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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第1期12卷 55-64页

作者： wei ZHANG Quan-wei wei Zheng-chao wang wei ding wei wang Fang-xiong SHI Laboratory of Animal Reproduction College of Animal Science and Technology Nanjing Agricultural University Nanjing 210095 China

Objective: The present study is designed to investigate the cellular expressions and immunolocalizations of three different nitric oxide synthase (NOS) isoforms and the related nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling pathway in the ovaries of neonatal and immature ***: The ovaries were obtained from ICR (Institute for Cancer Research) female Sprague-Dawley rats at postnatal days 1,5,7,10,and *** we carried out the histologic examination,immunohistochemistry,measurement of NOS activity,and modifications within the NO/cGMP ***: During postnatal days 1,5,7,10,and 19,all three isoforms of NOS were mainly localized to the oocytes and expressed as a gradual increase in granulosa cells and theca cells within the growing *** ovarian total NOS activities and NO levels were increased at postnatal days 7 and 10 compared with other ***: Our findings suggest that the locally produced NO and the NO/NOS signaling systems are involved in the follicular development to puberty.

关键词： Nitric oxide synthase Nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway Ovary Neonatal rats Prepuberty

New classification of the anatomic variations of cystic artery during laparoscopic cholecystectomy

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World Journal of Gastroenterology 2007年第42期13卷 5629-5634页

作者： You-Ming ding Bin wang wei-Xing wang Ping wang Ji-Shen Yan Department of Hepatobiliary & Laparoscopic Surgery Renmin Hospital of Wuhan University Wuhan 430060 HubeiProvince China

AIM： To investigate the anatomic variations in the cystic artery by laparoscopy, and to provide a new classification system for the guidance of laparoscopic ***： Six hundred patients treated with laparoscopic cholecystectomy from June 2005 to May 2006 were studied retrospectively, The laparoscope of 30° （Stryker, American） was applied, Anatomic structures of cystic artery and conditions of Calot＇s triangle under laparoscope were recorded respectively,RESULTS： Laparoscopy has revealed there are many anatomic variations of the cystic artery that occur frequently. Based on our experience with 600 laparoscopic cholecystectomies, we present a new classification of anatomic variations of the cystic artery, which can be divided into three groups：（1） Calot＇s triangle type, found in 513 patients （85.5%）; （2） outside Calot＇s triangle, found in 78 patients （13%）; （3） compound type, observed in 9 patients （1.5%）.CONCLUSION： Our classification of the anatomic variations of the cystic artery uncontrollable cystic artery extrahepatic bile duct injury. will be useful for decreasing hemorrhage, and avoiding extrahepatic bile duct injury.

关键词： Cystic artery Laparoscopic cholecystectomy Bile duct injury Calot's triangle

Soft Computing Based Procurement Planning of Time-variable Demand in Manufacturing Systems

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International Journal of Automation and computing 2007年第1期4卷 80-87页

作者： Kai Leung Yung Wai Hung Ip ding-wei wang Department of Industrial and Systems Engineering Hong Kong Polytechnic University Hung Horn Kowloon Hong Kong PRC School of Information Science and Engineering Northeastern University Shenyang 110004 PRC

Procurement planning with discrete time varying demand is an important problem in Enterprise Resource Planning （ERP）. It can be described using the non-analytic mathematical programming model proposed in this paper. To solve the model we propose to use a fuzzy decision embedded genetic algorithm. The algorithm adopts an order strategy selection to simplify the original real optimization problem into binary ones. Then, a fuzzy decision quantification method is used to quantify experience from planning experts. Thus, decision rules can easily be embedded in the computation of genetic operations. This approach is applied to purchase planning problem in a practical machine tool works, where satisfactory results have been achieved.

关键词： Purchase planning Enterprise Resource Planning (ERP) soft computing genetic algorithm fuzzy decision inventory control.

Study of the deuterated titanium Ti^2H_x sample by using nuclear reaction analysis and material analysis methods

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Nuclear Science and Techniques 2001年第3期12卷 190-194页

作者： wang Tie-Shan, ding Bao-wei, wang Zhi-Guo, ZHENG Shi-Kui, JIANG You-Rong, LI wei-Jun (Institute of Modern Physics, The Chinese Academy of Sciences, Lanzhou. 730000) (Institute of Nuclear Physics, Lanzhou University, Lanzhou 730000) (Nuclear Power inst 中科院近代物理所甘肃兰州 730000 兰州大学核物理研究所甘肃兰州 730000 中国核动力所四川成都 010041

Titanium is one of the best hydrogen loading material. The pre dieted maximum loading ratio of hydrogen in titanium may reach to 2.0. In this work, a titanium layer on molybdenum substrate was deuterated with the atomic: ratio X =2H/Ti≥1.6. The change of the surface topography and rnicrostructurc of the sample before and after loading was observed by using Scan Electron Microscopy (SEM). The surface segregation of the samples after deutcron bombardment was also observed. A fluctuatingly-incrcasing trend of the deutcriuin density in titanium target was detected in the deuteron implantation experiments. which indicated a suddenly explosion (segregation) or fast diffusion of deuterium in the titanium. Significant amount of nitrogen contamination was found in thc Ti2Hx sample by nuclear reaction analysis (NRA), which indicated that the Ti2Hx structure might have the feature to trap nitrogen from air. The nitrogen contamination in Ti2Hx significantly affects the increase of the atomic ratio X

关键词：氘化钛 Ti2Hx样品核反应试验材料分析

Expressions of Survivin and Caspase-3 in human hepatocellular carcinoma and the relationship with prognosis

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The Chinese-German Journal of Clinical Oncology 2010年第11期9卷 628-632页

作者： wei ding wei Hu Xiyan wang Xiaogang Dong Department of Hepatobiliopancreatic Surgery Tumor Hospital Affiliated to Xinjiang Medical University Urumqi 830011 China

Objective: The aim of our study was to investigate the expressions of Survivin and Caspase-3 in the hepatocellular carcinoma (HCC) and the paracancerous liver tissues, and define the relationship between the expression and the patients survival rate after surgery. Methods: The expressions of PCNA, Survivin and Caspase-3 were detected by immunohistochemistry. PCNA positive level was used to account proliferating cell nuclear antigen proliferating index (PCNA-PI). The apoptosis index of HCC tissues was detected by TUNEL. Results: The expression of Survivin in HCC tissue was higher than that in paracancerous tissue (P < 0.05), while it was related with portal vein thrombosis, tumor size and histological differentia- tion (P < 0.05). In HCC tissues, the PCNA-PI of the Survivin positive group was higher than the negative (P < 0.05) group, and the AI of the Survivin positive group was lower than the negative group (P < 0.05). The expression of Caspasse-3 in HCC tissue was lower than that in paracancerous tissue (P < 0.05), while it was related with HBsAg and histological differentiation (P < 0.05). In HCC tissues, the average PCNA-PI of the Caspase-3 positive group was lower than that of the negative group (P < 0.05), and the average AI of the Caspase-3 positive group was higher than that of the negative group (P < 0.05). There was negative correlation between the expressions of Survivin and Caspase-3 in HCC (r = -0.242, P < 0.05). The survival rate of the Survivin positive group was lower than that of the negative group (P < 0.05), while that of the Caspase-3 positive patients was higher than that of the negative group (P < 0.05). Conclusion: The expressions of Survivin and Caspase-3 in HCC can reflex the biological behavior of HCC and patients prognosis, they may be new targets of tumor diagnosis and treatment.

关键词： HCC Survivin Caspase-3 proliferation apoptosis

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基于ACL的UDP反射攻击拦截

华中科技大学学报（自然科学版） 2016年第11期44卷 21-25页

作者：丁伟王力苏琪东南大学计算机科学与工程学院江苏南京211189

为了对用户数据报协议(UDP)反射攻击进行安全响应,设计并实现了一种基于路由器访问控制列表(ACL)在网络边界对UDP反射攻击进行拦截的方法,并在中国教育与科研计算机网(CERNET)江苏省网边界对字符发生器协议(CHARGEN)和简单网络管理协议V... 详细信息

为了对用户数据报协议(UDP)反射攻击进行安全响应,设计并实现了一种基于路由器访问控制列表(ACL)在网络边界对UDP反射攻击进行拦截的方法,并在中国教育与科研计算机网(CERNET)江苏省网边界对字符发生器协议(CHARGEN)和简单网络管理协议V2版(SNMPv2)两种协议类型的UDP反射攻击进行了拦截实验.对实验数据进行的分析表明:该方法可以阻止这2种UDP反射攻击,且对控制命令的拦截比对攻击流量的拦截更加有效.对经过较长时间拦截后放大器攻击能力的恢复过程进行的观测表明:拦截时间的长短对放大器攻击强度的恢复的影响不明显,大部分放大器均可在短时间内恢复原有的攻击能力,从侧面证实了反射攻击的控制器全部位于实验网络之外.

关键词：反射攻击反射攻击放大器攻击拦截访问控制列表网络安全

Correlation between magnetic resonance T2 image signal intensity ratio and cell apoptosis in a rabbit spinal cord cervical myelopathy model

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Chinese Medical Journal 2014年第2期127卷 305-313页

作者： Ma Lei Zhang Di Chen wei Shen Yong Zhang Yingze ding Wenyuan Zhang wei wang Linfeng Yang Dalong Department of Spinal Surgery Third Hospital of Hebei Medical University Orthopaedic Biomechanics Laborafory of Hebei Province Shijiazhuang Hebei 050051 China

Background Cervical spondylotic myelopathy （CSM） is a common cause of disability in elderly *** studies have shown that spinal cord cell apoptosis due to spinal cord compression plays an important role in the pathology of *** changes in magnetic resonance imaging （MRI） T2 signal intensity ratio （SIR） are considered to be an indicator of CSM,little information is published supporting the correlation between changes in MRI signal and pathological *** study aims to testify the correlation between MRI T2 SIR changes and cell apoptosis using a CSM animal *** Forty-eight rabbits were randomly assigned to four groups：one control group and three experimental chronic compression groups,with each group containing 12 *** compression of the cervical spinal cord was implemented in the experimental groups by implanting a screw in the C3 *** control group underwent sham *** groups were observed for 3,6,or 9 months after *** T2-weighted SIR Tarlov motor scores and cortical somatosensory-evoked potentials （CSEPs） were periodically *** each time point,rabbits from one group were sacrificed to determine the level of apoptosis by histology （n=6） and Western blotting （n=6）.Results Tarlov motor scores in the compression groups were lower at all time points than the control group scores,with the lowest score at 9 months （P ＜0.001）.Electrophysiological testing showed a significantly prolonged latency in CSEP in the compression groups compared with the control *** rabbits in the compression groups showed higher MRI T2 SIR in the injury epicenter compared with controls,and higher SIR was also found at 9 months compared with 3 or 6 *** analysis showed significant apoptosis in the spinal cord tissue in the compression groups,but not in the control *** were significant differences in apoptosis degree over time （P ＜0.001）,with the 9-month group displaying the most

关键词： cervical myelopathy model apoptosis magnetic resonance imaging T2 signal intensity ratio compression

Association of renal function with cardiac reverse remodeling and long-term outcome in heart failure patients following cardiac resynchronization therapy

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Chinese Medical Journal 2014年第23期127卷 4036-4042页

作者： Cai Chi Hua wei ding Ligang wang Jing Chen Keping Yang Xinwei Liu Zhimin Zhang Shu Centre of Arrhythmia Diagnosis and Treatment Fuwai Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100037 China

Background Renal insufficiency （RI） is significantly associated with clinical prognosis in patients with heart failure （HF）,but direct evidences on the relation between renal function and clinical outcome in patients receiving cardiac resynchronization therapy （CRT） are *** aim of the current study was to systematically evaluate the association of baseline and 6-month renal function with cardiac reverse remodeling and long-term outcome after *** We retrospectively evaluated 190 consecutive patients who underwent CRT at Fuwai Hospital from January 2008 to April *** function tests,echocardiographic measurement,and clinical parameters at baseline and after 6 months of CRT were *** endpoint events included all-cause mortality,cardiac transplantation,and unplanned hospitalizations for *** At baseline,compared with normal renal function or mild RI （estimated glomerular filtration rate （eGFR）〉-60 ml·min-1·1.73 m-2）,moderate-to-severe RI （eGFR 〈60 ml·min-1·1.73 m-2） exerted a negative influence on cardiac reverse remodeling *** 6-month follow-up,114 （60.0%） patients were classified as responders and showed significant renal function improvement,whereas renal function deteriorated in non-responders and subsequently 41 （25.6%） patients developed worsening renal function （WRF）.During the mean follow-up of （24.3±17.1） months,both patients with baseline eGFR 〈60 ml·min^-1·1.73 m^-2 and those with WRF experienced worse event-free survival （P 〈0.01,respectively）.Conclusions：This analysis identified that baseline eGFR as well as WRF after CRT were found to be independent determinants of the combined endpoints of all-cause mortality and HF-related hospitalizations in CRT recipients.

关键词： heart failure renal insufficiency cardiac resynchronization therapy clinical outcome

Effects of O_2 Plasma Treatment on the Chemical and Electric Properties of Low-k SiOF Films

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Journal of Materials Science & Technology 2001年第6期17卷 643-645页

作者： Pengfei wang, Shijin ding, wei ZHANG and Jitao wang Dept.of Electronic Engineering., Fudan University, Shanghai 200433, China W. W.Lee Taiwan Semiconductor Manuf. Co., Taiwan, China [Manuscript received August 22, 2 Fudan Univ Dept Elect Engn Shanghai 200433 Peoples R China

With the progress of ULSI technology, materials with low dielectric constant are required to replace SiO2 film as the interlayer to scale down the interconnection delay. Fluorinated Si oxide thin films (SiOF) are a promising material for the low dielectric constant and the process compatibility in existing technology. However, SiOF films are liable to absorb moisture when exposed to air. By treating the SiOF films with O-2 plasma, it was found that the moisture resistibility of SiOF films was remarkably improved. The mechanism of the improvement in stability of dielectric constant was investigated. The results show that: 1) F atoms dissociated from the films and the bond angle of Si-O-Si decreased. 2) The plasma treatment enhanced the strength of Si-F bonds by removing unstable =SiF2 structures in the films. Resistibility of SiOF films in moisture was improved.

关键词： Effects of O2 Plasma Treatment on the Chemical and Electric Properties of Low-k SiOF Films Si mode FWHM

FUZZY COMPREHENSIVE EVALUATION FOR HOSPITAL SERVICE QUALITY

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FUZZY COMPREHENSIVE EVALUATION FOR HOSPITAL SERVICE QUALITY