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Acta Pharmaceutica Sinica B 2015年第1期5卷 34-37页

作者： Zilan Song Meining Wang ao Zhang CAS Key Laboratory of Receptor Research Synthetic Organic & Medicinal Chemistry LaboratoryShanghai Institute of Materia Medica (SIMM) Chinese Academy of Sciences

The development of inhibitors for the tyrosine anaplastic lymphoma kinase (ALK) has advanced rapidly, driven by biology and medicinal chemistry. The first generation ALK inhibitor crizotinib was granted US FDA approval with only four years of preclinical and clinical testing. Although this drug offers significant clinical benefit to the ALK-positive patients, resistance has been developed through a variety of mechanisms. In addition to ceritinib, alectinib is another second-generation ALK inhibitor launched in 2014 in japan. This drug has a unique chemical structure bearing a 5H-benzo[b] carbazol-11(611)-one structural scaffold with an IC50 value of 1.9 nmol/L, and is highly potent against ALK bearing the gatekeeper mutation L1196M with an IC50 of 1.56 nmoL/L. In the clinic, alectinib is highly efficacious in treatment of ALK-positive non-small cell lung cancer (NSCLC), and retains potency to combat crizotinib-resistant ALK mutations L11.96.M, F1174L, R1275Q and C1156Y. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. All rights reserved.

关键词： Tyrosine anaplastic lymphoma kinase Alectinib Crizotinib Non-suaall cell lung cancer Resistance ALK mutations EML4-ALK

Photo-piezoelectric synergistic degradation of typical volatile organic compounds on BaTiO_(3)

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Chinese Chemical Letters 2022年第1期33卷 410-414页

作者： Qin Liu Weina Zhao Zhimin ao Taicheng An Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control Guangdong Key Laboratory of Environmental Catalysis and Health Risk ControlSchool of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China

Explore the photo-piezoelectric synergistic micro-mechanism by density functional theory(DFT)calculations at the electronic and atomic level is *** this work,to understand the synergistic mechanism,atomic and electronic properties of typical piezoelectric and photocatalytic material BaTiO_(3)were initially investigated with different ***,the adsorption of volatile organic compounds(VOCs)on the BaTiO_(3)(001)surface was determined during the piezoelectric *** addition,the relationship between deformation ratio,the electronic structure and adsorption energy was understood in the deformation ratio range of 7%-12%for the optimal catalytic *** results of charge density differences and Born effective charge reveal the synergistic mechanism of piezoelectric *** built-in electric field formed by polarization results in the enhanced separation of charges,which makes the surface charges aggregation,enhancing the adsorption of VOCs,and benefiting the subsequent photocatalytic *** work can provide significant theoretical guidance for the piezoelectric photocatalytic degradation of pollutants with the optimal strain range.

关键词： Photocatalysis Photo-piezoelectric synergistic Polarization Charge separation BaTiO_(3) Volatile organic compounds(VOCs)

Zinc isotopic behavior of mafic rocks during continental deep subduction

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Geoscience Frontiers 2021年第5期12卷 182-191页

作者： Li-juan Xu Sheng-ao Liu Shuguang Li State Key Laboratory of Geological Processes and Mineral Resources School of Scientific ResearchChina University of GeosciencesBeijing 100083China

Zinc isotopes may act as a new tool of tracking recycling of crustal materials that causes compositional heterogeneity of the *** application relies on an investigation of Zn isotopic behaviors during slab *** this study,we report Zn isotopic compositions for a suite of metabasalts(greenschists,amphibolites,and coesitebearing eclogites)from the Dabie Orogen(China),which were formed via the subduction of mafic rocks into different depths and up to>200 *** out of eight greenschists are characterized by lighterδ^(66)ZnjMC-Lyon(0.10‰-0.16‰)than those of global basalts(0.28‰±0.05‰),which may be caused by crustal assimilation of the protoliths by sedimentary rocks due to their extremely high ^(87)Sr/^(86)Sr(up to 0.7130)and lowεNd values(down to−12.3).The remaining greenschists have relatively low ^(87)Sr/^(86)Sr and theirδ66Zn values(0.21‰-0.38‰)overlap the ranges of amphibolites(0.18‰-0.32‰)and coesite-bearing eclogites(0.18‰-0.36‰).There is no correlation betweenδ^(66)Zn and sensitive indicators of dehydration(Rb/TiO_(2),Ba/Yb,and H_(2)O+),suggesting that no detectable Zn isotope fractionation has occurred during the deep subduction of mafic rocks even into>200 km,which is attributed to the limited loss of Zn during prograde metamorphism and ***,Zn isotopic compositions of the deeply subducted mafic rocks are inherited from their *** that these metamorphosed rocks have higherδ66Zn than that of the mantle value by up to 0.2‰,the recycled/subducted mafic crust can incorporate isotopically heavy Zn into the *** subducted slabs may partially melt and generate a metasomatized mantle,resulting in changes of Zn isotopic composition of the hybridized mantle as have been observed in some mantle xenoliths and basaltic lavas.

关键词： Zn isotopes Metamorphosed rocks Dehydration Crustal deep subduction

Rural labor migration and farmers’arrangements of rice production systems in Central China:Insight from the intergenerational division of labor

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journal of Integrative Agriculture 2024年第9期23卷 3200-3214页

作者： Xue Shen Quanyu Yang Rongjun ao Shengsheng Gong Key Laboratory for Geographical Process Analysis&Simulation of Hubei Province/College of Urban and Environmental Sciences Central China Normal UniversityWuhan 430079China

Rice production is crucial for food security in China,and its relationship with rural labor migration has been studied *** migration in rural China has taken new forms in recent *** has been a discernible trend wherein adult children have started migrating to cities while their elderly parents return to villages to re-engage in on-farm *** phenomenon has notably shaped the intergenerational division of labor(IDL)within ***,it remains to be seen how farmers adjust their rice production systems in response to the *** age of 60 years for employment injury insurance is the eligibility threshold for off-farm employment and is used to obtain a source of exogenous variation in the *** on a representative household survey of 1,752 rice farmers in the Hubei Province of Central China,our fuzzy regression discontinuity analysis reveals that farmers in IDL households are more likely to adopt ratoon rice(RR)than single cropping rice(SR)or double cropping rice(DR).The effect of the IDL varies under different levels of operational scales and specialized agricultural service *** analysis suggests that farmers’arrangements are associated with two potential mechanisms of downward intergenerational *** transfer for urban housing purchases increases RR in IDL households,and time transfer for intergenerational childcare significantly promotes SR in IDL *** study enhances the understanding of the relationship between rural labor migration and rice production in China,providing a reference for adjusting rice production systems to ensure food security.

关键词： labor migration intergenerational division of labor rice production systems fuzzy regression discontinuity Central China

A robust and transparent nanosilica-filled silicone rubber coating with synergistically enhanced mechanical properties and barrier performance

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journal of Materials Science & Technology 2023年第20期151卷 219-226页

作者： Shiyao Du Hui Yan Zihe Liu ao Tang Ying Li Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Shenyang National Laboratory for Materials Science Northeastern UniversityShenyang 110819China

Implantable electronic devices(IEDs)are widely used by human beings to achieve medical treatment and diagnosis ***,ideal encapsulation of IEDs is still far from perfect as full prevention of body fluid diffusion into the coating remains ***,we develop a high-performance composite coating for IED encapsulation by introducing SiO_(2) nanoparticles into silicone rubber,which synergistically enhances mechanical properties and improves barrier *** fabricating composite coatings with different nanosilica contents,3%nanosilica is proved to be an optimal additive content with an excellent combination of improved fracture strength(from 2.5 MPa to 4.5 MPa),increased coating resistance(from 10^(4) to 10^(9) cm^(2))and ideal coating *** and electrochemical characterizations subsequently confirm substantially enhanced mechanical properties and barrier performance of the composite coating,which effectively resist crack propagation and impede penetrations of water and chloride ions through the *** calculations further uncover that modified SiO_(2) particles with enriched methyl groups endow a strong bridging effect to interact with silicone rubber monomer,which,together with anti-agglomeration property of methyl groups,contributes to a pronounced improvement in mechanical performance of nanosilica-filled silicone *** from the enhanced mechanical and barrier properties,the as-fabricated nanosilica-filled silicone rubber demonstrates superior protection for the encapsulated circuits with a significantly improved lifetime(709.1 h)compared to that of circuits coated by pure silicone rubber(472.8 h)and bare circuit boards(1 h),which offers great values for packaging material design in future IED encapsulation.

关键词： Organic coatings Implantable electronic devices Nanosilica DFT calculation Mechanical property

Dislocation me diate d dynamic tension-compression asymmetry of a Ni_(2)CoFeV_(0.5)Mo_(0.2) medium entropy alloy

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journal of Materials Science & Technology 2023年第28期159卷 204-218页

作者： ao Meng Xiang Chen Yazhou Guo Yiping Lu Yonghao Zhao Nano and Heterogeneous Materials Center School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Key Laboratory of Solidification Control and Digital Preparation Technology(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024China

Although tension-compression(T-C)asymmetry in yield strength was rarely documented in coarse-grained face centered cubic(FCC)metals as critical resolved shear stress(CRSS)for dislocation slip differs little between tension and compression,the T-C asymmetry in strength,i.e.,higher strength when loaded in compression than in tension,was reported in some FCC high entropy alloys(HEAs)due to twinning and phase transitions activated at high strain regimes in *** this paper,we demonstrate a reversed and atypical tension-compression asymmetry(tensile strength markedly exceeds compressive strength)in a non-equiatomic FCC Ni_(2)CoFeV_(0.5)Mo_(0.2) medium entropy alloy(MEA)under dynamic loading,wherein dislocation slip governs dynamic deformation without twins or phase *** asymme-try can be primarily interpreted as higher CRSS and more hard slip modes(lower average Schmid factor)activated in grains under dynamic tension than ***,larger strain rate sensitivity in dy-namic tension overwhelmingly contributes to the higher flow stress,thanks to the occurrence of more immobile Lomer-locks,narrower spacing of planar slip bands and higher dislocation *** finding may provide some insights into designing MEAs/HEAs with desired properties under extreme conditions such as blast,impact and crash.

关键词： Medium entropy alloy Dynamic deformation Tension-compression asymmetry Slip trace analysis EBSD and TEM

Experimental and numerical simulation of lignite chemical looping gasification with phosphogypsum as oxygen carrier in a fluidized bed

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Chinese journal of Chemical Engineering 2021年第9期34卷 197-207页

作者： Wang Du Liping Ma jing Yang Wei Zhang Ran ao Faculty of Environmental Science and Engineering Kunming University of Science and TechnologyKunming 650500China School of Environmental and Municipal Engineering Xi’an University of Architecture and TechnologyXi’an 710000China

Phosphogypsum(PG)is a solid waste produced in the wet process of producing phosphoric *** is a kind of promising chemical raw ***,the high sulfur of lignite limits the utilization of lignite as a *** on fluidized bed experiments,the optimal reaction conditions for the production syngas by lignite chemical looping gasification(CLG)with PG as oxygen carrier were *** study found that the optimal reaction temperature should not exceed 1123 K;the mole ratio of water vapor to lignite should be about 0.2;the mole ratio of PG oxygen carrier to lignite should be about ***,commercial software Comsol was used to establish a fuel reaction kinetics *** computational fluid dynamics(CFD)numerical simulation,the process of reaction in fluidized bed were well *** model was based on a two-fluid model and coupled mass transfer,heat transfer and chemical *** study showed that the fluidized bed presents a flow structure in which gas and solid *** was a high temperature zone in the middle and lower parts of the fluidized *** could be seen from the results of the flow field simulated that the fluidized bed was beneficial to the progress of the gasification reaction.

关键词： Phosphogypsum Lignite Chemical looping gasification Fluidized-bed Syngas Computational fluid dynamics

Strategies of selective electroreduction of aqueous nitrate to N_(2) in chloride-free system:A critical review

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Green Energy & Environment 2024年第2期9卷 198-216页

作者： Fukuan Li Weizhe Zhang Peng Zhang ao Gong Kexun Li College of Environmental Science and Engineering Nankai UniversityTianjin300350China MOE Key Laboratory of Pollution Processes and Environmental Criteria Tianjin Key Laboratory of Environmental Remediation and Pollution ControlTianjin Key Laboratory of Environmental Technology for Complex Trans-Media PollutionNankai UniversityTianjin300350China

Electroreduction of nitrate has been gaining wide attention in recent years owing to it's beneficial for converting nitrate into benign N_(2) from the perspective of electrocatalytic denitrification or into value-added ammonia from the perspective of electrocatalytic NH_(3) *** reason of the undesired formation of ammonia is dominant during electroreduction of nitrate-containing wastewater,chloride has been widely used to improve N_(2) ***,selective electroreduction of nitrate to N2 gas in chloride-containing system poses several *** this review,we focus on the key strategies for efficiently enhancing N_(2) selectivity of electroreduction of nitrate in chloride-free system,including optimal selection of elements,combining an active metal catalyst with another metal,manipulating the crystalline morphology and facet orientation,constructing core–shell structure catalysts,*** summarizing the strategies,four possible reaction pathways of electro-reduction of nitrate to N_(2) are ***,this review attempts to provide practical strategies for enhancing N2 selectivity without the aid of electrochlorination and highlight directions for future research for designing appropriate electrocatalyst for final electrocatalytic denitrifi-cation.

关键词： Nitrate Chloride Electroreduction Selectivity Nitrogen

Institutional Correction of Mediation under the View of Transformation:Taking the People’s Mediation as an Example

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学术界 2019年第12期 185-193页

作者： Li ao jin Shen School of Law Wuhan University

Under the dual driven forces of soaring disputes and national policy,the dispute resolution ecosystem of China showed the mediation centralism,and the revival of mediation presented the characteristics of adversary *** order to comply with the modern rule of law system,the traditional mediation is incorporated into the modern legal system through the three-level transformation of"discipline of laws","introduction of procedures"and"specialized cultivation",which was promoted by the popularity of social governance,the input of the idea of diversified solutions and the pragmatic impetus under the pressure of social *** mediation movement has the characteristics of both consciousness of pragmatism and the initial legalization,but will also face the mediation *** remodeling of mediation must be rooted in systematization and *** development trend includes expansion of fields,symbiosis of autonomy and specialization,and mandatory introduction.

关键词： mediation people's mediation transformation correction improvement

Multi-omics:Powerful accelerator for uncovering plant specialized metabolic pathways:The case of leonurine

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Molecular Plant 2024年第1期17卷 13-15页

作者： Priyanka Gupta Anuj Sharma dinesh A.Nagegowda Molecular Plant Biology and Biotechnology Lab CSIR-Central Institute of Medicinal and Aromatic PlantsResearch CentreBengaluru 560065India Academy of Scientific and Innovative Research Ghaziabad 201002India

As sessile organisms,plants employ a unique adaptive strategy to survive harsh terrestrial environments and defend against or interact with coevolving animals and *** strategy involves expanding their metabolic systems,resulting in the production of plant specialized metabolites(PSMs)or natural ***,PSMs constitute a highly diverse group of compounds based on their common core structure,comprising terpenoids,phenylpropanoids,benzenoids,alkaloids and nitrogen-containing compounds,glucosinolates,indoles and sulfur-containing indole compounds,phenolics,and fatty acid derivatives(Garagounis et al.,2021).

关键词： expanding alkaloids sulfur