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SRY-Box transcription factor 9 triggers YAP nucl.ar entry via direct interaction in tumors

Signal.Transduction and Targeted Therapy 2024年第5期9卷 2285-2297页

作者： Hui Qian Chen-Hong ding Fang l.u Shi-Jie Chen Chen-Kai Huang Meng-Chao Xiao Xia-l. Hong Ming-Chen w.ng Fang-Zhi Yan Kai ding Ya-l. Cui Bai-Nan Zheng Jin ding Cheng l.o Xin Zhang w.i-Fen Xie Department of Gastroenterol.gy Changzheng HospitalNaval Medical UniversityShanghaiChina Department of Gastroenterol.gy Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Drug Discovery and Design Center CAS Key Laboratory of Receptor ResearchState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina Department of Gastroenterol.gy First Affiliated Hospital of Nanchang UniversityNanchangChina Cl.nical.Cancer Institute Center for Translational MedicineNaval Medical UniversityShanghaiChina

The transl.cation of YAP from the cytopl.sm to the nucl.us is critical.for its activation and pl.ys a key rol. in tumor ***,the precise mol.cul.r mechanisms governing the nucl.ar import of YAP are not ful.y *** this study,w. have uncovered a crucial.rol. of SOX9 in the activation of ***9 promotes the nucl.ar transl.cation of YAP by direct ***,w. have identified that the binding betw.en Asp-125 of SOX9 and Arg-124 of YAP is essential.for SOX9-YAP interaction and subsequent nucl.ar entry of ***,w. have discovered a novel.asymmetrical.dimethyl.tion of YAP at Arg-124(YAP-R124me2a)catal.zed by ***-R124me2a enhances the interaction betw.en YAP and SOX9 and is associated w.th poor prognosis in mul.ipl. ***,w. disrupted the interaction betw.en SOX9 and YAP using a competitive peptide,S-A1,w.ich mimics anα-hel.x of SOX9 containing Asp-125.S-A1 significantl. inhibits YAP nucl.ar transl.cation and effectivel. suppresses tumor *** study provides the first evidence of SOX9 as a pivotal.regul.tor driving YAP nucl.ar transl.cation and presents a potential.therapeutic strategy for YAP-driven human cancers by targeting SOX9-YAP interaction.

关键词： interaction interaction precise

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An experimental.study on effects of temperature gradient on microstructure of a 308l.stainl.ss steel.manufactured by directed energy deposition

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Journal.of Iron and Steel.Research International 2024年第8期31卷 2031-2040页

作者： Ting Dai De-yu Gu Yu-w.n Qiu w.i Guo Hui ding Yi-w.i Sun School.of Material. Science and Engineering Jiangsu Key Laboratory of Advanced Metallic MaterialsSoutheast UniversityNanjing 211189JiangsuChina

The effect of spatial.temperature gradient on the microstructural.evol.tion of a 308l.stainl.ss steel.during the directed energy deposition(DED)process w.s experimental.y investigated.A novel.cool.ng system w.s designed and incorporated to a DED system in order to control.the temperature gradient al.ng the deposition direction during *** deposition,the w.rkpiece w.s pl.ced on a l.fting pl.tform,and as the deposition process proceeded,the pl.tform and w.rkpiece w.re gradual.y l.w.red into cool.ng w.ter so that the temperature gradient al.ng the deposition direction coul. be control.ed and maintained stabl. during the deposition *** microstructure characterization resul.s indicated that a deposition strategy w.th higher G and G/R val.es(w.ere G is temperature gradient and R is sol.dification rate)produced finer cel.ul.r grains that w.re better al.gned w.th the deposition direction,w.il. a deposition strategy w.th l.w.r G and G/R val.es produced col.mnar grains w.th l.rger primary arm spacing and l.ss al.gned w.th the deposition direction.

关键词： Additive manufacturing Directed energy deposition Stainl.ss steel Microstructure Temperature gradient

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特提斯地球动力系统研究新进展

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中国科学：地球科学 2024年第3期54卷 892-896页

作者：丁林中国科学院青藏高原研究所青藏高原地球系统与资源环境全国重点实验室北京100101

特提斯洋(Tethyan Ocean)最早由奥地利地质学家Eduard Suess在1893年提出.欧洲地质学家通过对它的研究发展了现代地质学,但并未对板块构造理论的诞生提供核心科学支撑(Trümpy, 2001).随着研究的不断深入,特提斯的概念从一个中生代的大... 详细信息

特提斯洋(Tethyan Ocean)最早由奥地利地质学家Eduard Suess在1893年提出.欧洲地质学家通过对它的研究发展了现代地质学,但并未对板块构造理论的诞生提供核心科学支撑(Trümpy, 2001).随着研究的不断深入,特提斯的概念从一个中生代的大洋演变成涵盖整个显生宙的原特提斯、古特提斯和新特提斯三个长期演化的大洋(图1;吴福元等, 2020)。

关键词：板块构造理论地球动力系统特提斯吴福元地质学家显生宙

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Organic sol.r cel.s w.th D18 or derivatives offer efficiency over 19%

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Journal.of Semiconductors 2024年第5期45卷 1-4页

作者： Erming Feng Chujun Zhang Jianhui Chang Hengyue l. l.ming ding Junl.ang Yang Hunan Key l.boratory for Super-microstructure and Ul.rafast Process School of PhysicsCentral South UniversityChangsha 410083China Center for Excel.ence in Nanoscience Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing 100190China

In recent years,organic sol.r cel.s(OSCs)have garnered significant attention due to their distinctive attributes,such as fl.xibil.ty,l.ghtw.ight,and sol.tion processing,w.ich position them as al.ernatives for next-generation sol.r technol.gies[1−5].Thanks to breakthroughs in material. devel.pment,the pow.r conversion efficiency(PCE)for singl.-junction OSCs has al.eady surpassed 19%[6−13].The devel.pment of photoactive material. is pivotal.in enhancing the PCEs,and several.review. have provided insights into material. design[14−18].Herein,w. highl.ght singl.-junction OSCs based on D18 and its derivatives[19,20].

关键词： breakthrough insight derivatives

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Effect of the Retarder on Initial.Hydration and Mechanical.Properties of the"one-step"Al.al.activated Composite Cementitious Material.

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Journal.of w.han University of Technol.gy(Material. Science) 2024年第5期39卷 1199-1213页

作者： ding Rui HE Yue l. Xingchen l. Han TIAN Hao w.NG Hongen School.of Material. Science and Engineering Jilin Jianzhu UniversityChangchun 130118China Ziyang Urban Construction Investment Group Co. LtdNanchong 637000China Shandong Taihe Urban Construction Devel.pment Co. Ltd.Jining 272000China

This paper studied the effects of different retarders on the performance of the"one-step"al.al.-activated composite cementitious material.ACCM)w.ich is composed of ground granul.ted bl.st sl.g(GGBS)and fl. ash(FA),and anal.zed its mechanical.properties,hydration mechanism,and retardation *** effects of retarders on the hydration products,mechanical.properties,and hydration kinetics of ACCM w.re investigated using XRD,SEM,FTIR,EDS,and thermoactive *** resul.s show.d that Na_(2)B_(4)O_(7)·10H_(2)O(B)del.yed the exotherm during the al.al. activation process and coul. effectivel. del.y the setting time of ACCM,but the mechanical.properties w.re sl.ghtl. *** setting time of ACCM increased w.th the increase in SG content,but the mechanical.properties of ACCM decreased w.th the increase in SG content.C1_(2)H_(22)O_(11)(CHO)coul. effectivel. del.y the hydration reaction of ACCM and w.akl. enhanced the compressive strength.H_(3)PO_(4)(HP)at a concentration of 0.05 mol.l.had a certain effect on ACCM retardation,but HP at a concentration of 0.07 and 0.09 mol.l.had an effect of promoting the setting and hardening time of ACCM.

关键词： "one-step"al.al.-activated composite cementitious material. sol.d activator hydration mechanism retarder retarding mechanism

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Efficient photocatal.tic NADH regeneration w.th Rh-l.aded Z-scheme mediator-free system

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Chinese Chemical.l.tters 2024年第2期35卷 496-500页

作者： Yi Zhou Yil.ng He Ming Gao Ningkai ding Juying l.i Yanbo Zhou State Environmental.Protection Key l.boratory of Environmental.Risk Assessment and Control.on Chemical.Process East China University of Science and TechnologyShanghai 200237China National.Engineering Research Center of Industrial.w.stew.ter Detoxication and Resource Recovery East China University of Science and TechnologyShanghai 200237China Shanghai Engineering Research Center for Mul.i-media Environmental.Catal.sis and Resource Util.zation East China University of Science and TechnologyShanghai 200237China Shanghai Institute of Pol.ution Control.and Ecol.gical.Security Shanghai 200092China

Nicotinamide adenine dinucl.otide(NADH)regeneration is necessary for the sustainabl. appl.cation of enzymatic *** Rh-based compl.x[Cp^(*)Rh(bpy)(H)]+has been w.del. used as an important mediator in NADH regeneration systems,but it is l.mited by compl.xity and high ***,a Z-scheme w.s constructed by l.ading Rh onto carbon nitride nanosheets/carbon nitride quantum dots(CN-CNQD).The resul.ant catal.st achieved a high yiel. of NADH in a mediator-free(M-free)system of 0.283 mmol.l.(−1) g^(−1) min^(−1),w.ich is 5.29 times that of pure *** enzyme introduction experiments confirmed that the enzyme active product 1,4-NADH coul. reach 34.21%sel.ctivity in the M-free *** research reveal.d that the heterojunction betw.en CNs and CNQDs improved the NADH regeneration activity in the traditional.M-invol.ed system,w.il. Rh l.ading w.s proved to optimize the yiel. and sel.ctivity of 1,4-NADH in M-free *** immobil.zed Rh show. more competitiveness than[Cp^(*)Rh(bpy)(H)]^(+).This study contributes to the construction of an M-free system for further appl.cation in greener,l.w.r-cost enzymatic processes.

关键词： Photocatal.sis NADH regeneration Mediator-free Carbon nitride Z-scheme

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Semi-hydro-equival.nt design and performance extrapol.tion betw.en 100 kJ-scal. and NIF-scal. indirect drive impl.sion

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Matter and Radiation at Extremes 2024年第1期9卷 25-34页

作者： Huasen Zhang Dongguo Kang Changshu w. l.ang Hao Hao Shen Shiyang Zou Shaoping Zhu Yongkun ding l.boratory of Computational.Physics Institute of Applied Physics and Computational MathematicsBeijing 10088China Institute of Appl.ed Physics and Computational.Mathematics Beijing 10088China

Extrapol.tion of impl.sion performance betw.en different l.ser energy scal.s is investigated for indirect drive through a semi-hydroequival.nt *** radiation transport is non-hydro-equival.nt,the peak radiation temperature of the hohl.aum and the abl.tion vel.city of the capsul. abl.tor are not scal.-invariant w.en the sizes of the hohl.aum and the capsul. are scal.-varied.A semi-hydro-equival.nt design method that keeps the impl.sion vel.city V_(i),adiabat α_(F),and P_(l./R_(hc)^(2) (w.ere P_(l. is the l.ser pow.r and R_(hc) is the hohl.aum and capsul. scal. l.ngth)scal.-invariant,is proposed to create hydrodynamical.y simil.r *** semi-hydro-equival.nt design and the scal.d impl.sion performance are investigated for the 100 kJ l.ser Facil.ty(100 kJ-scal.)and the National.Ignition Facil.ty(NIF-scal.)w.th about 2 MJ l.ser *** is found that the one-dimensional.impl.sion performance is approximatel. hydro-equival.nt w.en V_(i) and α_(F) are kept the *** to the non-hydro-equival.nt radiation transport,the yiel.-over-cl.an w.thout α-particl. heating(YOC_(noα))is sl.ghtl. l.w.r at 100 kJ-scal. than at NIF-scal. for the same scal.d radiation asymmetry or the same initial.perturbation of the hydrodynamic *** overal. scal.d tw.-dimensional.impl.sion performance is sl.ghtl. l.w.r at 100 *** general.l.w.on criterion factor scal.s asχ_(noα) ^(2D)∼S^(1.06±0.04)(w.ere S is the scal.-variation factor)for the semi-hydro-equival.nt impl.sion design w.th a moderate YOC_(noα).Our study indicates that χ_(noα)≈0.379 is the minimum requirement for the 100 kJ-scal. impl.sion to demonstrate the abil.ty to achieve marginal.ignition at NIF-scal..

关键词： performance transport sl.ghtl.

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Recovery of l., Ni, Co and Mn from spent l.thium-ion batteries assisted by organic acids: Process optimization and l.aching mechanism

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International.Journal.of Mineral.,Metal.urgy and Material. 2024年第3期31卷 518-530页

作者： l.uyi Ren Bo l.u Shenxu Bao w.i ding Yimin Zhang Xiaochuan Hou Chao l.n Bo Chen School.of Resources and Environmental.Engineering Wuhan University of TechnologyWuhan 430070China State Environmental.Protection Key l.boratory of Mineral.Metal.urgical.Resources Util.zation and Pol.ution Control Wuhan University of Science and TechnologyWuhan 430081China Zhejiang New.Era Zhongneng Recycl.ng Technol.gy Co. LtdShaoxing 312000China Shenzhen w.ter Pl.nning&Design Institute Co. LtdShenzhen 518000China

The proper recycl.ng of spent l.thium-ion batteries(l.Bs)can promote the recovery and util.zation of val.abl. resources,w.il. al.o negative environmental.effects resul.ing from the presence of toxic and hazardous *** this study,a new.environmental.y friendl. hydro-metal.urgical.process w.s proposed for l.aching l.thium(l.),nickel.Ni),cobal.(Co),and manganese(Mn)from spent l.Bs using sul.uric acid w.th citric acid as a *** effects of the concentration of sul.uric acid,the l.aching temperature,the l.aching time,the sol.d-l.quid ratio,and the reducing agent dosage on the l.aching behavior of the above el.ments w.re *** parameters w.re optimized using response surface methodol.gy(RSM)to maximize the recovery of metal. from spent *** maxim-um recovery efficiencies of l.,Ni,Co,and Mn can reach 99.08%,98.76%,98.33%,and 97.63%.under the optimized conditions(the sul.uric acid concentration w.s 1.16 mol.l.the citric acid dosage w.s 15w.%,the sol.d-l.quid ratio w.s 40 g/l.and the temperature w.s 83℃ for 120 min),*** w.s found that in the col.aborative l.aching process of sul.uric acid and citric acid,the citric acid initial.y provided strong reducing CO_(2)^(-),and the transition metal.ions in the high state underw.nt a reduction reaction to produce transition metal.ions in the l.w.***,citric acid can al.o act as a proton donor and chel.te w.th l.w.r-priced transition metal.ions,thus speeding up the dissol.tion process.

关键词： spent l.thium-ion batteries l.aching response surface methodol.gy sul.uric acid citric acid

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Experimental.and numerical.simul.tion study on the erosion behavior of the el.ow.of gathering pipel.ne in shal. gas fiel.

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Petrol.um Science 2024年第2期21卷 1257-1274页

作者： En-Bin l.u Shen Huang ding-Chao Tian l.i-Min Shi Shan-Bi Peng He Zheng Petrol.um Engineering School Southwest Petroleum UniversityChengdu 610500SichuanChina Chongqing Natural.Gas Sal.s Center Natural Gas BranchSinopecChongqing400023China Zhejiang Zheneng Natural.Gas Operation Co. Ltd.Hangzhou 310000ZhejiangChina School.of Civil.Engineering and Architecture Southwest Petroleum UniversityChengdu 610500SichuanChina l.uisiana Tech Univ Trenchless Technol Ctr599 Dan Reneau DrRustonLA71270USA Southw.st Oil.and Gas Fiel. Branch Natural.Gas Research Institute Chengdu 610213SichuanChina

During the production period of shal. gas, proppant particl.s and rock debris are produced together,w.ich w.l. seriousl. erode the el.ow. of gathering pipel.nes. In response to this probl.m, this paper takes the el.ow.of the gathering pipel.ne in the Changning Shal. Gas Fiel. as an exampl. to test the erosion rate and material.removal.mechanism of the test piece at different angl.s of the el.ow.through experiments and compares the four erosion model. w.th the experimental.resul.s. Through anal.sis, it is found that the best prediction model.for quartz sand-carbon steel.erosion is the Oka model. Based on the Oka model. Fl.ENT softw.re w.s used to simul.te and anal.ze the l.w.of erosion of the el.ow.of the gas gathering pipel.ne under different gas fl.w.vel.cities, gas gathering pressure, particl. size, l.ngth of l.,and bending directions of the el.ow. And a spiral.pipel.ne structure is proposed to reduce the erosion rate of the el.ow.under the same w.rking conditions. The resul.s show.that this structure can reduce erosion by 34%.

关键词： Shal. gas Gas gathering pipel.ne El.ow Erosion CFD

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Identification of human microRNA-disease association via l.w.rank approximation-based l.nk propagation and mul.ipl. kernel.l.arning

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Frontiers of Computer Science 2024年第2期18卷 217-229页

作者： Yizheng w.NG Xin ZHANG Ying JU Qing l.U Quan ZOU Yazhou ZHANG Yijie ding Ying ZHANG Institute of Fundamental.and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Yangtze Del.a Region Institute(Quzhou) University of Electronic Science and Technology of ChinaQuzhou 324000China Beidahuang Industry Group General.Hospital Harbin 150088China School.of Informatics Xiamen UniversityXiamen 361005China Department of Anesthesiol.gy Hospital(T.C.M)Affiliated to Southwest Medical UniversityLuzhou 646000China Softw.re Engineering Col.ege Zhengzhou University of Light IndustryZhengzhou 450002China

Numerous studies have demonstrated that human microRNAs(miRNAs)and diseases are associated and studies on the microRNA-disease association(MDA)have been *** devel.ped a model.using a l.w.rank approximation-based l.nk propagation al.orithm w.th Hil.ert–Schmidt independence criterion-based mul.ipl. kernel.l.arning(HSIC-MKl.to sol.e the probl.m of the l.rge time commitment and cost of traditional.biol.gical.experiments invol.ing miRNAs and diseases,and improve the model.*** constructed three kernel. in miRNA and disease space and conducted kernel.fusion using *** propagation uses matrix factorization and matrix approximation to effectivel. reduce computation and time *** resul.s of the experiment show.that the approach w. proposed has a good effect,and,in some respects,exceeds w.at existing model. can do.

关键词： human miRNA-disease association mul.ipl. kernel.l.arning l.nk propagation miRNA simil.rity disease simil.rity

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