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Dual functions:A coumarin–chalcone conjugate inhibits cyclic-di-GMP and quorum-sensing signaling to reduce biofilm formation and virulence of pathogens

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mLife 2023年第3期2卷 283-294页

作者： Yu Zhang Pramod Bhasme dinesh S.reddy Dejian Liu Zhaoxiao Yu Tianhu Zhao Yaqian Zheng Amit Kumar Haiying Yu Luyan Z.Ma State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina Centre for Nano and Material Sciences Jain UniversityBangaloreKarnatakaIndia

Antibiotic resistance or tolerance of pathogens is one of the most serious global public health *** in biofilms show extreme tolerance to almost all antibiotic ***,use of antibiofilm drugs without bacterial-killing effects is one of the strategies to combat antibiotic *** this study,we discovered a coumarin–chalcone conjugate C9,which can inhibit the biofilm formation of three common pathogens that cause nosocomial infections,namely,Pseudomonas aeruginosa,Staph-ylococcus aureus,and Escherichia coli,with the best antibiofilm activity against *** investigations indicate that C9 decreases the synthesis of the key biofilm matrix exopolysaccharide Psl and bacterial second messenger ***,C9 can interfere with the regulation of the quorum sensing(QS)system to reduce the virulence of ***.C9 treatment enhances the sensitivity of biofilm to several antibiotics and reduces the survival rate of *** under starvation or oxidative stress conditions,indicating its excellent potential for use as an antibiofilm-forming and anti-QS drug.

关键词： biofilm cyclic-di-GMP exopolysaccharide Psl Pseudomonas aeruginosa quorum sensing

IoT Task Offloading in Edge Computing Using Non-Cooperative Game Theory for Healthcare Systems

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1487-1503页

作者： dinesh Mavaluru Chettupally Anil Carie Ahmed I.Alutaibi Satish Anamalamudi Bayapa reddy Narapureddy Murali Krishna Enduri Md Ezaz Ahmed School of Computing and Informatics Saudi Electronic UniversityRiyadhSaudi Arabia Department of Computer Engineering SRM University APGunturIndia College of Computer and Information Sciences Majmaah UniversityAl Majma’ahSaudi Arabia Department of Public Health College of Applied Medical SciencesKing Khalid UniversityAbhaSaudi Arabia

In this paper,we present a comprehensive system model for Industrial Internet of Things(IIoT)networks empowered by Non-Orthogonal Multiple Access(NOMA)and Mobile Edge Computing(MEC)*** network comprises essential components such as base stations,edge servers,and numerous IIoT devices characterized by limited energy and computing *** central challenge addressed is the optimization of resource allocation and task distribution while adhering to stringent queueing delay constraints and minimizing overall energy *** system operates in discrete time slots and employs a quasi-static approach,with a specific focus on the complexities of task partitioning and the management of constrained resources within the IIoT *** study makes valuable contributions to the field by enhancing the understanding of resourceefficient management and task allocation,particularly relevant in real-time industrial *** results indicate that our proposed algorithmsignificantly outperforms existing approaches,reducing queue backlog by 45.32% and 17.25% compared to SMRA and ACRA while achieving a 27.31% and 74.12% improvement in Qn ***,the algorithmeffectively balances complexity and network performance,as demonstratedwhen reducing the number of devices in each group(Ng)from 200 to 50,resulting in a 97.21% reduction in complexity with only a 7.35% increase in energy *** research offers a practical solution for optimizing IIoT networks in real-time industrial settings.

关键词： Internet of Things edge computing offloading NOMA

Synthesis to Access Tetrahydroprotoberberine-derived Benzimidazoles

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Synthesis to Access Tetrahydroprotoberberine-derived Benzimi...

Schwannoma of the Superficial Peroneal Nerve in 12-Year-Old Female Child: A Case Report

中国化学会第十三届全国有机合成化学学术研讨会

作者： Ponmani Jeyakkumar 彭莘媚 Addla dinesh Tangadanchu Vijai Kumar reddy 周成合 Laboratory of Bioorganic ＆ Medicinal Chemistry School of Chemistry and Chemical EngineeringSouthwest University

Tetracyclic tetrahydroprotoberberines（THPB） alkaloids contain an isoquinoline backbone and was endowed with various biological properties such as analgesic,anti-convulsant,anti-depressant and anti-psychotic abilities in the central nervous *** the rapid progress of science,the treatment of infectious diseases still remains a serious problem to the scientific community.A key intermediate containing an aldehyde group at 12-position of tetrahydroprotoberberrubine was developed for future *** aldehyde is easy to be attacked by neucleophilic reagents to access a series of berberrubine modified benzimidazole derivatives that can ameliorate the weakness of *** 1 H-NMR spectra of ±-Tetrahydroprotoberberrubine-12-（4-flurobenzyl-benzimidazole） in DMSO-d6 indicated the appearance of –OH proton（1 singlet at 9.17 ppm）.Two doublet at 7.67,7.58 ppm and one multiplets at 7.28 – 7.22 ppm integrating 1 H,1 H and 2 H respectively for benzimidazole *** triplet at 7.08 ppm,one doublet of doublet at 7.00 ppm and two doublets at 5.40（d,J = 16.3 Hz,1 H）,and 5.24（d,J = 16.2 Hz,1 H）（geminal coupling） integrating 2 H,2 H,1 H,1 H respectively for aromatic benzyl group.

关键词： berberine benzimidazole antibacterial antifungal MRSA

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Open Journal of Orthopedics 2014年第7期4卷 189-193页

作者： Siddaram N. Patil K. B. dinesh Babu Sandeep reddy Divya Bandari Gannerla Sudhaker V. Pranavi Mamata Medical College Mamata General & Superspeciality Hospital Khammam India

We present a case of Schwannoma of superficial peroneal nerve that presents as single enlarging mass in anterolateral aspect of right leg. After clinical diagnosis work-up is done with ultrasound, MRI and excision bio... 详细信息

关键词： Nerve Sheath Superficial Peronial Nerve Schwannoma Neurilemmomas

Five “Ds” of plastic surgery

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Plastic and Aesthetic Research 2017年第1期4卷 13-14页

作者： Preethitha Babu Ravi Kumar Chittoria Sudhanva Hemanth Kumar Senthil Kumaran Marimuthu Elan Kumar Subbarayan Konda Sireesha reddy Vinayak Chavan Devi Prasad Mohapatra Meethale Thiruvoth Friji dinesh Kumar Sivakumar Department of Plastic Surgery Jawaharlal Institute of Postgraduate Medical Education and ResearchPondicherry 605006India

Although there are a variety of definitions that describe plastic surgery,confusion persists in the minds of both the lay public and doctors.A common lay misconception is that actual pieces of plastic are used to repair injured tissues or placed over defects to make them appear *** the other hand,resident doctors from specialities such as ear-nose-throat and general surgery fail to appreciate the vast scope that plastic surgery specialty *** recognition of this,trainee plastic surgeons are often asked to briefly define our specialty in their final exams,so that subsequent misconceptions are minimized.

关键词： Definitions Plastic surgery Confusion persists

Surface Modification of AH36 Steel Using ENi-P-nano TiO2 Composite Coatings Through ANN-Based Modelling and Prediction

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Journal of Marine Science and Application 2022年第3期21卷 193-203页

作者： R Anthoni Sagaya Selvan dinesh G.Thakur M.Seeman Mahesh Naik Department of Mechanical Engineering DIAT(DU)Pune-411025India Centre for Materials Joining and Research(CEMAJOR) Department of Manufacturing EngineeringAnnamalai UniversityAnnamalai Nagar-608002India

This study aims to analyse and forecast the significance of input process parameters to obtain a better ENi-P-TiO_(2) coated surface using artificial neural networks(ANN).By varying the four process parameters with the Taguchi L9 design,fortyfive numbers of AH36 steel specimens are coated with ENi-P-TiO_(2) composites,and their microhardness values are *** ANN model was formulated using the input and output data obtained from the 45 *** optimal design was developed based on mean squared error(MSE)and R2 *** experimentally measured values were compared with their predicted values to determine the ANN model’s *** efficiency of the ANN model is evaluated with an R2 value of 0.959 and an MSE value of *** authors have concluded that the developed model is suitable for designing and predicting ENi-P-TiO_(2) composite coatings to avoid extensive experimentation with economic *** Electron Microscope(SEM)and X-ray diffraction analysis(XRD)are also utilised to compare the base metal and optimal coated surface.

关键词： AH36 steel ENi-P-nanoTiO2 composite coatings Artificial neural networks Taguchi DOE Microhardness Mean squared error