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SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2285-2297页

作者： Hui Qian Chen-hong ding Fang Liu Shi-Jie Chen Chen-Kai Huang Meng-Chao Xiao Xia-Lu hong Ming-Chen Wang Fang-Zhi Yan Kai ding Ya-Lu Cui Bai-Nan Zheng Jin ding Cheng Luo Xin Zhang Wei-Fen Xie Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghaiChina Department of Gastroenterology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Drug Discovery and Design Center CAS Key Laboratory of Receptor ResearchState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina Department of Gastroenterology First Affiliated Hospital of Nanchang UniversityNanchangChina Clinical Cancer Institute Center for Translational MedicineNaval Medical UniversityShanghaiChina

The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor ***,the precise molecular mechanisms governing the nuclear import of YAP are not fully *** this study,we have uncovered a crucial role of SOX9 in the activation of ***9 promotes the nuclear translocation of YAP by direct ***,we have identified that the binding between Asp-125 of SOX9 and Arg-124 of YAP is essential for SOX9-YAP interaction and subsequent nuclear entry of ***,we have discovered a novel asymmetrical dimethylation of YAP at Arg-124(YAP-R124me2a)catalyzed by ***-R124me2a enhances the interaction between YAP and SOX9 and is associated with poor prognosis in multiple ***,we disrupted the interaction between SOX9 and YAP using a competitive peptide,S-A1,which mimics anα-helix of SOX9 containing Asp-125.S-A1 significantly inhibits YAP nuclear translocation and effectively suppresses tumor *** study provides the first evidence of SOX9 as a pivotal regulator driving YAP nuclear translocation and presents a potential therapeutic strategy for YAP-driven human cancers by targeting SOX9-YAP interaction.

关键词： interaction interaction precise

Nomogram based on liver stiffness and spleen area with ultrasound for posthepatectomy liver failure:A multicenter study

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World Journal of Gastroenterology 2024年第27期30卷 3314-3325页

作者： Guang-Wen Cheng Yan Fang Li-Yun Xue Xiao-Hui Qiao Xue-Qi Li Yan Zhang Jia Guo Xiao-Yan Xie hong ding Department of Ultrasound Huashan HospitalFudan UniversityShanghai 200040China Department of Ultrasound Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Medical Ultrasonics Institute of Diagnostic and Interventional UltrasoundSun Yat-sen University First Affiliated HospitalGuangzhou 510080Guangdong ProvinceChina Institute of Ultrasound in Medicine and Engineering Shanghai Cancer CenterShanghai 200040China Department of Ultrasound Eastern Hepatobiliary Surgical HospitalSecond Military Medical UniversityShanghai 200433China Department of Ultrasound National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghai 200040China

BACKGROUND Liver stiffness(LS)measurement with two-dimensional shear wave elastography(2D-SWE)correlates with the degree of liver fibrosis and thus indirectly reflects liver function *** size of the spleen increases due to tissue proliferation,fibrosis,and portal vein congestion,which can indirectly reflect the situation of liver fibrosis/*** was reported that the size of the spleen was related to posthepatectomy liver failure(PHLF).So far,there has been no study combining 2D-SWE measurements of LS with spleen size to predict *** prospective study aimed to investigate the utility of 2D-SWE assessing LS and spleen area(SPA)for the prediction of PHLF in hepatocellular carcinoma(HCC)patients and to develop a risk prediction *** To investigate the utility of 2D-SWE assessing LS and SPA for the prediction of PHLF in HCC patients and to develop a risk prediction *** This was a multicenter observational study prospectively analyzing patients who underwent hepatectomy from October 2020 to March *** 1 wk before partial hepatectomy,ultrasound examination was performed to measure LS and SPA,and blood was drawn to evaluate the patient’s liver function and other *** absolute shrinkage and selection operator logistic regression and multivariate logistic regression analysis was applied to identify independent predictors of PHLF and develop a *** performance was validated *** diagnostic performance of the nomogram was evaluated with receiver operating charac-teristic curve compared with the conventional models,including the model for end-stage liver disease(MELD)score and the albumin-bilirubin(ALBI)*** A total of 562 HCC patients undergoing hepatectomy(500 in the training cohort and 62 in the validation cohort)were enrolled in this *** independent predictors of PHLF were LS,SPA,range of resection,blood loss,international normalized ratio,and total *** diagnostic performanc

关键词： Shear-wave elastography Spleen Hepatectomy Posthepatectomy liver failure Hepatocellular carcinoma

柔性多功能Fe_(2)O_(3)/CC正极宿主实现高效吸附与催化多硫化物的锂硫电池

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新型炭材料（中英文） 2024年第2期39卷 345-353页

作者：田真薛磊磊丁红元中北大学材料科学与工程学院山西太原030051 中北大学先进能源材料与系统研究院山西太原030051 武汉第二船舶设计研究所湖北武汉430205

锂硫电池因其高能量密度和低成本而成为最有发展前景的电化学储能器件之一。然而,多硫化物的“穿梭效应”、硫导电率低是锂硫电池商业化面临的主要挑战。本工作中,以Fe(NO)_(3)·9H_(2)O为铁源,NH4F为表面活性剂,通过简单的水热及煅烧... 详细信息

锂硫电池因其高能量密度和低成本而成为最有发展前景的电化学储能器件之一。然而,多硫化物的“穿梭效应”、硫导电率低是锂硫电池商业化面临的主要挑战。本工作中,以Fe(NO)_(3)·9H_(2)O为铁源,NH4F为表面活性剂,通过简单的水热及煅烧处理制备了Fe_(2)O_(3)纳米棒修饰炭布(CC)的柔性Fe_(2)O_(3)/CC复合材料。其中,Fe_(2)O_(3)中介孔的存在有利于电解质的渗透和充放电过程中锂离子的传输和扩散,同时其密集阵列暴露出的丰富活性位点可以实现多硫化物的高效吸附和快速转化,降低多硫化物的穿梭效应。电化学分析显示:Fe_(2)O_(3)/CC正极在0.1 C(1 C=1672 mA g^(−1))的电流密度下具有1250 mAh g^(-1)的高放电比容量,经100圈循环后比容量保持在789 mAh g^(-1)。在2 C的倍率下循环1000圈后仍能达到576 mAh g^(-1)的放电比容量,容量保持率为70%,明显优于对比样品。因此,Fe_(2)O_(3)/CC能够很好地抑制多硫化物的穿梭,提高电池倍率性能和循环稳定性。

关键词：锂硫电池 Fe_(2)O_(3) 正极材料纳米棒

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铁基超导体中的马约拉纳零能模及其阵列构筑

物理学报 2024年第3期73卷 1-15页

作者：李更丁洪汪自强高鸿钧中国科学院物理研究所纳米物理与器件实验室北京100190 中国科学院大学物理科学学院北京100049 合肥国家实验室合肥230088 上海交通大学李政道研究所上海201210 波士顿学院美国马萨诸塞州02467

马约拉纳零能模服从非阿贝尔统计,其编织操作可用于构筑拓扑量子比特,是拓扑量子计算的基本单元,可从原理上解决量子计算中环境噪声带来的退相干问题.现有的马约拉纳零能模平台包括复合异质结构,如拓扑绝缘体/超导体、半导体纳米线/超... 详细信息

马约拉纳零能模服从非阿贝尔统计,其编织操作可用于构筑拓扑量子比特,是拓扑量子计算的基本单元,可从原理上解决量子计算中环境噪声带来的退相干问题.现有的马约拉纳零能模平台包括复合异质结构,如拓扑绝缘体/超导体、半导体纳米线/超导体或一维磁性原子链/超导体等,以及单一材料,如2M-WS_(2),4Hb-TaS_(2)和铁基超导体等.铁基超导体中的马约拉纳零能模具有材料平台简单、零能模纯净以及存活温度较高等一系列优势,引起了广泛关注.最近,大面积、有序和可调控的马约拉纳零能模晶格阵列在铁基超导体LiFeAs中被观测到,为未来的拓扑量子计算提供了一个理想平台.本综述首先回顾铁基超导体中马约拉纳零能模的实验观测,其中将重点介绍FeTe_(0.55)Se_(0.45),(Li_(0.84)Fe_(0.16))OHFeSe,CaKFe_(4)As_(4)和LiFeAs等材料体系.接着介绍给出铁基超导体中马约拉纳零能模关键性实验证据的一系列工作.然后进一步详细介绍近期LiFeAs中观测到有序和可调马约拉纳零能模晶格阵列的工作.最后给出总结和对未来马约拉纳领域研究的展望.

关键词：铁基超导体拓扑能带结构马约拉纳零模

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古米廖夫欧亚主义与俄罗斯的“向东看”战略

世界民族 2024年第1期 35-46页

作者：丁宏陈曦中央民族大学中国少数民族研究中心中央民族大学民族学与社会学学院北京100081

列夫·古米廖夫是俄罗斯著名民族学家,其欧亚主义思想旨在尝试解答俄罗斯的国家身份认同、历史根源与发展道路问题,在俄罗斯具有较强的社会影响力,这使得俄罗斯总统普京多次将古米廖夫的观点应用于该国“向东看”战略的政治话语中。本... 详细信息

列夫·古米廖夫是俄罗斯著名民族学家,其欧亚主义思想旨在尝试解答俄罗斯的国家身份认同、历史根源与发展道路问题,在俄罗斯具有较强的社会影响力,这使得俄罗斯总统普京多次将古米廖夫的观点应用于该国“向东看”战略的政治话语中。本文从民族学理论思想史的视角出发,追溯了古米廖夫欧亚主义思想的源头与流变,介绍了古米廖夫借由“互补性”“激情”等概念对欧亚时空中民族关系的论述,剖析了古米廖夫欧亚主义在当代俄罗斯政治话语中,特别是在俄乌冲突中所展现的含义。

关键词：古米廖夫欧亚主义互补性 “向东看” 俄乌冲突

Chinese Medicine Prolongs Overall Survival of Chinese Patients with Advanced Gastric Cancer: Treatment Pattern and Survival Analysis of a 20-Year Real-World Study

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Chinese Journal of Integrative Medicine 2024年第6期30卷 489-498页

作者： CAO Ni-da ZHU Xiao-hong MA Fang-qi XU Yan DONG Jia-huan QIN Meng-meng LIU Tian-shu ZHU Chun-chao GUO Wei-jian ding hong-hua GUO Yuan-biao LIU Li-kun SONG Jin-jie WU Ji-ping CHENG Yue-lei ZENG Lin ZHAO Ai-guang Oncology Department I Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai200032China Oncology Department Zhongshan HospitalFudan UniversityShanghai200032China Gastrointestinal Surgery Department Renji HospitalShanghai Jiaotong University School of MedicineShanghai200127China Oncology Department Fudan University Shanghai Cancer CenterShanghai200032China Oncology Department Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai200080China Traditional Chinese Medicine Department Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai200025China Oncology Department Shanxi Traditional Chinese Medicine HospitalTaiyuan030012China Oncology Department Xiyuan HospitalChina Academy of Chinese Medical ScienceBeijing102445China Oncology Department Yunnan Province Hospital of Traditional Chinese MedicineKunming650021China Oncology Department Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203China Shanghai NewCore Biotechnology Co. Ltd.Shanghai200240China

Objective To describe the treatment patterns and survival status of advanced gastric cancer(AGC)in China in the past two decades,and objectively evaluate the impact of standardized Chinese medicine(CM)treatment on the survival of AGC *** This multicenter registry designed and propensity score analysis study described the diagnosis characteristics,treatment-pattern development and survival status of AGC from 10 hospitals in China between January 1,2000 and July 31,*** survival(OS)was evaluated between non-CM cohort(standard medical treatment)and CM cohort(integrated standard CM treatment≥3 months).Propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)were performed to adjust any difference in average outcomes for *** A total of 2,001 patients histologically confirmed locally advanced and/or metastasis stomach and gastroesophageal junction adenocarcinoma were *** them,1,607 received systemic chemotherapy,215(10.74%)accepted molecular targeted therapy,44(2.2%)received checkpoint inhibitor therapy,and 769(38.43%)received ***-drug regimen was the main choice for first-line treatment,with fluoropyrimidine plus platinum as the most common regimen(530 cases,60.09%).While 45.71%(16 cases)of patients with HER2 amplification received trastuzumab in *** application of apatinib increased(33.33%)in *** application of checkpoint inhibitors has increased since *** analysis showed that Lauren mixed type(P=0.017),cycles of first-line treatment>6(P=0.000),CM(P=0.000),palliative gastrectomy(P=0.000),trastuzumab(P=0.011),and apatinib(P=0.008)were independent prognostic factors for the OS of *** PSM and IPTW,the median OS of CM cohort and non-CM cohort was 18.17 and 12.45 months,respectively(P<0.001).Conclusions In real-world practice for AGC in China,therapy choices consisted with ***-drug regimen was the main first-line *** CM treatment was an independent

关键词： advancedgastriccancer real-world study treatment pattern survival analysis Chinese medicine

汉魏六朝北地傅氏籍贯考察——以《宋书·傅弘之传》的载述为中心

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西北师大学报（社会科学版） 2024年第1期61卷 48-56页

作者：丁宏武西北师范大学文学院甘肃兰州730070

魏晋南北朝是一个特殊的时代,关于世族籍贯的认定,不能只是简单地考察地理沿革和家族迁徙等表层问题,而应综合考量家族认同、国家认同、历史认同等诸多层面的历史信息。北地傅氏虽然自汉末以来寄寓关中冯翊境内,此后又流寓江南,但其姓... 详细信息

魏晋南北朝是一个特殊的时代,关于世族籍贯的认定,不能只是简单地考察地理沿革和家族迁徙等表层问题,而应综合考量家族认同、国家认同、历史认同等诸多层面的历史信息。北地傅氏虽然自汉末以来寄寓关中冯翊境内,此后又流寓江南,但其姓望所系与文化根脉仍在河陇地区(义渠、灵州、泥阳)。其亦文亦武、刚直尚气的家族风尚,正是秦汉以来河陇地区风声气俗的本色呈现。如果将汉末以来北地傅氏的籍贯确定在今陕西耀县境内,不仅与北地傅氏家族兴起于河陇边塞、流离迁徙中仍然情系河陇故土的历史事实不符,而且与门阀制度背景下“寄寓他所”“仍冠旧邦”的时代风气不合,显然不是合理公允的结论。

关键词：汉魏六朝北地郡望傅氏家族籍贯归属

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基于共享储能的台区多元负荷协同控制策略

电力自动化设备 2024年第1期44卷 32-39页

作者：吕斌黄丹丁宏吕朋朋国网安徽省电力有限公司安徽合肥230022 国网安徽省电力有限公司营销服务中心安徽合肥230088 国网电力科学研究院江苏南京211106

大规模不确定可再生能源的接入,对台区电网负荷的灵活性调整提出了更高的要求。基于共享储能的商业模式,考虑各类电器设备的用电及功能特性,提出了台区多元负荷协同控制策略。提出了基于共享储能的台区多元负荷协同优化框架,并详细阐述... 详细信息

大规模不确定可再生能源的接入,对台区电网负荷的灵活性调整提出了更高的要求。基于共享储能的商业模式,考虑各类电器设备的用电及功能特性,提出了台区多元负荷协同控制策略。提出了基于共享储能的台区多元负荷协同优化框架,并详细阐述了多元负荷的协同控制过程;根据负荷的可调特性,对用户负荷进行分类,建立负荷功率模型和舒适度成本模型;建立了以用电综合成本最低为目标的用户层优化模型和以调峰为目标的台区层优化模型。基于实际数据进行仿真验证,结果表明所提控制策略可以有效保证新能源的消纳,降低峰值负荷,并协助用户参与电力辅助服务市场。

关键词：共享储能可再生能源消纳多元负荷需求响应调峰辅助服务协同控制

离散时间的完全服务并行优化轮询排队系统特性分析

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电子学报 2024年第3期52卷 838-848页

作者：保利勇丁新昱丁洪伟官铮葛俊阳云南大学信息学院云南昆明650091

轮询是一种依次有序服务的系统资源动态调度机制.针对服务器在站点间查询、服务和转移过程中的流水线作业方式导致了系统整体服务效率较低的问题,本文提出了完全服务的并行优化轮询系统.首先,构建了系统的单服务器多队列排队模型和相应... 详细信息

轮询是一种依次有序服务的系统资源动态调度机制.针对服务器在站点间查询、服务和转移过程中的流水线作业方式导致了系统整体服务效率较低的问题,本文提出了完全服务的并行优化轮询系统.首先,构建了系统的单服务器多队列排队模型和相应的系统状态方程,并精确解析出系统特性参数的完整数学解析表达式.此外,还提出了一种系统状态稳定性的判定方法,对不同负载状态下的系统稳定性进行了定量分析.计算机仿真的统计分析结果与理论计算值相一致.最后,系统性能分析表明,在保持周期性、无冲突服务的基础上,系统的队长、时延特性和稳定状态下负载能力均得到了较大的提高.

关键词：轮询并行优化调度完全服务队长特性时延特性系统稳定性