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A Review on Pharmacological and Analytical Aspects of Diosmetin:A Concise Report

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Chinese Journal of Integrative Medicine 2013年第10期19卷 792-800页

作者： Kanika patel Manoj Gadewar Vijay Tahilyani dinesh kumar patel GLA Institute of Pharmaceutical Research Mathura(281406)India SKIPS Warangal-Andhra Pradesh(506015)India Sonekar College of Pharmacy KoradiNagpur(440001)India Department of Pharmaceutics Institute of TechnologyBanaras Hindu UniversityVaranasi(221005)India

Plants have been used as a source for food material and natural remedies for the treatment of vast range of diseases. Nature provides us remedies for the treatment of various types of disorders ranging from simpte aitments to complicated diseases. Plants are known to possess different pharmacological activities due to the presence of various phytoconstituents, Flavonoids are one of the main active phytoconstituents found in fruits, vegetables, wines, tea and cocoa. Flavonoids exhibit various pharmacological activities such as antioxidant, anti-inflammatory, anti-allergic, antibacterial, oestrogenic, cytotoxic antitumoural, hepatoprotective, antithrombotic and antiviral activity. Diosmetin （3＇, 5, 7-trihydroxy-4＇-methoxyflavone）, the aglycone part of the flavonoid glycosides diosmin occurs naturally in citrus fruit. Although it is found in herbal medicines and plays an important role in the treatment of various ailments, only limited scientific researches have been conducted. The aim of this review is to collect all available scientific literature published on diosmetin and combine it into this paper. This review contains an overview of pharmacological activities, isolation techniques and analytical techniques for diosmetin. Thus, valuable information provided in the present review will help researchers in developing alternative methods for the treatment of diseases from diosmetin.

关键词： analytical techniques diosmetin flavonoid pharmacological activity phytoconstituents

Evaluation of phytochemical and antioxidant activities of the different fractions of Hybanthus enneaspermus (Linn.) ***. (Violaceae).

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Asian Pacific Journal of Tropical Medicine 2011年第5期4卷 391-396页

作者： dinesh kumar patel Rajesh kumar Damiki Laloo Siva Hemalatha Pharmacognosy Research Laboratory Department of PharmaceuticsInstitute of TechnologyBanaras Hindu UniversityVaranasi-221005.India

Objective:To investigate the naturally occurring antioxidant for the first time from the different solvent fractions of Hybanthus enneaspermus（***） Linn ***（Violaceae）. Methods:Different fractions of *** were tested for total phenolic content,and in vitro antioxidant activity was measured by total antioxidant assay,DPPH assay,reducing power, nitric oxide（NO）,hydrogen peroxide（H2O2） scavenging ***:The ethyl acetate（EA） fraction was found to have high levels of phenolic content[（212.15±0.79） mg GAE/g].The EA fraction exhibited higher total antioxidant capacity,higher percentage of DPPH radical scavenging activity[（127.07±2.29） Fg/mL],nitric oxide[（245.16±1.44）μg/mLJ,hydrogen peroxide[（227.38±7.18）μg/mL],deoxyribose[（270.61±8.72）μg/mL]and higher reducing *** was a significant correlation between total phenolic content and total antioxidant activity（r =0.972）. Conclusions:These results reveal that EA fraction of *** has strong antioxidant potential compared with other *** further study has been extended to the isolation of the possible compound that is responsible for having antioxidant property.

关键词： Hybanthus enneaspermus Antioxidant Total phenolics

Pedalium murex Linn.:An overview of its phytopharmacological aspects

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Asian Pacific Journal of Tropical Medicine 2011年第9期4卷 748-755页

作者： dinesh kumar patel Damiki Laloo Rajesh kumar Siva Hemalatha Pharmacognosy Research Laboratory Department of PharmaceuticsInstitute of Technology.Banana Hindu University

Pedalium murex Linn(family:Pedaliaceae)(***) commonly known as Large Caltrops and Gokhru(India) is a shrub found in the Southern *** region of India and in some parts of *** parts of the plant are used to treat various ailments like,cough,cold and as an *** is reported traditionally to have an excellent cure in patients with reproductive disorders which are mainly impotency in *** emissions,gonorrhoea as well as leucorrhoea in *** plant has also benifiled in complications like urinary track disorder as well as gastro intestinal tract *** the plant is popular for the presence of a considerable amount of diosgenin and vanillin which are regarded as an important source and useful starting materials for synthesizing steroidal contraceptive drugs and isatin *** phytochemicals reported in the plant includes *** acid,caffeic acid,amino acids(glycine,histidine,tyrosine,threonine,aspartie acid and glutamic acid) and various classes of fatty acids(triacontanoic acid,*** and heptatriacontan-4-one).Pharmacologically,the plant have been investigated for antiulcerogenic. ***,aphrodisiac,antioxidant,antimicrobial and insecticidal *** all these reports it can be concluded that the plant were found to have a better profile with potential natural source for the treatment of various range of either acute or chronic *** overall database of our review article was collected from the scientific sources in regards with all the information ol the research article for *** published so far.

关键词： Pedalium murex Tissue culture Phytochemistry Ulcerogenic Aphrodisiac Nephroprotective Antioxidant Antimicrobial

Inhibitory effect of two Indian medicinal plants on aldose reductase of rat lens in vitro

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Asian Pacific Journal of Tropical Medicine 2011年第9期4卷 694-697页

作者： Rajesh kumar dinesh kumar patel Damiki Laloo Krishnamurthy Sairam Siva Hemalatha Deportment of Pharmaceutics Institute of Technology.Banana Hindu UniversityVaranasi-221005India

Objective:To assesse the inhibitor) effect of alcoholic extract of two Indian medicinal plants namely Ceasalpinia digyna Rottler *** lamarckii Thwaits on aldose reductase（AR） of rat ***:Rats lens were enucleated through posterior approach and their homogenate was prepared and centrifuged to obtain a clear supernatant for the determination of AR activity and protein ***:The alcoholic extract of Ceasalpirda digyna and Alangium lamarckii had a potent inhibitory effect on the lens AR *** IC50 values of alcoholic extract of the selected plants were calculated and were（46.29±11.17） and（106.00±5.11）μg/mL,respectively. Quercetin was used as a positive control and its IC50 value was（2.95±1.53）μg/***:Thus,it is concluded that alcoholic extracts of the selected plant exhibit significant inhibitory effects on AR in the rat lens in vitro.

关键词： Caesalpinia digyna Alangium lamarckii Aldose reductase Diabetic cataract

A review on pharmacological and analytical aspects of diosgenin:a concise report

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Natural Products and Bioprospecting 2012年第2期2卷 46-52页

作者： Kanika patel Manoj GADEWAR Vijay TAHILYANI dinesh kumar patel G.L.A Institute of Pharmaceutical Research MathuraIndia S.K.I.P.S.Warangal A.P.India Sonekar College of Pharmacy KoradiNagpurIndia Department of Pharmaceutics Institute of TechnologyBanaras Hindu UniversityVaranasi 221005India

Diosgenin is a steroidal sapogenin found in plants such as Dioscorea nipponoca,Solanum incanum,Solanum xanthocarpum and Trigonella foenum ***,biologically active phytochemicals have been used for the treatment of various types of disorder such as leukemia,inflammation,hypercholesterolemia and *** is also able to prevent bone loss to the same extent as that of *** is a typical initial intermediate for synthesis of steroidal compounds,oral contraceptives and sex ***,Costus and Trigonella are mainly used for the production of *** the basis of literature survey it divulges that diosgenin has very impressive pharmacological profile and could be used as a medicine for the treatment of different types of disorders in the ***,the present work aims to provide collective information in concern with its pharmacological activity and phytoanalytical *** review will be beneficial to researches for the development of an alternative method for the treatment of innumerable diseases from diosgenin.

关键词： analytical techniques cancer diosgenin pharmacological activity plant source seperation techniques

A review on medicinal importance,pharmacological activity and bioanalytical aspects of beta-carboline alkaloid "Harmine"

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Asian Pacific Journal of Tropical Biomedicine 2012年第8期2卷 660-664页

作者： K patel M Gadewar R Tripathi SK Prasad dinesh kumar patel G.L.A Institute of Pharmaceutical Research S.K.I.P.S Department of Pharmaceutics Institute of TechnologyBanaras Hindu University

Harmine,a beta-carboline alkaloid,is widely distributed in the plants,marine creatures,insects, mammalians as well as in human tissues and body *** was originally isolated from seeds of Peganum harmal in 1847 having a core indole structure and a pyridine *** has various types of pharmacological activities such as antimicrobial,antifungal,antitumor,cytotoxic, antiplasmodial,antioxidaant,antimutagenic,antigenotoxic and hallucinogenic *** acts on gamma-aminobutyric acid type A and monoamine oxidase A or B receptor,enhances insulin sensitivity and also produces vasorelaxant *** prevents bone loss by suppressing *** current review gives an overview on pharmacological activity and analytical techniques of harmine,which may be useful for researcheres to explore the hidden potential of harmine and and will also help in developing new drugs for the treatment of various diseases.

关键词： Harmine Alkaloid Pharmacological activity Analytical technique Peganum harmala

Ascaridole: A phytochemical of modern medicinal perspective

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Journal of Coastal Life Medicine 2017年第2期5卷 88-94页

作者： dinesh kumar patel Christian School of Pharmacy Faculty of Health SciencesSam Higginbottom Institute of AgricultureTechnology and Sciences(SHIATS)Deemed-to-be UniversityAllahabad211007Uttar PradeshIndia

American wormseed oil, also known as Chenopodium ambrosioides oil, is obtained from the herbs of the genus Chenopodium which comprises more than 200 species and belongs to the geographical region of Asia, Europe, China, India, America and other *** has been traditionally used for digestive, respiratory, diabetes, uro-genital, nervous and vascular disorders and has antihelminthic, vermifuge, emmenagogue sedative, antipyretic, antirheumatic and abortifacient activities. Ascaridole is a bicyclic monoterpene commonly known as ascarisin or 1,4-epidioxy-p-menth-2-ene which have sedative, antifungal and pain-relieving properties. It is a potent inhibitor of Trypanosoma cruzi,Plasmodium falciparum, and Leishmania amazonensis and is well known for its worm-expelling potential. Ascaridole was firstly isolated by a German pharmacist in the 1900's and at that time it was one of the best antihelmintics for the treatment of ascarids and hookworms in humans and other species like cats, dogs, horses and pigs. Ascaridole could be extracted by using a non-polar solvent hexane due to its very poor solubility in water. From the literature support, it has been proved that ascaridole have very high potential in the modern and other system of medicine for the treatment of various disorders. So on the basic of its uses, here we have collected and compiled all the data regarding its medicinal uses, pharmacological activities and analytical techniques of the ascaridole in the present review and expected that this review will be beneficial for the researcher in the field of medicine and other allied science.

关键词： Analytical techniques Antihelminthic Ascaridole Chenopodium ambrosioides Medicinal uses Pharmacological uses

Medicinal significance,pharmacological activities,and analytical aspects of ricinine:A concise report

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Journal of Coastal Life Medicine 2016年第8期4卷 663-667页

作者： Kanika patel dinesh kumar patel Jubilant Life Sciences NoidaUttar Pradesh 201301India Department of Pharmacy Galgotias UniversityGreater Noida 203201Uttar PradeshIndia

Ricinine(3-cyano-4-methoxy-N-methyl-2-pyridone)is an alkaloid present in leaves and seeds of castor plant *** *** can cause vomiting,convulsions,hypotension,liver and kidney damage and several other complications in *** presents mainly in young plant and it is the only cyano-substituted pyridine compounds occurred *** also found in some other plants such as Piper nigrum,Discocleidion rufescens,Aparisthmium cordatum and Nicotiana *** and intended Ricinus communis intoxications in humans and animals have been known for *** the present review,we summarize the information regarding its medicinal uses,pharmacological activities,analytical techniques and intended and unintended poisoning cases in humans and *** review will be beneficial for the researcher in the field of herbal medicine and other allied sciences.

关键词： Analytical techniques Pharmacological activities Poisoning Ricinine Ricinus communis

Gossypin: A phytochemical of multispectrum potential

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Journal of Coastal Life Medicine 2017年第8期5卷 365-370页

作者： Kanika patel Vikas kumar AmitaVerma dinesh kumar patel Faculty of Health Science Shalom Institute of Health and Allied SciencesSam Higginbottom University of AgricultureTechnology and Sciences(SHUATS)(Formerly Allahabad Agriculture Institute)NainiAllahabad 211007Uttar PradeshIndia

Nature is the source of the various raw chemicals in the form of oils, food supplement, neutraceuticals, and colour pigments. A lot of presently existing drugs available in the market mainly belong to the natural sources including the plants, animal, microorganism, minerals and marine source. Flavonoids, benzo-c-pirone derivates are one of the main secondary flavonoid liable for the different shades of flowers like orange, yellow and red color. More than 4000 flavonoids like flavanols, flavonols, isoflavones, flavanones, flavanonols and flavones are found in the different edible plants which are also found in the regular human diet. Flavonoids are present in vegetables, spices, tea, whole grains, fruits, wine, herbs and seeds. Gossypin, a flavonol glucoside, is present in the flowers of different plants like Gossypium indicum, Hibiscus esculentus and Hibiscus vitifolius and is one of the major chemical of plants belonging to 'Malvaceae' family. In the present review, we have collected all the information of gossypin and found that it has antioxidant, antiinflammatory, anticancer, anticataract, antidiabetic, analgesic and hepatoprotective activities. It also protects against beta-amyloid induced toxicity. The information provided in the present review will be beneficial to the researchers of the various field of science for the development of better alternate for various disorders. On the basis of the presented database of this review we can conclude that gossypin has various beneficial effects and it could be used for the treatment of various disorders.

关键词： Flavonoids Gossypin Pharmacological activity Phytochemical Polyphenol