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Evaluation of the anti-biofilm activities of bacterial cellulose-tannic acid-magnesium chloride composites using an in vitro multispecies biofilm model

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Regenerative Biomaterials 2021年第6期8卷 119-135页

作者： Wei He Zhaoyu Zhang Jing Chen Yudong Zheng Yajie Xie Wenbo Liu Jian Wu dina AMosselhy School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Suzhou Xiangcheng Medical Materials Science and Technology Co. LtdSuzhou 215028China Center for Medical Device Evaluation National Medical Products AdministrationBeijingChina Advanced Materials Division Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China Division of Nanomaterials Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesNanchang 330200China Department of Virology Faculty of MedicineUniversity of HelsinkiP.O.Box 21Helsinki 00014Finland Department of Veterinary Biosciences Faculty of Veterinary MedicineUniversity of HelsinkiP.O.Box 66Helsinki 00014Finland

Chronic wounds are a serious worldwide problem,which are often accompanied by wound *** this study,bacterial cellulose(BC)-based composites introduced with tannic acid(TA)and magnesium chloride(BC-TA-Mg)were fabricated for anti-biofilm *** prepared composites’surface properties,mechanical capacity,thermal stability,water absorption and retention property,releasing behavior,anti-biofilm activities and potential cytotoxicity were *** showed that TA and MgCl_(2) particles closely adhered to the nanofibers of BC membranes,thus increasing surface roughness and hydrophobicity of the *** the introduction of TA and MgCl_(2) did not influence the transparency of the membranes,making it beneficial for wound ***-TA and BC-TA-Mg composites displayed increased tensile strength and elongation at break compared to pure ***,BC-TA-Mg exhibited higher water absorption and retention capacity than BC and BC-TA,suitable for the absorption of wound ***-TA-Mg demonstrated controlled release of TA and good inhibitory effect on both singly cultured Staphylococcus aureus and Pseudomonas aeruginosa biofilm and co-cultured biofilm of *** and ***,the cytotoxicity grade of BC-TA-6Mg membrane was eligible based on standard toxicity *** indicated that BC-TA-Mg is potential to be used as wound dressings combating biofilms in chronic wounds.

关键词： bacterial cellulose tannic acid magnesium chloride anti-biofilm activities

Radiolabeling, docking studies, in silico ADME and biological evaluation of serotonin with 125I for 5-HTRs imaging

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Nuclear Science and Techniques 2020年第8期31卷 64-71页

作者： dina M.El-Sharawy Marwa S.El Refaye H.Hussien Asmaa M.AboulMagd Labeled Compounds Department Hot Lab.CenterEgyptian Atomic Energy Authority(EAEA)P.O.Box 13759CairoEgypt Radioactive Isotopes and Generators Department Hot Lab.CenterEgyptian Atomic Energy Authority(EAEA)P.O.Box 13759CairoEgypt Cyclotron Project Nuclear Research CenterCairoEgypt Pharmaceutical Chemistry Department Faculty of PharmacyNahda UniversityBeni SuefEgypt Pharmaceutics and Clinical Pharmacy Department Faculty of PharmacyNahda UniversityBeni SuefEgypt

Serotonin is one of the significant signaling molecules used by several neural systems in the gut and brain. This study aimed to develop a novel and potent tracer for targeting, detecting, and imaging serotonin receptors(5-HTRs), which is a promising tool in the determination of the receptor’s function and relationship with the diseases related to serotonin and its receptor dysfunction. Serotonin was effectively labeled via a direct electrophilic substitutional reaction using an oxidizing agent such as iodogen with 125I in a neutral medium, and 125I-serotonin was achieved with a maximum labeling yield of 91 ± 0.63% with in vitro stability up to 24 h. Molecular modeling was conducted to signify 125I-serotonin structure and confirm that the radiolabeling process did not affect serotonin binding ability to its receptors. Biodistribution studies show that the maximum gastro intestinal tract uptake of 125I-serotonin was 17.8 ± 0.93% ID/organ after 30 min postinjection and the tracer’s ability to pass the blood–brain barrier. Thus, 125I-serotonin is a promising single photon emission computed tomography tracer in the detection of 5 HTRs.

关键词： Serotonin Electrophilic substitution Molecular modeling 5HTRs

Impact of Network and Environment Conditions on the Performance Assessment of Energy Efficient Dynamic Routing Protocol for Wireless Ad Hoc Networks

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通讯和计算机（中英文版） 2012年第2期9卷 189-199页

作者： dina Darwish International Academy for Engineering and Media Science Internet and Multi-Media Dept. 33 El-Roda Square Manial-Cairo Egypt.

Oral Cadmium Intake Enhances Contact Allergen-induced Skin Reaction in Rats

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Biomedical and Environmental Sciences 2022年第11期35卷 1038-1050页

作者： dina Tucovic Jelena Kulas Ivana Mirkov Dusanka Popovic Lidija Zolotarevski Marta Despotovic Milena Kataranovski Aleksandra Popov Aleksandrov Immunotoxicology Group Department of EcologyInstitute for Biological Research"Sinisa Stankovic"-National Institute of Republic of SerbiaUniversity of Belgrade142 Bulevar despota Stefana11060 BelgradeSerbia Medical College of Applied Sciences 254 Cara Dusana11080 BelgradeSerbia Centre of Research Excellence in Nutrition and Metabolism Institute for Medical ResearchUniversity of Belgrade11 Tadeusa Koscuska 111000 BelgradeSerbia

Objective The effect of oral cadmium(Cd)intake to influence contact skin allergies was examined,since it is known that Cd is a heavy metal that affects many tissues,including the skin,in which it disturbs homeostasis,thus resulting in inflammation and *** Male rats were evoked with experimental contact hypersensitivity reaction(CHS)to hapten dinitrochlorobenzene(DNCB),after prolonged(30 day)oral exposure to an environmentally relevant Cd dose(5 ppm).The ear cell population was analyzed with flow *** production by ear skin cells and the activity of skin-draining lymph node(DLN)cells were measured using enzyme-linked immunosorbent assay(ELISA).Results Orally acquired Cd(5 ppm)increased CHS intensity only in Dark Agouti(DA)rats by affecting inflammatory responses in both the sensitization(an increase of IFN-γ and IL-17 cytokine production)and challenge(an increase of CD8^(+)and CD4^(+)cell number and TNF,IFN-γ and IL-17 cytokine production)*** increased CHS reaction was seen in Albino Oxford(AO)rats only at a high Cd dose(50 ppm),during the challenge phase(an increase of CD8^(+)and CD4^(+)cell number and TNF,IFN-γ and IL-17 cytokine production).Conclusion These novel data indicate that oral Cd intensifies the skin response to sensitizing chemicals such as DNCB.

关键词： Cadmium(Cd) Contact hypersensitivity reaction(CHS) Dinitrochlorobenzene(DNCB)

Postnatal germ cell development in cryptorchid boys

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Asian Journal of Andrology 2020年第3期22卷 258-264页

作者： Li-Hua Dong Simone HildorF Erik Clasen-Linde Kolja Kvist dina Cortes Jorgen Thorup Claus Yding Andersen Laboratory of Reproductive Biology Copen hagen University Hospital RigshospitaletCopenhage n 2100Den mark Faculty of Health and Medical Scie nces University of CopenhagenCopenhagen 2200Denmark Department of Pathology Copenhagen University Hospital RigshospitaletCopenhagen 2100Denmark Department of Pediatric Surgery Copenhagen University Hospital RigshospitaletCopenhagen 2100Denmark Department of Pediatrics Copenhagen University Hospital HvidovreCopenhagen 2650Denmark.

Cryptorchidism is associated with infertility in *** orchiopexy is suggested to reduce the *** is lacking on the potential link between infant germ cell maturation and the risk of future *** objective of the study was to evaluate age-related germ cell development in *** for markers of germ cell development(octamerbinding transcription factor 3/4[0CT3/4],placental alkaline phosphatase[PLAP],KIT proto-oncogene[C-KIT],podoplanin[D2-40],Lin-28 homolog A[LIN28],and G antigen 7[GAGE-7])was performed in testicular biopsies from 40 cryptorchid boys aged 4-35 mon *** cell nu mbers and distributi ons were evaluated in cross sectio ns of semi niferous tubules,with and without immuno staini ***3/4,D2-40,and LIN 28 were gen erally expressed in the early stages of germ cell development,as show n by positive expression in germ cells in the central region of seminiferous tubules・In contrast,PLAP and GAGE-7 were expressed in both central and peripheral parts of the tubules in the early stages of development and expressed mainly in a peripheral position with advancing *** cell maturation was delayed in this study population as compared with that observed in our previous study on germ cell markers in a healthy *** number of GAGE-7-positive germ cells per tubular cross section obtained by immunostaining was significantly higher than that obtained by standard hematoxylin and eosin *** immunostaining revealed heterogeneity in germ cell development in cryptorchid *** results shed light on the pathophysiology of germ cell development in boys with cryptorchidism.

关键词： cryptorchidism germ cells immunostaining male fertility preservation reproductive index testis

Crypto-Giardia antigen rapid test versus conventional modified Ziehl-Neelsen acid fast staining method for diagnosis of cryptosporidiosis

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Asian Pacific Journal of Tropical Medicine 2013年第3期6卷 212-215页

作者： dina Abdulla Muhammad Zaglool Amr Mohamed Yousif Abdul Wahid Khodari Mian Usman Farooq Parasitology Department Assuit UniversityAssuitEgypt Department of Laboratory Medicine Faculty of Applied Medical SciencesUmm Al-Qura UniversityMakkahSaudi Arabia Consultant Molecular Virology Head of Laboratory & Blood BankAlnoor Specialist HospitalMakkahSaudi Arabia Development and Planning King Abdullah Medical CityMakkahSaudi Arabia

Objectove:To evaluate the validity of Crypto-Giardia antigen rapid test(CA-RT) in comparison with the conventional mollified Ziehl-Neelsen acid fast(MZN-AF) staining method for the diagnosis of ***:Fifteen preserved stool samples from previously confirmed infections were used as positive controls and 40 stool samples from healthy people were used as negative control.A total of 85 stool samples were collected from suspected patients with cryptosporidiosis over 6 months during the period from January till *** stud) was conducted in the department of parasitology,central *** Specialist Hospital, *** *** samples were subjected to CA-RT and conventional MZN-AF staining *** parameters including sensitivity(SN).specificity(SP),accuracy index (AI).positive predictive value(PPV).and negative predictive value(NPV) were evaluated for both ***:Out of 15[lositive controls,CA-RT detected 13(86.7%) while MZN-AF detected 11(73.3%) positive ***-RT detected no positive case in 40 normal controls but MZN-AF detected 2(5%) as positive *** on the results,the *** and NPV were high in CA-RT than MZN-AF staining method,ie..86.7%vs.73.3%.100%vs.95%.96.4%vs.89.1%. 100%vs.84.6%and 95.2%vs.90.5%.*** of a total of 85 suspected *** detected 7(8.2%) but MZN-AF detected 6(7.1%) cases as ***:CA-RT immunoassay is more valid and reliable than MZN-AF staining method.

关键词： Cryptosporidiosis Validity Reliability Parasitology

Intraluminal stenting versus external ligation of Ahmed glaucoma valve in prevention of postoperative hypotony

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International Journal of Ophthalmology(English edition) 2021年第10期14卷 1560-1564页

作者： dina Abd Elfattah Faried Wagdy Tharwat Mokbel Hisham Elsorogy Abd-Elmonem A.Elhesy Mansoura Ophthalmic Center Faculty of MedicineMansoura UniversityMansoura 35516Egypt Menofia University Hospital Menofia UniversityMenofia 32511Egypt

AIM:To compare intraluminal stenting and external ligation of Ahmed glaucoma valves(AGV)for refractory glaucoma management and postoperative hypotony ***:This randomized prospective blind study included 30 eyes of 25 patients(age range:44-56y)with refractory *** study was conducted from September 2018 to January *** study included two groups,AGV with intraluminal stenting group(n=15 eyes)and AGV with external ligation group(n=15 eyes).Follow-up period was one year *** primary outcome was intraocular pressure(IOP)and its association with the number of postoperative glaucoma ***≤21 mm Hg without medications indicated complete success while IOP≤21 mm Hg with medications indicated qualified success;and IOP<6 mm Hg was defined as ***:After a year of follow-up,IOP was significantly reduced in the intraluminal stenting group than in the external ligation group(11.67±0.89 vs 14.2±4.0 mm Hg,respectively,P=0.024).Postoperative hypotony was more common in the external ligation group(2 cases,13.33%)than in the intraluminal stenting group(1 case,6.67%).CONCLUSION:Application of intraluminal stenting or external ligation during AGV surgery usually prevents postoperative hypotony(transient and persistent)that occurs in conventional AGV surgery.

关键词： stenting ligation Ahmed valve hypotony glaucoma

Effects of Glutamine Supplementation on Patients Undergoing Abdominal Surgery

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Chinese Medical Sciences Journal 2009年第1期24卷 55-59页

作者： Yue-dina Fan Jian-chun Yu Wei-ming Kang Qun Zhang Department of Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To evaluate the effects of supplementation of glutamine （GLN） on maintaining glu- tathione （GSH） level, immune system function, liver function, and clinical outcome of patients receiving abdominal operation. Methods Forty patients undergoing elective abdominal surgical treatment were randomly divided into 2 groups： study group （n=20） and control group （n=20）. All patients received total parenteral nutrition （TPN） for up to 7 days during perioperative period. The study group received TPN supplemented with GLN dipeptide while the control group received TPN without GLN dipeptide. Patients in both groups received equivalent nitrogen and caloric intake. Blood sample was taken on preoperative day, and the 1st, 3rd, 6th postoperative day to measure GSH level, immune indexes, and liver function indexes. Results The decrease of GSH level in plasma and red blood cell （RBC） in study group was less than that in control group during postoperative period. Ratio of GSH/glutathione disulfide （GSSG） in plasma in study grouP was higher than that in control group on the 3rd postoperative day （52.53±11.46 vs. 31.43±7.27, P = 0.001）. Albumin level in study group was higher than that in control group on the 3rd postoperative day （37.7±3.8 g/L vs. 33.8±4.2 g/L, P = 0.02）. There was no significant difference in the levels of immunoglobin （IgG, IgM, IgA） or T lymphocyte subgroup （CD4, CD8, CD4/CD8） in both groups during postoperative period. There was one case with infectious complication in control group, while none in study group. A trend of shortened hospital stay was observed in study group compared with control group （22.3±2.1 d vs. 24.9±1.7 d,P= 0.32）. Conclusions Supplementation of GLN-enriched TPN has beneficial effects on maintaining GSH levels in plasma and RBC, sustaining GSH/GSSG ratio and albumin level, and keeping antioxidant abilities during postoperative period in patients with abdominal operation, with the trends of decreasing incidence of infectious complicati

关键词： glutamine dipepfide glutathione total parenteral nutrition abdominal operation

Polysaccharide composition during cotton seed fibre development:temporal differences between species and in different seasons

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Journal of Cotton Research 2022年第4期5卷 12-24页

作者： PETTOLINO Filomena A. YULIA dina BACIC Antony LLEWELLYN Danny J. Commonwealth Scientific and Industrial Research Organisation(CSIRO) Agri-culture and FoodCanberraACT 2601Australia Department of Animal Plant&Soil SciencesLa Trobe Institute for Agriculture and FoodLa Trobe UniversityAgriBio BuildingBundooraVIC 3083Australia

Background:Cotton seed fibres are long single-celled epidermal trichomes that first appear on the surface of the ovule at anthesis and then elongate rapidly over a period of 15-25 days until a secondary cell wall(SCW)begins to develop through a rapid increase in the deposition of microfibrillar cellulose between the plasma membrane and the primary cell wall that eventually terminates *** measurements of the different polysaccharide components in both wall types over time and how they influence fibre quality can direct studies involved in enhanc-ing fibre properties for yarn quality through cell wall manipulation or molecular ***:A detailed chemical analysis of cell wall composition by differential solvent fractionation was used to identify the range of polysaccharides present in mature cotton fibres and used to validate a simpler total cell wall monosaccharide linkage analysis protocol for wall compositional *** of fibres from 5 days post-anthesis through maturity for three cultivated species,Gossypium hirsutum,***,and ***,showed the dynamic nature of cell wall polysaccharide composition through fibre development and that it progressed differently for each *** grown in the glasshouse during either autumn to winter or spring to summer and within each species had fibre qualities and temporal aspects of cell wall development that were different for each ***,the timing of the deposition of the SCW was delayed in winter grown plants and appeared to influence key fibre qual-ity ***:These results suggest that the temporal aspects of cell wall polysaccharide biogenesis during fibre development influence final fibre quality,and this timing is determined by both genetic and environmental *** onset of SCW synthesis appears to be a critical factor coinciding with termination of fibre elongation and specify-ing the duration of wall thickening that then affects fibre le

关键词： Fibre development Gossypium hirsutum Gossypium barbadense Gossypium arboreum