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Resolving the developmental mechanisms of cardiac microthrombosis of SARS-CoV-2 based on single-cell transcriptome analysis

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Science China Life Sciences 2025年第1期68卷 103-115页

作者： Xizi Luo Nan Zhang Yuntao Liu Beibei Du xuan Wang Tianxu Zhao Bingqiang Liu Shishun Zhao Jiazhang Qiu Guoqing Wang State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Basic MedicineJilin University State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Veterinary MedicineJilin University College of Mathematics Jilin University Bioinformatic Lab School of MathematicsShandong University Department of Cardiology China-Japan Union HospitalJilin University

The coronavirus disease 2019（COVID-19） outbreak caused by the severe acute respiratory syndrome coronavirus-2（SARS-CoV-2） developed into a global health emergency. Systemic microthrombus caused by SARS-CoV-2 infection is a common complication in patients with COVID-19. Cardiac microthrombosis as a complication of SARS-CoV-2 infection is the primary cause of cardiac injury and death in patietns with severe COVID-19. In this study, we performed single-cell sequencing analysis of the right ventricular free wall tissue from healthy donors,patients who died during the hypercoagulable period of characteristic coagulation abnormality（CAC）, and patients who died during the fibrinolytic period of CAC. We collected 61,187 cells enriched in 24 immune cell subsets and 13 cardiac-resident cell subsets. We found that in the course of SARS-CoV-2 infected heart microthrombus, MYO1EhighRASGEF1Bhighmonocyte-derived macrophages promoted hyperactivation of the immune system and initiated the extrinsic coagulation pathway by activating chemokines CCL3, CCL5. This series of events is the main cause of cardiac microthrombi following SARS-CoV-2 infection. In a SARS-CoV-2 infected heart microthrombus, excessive immune activation is accompanied by an increase in cellular iron content, which in turn promotes oxidative stress and intensifies intercellular competition. This induces cells to alter their metabolic environment, resulting in increased sugar uptake via the glycosaminoglycan synthesis pathway. In addition, high levels of reactive oxygen species generated by elevated iron levels promote increased endogenous malondialdehyde synthesis in a subpopulation of cardiac endothelial cells. This exacerbates endothelial cell dysfunction and exacerbates the coagulopathy process.

关键词： SARS-CoV-2 cardiac microthrombosis immune hyperactivation cell competition

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高压旋喷桩法在既有高速公路软基治理中的应用

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建筑机械化 2015年第1期36卷 70-73页

作者：吕若冰孔纲强沈扬丁选明河海大学岩土力学与堤坝工程教育部重点实验室江苏南京210098 河海大学土木与交通学院江苏南京210098

结合江苏省沿海高速公路软基工程实例,介绍了高压旋喷桩法的加固机理、设计方法、施工工艺以及质量控制方法,对施工过程中的路面隆起情况进行监控分析。研究表明,高压旋喷桩技术可以有效处治既有高速公路软基工后沉降问题。本工程实例... 详细信息

结合江苏省沿海高速公路软基工程实例,介绍了高压旋喷桩法的加固机理、设计方法、施工工艺以及质量控制方法,对施工过程中的路面隆起情况进行监控分析。研究表明,高压旋喷桩技术可以有效处治既有高速公路软基工后沉降问题。本工程实例为后续类似工程优化设计和质量监控提供参考。

关键词：既有高速公路软土地基路面隆起高压旋喷桩现场监测

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Multiple dynamic bonds enable high mechanical strength and efficient room-temperature self-healable polyurethane for triboelectric nanogenerators

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Science China Chemistry 2025年

作者： Wenwen Zhang Huixia xuan Xiaofei Xu Jiaming Lou Qingbao Guan Zhengwei You State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Institute of Functional Materials College of Materials Science and Engineering Shanghai Key Laboratory of Lightweight Composite Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine Donghua University

For room temperature self-healing triboelectric nanogenerators（TENGs）, the inherent contradiction between mechanical strength and self-healing properties was an urgent problem to be solved. Based on the phenol-carbamate bond, this paper proposed a strategy to design a new molecular structure and coordinate the triple dynamic bonds, which provided a feasible strategy to solve this contradiction. With polytetramethylene ether glycol（M_n= 1,000） as the soft segment in the main chain of polyurethane（PU）, meanwhile methylene diphenyl diisocyanate and 4,4′-dihydroxybiphenyl（BP） as the hard segment and chain extension agent, respectively, the combination of tetrad benzene ring endowed the resultant 4BP-PU with π-π interaction. The effective reversible dissociation and association with hydrogen bond not only bestowed 4BP-PU with high mechanical strength（16.14 MPa）, but also promoted high self-healing efficiency（94.8%） at room temperature. 4BP-PU was selected as the elastic substrate between polydimethylsiloxane and copper sheet to prepare a self-healing TENG to collect energy from natural ***, the rational molecular structure design provided new ideas for developing self-healing materials and fabricating energy harvest electronics.

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现浇X型混凝土桩的荷载传递机理初探

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防灾减灾工程学报 2009年第3期29卷 267-271页

作者：刘汉龙雍君丁选明陈育民河海大学岩土力学与堤坝工程教育部重点实验室南京210098 河海大学岩土工程科学研究所南京210098 河海大学工程力学系南京210098 河海大学水资源高效利用与工程安全国家工程研究中心南京210098

现浇X型混凝土桩技术是河海大学开发研制的用于地基加固处理的一项新技术。在模型试验的基础上,通过有限元方法研究了现浇X型混凝土桩的荷载传递机理,并与模型槽试验结果进行了对比,分析中考虑了桩和土之间的接触和土的非线性。通过数... 详细信息

现浇X型混凝土桩技术是河海大学开发研制的用于地基加固处理的一项新技术。在模型试验的基础上,通过有限元方法研究了现浇X型混凝土桩的荷载传递机理,并与模型槽试验结果进行了对比,分析中考虑了桩和土之间的接触和土的非线性。通过数值分析,揭示了X型桩的截面形式对侧摩阻力分布、端阻力发挥的影响。计算结果表明,由于桩的泊松比效应,X型桩截面周边不同位置的侧阻力大小有所不同;X型桩中出现了类似于H型桩的"半封闭土塞",与圆截面桩相比,桩端附近的侧摩阻力有较明显的增加;X型桩的桩端承载力系数要小于圆截面桩的情况,体现了X型桩截面形状的影响。

关键词：现浇X型混凝土桩侧阻力端阻力

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风力发电结构在风沙荷载激励下的动力响应分析

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兰州理工大学学报 2022年第2期48卷 107-114页

作者：李万润黄杰丁明轩李德强王雪平杜永峰兰州理工大学防震减灾研究所甘肃兰州730050 兰州理工大学甘肃省土木工程减震隔震国际科技合作基地甘肃兰州730050 兰州理工大学西部土木工程防灾减灾教育部工程研究中心甘肃兰州730050 中国华电集团有限公司甘肃公司

为研究风沙荷载对风力发电结构的危害,对风力发电结构进行风沙荷载作用下的动力响应分析.基于某2 MW风力发电机,建立不考虑风机叶片、考虑叶片旋转以及考虑土-结构相互作用的三种有限元模型.采用Davenport风速谱和谐波叠加法模拟脉动风... 详细信息

为研究风沙荷载对风力发电结构的危害,对风力发电结构进行风沙荷载作用下的动力响应分析.基于某2 MW风力发电机,建立不考虑风机叶片、考虑叶片旋转以及考虑土-结构相互作用的三种有限元模型.采用Davenport风速谱和谐波叠加法模拟脉动风速时程,利用动量守恒定律和风沙流密度建立风沙荷载力学计算模型.通过ANSYS分别模拟三种模型在风荷载和风沙荷载作用下的动力响应.结果表明:风力发电结构在风沙荷载作用下响应较大,其作用不容忽略;采用简化的集中质量模型进行数值模拟时得到的结果偏于不安全;土-结构相互作用对风荷载及风沙荷载作用下的位移响应均具有明显的放大效应.

关键词：风力发电结构有限元模型风荷载风沙荷载动力响应

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Large scale synthesis of full-color emissive carbon dots from a single carbon source by a solvent-free method

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Nano Research 2022年第4期15卷 3548-3555页

作者： Hui ding xuan-xuan Zhou Zi-Hui Zhang Yun-Peng Zhao Ji-Shi Wei Huan-ming Xiong Key Laboratory of Coal Processing and Efficient Utilization of Ministry of Education and College of Chemical Engineering China University of Mining and TechnologyXuzhou 221116China Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan UniversityShanghai 200433China

Full-color emissive carbon dots(CDs)hold a great promise for various applications,especially in light emitting diodes(LEDs).However,the existing synthetic routes for CDs are carried out in solutions,which suffer from low yields,high pressures,various byproducts,large amounts of waste solvents,and complicated photoluminescence(PL)***,it is necessary to explore large scale synthesis of CDs with high quantum yield(QY)across the entire visible range from a single carbon source by a solvent-free *** this work,a series of CDs with tunable PL emission from 442 to 621 nm,QY of 23%-56%,and production yield within 34%-72%,are obtained by heating o-phenylenediamine with the catalysis of *** characterizations identify that,the differences between these CDs with respect to the graphitization degree,graphitic nitrogen content,and oxygen-containing functional groups,are responsible for their distinct optical properties,which can be modulated by controlling the deamination and dehydrogenation processes during ***,green,yellow,red emissive films,and LEDs are prepared by dispersing the corresponding CDs into polyvinyl alcohol(PVA).All types of white LEDs(WLEDs)with high colorrendering-index(CRI),including warm WLEDs,standard WLEDs,and cool WLEDs,are also fabricated by mixing the red,green,and blue emissive CDs into PVA matrix by the appropriate ratios.

关键词： carbon dots solvent-free synthesis full-color luminescence surface state white light emitting diodes

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Formation and evolution of supercritical geofluid

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Science China Earth Sciences 2025年第1期68卷 39-51页

作者： Huaiwei NI Yilin XIAO Xiaolin XIONG Xiandong LIU Chunxiao GAO Yi-Xiang CHEN Yunguo LI Wan-Cai LI xuan GUO Yang-Yang WANG Dong-Bo TAN Li ZHANG State Key Laboratory of Lithospheric and Environmental Coevolution University of Science and Technology of China Deep Space Exploration Laboratory/School of Earth and Space Sciences University of Science and Technology of China Guangzhou Institute of Geochemistry Chinese Academy of Sciences School of Earth Sciences and Engineering Nanjing University State Key Lab of Superhard Materials Jilin University

In this work, we provide a comprehensive review on the formation, evolution, properties, and effects of supercritical geofluid. In Earth's interior, enhanced miscibility between H2O and silicate by the addition of special components or by the increase of pressure and temperature gives rise to supercritical geofluid with a significant amount of both H2O and silicate *** formation of supercritical geofluid in magmatic-hydrothermal systems, typified by pegmatite system, is governed by meltfluid critical curve. The formation of supercritical geofluid in metamorphic systems, typified by subducted slab, is governed by the second critical end point. Experimental results suggest that the presence of boron and fluorine in pegmatite system makes it possible to form supercritical geofluid at crustal depths, but the release of supercritical geofluid from subducted slab is withheld until almost 100 km depth. A major presence of both H2O and depolymerized structural units（monomers, dimers, etc.） endows supercritical geofluid with unique physical properties including low density, low elastic moduli, low viscosity, high diffusivity,and high electrical conductivity. Supercritical geofluid can effectively mobilize a variety of elements even including high field strength elements and heavy rare earth elements. The chemical signatures of supercritical geofluid can be inherited by metasomatized mantle and mantle-derived melts, and this could give an explanation of the oxidation of arc magmas. Phase separation of supercritical geofluid through the mechanism of spinodal decomposition leads to formation of a melt network. Multiphase fluid inclusions recovered from subduction zone rocks and pegmatites are possible relics of supercritical geofluid. Supercritical geofluid can cause electrical anomaly and low seismic velocity near the top of subducted slab, and can be linked with intermediate-focus earthquakes. Supercritical geofluid may have played a crucial role in the formation of pe

关键词： Supercritical geofluid Miscibility Subduction zone Pegmatite

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Study on influence of key blasthole parameters on tunnel overbreak

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Underground Space 2023年第2期9卷 76-90页

作者： Zi-qiang Li Zheng Li Wei-wei Huang xuan-ming ding Hang Zhang School of Civil Engineering and Architecture Chongqing University of Science&TechnologyChongqing 401331China Key Laboratory of New Technology for Construction of Cities in Mountain Area Ministry of EducationChongqing UniversityChongqing 400045China Chongqing City Construction Investment(Group)Co. Ltd.Chongqing 400023China School of Civil Engineering Chongqing University400045China

To determine the influence of key blasthole parameters on tunnel overbreak during blasting construction,an intelligent detection sys-tem for tunnel blasting construction is independently *** the key blasthole parameters and overbreak of a typical section of a single line tunnel under the condition of Class V surrounding rock are analyzed and *** actual data obtained is compared with the results of numerical simulations and theoretical *** results are as follows:(1)Quantitative analysis is performed based on the blasthole angle,opening position,and charge mass by the self-developed intelligent detection equipment for blasthole parameters,which can be used to guide the drilling *** scanning equipment for outline excavation can be used to image the actual excavation section in real-time and has the advantages of high precision and fast speed;(2)Tunnel overbreak can be regarded as consisting of two parts:the surrounding rock damage caused by the blasting load,and the collapse of the surrounding rock caused by the blasthole opening *** parameter of the peripheral hole will affect the tunnel overbreak;however,the key parameter is the blasthole opening position;(3)The distributions of the tunnel overbreak volume obtained with the theoretical analysis,finite element simulation,and measurements are basically *** the condition of Class V surrounding rock,the overbreak of this single line tunnel can reach 14.1–78.2 *** meet the specification requirements,the opening position and construction accuracy of the peripheral hole should be strictly controlled.

关键词： Tunnel blasting Blasthole parameters Tunnel overbreak Surrounding rock damage Smooth surface blasting

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微生物加固岛礁地基现场试验研究

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地基处理 2019年第1期1卷 26-31页

作者：刘汉龙马国梁肖杨丁选明方祥位重庆大学土木工程学院重庆400045 重庆大学山地城镇建设与新技术教育部重点试验室重庆400045

人工吹填岛礁是我国南海开发的重要战略工程,但是吹填岛礁地基不能直接用于工程建设,必须对岛礁地基进行加固处理。微生物诱导碳酸钙沉淀(MICP)技术是近年来提出的一种新型加固技术,可以用于提高砂土强度并降低砂土渗透性能。本文开展... 详细信息

人工吹填岛礁是我国南海开发的重要战略工程,但是吹填岛礁地基不能直接用于工程建设,必须对岛礁地基进行加固处理。微生物诱导碳酸钙沉淀(MICP)技术是近年来提出的一种新型加固技术,可以用于提高砂土强度并降低砂土渗透性能。本文开展了人工吹填岛礁钙质砂地基现场微生物加固试验研究,结果表明经过3?4次微生物加固处理后,开始检测到地基表面强度提升;经过9次微生物加固处理后,地基表面强度大于10 MPa,最高可达20 MPa,地基加固深度达70 cm,无侧限抗压强度最高可达821 kPa。

关键词：微生物诱导碳酸钙沉淀技术人工吹填岛礁钙质砂地基强度

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Construction of atomic-level charge transfer channel in Bi_(12)O_(17)C_(l2)/MXene heterojunctions for improved visible-light photocatalytic performance

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Rare Metals 2022年第7期41卷 2405-2416页

作者： Song-Song Cui xuan Liu Yin-Biao Shi ming-Ye ding Xiao-Fei Yang College of Science Nanjing Forestry UniversityNanjing 210037China

Exploring efficient co-catalysts to accurately steer the charge separation of semiconductor photocatalysts is highly desired yet remains ***,we tackle the significant challenge by in situ growing the Bi_(12)O_(17)C_(l2)photocatalyst onto two-dimensional(2D)Cl-terminated Ti_(3)C_(2)MXene to construct 2D/2D heterojunction of Bi_(12)O_(17)C_(l2)and Ti_(3)C_(2).Firstly,2D few-layered Ti_(3)C_(2)MXene with chlorine groups has been successfully syn-thesized by Lewis acidic etching strategy with subsequent ultrasonic *** grafting of chlorine terminations on the surface of MXene serves as nucleating centers and growth platform,resulting in the formation of strong interfacial bonds(Bi-Cl-Ti)between Bi_(12)O_(17)C_(l2)and Ti_(3)C_(2).These strong bonds can facilitate the separation and transfer of photo-generated charge carriers between Bi_(12)O_(17)C_(l2)photocatalyst and Ti_(3)C_(2)*** expec-ted,the photocatalytic degradation rate of Bi_(12)O_(17)C_(l2)/Ti_(3)C_(2)hybrids is 9.7 times higher than that of bare Bi_(12)O_(17)C_(l2)*** work not only exhibits a new design concept to effectively steer the charge separation for photocatalysis,but also gives a reference for constructing efficient MXene-based photocatalytic systems.

关键词： Photocatalysis Ti3C2 MXenes Cocatalyst Schottky junction Heterojunction Charge transfer channels

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