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基于分子束外延技术可控制备Ga原子团簇的研究

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原子与分子物理学报 2025年第3期42卷 77-84页

本研究基于分子束外延(Molecular Beam Epitaxy,MBE)技术在Si(100)衬底表面成功制备金属Ga原子团簇.通过控制变量法,研究其尺寸形貌与工艺参数之间的关系.第一组对照实验分别在940℃、970℃、1000℃的Ga源温度下制备Ga原子团簇.实验结... 详细信息

本研究基于分子束外延(Molecular Beam Epitaxy,MBE)技术在Si(100)衬底表面成功制备金属Ga原子团簇.通过控制变量法,研究其尺寸形貌与工艺参数之间的关系.第一组对照实验分别在940℃、970℃、1000℃的Ga源温度下制备Ga原子团簇.实验结果表明,Ga源温度的升高导致Ga的蒸发量增加,进而沉积在Si衬底表面的Ga原子增多,Ga原子自组装成团簇,最终表现为Ga原子团簇的高度升高.第二组对照实验分别在3 s、6 s、10 s、40 s、50 s、60 s的沉积时长下制备Ga原子团簇.实验结果表明,沉积时长增加导致团簇的高度逐渐增加,主要由新吸附原子和竞争效应驱动.第三组对照实验分别在0 s、60 s、300 s的退火时长下制备Ga原子团簇.实验结果表明,退火时长的增加导致团簇的高度下降和团簇内的原子重新排列和分布有关.第四组对照实验分别在420℃、500℃的退火温度下制备Ga原子团簇.实验结果表明,升温至500℃退火会促进Ga原子团簇呈现有序排列,是表面原子的热运动和Ga原子团簇与Si(100)的晶格匹配度的共同作用的结果.

关键词： MBE Ga原子团簇 Ga源温度沉积时长退火时长

Ice lithography for 3D nanofabrication

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Science Bulletin 2019年第12期64卷 865-871页

作者： ding zhao Anpan Han Min Qiu National Centre for Nano Fabrication and Characterization Technical University of DenmarkKongens Lyngby2800Denmark Department of Mechanical Engineering Technical University of DenmarkKongens Lyngby2800Denmark Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province School of EngineeringWestlake UniversityHangzhou 310024China Institute of Advanced Technology Westlake Institute for Advanced StudyHangzhou 310024China

Nanotechnology and nanoscience are enabled by nanofabrication. Electron-beam lithography, which makes 2 D patterns down to a few nanometers, is one of the fundamental pillars of ***, significant progress in 3 D electron-beam-based nanofabrication has been made, such as the emerging ice lithography technology, in which ice thin-films are patterned by a focused electronbeam. Here, we review the history and progress of ice lithography, and focus on its applications in efficient 3 D nanofabrication and additive manufacturing or nanoscale 3 D printing. The finest linewidth made using frozen octane is below 5 nm, and nanostructures can be fabricated in selected areas on non-planar surfaces such as freely suspended nanotubes or nanowires. As developing custom instruments is required to advance this emerging technology, we discuss the evolution of ice lithography instruments and highlight major instrumentation advances. Finally, we present the perspectives of 3 D printing of functional materials using organic ices. We believe that we barely scratched the surface of this new and exciting research area, and we hope that this review will stimulate cutting-edge and interdisciplinary research that exploits the undiscovered potentials of ice lithography for 3 D photonics, electronics and 3 D nanodevices for biology and medicine.

关键词： Nanotechnology Nanofabrication Electron-beam lithography Ice lithography 3D nanofabrication Additive manufacturing Organic ice

烟酰胺磷酸核糖转移酶与糖尿病肾脏疾病关系的研究进展

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医学综述 2025年第1期31卷 80-86页

作者：沈倩秦宇婷赵鼎盐城师范学院药学院江苏盐城224002 南京中医药大学附属盐城中医院盐城市中医院肿瘤科江苏盐城224000

烟酰胺磷酸核糖转移酶(Nampt)在体内分布广泛,通过多种途径发挥不同的生物学作用。细胞内Nampt作为烟酰胺腺嘌呤二核苷酸生物合成的限速酶在机体能量代谢、细胞存活及死亡中发挥重要作用;细胞外Nampt作为细胞因子,参与调控糖脂代谢、炎... 详细信息

烟酰胺磷酸核糖转移酶(Nampt)在体内分布广泛,通过多种途径发挥不同的生物学作用。细胞内Nampt作为烟酰胺腺嘌呤二核苷酸生物合成的限速酶在机体能量代谢、细胞存活及死亡中发挥重要作用;细胞外Nampt作为细胞因子,参与调控糖脂代谢、炎症反应、氧化应激、血管损伤、细胞自噬等病理生理过程。Nampt在糖尿病肾脏疾病(DKD)肾组织和血清中表达增加,其与DKD的发生发展密切相关,可加重代谢紊乱、诱导炎症纤维化、介导血管内皮损伤、增强氧化应激反应等。DKD发病机制复杂,揭示并阐明Nampt在其不同阶段的生物作用具有重要意义。

关键词：糖尿病肾脏疾病烟酰胺磷酸核糖转移酶炎症纤维化氧化应激血管损伤

Activity Model of Fe-Si-B Ternary Metallic Melts

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Journal of Iron and Steel Research International 2011年第6期18卷 16-21页

作者： zhao ding-guo GUO Pei-min zhao Pei State Key Laboratory for Advanced Iron and Steel Processes and Materials Central Iron andSteel Research Institute Beijing 100081 China

According to the ion and molecule coexistence theory, the activity model of Fe-Si-B ternary system was es- tablished, and the influence of ratio ：Csi/XZe, boron content and temperature, etc. on the activity of the melt com- pound was investigated. The results show that the FeB activity is high in the liquid iron, when Xsl/XFo is 0. 5 ; the ac- tivity of boron increases with increasing the boron content for different contents of xe and xs, and the activity of boron at the ratio xFo = 0.4 is about one order of magnitude higher than that for the XFo = 0. 8; The activities of the melt compound were also affected by temperature, but the influencing extent was little. The equal activity diagrams of silicon and boron were drawn for the first time according to the model results.

关键词： activity metallic melt ion and molecule coexistence model equal activity diagram

黄河下游豫鲁地区创新网络时空演化及环境效应研究

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河南师范大学学报（自然科学版） 2025年第1期53卷 1-12,F0002页

作者：刘建华赵鼎葛世帅黄亮朝崔源郑州大学管理学院郑州450001 郑州大学黄河生态保护与区域协调发展研究院郑州450001 河南交通职业技术学院交通信息工程系郑州450000

创新是城市与区域发展的核心动力,创新网络是提升区域创新能力的重要支撑.以黄河下游豫鲁地区为研究对象,采用修正后的引力模型来构建城市间的创新关联网络,运用社会网络分析法探究2014-2022年空间关联网络的演化与特征,并探析黄河下游... 详细信息

创新是城市与区域发展的核心动力,创新网络是提升区域创新能力的重要支撑.以黄河下游豫鲁地区为研究对象,采用修正后的引力模型来构建城市间的创新关联网络,运用社会网络分析法探究2014-2022年空间关联网络的演化与特征,并探析黄河下游豫鲁地区创新网络对环境的影响.研究发现,整体来看,黄河下游豫鲁地区整体创新网络发展水平逐步提高,但空间分布不均的特征明显,创新网络整体发展水平仍处于起步阶段;分区域来看,河南省创新网络水平存在严重的两极分化现象,在空间上呈“米”字形分布.山东省整体创新网络水平高于河南省,创新资源分布较为均衡;研究期内,郑州、济南、青岛等城市是网络中的溢出主体,其中郑州、青岛是网络中的关键节点,影响整个网络稳定性.此外,研究区凝聚子群呈现出以郑州、济南、青岛为引领的“三核心”创新网络格局,但子群倾向于“抱团”,行政壁垒尚未消除;黄河下游豫鲁地区创新网络与环境污染呈倒“U”型关系,当创新网络水平跨过“拐点”时,才会对环境污染产生抑制作用,从而有效改善环境质量.在创新网络发展初期,开放程度、经济水平和人口规模扩大会加剧环境污染程度,而环境治理支出的增长和产业结构的优化能有效抑制环境污染.

关键词：黄河下游豫鲁地区空间联系网络引力模型社会网络分析环境污染

THREE-DIMENSIONAL NUMERICAL SIMULATION OF WAVE SLAMMING ON AN OPEN STRUCTURE

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Journal of Hydrodynamics 2012年第4期24卷 526-534页

作者： ding zhao-qiang WANG Guo-yu REN Bing State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

The three-dimensional numerical simulation of wave slamming on an open structure in the splash zone is carried out based upon the Volume Of Fluid （VOF） method. A wave basin is established by solving the continuity equation and the Navier-Stoke equations. The linear wave-maker is placed on the left side of the basin, and the numerical sponge layer and the SRC are placed on the right side of the basin to damp the incident waves. The three-dimensional wave slamming boundary condition is adopted to model waves in contact with and separated from the underside of the structure. The numerical results of wave slamming on a foursquare structure for various parametric cases are verified by the experimental results. Meanwhile, the characteristics of the wave impact forces on the undersides of the rectangular structures with various length-breadth ratios are discussed.

关键词： wave slamming three-dimensional Volume Of Fluid (VOF)

Chemo–immunotherapy for chemo-resistance and metastasis of triple-negative breast cancer by combination of iron-oxide nanoparticles and dual-targeting doxorubicin liposomes

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Chinese Chemical Letters 2023年第10期34卷 76-81页

作者： Heping Hu Lijia Yu zhao ding Jinsong ding Yiguo Hu Zongning Yin Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education West China School of PharmacySichuan UniversityChengdu 610041China Sichuan Huiyu Seacross Medical Technology Co. Ltd.Chengdu 610031China Sichuan Huiyu Pharmaceutical Co. Ltd.Neijiang 641000China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan Universityand Collaborative Innovation Center for BiotherapyChengdu 610044China

Triple-negative breast cancer(TNBC)lacks specific regimens for targeted *** chemotherapy promotes the evolution of TNBC into highly chemo-resistant tumors that metastasize to multiple organs ***,polyacrylic acid-coated ultrasmall superparamagnetic iron-oxide nanoparticles(PAA@IONs)and dual-targeting doxorubicin liposomes achieved chemo–immunotherapy through intermittent *** inhibited tumor-drug resistance and multiorgan-specific metastasis significantly by targeting tumors and the *** deciphered an immunosuppressive pre-metastatic niche and discovered that PAA@IONs could target tumors,tumor-draining lymph nodes(TDLNs),the liver,bone,and *** promoted the polarization of macrophages into M1 macrophages in these organs and *** action remodeled the immunosuppressive microenvironment and induced a sustained immune response,thereby reducing organ-specific *** the disadvantages of doxorubicin-induced cardiotoxicity as well as low tumor specificity,dual peptide-modified liposomes could target CD206 and CD13 simultaneously,and reverse *** properties resulted in a significant decrease in the numbers of myeloid-derived suppressor cells(MDSCs)and cancer stem cells(CSCs)in the liver,lungs,and bone,thereby reducing protein expression of Ki-67 in TDLNs,and dramatically increasing the number of cluster of differentiation(CD)8+T cells and CD8+T cell/T-regulatory-cell ratio in tumors and TDLNs(P<0.0001).Compared with the control(P<0.05 and P<0.01,respectively)or free drug(P<0.0001 and P<0.01,respectively),multi-organ metastases were suppressed significantly,tumor-growth rate reduced,and survival *** drug-delivery system overcame TNBC chemo-resistance and inhibited multiorgan-specific *** circumvents the lack of effective therapeutic targets,the problem of patient selection due to a low mutation rate,and can simultaneously offer the possibility of avoid

关键词： Multidrug resistance Multiorgan-specific metastases Immunogenic cell death Intermittent dosing Immunosuppressive tumor microenvironment Tumor-associated macrophages

A New Taxane Diterpenoid from the Seeds of Taxus yunnanensis

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Chinese Chemical Letters 2000年第3期11卷 235-238页

作者： Qing Wen SHI Takayuki ORITANI ding zhao Laboratory of Applied Bioorganic Chemistry Division of Life ScienceGraduate School of Agricultural SciencesTohoku UniversityTsutsumidori-AmamiyaAoba-kuSendai 981-8555Japan Department of Chemistry of Medicinal Natural Products Faculty of Pharmaceutical SciencesHebei Medical University361 Zhongshan East StreetShijiazhuang 050017

A new taxane diterpenoid with a rearranged 5/7/6-membered ring system was isolated from the seeds of the Chinese pew, Taxus yunnanensis. Its structure was established as 9 alpha-acetoxy-5 alpha-cinnamoy]-11(15 --> 1)-abeotaxa-4(20), 11-diene-10 beta, 13 alpha, 15-triol on the basis of spectroscopic analysis. Its relative stereochemistry is proposed from the results of a NOESY experment.

关键词： Taxus yunnanensis taxoid isolation Taxus

Unlocking high-efficiency oxygen evolution reaction through Co-N coordination engineering in Co@N-doped porous carbon core–shell nanoparticles

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Nano Research 2024年第8期17卷 7068-7076页

作者： Shucheng Liu Yu Shuai Xiaosi Qi zhao ding Yi Liu College of Big Data and Information Engineering Guizhou UniversityGuiyang 550025China College of Physics Guizhou Province Key Laboratory for Photoelectrics Technology and ApplicationGuizhou UniversityGuiyang 550025China

Modulation of metal sites coordination can significantly refine the electronic architecture of catalysts,thereby improving their catalytic *** work successfully developed a core–shell Co@N-doped porous carbon(Co@NC)catalyst by pyrolyzing the COF/MOF(IISERP-COF3/ZIF-67)composite in an inert *** Co@NC catalyst exhibited impressive oxygen evolution reaction(OER)performance,with a small overpotential of 304 mV and a modest Tafel slope of 88.6 mV·dec^(−1) in a 1 M KOH,alongside remarkable stability,maintaining 98.5%of its activity over 13 *** role of IISERP-COF3 was pivotal in preventing Co atom aggregation during the ZIF-67 pyrolysis,which facilitated the creation of mesopores for enhanced mass transport and ***,it effectively modulated the Co-N coordination to fine-tune the electronic structure,thereby optimizing the catalyst's capacity for adsorption of intermediates and boosting its intrinsic *** functional theory(DFT)studies corroborate that the exceptional OER efficiency of Co@NC can be linked to the enhanced Co-N coordination,optimizing the localized electronic structure at the Co active *** study not only proposes an innovative approach for optimizing COF/MOF as effective electrocatalysts but also clears the path for the emergence of affordable,high-performance alternatives to precious metal-based catalysts,marking a significant advancement in sustainable energy technologies.

关键词： covalent organic framework(COF) metal-organic framework(MOF) core-shell structure catalysts oxygen evolution reaction