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增强CT影像组学在鉴别TI-RADS 4A、4B类甲状腺微小结节良恶性的价值

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中国CT和MRI杂志 2024年第7期22卷 39-42页

作者：陈鹏张成孟周艳艳丁治民皖南医学院弋矶山医院放射科安徽芜湖241000

目的探讨基于增强计算机断层扫描(computed tomography,CT)影像组学在鉴别超声甲状腺成像报告和数据系统(thyroid imaging reporting and data system,TI-RADS)诊断为4A、4B类甲状腺微小结节良恶性的价值。方法回顾性入组2018年1月至202... 详细信息

目的探讨基于增强计算机断层扫描(computed tomography,CT)影像组学在鉴别超声甲状腺成像报告和数据系统(thyroid imaging reporting and data system,TI-RADS)诊断为4A、4B类甲状腺微小结节良恶性的价值。方法回顾性入组2018年1月至2022年1月经过术后病理证实甲状腺结节患者300例(115例良性,185例恶性)。从增强CT图像中提取影像组学特征分别构建动脉期、静脉期、延迟期及多期联合(动脉期+静脉期+延迟期)影像组学模型,联合诊断效能最高的影像组学模型和临床特征构建综合诊断模型并绘制诺莫图。使用接受者工作特征曲线下面积(area under the receiver operating characteristic curve,AUC)评估模型的诊断性能,决策曲线分析(decision curve analysis,DCA)评价模型的临床效用。结果多期联合组学模型的诊断表现(训练集AUC vs测试集AUC:0.814 vs 0.718)优于单一期像组学模型(动脉期:0.730 vs 0.601;静脉期:0.794 vs 0.678;延迟期:0.793 vs 0.622);与临床模型(训练集AUC:0.732;测试集AUC:0.766)和多期联合组学模型相比,综合诊断模型在训练集(AUC:0.876)和测试集(AUC:0.813)均具有更好的诊断表现。决策曲线分析表明,该综合诊断模型具有更高的临床应用价值。结论增强CT影像组学能够在术前有效鉴别TI-RADS 4A和4B类甲状腺微小结节的良恶性。

关键词：计算机断层扫描影像组学甲状腺微小结节甲状腺成像报告和数据系统

Compliance motion control of the hydraulic dual-arm manipulator with adaptive mass estimation of unknown object

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Frontiers of Mechanical Engineering 2024年第1期19卷 35-52页

作者： Bolin SUN min CHENG Ruqi ding Bing XU State Key Laboratory of Mechanical Transmissions Chongqing UniversityChongqing 400044China Key Laboratory of Conveyance and Equipment(ministry of Education) East China Jiaotong UniversityNanchang 330013China State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China

Given the limited operating ability of a single robotic arm,dual-arm collaborative operations have become increasingly *** with the electrically driven dual-arm manipulator,due to the unknown heavy load,difficulty in measuring contact forces,and control complexity during the closed-chain object transportation task,the hydraulic dual-arm manipulator(HDM)faces more difficulty in accurately tracking the desired motion trajectory,which may cause object deformation or even *** overcome this problem,a compliance motion control method is proposed in this paper for the *** mass parameter of the unknown object is obtained by using an adaptive method based on velocity *** to the difficulty in obtaining the actual internal force of the object,the pressure signal from the pressure sensor of the hydraulic system is used to estimate the contact force at the end-effector(EE)of two hydraulic manipulators(HMs).Further,the estimated contact force is used to calculate the actual internal force on the ***,a compliance motion controller is designed for HDM closed-chain *** position and internal force errors of the object are reduced by the feedback of the position,velocity,and internal force errors of the object to achieve the effect of the compliance motion of the HDM,i.e.,to reduce the motion error and internal force of the *** required velocity and force at the EE of the two HMs,including the position and internal force errors of the object,are inputted into separate position *** addition,the position controllers of the two individual HMs are designed to enable precise motion control by using the virtual decomposition control ***,comparative experiments are carried out on a hydraulic dual-arm test *** proposed method is validated by the experimental results,which demonstrate improved object position accuracy and reduced internal force.

关键词： hydraulic dual-arm manipulator compliance motion control unknown object adaptive mass estimation nonlinear control

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直接前入路全髋关节置换的学习曲线

中国矫形外科杂志 2024年第1期32卷 80-83页

作者：肖守允沈思远梁锋田纪伟张云鹏丁惠民南京医科大学附属明基医院骨科江苏南京210019

[目的]分析直接前入路(direct anterior approach,DAA)全髋关节置换术(total hip arthroplasty,THA)治疗股骨颈骨折的临床疗效,并探讨其学习曲线。[方法]回顾性分析2020年1月—2021年12月在本院骨科采用用DAA入路行THA58例股骨颈骨折患... 详细信息

[目的]分析直接前入路(direct anterior approach,DAA)全髋关节置换术(total hip arthroplasty,THA)治疗股骨颈骨折的临床疗效,并探讨其学习曲线。[方法]回顾性分析2020年1月—2021年12月在本院骨科采用用DAA入路行THA58例股骨颈骨折患者,采用累积和分析法分析学习曲线,比较不同学习阶段患者临床资料。[结果]依据CUSUM学习曲线,初始期为编序1~22病例,成长期为编序23~32病例,成熟期为编序33~58病例。随手术例数的积累,手术时间[(165.1±16.5)min,(139.8±7.2)min,(120.4±8.2)min,P0.05)。[结论]股骨颈骨折DAA-THA具有术中损伤小,恢复快等优势,但其有较长学习曲线,需经过23~32例才能达到技术成熟期。

关键词：股骨颈骨折全髋关节置换术直接前入路学习曲线累积和分析法

Clinical analysis of Wernicke encephalopathy after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 352-357页

作者： Li-min ding Li-Shan Deng Jun-Jie Qian Gang Liu Lin Zhou Shu-Sen Zheng Division of Hepatobiliary Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China NHFPC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Key Laboratory of the Diagnosis and Treatment of Organ Transplantation Chinese Academy of Medical SciencesHangzhou 310003China Key Laboratory of Organ Transplantation Research Center for Diagnosis and Treatment of Hepatobiliary DiseasesHangzhou 310003China Culture and Sports Center for the Disabled of Jiangxi Province Nanchang 330000China Department of Transplantation Jiangxi Provincial People’s HospitalNanchang 330000China Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases Hangzhou 310003China

Background:Wernicke encephalopathy(WE)is an acute neurological disease resulting from vitamin B1 deficiency,and there are only very few case reports of WE after liver *** present study aimed to investigate the clinical characteristics,etiology,magnetic resonance imaging(MRI)features,treatment and prognosis of patients with WE after liver ***:Twenty-three patients with WE after liver transplantation from the First Affiliated Hospital,Zhejiang University School of Medicine and Jiangxi Provincial People’s Hospital between January 2011 and December 2021 were retrospectively ***:Among the 23 patients diagnosed with WE after liver transplantation,6(26%)had a classic triad of impaired consciousness,oculomotor palsy and ataxia,and 17(74%)had two *** misdiagno-sis rate was 65%.After treatment with high-dose vitamin B1,19(83%)patients showed improvement,whereas 4(17%)showed no improvement,including 3 with residual short-term memory impairments and 1 with residual spatial and temporal disorientation and ***:The misdiagnosis rate is high in the early stage of WE,and the prognosis is closely asso-ciated with whether WE is diagnosed early and treated ***-dose glucose or glucocorticoids can trigger WE and cannot be administered before vitamin B1 *** B1 is suggested to be used as a prophylactic treatment for patients with WE after liver transplantation.

关键词： Liver transplantation Wernicke encephalopathy Vitamin B1 Clinical presentations Imaging features Diagnosis Treatment Prognosis

New insights into the biological roles of immune cells in neural stem cells in post-traumatic injury of the central nervous system

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Neural Regeneration Research 2023年第9期18卷 1908-1916页

作者： Ning He Xing-Jia Mao Yue-min ding Tong Zuo Ying-Ying Chen Lin-Lin Wang Department of Basic Medicine Sciences and Department of Orthopaedics of Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina School of Medicine Hangzhou City UniversityHangzhouZhejiang ProvinceChina University of Chicago College University of ChicagoChicagoILUSA Department of Basic Medicine Sciences and Department of Obstetrics of the Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Traumatic injuries in the central nervous system,such as traumatic brain injury and spinal cord injury,are associated with tissue inflammation and the infiltration of immune cells,which simultaneously affect the self-renewal and differentiation of neural stem *** r,the tissue repair process instigated by endogenous neural stem cells is incapable of restoring central nervous system injuries without external ***,resident/peripheral immune cells have been demonstrated to exert significant effects on neural stem ***,the resto ration of traumatic injuries in the central nervous system by the immune intervention in neural stem cells represents a potential therapeutic *** this review,we discuss the roles and possible mechanisms of immune cells on the selfrenewal and differentiation of neural stem cells along with the prognosis of central nervous system injuries based on immune ***,we discuss remaining research challenges that need to be considered in the *** elucidation of these challenges will fa cilitate the successful application of neural stem cells in central nervous system injuries.

关键词： B cells central nervous system injury macrophages microglia neural stem cells spinal cord injury T cells traumatic brain injury

Papillary thyroid microcarcinoma with contralateral lymphatic skip metastasis and breast cancer: A case report

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World Journal of Clinical Cases 2022年第11期10卷 3609-3614页

作者： min ding Ya-Hui Kong Jian-Hua Gu Rong-Li Xie Jian Fei Department of General Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of General Surgery Shanghai Changhang HospitalShanghai 200122China Department of General Surgery Shanghai Ruijin Rehabilitation HospitalShanghai 200023China Department of General Surgery Ruijin Hospital Luwan BranchShanghai Jiao Tong University School of MedicineShanghai 200020China

BACKGROUND The recognized pattern of cervical lymph node metastasis(CLNM)of papillary thyroid carcinoma involves a stepwise *** lymph node skip metastasis is very *** addition,the patient in our case report also suffered from a breast carcinoma accompanied by left supraclavicular lymphadenopathy,which made it difficult to distinguish the origin of the *** on this case,we recommended that more detailed physical and imaging examinations are needed for patients with uncommon cervical lymphatic metastasis of primary *** SUMMARY A 53-year-old women was admitted to the hospital for a neck mass in the left cervical region that had existed for 2 *** neck mass was suspected to be an enlarged lateral LN originating from papillary thyroid microcarcinoma of the contralateral thyroid lobe,according to ultrasound and ultrasound-guided fine needle aspiration *** patient underwent total thyroidectomy and radical cervical LN *** pathology confirmed the diagnosis of papillary thyroid microcarcinoma with contralateral lymphatic skip ***,a breast cancer was discovered 4 mo later,which was accompanied by ipsilateral supraclavicular LN *** accepted neoadjuvant chemotherapy and subsequent left modified radical mastectomy for *** patient is currently receiving postoperative radiotherapy,and no local recurrence was observed in the 6-mo follow-up after *** present a rare case of papillary thyroid microcarcinoma with contralateral lymphatic skipmetastasis and breast cancer with supraclavicular lymphatic metastasis.

关键词： Thyroid cancer Papillary Breast neoplasms Lymphatic metastasis Skip metastasis Contralateral metastasis Case report

苓桂术甘汤干预非酒精性脂肪肝病的药效学研究及作用机制探讨

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海南医学院学报 2024年第1期30卷 29-38页

作者：赵传志丁慧敏胡紫晴都永勤周兰周鹏王靓安徽中医药大学中西医结合学院安徽合肥230012

目的:通过体内动物实验探究苓桂术甘汤对非酒精性脂肪肝病的治疗效果,网络药理学及分子对接技术探究苓桂术甘汤干预非酒精性脂肪肝病的作用机制。方法:高脂喂养20周建立非酒精性脂肪肝病大鼠模型,将大鼠分为6组,正常组、模型组、辛伐他... 详细信息

目的:通过体内动物实验探究苓桂术甘汤对非酒精性脂肪肝病的治疗效果,网络药理学及分子对接技术探究苓桂术甘汤干预非酒精性脂肪肝病的作用机制。方法:高脂喂养20周建立非酒精性脂肪肝病大鼠模型,将大鼠分为6组,正常组、模型组、辛伐他汀组(4 mg/kg)、苓桂术甘汤低剂量组(2.1 g/kg)、苓桂术甘汤中剂量组(4.2 g/kg)、苓桂术甘汤高剂量组(8.4 g/kg),观察苓桂术甘汤干预后的HE染色及油红O染色的肝脏形态学变化,酶标仪检测血清中谷草转氨酶、谷丙转氨酶、血脂四项水平。利用网络药理学结合分子对接筛选苓桂术甘汤干预非酒精性脂肪肝病潜在作用机制及靶点。结果:苓桂术甘汤可显著改善模型大鼠的谷草转氨酶、谷丙转氨酶水平(P<0.05);HE染色和油红O染色显示苓桂术甘汤显著降低模型组大鼠的肝脏脂质沉积;苓桂术甘汤可显著降低模型大鼠血脂四项水平(P<0.05);网络药理学筛选出关键靶点10个,关键信号通路5条;分子对接结果表明前20活性成分均对前十靶点有良好结合能力。结论:表明苓桂术甘汤对非酒精性脂肪肝病有调节血脂及改善肝组织病变作用,并初步验证了苓桂术甘汤对脂质代谢相关基因的调控作用。

关键词：网络药理学分子对接苓桂术甘汤非酒精性脂肪肝

临床特征联合血清CA19-9、HE4对子宫内膜异位症相关卵巢癌症的诊断价值

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海南医学 2024年第1期35卷 76-79页

作者：陈丽赵威李珊珊梁爽丁瑞敏河南中医药大学第三附属医院检验科河南郑州450003 河南中医药大学第三附属医院妇产科河南郑州450003

目的探讨临床特征联合血清糖类抗原(CA) 19-9、人附睾蛋白4 (HE4)对子宫内膜异位症相关卵巢癌症(EAOC)的诊断价值。方法选择2020年1月至2022年12月在河南中医药大学第三附属医院接受手术且经术后病理确诊为EAOC的43例患者作为观察组,... 详细信息

目的探讨临床特征联合血清糖类抗原(CA) 19-9、人附睾蛋白4 (HE4)对子宫内膜异位症相关卵巢癌症(EAOC)的诊断价值。方法选择2020年1月至2022年12月在河南中医药大学第三附属医院接受手术且经术后病理确诊为EAOC的43例患者作为观察组,按照1∶2的比例抽取同期在我院手术且经术后证实为卵巢子宫内膜异位症(OEM)的86例患者作为对照组。比较两组患者的临床资料及血清CA125、CA19-9和HE4水平,采用多因素Logistic回归分析影响EAOC的独立风险因素,并采用受试者工作特征曲线(ROC)分析临床特征、CA19-9和HE4诊断EAOC的价值。结果观察组患者的CA19-9和HE4水平分别为[20.99 (17.06,32.40)] U/mL和[64.47 (55.93,72.01)] U/mL,明显高于对照组的[4.98(2.18,10.86)] U/mL和[43.39(34.61,52.40)] U/mL,差异均有统计学意义(P0.05)。经多因素Logistic回归分析结果显示,CA19-9、HE4、年龄、肿瘤最长径是影响EAOC的风险因素(P<0.05)。经ROC分析结果显示,年龄、肿瘤最长径、CA19-9、HE4联合检测的曲线下面积(AUC)为0.958,明显高于单独检测(年龄:0.857;肿瘤最长径:0.767;CA19-9:0.767;HE4:0.808)(P<0.05)。结论 CA19-9、HE4、年龄、肿瘤最长径可用于预测EAOC,联合检测可提高诊断效能。

关键词：子宫内膜异位症子宫内膜异位症相关卵巢癌症糖类抗原19-9 人附睾蛋白4 诊断价值

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PP复合材料的性能研究

合成材料老化与应用 2024年第2期53卷 10-13页

作者：丁将敏王芳田敬晓刘艳丽国家能源集团宁夏煤业公司煤炭化学工业技术研究院宁夏银川750411􁽈

通过添加改性碳酸钙、POE、玻璃纤维、碳纤维研究其对PP复合材料性能的影响。研究表明:随着改性CaCO3含量的逐渐增加,PP复合材料的拉伸强度和冲击强度呈先增后减的趋势,改性CaCO3添加量为2%(wt.)时,拉伸强度为23.7MPa,冲击强度为17kJ·m... 详细信息

通过添加改性碳酸钙、POE、玻璃纤维、碳纤维研究其对PP复合材料性能的影响。研究表明:随着改性CaCO3含量的逐渐增加,PP复合材料的拉伸强度和冲击强度呈先增后减的趋势,改性CaCO3添加量为2%(wt.)时,拉伸强度为23.7MPa,冲击强度为17kJ·m^(-2);随着POE添加量的增加,复合材料的拉伸强度和弯曲模量降低,冲击强度增大,当POE添加量超过17%(wt.)时,冲击强度增幅减缓,综合力学性能及经济性,确定POE的添加量为17%~20%(wt.);添加玻璃纤维后,复合材料的拉伸强度、弯曲模量是增加的,冲击强度明显下降,但当玻璃纤维添加量为10%(wt.)以上,复合材料的拉伸强度和弯曲模量是逐渐增大的,冲击强度明显下降。通过复合材料冲击断面SEM表征发现:断面粗糙,有较多的片状结构,部分可见明显的“拉丝”形态,是典型的韧性断裂特征;玻璃纤维和碳纤维集束在树脂基体中随机取向分布,形成了足够的骨架网络,起到增强增韧作用。

关键词：聚丙烯玻璃纤维碳纤维

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