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A Positive Signal

China Today 2025年第1期74卷 24-27页

作者： song jie China Economic Weekly

China removes last curbs on foreign investment in manufacturing to make the industry high-end,intelligent,and *** October,Japanese electronics giant Panasonic Group opened its co-creation center in Shanghai,the group... 详细信息

关键词： finance investment integrating

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian ding Chun Chen Heng Zhao Bin Dai Lei Ye Tao song Shuai Huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

A Flexible Smart Healthcare Platform Conjugated with Artificial Epidermis Assembled by Three‑Dimensionally Conductive MOF Network for Gas and Pressure Sensing

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Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing Zhou Qihang ding Zixun Geng Chencheng Hu Long Yang Zitong Kan Biao Dong Miae Won Hongwei song Lin Xu Jong Seung Kim State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea TheranoChem Incorporation Seoul 02856Republic of Korea

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic ***,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning *** work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2)composites NO_(2)/pressure flexible sensors Health-monitoring Machine learning

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直升机使用维修保障一体化的分析和研究

直升机技术 2017年第2期 65-72页

作者：陈圣斌丁杰宋永磊曾曼成中国直升机设计研究所可靠性工程研究室江西景德镇333001

目前国内直升机的可靠性、维修性水平都得到了很大的提高,但是,由于后勤延误时间太长,直升机的使用可用度没有得到明显改进。分析了造成这种状况的原因,提出了使用维修保障一体化系统的设想,试图使维修保障之间实现无缝连接,以消除或减... 详细信息

目前国内直升机的可靠性、维修性水平都得到了很大的提高,但是,由于后勤延误时间太长,直升机的使用可用度没有得到明显改进。分析了造成这种状况的原因,提出了使用维修保障一体化系统的设想,试图使维修保障之间实现无缝连接,以消除或减少平均维修时间(MTTR)和后勤延误时间(ADT),真正实现可靠性工程"二提高二减少"的目标。文中讨论了使用维修保障系统的构建及实现一体化的技术基础和关键技术,其目的是与业内同行在现存HUMS系统的基础上,通过技术提升实现直升机使用维修保障一体化。

关键词：基于状态的维修维修保障一体化设计

Sintering of monoclinic SrAl_(2)Si_(2)O_(8) ceramics and their Sr immobilization

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International Journal of Minerals,Metallurgy and Materials 2021年第6期28卷 1057-1062页

作者： jie Luo Xin Li Fu-jie Zhang song Chen ding Ren Key Laboratory of Radiation Physics and Technology of Ministry of Education Institute of Nuclear Science and TechnologySichuan UniversityChengdu 610065China Nuclear Power Institute of China Chengdu 610005China Department of Radiotherapy Division of Radiation PhysicsState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China School of Materials Science and Engineering Southwest Jiaotong UniversityChengdu 610031China

Monoclinic SrAl_(2)Si_(2)O_(8) ceramics for Sr immobilization were prepared by a liquid-phase sintering *** sintering temperature,mineral phase composition,microstructure,flexural strength,bulk density,and Sr ion leaching characteristics of the SrAl_(2)Si_(2)O_(8) ceramics were investigated.A crystalline monoclinic SrAl_(2)Si_(2)O_(8) phase formed through liquid-phase sintering at 1223 *** introduction of four flux agents(B_(2)O_(3),CaO·2B_(2)O_(3),SrO·2B_(2)O_(3),and BaO·2B_(2)O_(3))to the SrAl_(2)Si_(2)O_(8) ceramics not only reduced the densification temperature and decreased the volatilization of Sr during high-temperature sintering but also impacted the mechanical properties of the *** consistency tests showed that the leaching concentration of Sr ions in the sample with flux agent B_(2)O_(3) was the lowest,whereas that of Sr ions in the sample with flux agent BaO·2B_(2)O_(3) was the *** results show that the leaching concentration of Sr ions depends largely on the amorphous phase in the ***,the formation of mineral analog ceramics containing Sr is an important factor to improve Sr immobilization.

关键词： low-temperature liquid-phase sintering strontium immobilization monoclinic strontium feldspar flux agent

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-jie Zhu Xiao-Jia Yang Qian-Ru He Fei ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

AAV-mediated expression of p65shRNA and bone morphogenetic protein 4 synergistically enhances chondrocyte regeneration

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中国组织工程研究 2025年第17期29卷 3537-3547页

作者： Yu Yangyi song Zhuoyue Lian Qiang ding Kang Li Guangheng Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration Division of Adult Joint Reconstruction and Sports MedicineDepartment of Orthopedic SurgeryShenzhen People’s Hospital(The Second Clinical Medical College Jinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020Guangdong ProvinceChina Department of Orthopedics Zhengzhou Orthopedics HospitalZhengzhou 450000Henan ProvinceChina Department of Orthopedics Shenzhen Pingle Orthopedics HospitalShenzhen 518000Guangdong ProvinceChina

BACKGROUND:Adeno-associated virus(AAV)gene therapy has been proven to be reliable and safe for the treatment of osteoarthritis in recent ***,given the complexity of osteoarthritis pathogenesis,single gene manipulation for the treatment of osteoarthritis may not produce satisfactory *** studies have shown that nuclear factorκB could promote the inflammatory pathway in osteoarthritic chondrocytes,and bone morphogenetic protein 4(BMP4)could promote cartilage ***:To test whether combined application of AAV-p65shRNA and AAV-BMP4 will yield the synergistic effect on chondrocytes regeneration and osteoarthritis ***:Viral particles containing AAV-p65-shRNA and AAV-BMP4 were *** efficacy in inhibiting inflammation in chondrocytes and promoting chondrogenesis was assessed in vitro and in vivo by transfecting AAV-p65-shRNA or AAV-BMP4 into *** experiments were divided into five groups:PBS group;osteoarthritis group;AAV-BMP4 group;AAV-p65shRNA group;and BMP4-p65shRNA 1:1 *** were collected at 4,12,and 24 weeks *** staining,including safranin O and Alcian blue,was applied after collecting articular ***,the optimal ratio between the two types of transfected viral particles was further investigated to improve the chondrogenic potential of mixed cells in *** AND CONCLUSION:The combined application of AAV-p65shRNA and AAV-BMP4 together showed a synergistic effect on cartilage regeneration and osteoarthritis *** cells transfected with AAV-p65shRNA and AAV-BMP4 at a 1:1 ratio produced the most extracellular matrix synthesis(P<0.05).In vivo results also revealed that the combination of the two viruses had the highest regenerative potential for osteoarthritic cartilage(P<0.05).In the present study,we also discovered that the combined therapy had the maximum effect when the two viruses were administered in equal *** either p65shRNA or BMP4

关键词： osteoarthritis adeno-associated virus bone morphogenetic protein 4 p65-short hairpin RNA gene therapy short hairpin RNA transforming growth factor-β1 extracellular matrix articular cartilage chondrocytes.

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汉末三国的军师

南都学坛 2025年第1期45卷 1-12页

作者：宋杰首都师范大学历史学院北京100089

“军师”是为君主将帅谋划作战事务的文职官员,周代尊称为“师”,两汉之际始称“军师”。汉末三国曹操的首位军师是周,后来荀攸作为军师跟随他征伐中原,屡立奇功。曹操被封魏公后,设立有中军师、前军师、左右军师等,文帝以降又在中军和... 详细信息

“军师”是为君主将帅谋划作战事务的文职官员,周代尊称为“师”,两汉之际始称“军师”。汉末三国曹操的首位军师是周,后来荀攸作为军师跟随他征伐中原,屡立奇功。曹操被封魏公后,设立有中军师、前军师、左右军师等,文帝以降又在中军和边防外军都督属下置军师,参赞军务,代表朝廷监督主将。蜀汉刘备先后任命诸葛亮为军师中郎将、军师将军,有带兵的权力。诸葛亮执政后设前军师、中军师等荣誉官衔,到他死后逐渐取消。孙吴长期未设军师,曾经颁授的也只是荣誉性的附加职衔,起不到为君主参议军事的作用。吴、蜀军师的虚设与消亡,与其人才匮乏有密切关系。

关键词：师军师祭酒周荀攸诸葛亮

Shell-driven Fine Structure Transition of Core Materials in Co@Au Core-shell Nanoparticles

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Nano-Micro Letters 2012年第4期4卷 235-242页

作者： Yujun song Yinghui Wang Shaoxia Ji jie ding School of Materials Science and Engineering Beihang University

Co@Au core shell nanoparticles(NPs) of different shell thicknesses were fabricated by a combination of the displacement process and the reduction-deposition process in a microfluidic reactor. The effect of the shell thickness on the fine structures(local atom arrangement) of core materials was investigated by X-ray Absorption Near Edge Structure(XANES) and Extended X-ray Absorption Fine Structure(EXAFS).The results indicate that the shell thickness affects the fine structure of the core materials by causing atomic re-arrangement between the hexagonal close pack(hcp) and the face centered cubic(fcc) structure, and forming Co-Au bonds in the core-shell interface.

关键词： Nanoparticle Core-shell Fine Structure Microfluidic