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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han ying ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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Improving neural sentence alignment with word translation

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Frontiers of Computer Science 2021年第1期15卷 81-90页

作者： ying ding Junhui LI Zhengxian GONG Guodong ZHOU School of Computer Science and Technology Soochow UniversitySuzhou 215006China

Sentence alignment is a basic task in natural lan-guage processing which aims to extract high-quality paral-lel sentences *** by the observation that aligned sentence pairs contain a larger number of aligned words than unaligned ones,we treat word translation as one of the most useful external *** this paper,we show how to explicitly integrate word translation into neural sentence ***,this paper proposes three cross-lingual encoders to incorporate word translation:1)Mixed Encoder that learns words and their translation annotation vectors over sequences where words and their translations are mixed alterma-tively;2)Factored Encoder that views word translations as fea-tures and encodes words and their translations by concatenating their embeddings;and 3)Gated Encoder that uses gate mechanism to selectively control the amount of word translations moving *** on NIST MT and Opensub-titles Chinese-English datasets on both non-monotonicity and monotonicity scenarios demonstrates that all the proposed encoders significantly improve sentence alignment performance.

关键词： sentence alignment word translation mixeden coder factored encoder gated encoder

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Free Completely J^(e)-simple Semigroups

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Acta Mathematica Sinica,English Series 2015年第7期31卷 1086-1096页

作者： Jun ying GUO Xiao Jiang GUO Juan ying ding Department of Mathematics Jiangxi Normal University

A semigroup is called completely J（e）-simple if it is isomorphic to some Rees matrix semi- group over a left cancellative monoid and each entry of whose sandwich matrix is in the group of units of the left cancellative monoid. It is proved that completely J（e）-simple semigroups form a quasivarity. Moreover, the construction of free completely J（e）simple semigroups is given. It is found that a free completely J（e）-simple semigroup is just a free completely J＊-simple semigroup and also a full subsemigroup of some completely simple semigroups.

关键词： Strongly rpp semigroup free semigroup completely J(e)-simple semigroup quasivariety

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Hf_(2)CF_(2)单层热传输及热电性质的第一原理研究

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原子与分子物理学报 2025年第4期42卷 168-176页

作者：董文欣李铁平张莉丁迎春何开华中国地质大学(武汉)数学与物理学院武汉430074 宜宾学院材料与化学工程学部宜宾644000

二维MXene材料是一种新型的功能性材料,其在热电领域具有潜在应用价值.本文采用第一性原理计算方法,通过求解声子和电子的玻尔兹曼输运方程,计算研究了MXene Hf_(2)CF_(2)单层的热传输特征和热电性质.声子谱揭示了Hf_(2)CF_(2)单层具有... 详细信息

二维MXene材料是一种新型的功能性材料,其在热电领域具有潜在应用价值.本文采用第一性原理计算方法,通过求解声子和电子的玻尔兹曼输运方程,计算研究了MXene Hf_(2)CF_(2)单层的热传输特征和热电性质.声子谱揭示了Hf_(2)CF_(2)单层具有热力学稳定性.在室温条件下,Hf_(2)CF_(2)单层的晶格热导率为14.25 Wm^(-1)K^(-1),且随着温度的升高而降低;电子热导率却随着温度和掺杂浓度的增加而升高.电输运性质中,电导率和Seebeck系数随载流子浓度的变化相反,确保能够获得优异的热电性能.在600 K条件下,n型MXene Hf_(2)CF_(2)单层的最大功率因子可以达到61.24 mW/(mK^(2)).载流子迁移率具有较高的各向异性,且电子的迁移率远远高于空穴的迁移率.基于热导及电导计算结果,n型MXene Hf_(2)CF_(2)单层沿x轴方向的热电优值可达到1.75,高于其他已报道的类似结构的热电优值,表明了MXene Hf_(2)CF_(2)单层是一种潜在的高性能n型热电材料.

关键词： MXene Hf_(2)CF_(2) 热电性能晶格热导率第一性原理

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Effect of Tongxieyaofang decoction on colonic mucosal protein expression profiles in rats with visceral hypersensitivity

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Journal of Traditional Chinese Medicine 2020年第2期40卷 245-252页

作者： Lin Yongjun ding ying Lü Bin Liu Nan Department of Intensive Care Unit Sir Run Run Shaw HospitalMedicine School of Zhejiang UniversityHangzhou 310016China Department of Intensive Care Unit Sir Run Run Shaw Hospital XiaSha CampusMedicine School of Zhejiang UniversityHangzhou 310018China Department of Gastroenterology the First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006China

OBJECTIVE: To explore the underlying mechanism of action of Tongxieyaofang decoction in rats with visceral hypersensitivity using proteomics ***: Twenty-four female Sprague-Dawley rats were randomly divided into three groups: control group, irritable bowel syndrome(IBS) group and Tongxieyaofang treatment group. An IBS model, characterized as visceral hypersensitivity, was established using the odour of mothballs as conditional stimulation and colorectal distension combined with classic physical restraint as non-conditional stimulation. Rats were intragastrically treated with Tongxieyaofang(2 or 4 m L · kg^(-1)· d^(-1))for 4 weeks. On the 45 th day, the rats were dissected and the colonic mucosal proteins were extracted. Differential protein spots were screened by fluorescent two-dimensional differential gel electrophoresis(2 D-DIGE), and identified by matrix-assisted laser desorption/ionisation time of flight mass spectrometry(MALDI-TOF-MS). Western blotting experiments were performed to verify the changes observed in 2 D-DIGE and ***: It was found that the visceral sensitivity of rats in the Tongxieyaofang treatment group(4 m L/kg) was lower than that in the IBS group(P <0.01). Sixty-one protein spots were differentially expressed between the IBS group and the Tongxieyaofang treatment group. Of these, 23 spots were upregulated in the Tongxieyaofang treatment group, while 38 spots were downregulated. Three specific proteins were successfully identified from the five protein spots with the most obvious changes. The two upregulated proteins were transgelin(TAGLN) and acetaldehyde dehydrogenase 2(Aldh2) and the downregulated protein was cytokeratin 8(CK8).CONCLUSION: Tongxieyaofang can dose-dependently ameliorate visceral hypersensitivity in rats and the mechanism of action may involve the upregulation of TAGLN and Aldh2 and the downregulation of CK8.

关键词： Irritable bowel syndrome Hypersensitivity Acetaldehyde dehydrogenase inhibitor Keratin-8 Tongxieyaofang

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Visualizing the charge order and topological defects in an overdoped （Bi,Pb）2Sr2CuO6+x superconductor

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Science China(Physics,Mechanics & Astronomy) 2020年第2期63卷 117-123页

作者： ying Fei Yuan Zheng KunLiang Bu WenHao Zhang ying ding XingJiang Zhou Yi Yin Department of Physics Zhejiang UniversityHangzhou 310027China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Collaborative Innovation Center of Quantum Matter Beijing 100871China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

Electronic charge order is a symmetry breaking state in high-Tc cuprate superconductors. In scanning tunneling microscopy, the detected charge-order-induced modulation is an electronic response of the charge order. For an overdoped(Bi,Pb)2Sr2CuO6+x sample, we apply scanning tunneling microscopy to explore local properties of the charge order. The ordering wavevector is nondispersive with energy, which can be confirmed and determined. By extracting its order-parameter field, we identify dislocations in the stripe structure of the electronic modulation, which correspond to topological defects with an integer winding number of ±1. Through differential conductance maps over a series of reduced energies, the development of different response of the charge order is observed and a spatial evolution of topological defects is detected. The intensity of charge-order-induced modulation increases with energy and reaches its maximum when approaching the pseudogap energy. In this evolution, the topological defects decrease in density and migrate in space. Furthermore, we observe appearance and disappearance of closely spaced pairs of defects as energy changes. Our experimental results could inspire further studies of the charge order in both high-Tccuprate superconductors and other charge density wave materials.

关键词： cuprate superconductors scanning tunneling microscopy charge order topological defects

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Significant roles of anti-aging protein klotho and fibroblast growth factor23 in cardiovascular disease

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Journal of Geriatric Cardiology 2015年第4期12卷 439-447页

作者： Hong-ying ding Hou-Xun MA Department of Geriatrics The First Affiliated Hospital of Chongqing Medical University Chongqing China

The klotho gene has been identified as an aging suppressor that encodes a protein involved in cardiovascular disease （CVD）. The inac- tivation of the klotho gene causes serious systemic disorders resembling human aging, such as atherosderosis, diffuse vascular calcification and shortened life span. Klotho has been demonstrated to ameliorate vascular endothelial dysfunction and delay vascular calcification. Fur- thermore, klotho gene polymorphisms in the human are associated with various cardiovascular events. Recent experiments show that klotho may reduce transient receptor potential canonical6 （TRPC6） channels, resulting in protecting the heart from hypertrophy and systolic dys- function. Fibroblast growth factor23 （FGF23） is a bone-derived hormone that plays an important role in the regulation of phosphate and vi- tamin D metabolism. FGF23 accelerates urinary phosphate excretion and suppresses 1,25-dihydroxy vitaminD3 （1,25（OH）2D3）synthesis in the presence ofFGF receptorl （FGFR1） and its co-receptor ldotho, principally in the kidney. The hormonal affects of circulating klotho pro- tein and FGF23 on vascular and heart have contributed to an understanding of their roles in the pathophysiology of arterial stiffness and left ventricular hypertrophy. Klotho and FGF23 appear to play a critical role in the pathogenesis of vascular disease, and may represent a novel potential therapeutic strategy for clinical intervention.

关键词： Cardiac hypertrophy Cardiovascular Fibroblast growth factor23 Gene polymorphisms Klotho Vascular calcification

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Word-Pair Relevance Modeling with Multi-View Neural Attention Mechanism for Sentence Alignment

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Journal of Computer Science & Technology 2020年第3期35卷 617-628页

作者： ying ding Jun-Hui Li Zheng-Xian Gong Guo-Dong Zhou School of Computer Science and Technology Soochow UniversitySuzhou 215006China

Sentence alignment provides multi-lingual or cross-lingual natural language processing(NLP)applications with high-quality parallel sentence ***,an aligned sentence pair contains multiple aligned words,which intuitively play different roles during sentence *** by this intuition,we propose to deal with the problem of sentence alignment by exploring the semantic interactionship among fine-grained word pairs within the framework of neural *** particular,we first employ various relevance measures to capture various kinds of semantic interactions among word pairs by using a word-pair relevance network,and then model their importance by using a multi-view attention *** results on both monotonic and non-monotonic bitexts show that our proposed approach significantly improves the performance of sentence alignment.

关键词： sentence alignment neural network word-pair relevance network multi-view attention network

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Cathodic process of nickel electrodeposition from ammonia-ammonium chloride solutions

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Rare Metals 2023年第3期42卷 1061-1066页

作者： Liang Yuan Zhi-ying ding Shi-Jun Liu Ya-Ning He School of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China

Mechanism of cathodic process on nickel electrodeposition from ammonia-ammonium chloride solutions was studied by Tafel polarization curves,linear sweep voltammetry(LSV),cyclic voltammograms(CV)and chronopotentiometry(CE)*** the electrolyte with 1.0 mol·L^(-1) NiCl_(2)·6H_(2)O,4.0 mol·L^(-1) NH_(3)·H_(2)O and2.5 mol·L^(-1) NH4Cl,nickel ion mainly complexed with ammonia and almost no free nickel ion could be *** is confirmed that the dominant form of nickel ammonia complex ion in the system is Ni(NH_(3))_(4)^(2+)by measuring the equilibrium potential of the electrode at various concentrations of *** species of Ni(NH_(3))42+turns into Ni(NH_(3))_(2)^(2+)during pre-chemical reaction step before discharging reduction ***,Ni(NH_(3))_(2)^(2+)discharges at the cathodic interface to form metal nickel deposit *** process is involved during nickel electrodeposition according to CV *** reduction reaction of Ni(NH_(3))_(2)^(2+)is irreversible which is controlled by diffusion *** processes are also accompanied during the electrodeposition process,except for the diffusioncontrolled process.

关键词： Electrodeposition Nickel Cathodic process Ammoniacal solution

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Electronic effect of doped oxygen atoms in Bi2201 superconductors determined by scanning tunneling microscopy

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Science China(Physics,Mechanics & Astronomy) 2018年第12期61卷 30-36页

作者： ying Fei KunLiang Bu WenHao Zhang Yuan Zheng Xuan Sun ying ding XingJiang Zhou Yi Yin Department of Physics Zhejiang UniversityHangzhou 310027China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Collaborative Innovation Center of Quantum Matter Beijing 100871China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China

Oxygen dopants are essential for tuning the electronic properties of the cuprate superconductors Bi_2Sr_2Ca_(n-1)Cu_nO_(2n+4+δ).Here,we study an optimally doped Bi_2Sr_(2-x)La_xCuO_(6+δ)and an overdoped Bi_(2-y)Pb_ySr_2CuO_(6+δ)by scanning tunneling microscopy and spectroscopy(STM/STS).Based on the characteristic features of local STS,three forms of oxygen dopants are identified:interstitial oxygen atoms on the SrO layers,oxygen vacancies on the SrO layers,and interstitial oxygen atoms on the BiO *** both samples,the first form dominates the number of oxygen *** the extracted spatial distribution of the oxygen dopants,we calculate the dopant concentrations and estimate the average hole carrier *** magnitudes of the electronic pseudogap state in both samples are inhomogeneously distributed in *** statistical analysis on the spatial distributions of the oxygen dopants and the pseudogap magnitude demonstrates that the doped oxygen atoms on the SrO layers tend to suppress the nearby pseudogap magnitude.

关键词： cuprate superconductor scanning tunneling spectroscopy doping hole concentration pseudogap

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