at the distal end of the anastomosis of the LIMA-LAD *** via LIMA was determined at ***,balloon dilation was performed in Case *** after balloon dilation was *** 2 was a 60-year-old male who was admitted due to“chest tightness after CABG.”The patient underwent CABG 6 years prior due to coronary heart *** was 60%segmental stenosis in the middle segment of LAD and 75%anastomotic *** measured via LIMA was 0.83(negative);thus the intervention was not *** 2 was given drug *** the 3-mo follow-up,there was no recurrence of chest tightness or shortness of breath in both *** are currently under continual *** We provided evidence that FFR measurement via grafted blood vessels,especially LIMA,after CABG is a good method to determine the intervention course.

关键词： Left internal mammary artery Fractional flow reserve Coronary artery bypass Intervention Case report

Investigation into enhanced performance of toluene and Hg0 stimulative abatement over Cr-Mn oxides co-modified columnar activated coke

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Journal of Environmental Sciences 2025年第2期148卷 88-106页

作者： Jiajie Wang Jie Liu Lei Gao Dong xie Caiting Li Liping Xiang Huiyu xiong Jiaqi xie Tianren Zhang Yueguo Pan School of Resources Environment and Safety Engineering University of South ChinaHengyang 421001China National&Local Joint Engineering Research Center for Airborne Pollutants Control and Radioactivity Protection in Buildings Hengyang 421001China Key Laboratory of Prefabricated Building Energy Saving Technology of Hunan Province Hengyang 421001China College of Environmental Science and Engineering Hunan UniversityChangsha 410082China

In this study,a string of Cr-Mnco-modified activated coke catalysts(XCryMn1-y/AC)were prepared to investigate toluene and Hg0 removal *** characterizations including XRD,TEM,SEM,in situ DRIFTS,BET,XPS and H_(2)-TPR showed that 4%Cr0.5Mn0.5/AC had excellent physicochemical properties and exhibited the best toluene and Hg0 removal efficiency at 200◦*** varying the experimental gas components and conditions,it was found that too large weight hourly space velocity would reduce the removal efficiency of toluene and *** O_(2) promoted the abatement of toluene and Hg0,the inhibitory role of H_(2)O and SO_(2) offset the promoting effect of O_(2) to some *** significantly inhibited Hg0 removal,resulting from that toluene was present at concentrations orders of magnitude greater than mercury’s or the catalyst was more prone to adsorb toluene,while Hg0 almost exerted non-existent influence on toluene *** mechanistic analysis showed that the forms of toluene and Hg0 removal included both adsorption and oxidation,where the high-valent metal cations and oxygen vacancy clusters promoted the redox cycle of Cr^(3+)+Mn^(3+)/Mn^(4+)+Cr^(6+)+Mn^(2+),which facilitated the conversion and replenishment of reactive oxygen species in the oxidation process,and even the CrMn1.5O4 spinel structure could provide a larger catalytic interface,thus enhancing the adsorption/oxidation of toluene and ***,its excellent physicochemical properties make it a costeffective potential industrial catalyst with outstanding synergistic toluene and Hg0 removal performance and preeminent resistance to H_(2)O and SO_(2).

关键词： Toluene Element mercury Cr-Mn oxides Activated coke

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China(Life Sciences) 2025年第1期68卷 204-218页

作者： Chen xiong Hong Ling Yingdan Huang Hanzhi Dong Bangxiang xie Qian Hao Xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032China Department of Oncology First Affiliated Hospital of Nanchang UniversityNanchang 330006China Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Beijing 100069China Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032China Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)Institutes of Biomedical SciencesFudan UniversityShanghai 200032China

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies,including WEE1 *** that p53 activation can also lead to multiple types of cell death,the role of this tumor suppressor in WEE1 inhibitor-based therapies remains *** this study,we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer *** findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake,an action similar to that of ***,inhibition of WEE1 by the WEE1 inhibitors or siRNAs induced compensatory upregulation of SLC7A11,which conferred resistance to ***,AZD1775 prevented the enrichment of H3K9me3,a histone marker of transcriptional repression,on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1,thereby enhancing NRF2-mediated SLC7A11 *** finding was also validated using the H3K9me3 inhibitor ***,we found that the nucleolar stress-inducing agent Actinomycin D(Act.D)inhibited SLC7A11 expression by activating p53,thus augmenting AZD1775-induced ***,the combination of AZD1775 and Act.D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in ***,our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription,and inhibition of SLC7A11 by Act.D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

关键词： p53 NRF2 SLC7A11 WEE1 AZD1775 ferroptosis nucleolar stress

Metabolomics as an emerging tool for the pharmacological and toxicological studies on Aconitum alkaloids

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Chinese Journal of Natural Medicines 2025年第02期23卷 182-190页

作者： Han ding Yamin Liu Sifan Wang Yuqi Mei Linnan Li Aizhen xiong Zhengtao Wang Li Yang The MOE Key Laboratory of Standardization of Chinese Medicines the SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines Shanghai Key Laboratory of Compound Chinese Medicines Institute of Chinese Materia Medica Shanghai University of Traditional Chinese Medicine Longhua Hospital Shanghai University of Traditional Chinese Medicine

Aconitum(Ranunculaceae) has a long-standing history in traditional Chinese medicine(TCM),where it has been widely used to treat conditions such as rheumatoid arthritis(RA), myocardial infarction, and heart failure. However, the potency of Aconitum alkaloids, the primary active components of Aconitum, also confers substantial toxicity. Therefore, assessing the efficacy and toxicity of these Aconitum alkaloids is crucial for ensuring clinical effectiveness and safety. Metabolomics, a quantitative method for analyzing low-molecular-weight metabolites involved in metabolic pathways, provides a comprehensive view of the metabolic state across multiple systems in vivo. This approach has become a vital investigative tool for facilitating the evaluation of their efficacy and toxicity, identifying potential sensitive biomarkers, and offering a promising avenue for elucidating the pharmacological and toxicological mechanisms underlying TCM. This review focuses on the applications of metabolomics in pharmacological and toxicological studies of Aconitum alkaloids in recent years and highlights the significant role of metabolomics in exploring compatibility detoxification and the mechanisms of TCM processing, aiming to identify more viable methods for characterizing toxic medicinal plants.

关键词： Aconitum alkaloids Biomarkers Metabolic pathway Metabolites Metabolomics

Materials and devices for high-density, high-throughput micro-electrocorticography arrays

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Fundamental Research 2025年第1期5卷 17-28页

作者： xie, Yang Peng, Yanxiu Guo, Jinhong Liu, Muyang Zhang, Bozhen Yin, Lan ding, He Sheng, Xing Department of Electronic Engineering Beijing National Research Center for Information Science and Technology Institute for Precision Medicine Laboratory of Flexible Electronics Technology IDG/McGovern Institute for Brain Research Tsinghua University Beijing 100084 China Beijing Engineering Research Center of Mixed Reality and Advanced Display School of Optics and Photonics Beijing Institute of Technology Beijing 100081 China School of Materials Science and Engineering The Key Laboratory of Advanced Materials of Ministry of Education State Key Laboratory of New Ceramics and Fine Processing Laboratory of Flexible Electronics Technology Tsinghua University Beijing 100084 China

The pursuit of precisely recording and localizing neural activities in brain cortical regions drives the development of advanced electrocorticography (ECoG) devices. Remarkable progress has led to the emergence of micro-ECoG (µECoG) devices with sub-millimeter resolutions. This review presents the current research status, development directions, potential innovations and applications of high-density, high-throughput µECoG devices. First, we summarize the challenges associated with accurately recording single or multiple neurons using existing µECoG devices, including passive multielectrode and active transistor arrays. Second, we focus on cutting-edge advancements in passive µECoG devices by discussing the design principles and fabrication strategies to optimize three key parameters: impedance, mechanical flexibility, and biocompatibility. Furthermore, recent findings highlight the need for further research and development in active transistor arrays, including silicon, metal oxide, and solution-gated transistors. These active transistor arrays have the potential to unlock the capabilities of high-density, high-throughput µECoG devices and overcome the limitations of passive multielectrode arrays. The review explores the potential innovations and applications of µECoG devices, showcasing their effectiveness for both brain science research and clinical applications. © 2024

关键词： Bioelectronics Electrocorticography Flexible electronics Micro-electrocorticography Neural electrode array

Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jiang Zhenjie Lu Yanwen ding Shujun Liu Zhijie Qi Tian Tang Yunfan Zhang Zhiyuan Ma Jingwen Sun Liang Xue Wenyao Zhang Pan xiong Xin Wang Junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and TechnologyNanjing 210094JiangsuChina Jiangsu Pylon Battery Co.Ltd Yangzhou 211400JiangsuChina

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene (PP) *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance(145.88 MPa) of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm^(-2)with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Lithium-sulfur batteries Staged dendrite suppression Shuttle effect Surface-negatively-charged nanodiamond

Efficient large-area flexible organic photovoltaic modules on transparent thin silver electrodes

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Science China Chemistry 2025年第3期 1199-1206页

作者： Cong xie Zedong xiong Xinlu Liu Wen Wang Yang Liu Xueshi Jiang Xin Lu Lulu Sun Yinhua Zhou Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Kunming Institute of Physics

Large-area flexible organic photovoltaic（OPV） modules are challenging to achieve high power conversion efficiency（PCE）.Electrical shunts or shortages generally occur in large-area OPV modules due to the ultrathin（100–200 nm） and soft active *** the surface smoothness of bottom transparent electrode will be able to suppress the shunts and *** this work,we report a method to fabricate smooth and flexible transparent electrodes based on thin silver film,and further to fabricate efficient large-area flexible OPV *** fabricated thin silver transparent electrodes simultaneously have high conductivity,high optical transmittance,good mechanical flexibility and low surface *** exposure（h.e.）treatment on MoO3effectively facilitates the continuous growth of the thin transparent silver electrode.6 nm silver film on MoO3（h.e.） on plastic substrate shows a transmittance up to 89%,a sheet resistance of 15 Ω/sq,and a low surface roughness with a rootmean-square value of 0.276 ***,52-cm2flexible organic solar modules（15 subcells） showed a certified PCE of 12.66%.Furthermore,a 1350 cm2flexible component assembled by 25 pieces of 52–55 cm2modules showed certified PCE of 12.10% with an open-circuit voltage of 62.85 V.

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Pulsed dynamic electrolysis enhanced PEMWE hydrogen production:Revealing the effects of pulsed electric fields on protons mass transport and hydrogen bubble escape

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Journal of Energy Chemistry 2025年第1期100卷 201-214页

作者： Xuewei Zhang Wei Zhou Yuming Huang Liang xie Tonghui Li Huimin Kang Lijie Wang Yang Yu Yani ding Junfeng Li Jiaxiang Chen Miaoting Sun Shuo Cheng Xiaoxiao Meng Jihui Gao Guangbo Zhao School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001HeilongjiangChina China Datang Technology Innovation Co. LtdXiong’an 071799HebeiChina

The transition of hydrogen sourcing from carbon-intensive to water-based methodologies is underway,with renewable energy-powered proton exchange membrane water electrolysis(PEMWE)emerging as the preeminent pathway for hydrogen *** remarkable advancements in this field,confronting the sluggish electrochemical kinetics and inherent high-energy consumption arising from deteriorated mass transport within PEMWE systems remains a formidable *** impediment stems primarily from the hindered protons mass transfer and the untimely hydrogen bubbles *** address these challenges,we harness the inherent variability of electrical energy and introduce an innovative pulsed dynamic water electrolysis *** to constant voltage electrolysis(hydrogen production rate:51.6 m L h^(-1),energy consumption:5.37 kWh Nm-^(3)H_(2)),this strategy(hydrogen production rate:66 m L h^(-1),energy consumption:3.83 kWh Nm-^(3)H_(2))increases the hydrogen production rate by approximately 27%and reduces the energy consumption by about 28%.Furthermore,we demonstrate the practicality of this system by integrating it with an off-grid photovoltaic(PV)system designed for outdoor operation,successfully driving a hydrogen production current of up to 500 mA under an average voltage of approximately 2 *** combined results of in-situ characterization and finite element analysis reveal the performance enhancement mechanism:pulsed dynamic electrolysis(PDE)dramatically accelerates the enrichment of protons at the electrode/solution interface and facilitates the release of bubbles on the electrode *** such,PDE-enhanced PEMWE represents a synergistic advancement,concurrently enhancing both the hydrogen generation reaction and associated transport *** promising technology not only redefines the landscape of electrolysis-based hydrogen production but also holds immense potential for broadening its application across a diverse spectrum of electrocatalytic end

关键词： Water electrolysis Hydrogen production Pulsed dynamic electrolysis Proton exchange membrane water electrolysis Mass transport

LSBSP: A Lightweight Sharding Method of Blockchain Based on State Pruning for Efficient Data Sharing in IoMT

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Computers, Materials & Continua 2025年第2期82卷 3309-3335页

作者： Guoqiong Liao Yinxiang Lei Yufang xie Neal N.xiong College of Virtual Reality(VR)Modern Industry Jiangxi University of Finance and EconomicsNanchang330032China School of Computer Science Jiangxi University of Traditional Chinese MedicineNanchang330004China Jiangxi Tourism&Commerce Vocational College Nanchang330100China Department of Computer Mathematical and Physical SciencesSul Ross State UniversityAlpineTX 79830USA

As the Internet of Medical Things (IoMT) continues to expand, smart health-monitoring devices generate vast amounts of valuable data while simultaneously raising critical security and privacy challenges. Blockchain technology presents a promising avenue to address these concerns due to its inherent decentralization and security features. However, scalability remains a persistent hurdle, particularly for IoMT applications that involve large-scale networks and resource-constrained devices. This paper introduces a novel lightweight sharding method tailored to the unique demands of IoMT data sharing. Our approach enhances state bootstrapping efficiency and reduces operational overhead by utilizing a dual-chain structure comprising a main chain and a snapshot chain. The snapshot chain periodically records key blockchain states, allowing nodes to synchronize more efficiently. This mechanism is critical in reducing the time and resources needed for new nodes to join the network or existing nodes to recover from outages. Additionally, a block state pruning technique is implemented, significantly minimizing storage requirements and lowering transaction execution overhead during initialization and reconfiguration processes. This is crucial given the substantial data volumes inherent in IoMT ecosystems. By adopting an optimistic sharding strategy, our model allows nodes to swiftly join the snapshot shard, while full shards retain the complete ledger history to ensure comprehensive transaction verification. Extensive evaluations across diverse shard configurations demonstrate that this method significantly outperforms existing baseline models. It provides a comprehensive solution for IoMT blockchain applications, striking an optimal balance between security, scalability, and operational efficiency.

关键词： Internet of medical things blockchain sharding lightweight snapshot