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Persea americana attenuates inflammatory response associated with hyperlipidemia in ovariectomized and irradiated rats by regulating MMP-3/TIMP-1 levels

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Asian Pacific Journal of Tropical Biomedicine 2022年第9期12卷 374-382页

作者： dina F.Elmaghraby Fatma A.M.Salem Esraa S.A.Ahmed Department of Health Radiation Research National Center for Radiation Research and TechnologyEgyptian Atomic Energy AuthorityCairoEgypt Department of Chemistry Faculty of ScienceHelwan UniversityCairoEgypt Radiation Biology Research National Center for Radiation Research and TechnologyEgyptian Atomic Energy AuthorityCairoEgypt

Objective:To explore the effect of Persea americana supplementation on inflammation,oxidative stress,and lipid profiles in ovariectomized rats fed with a high-fat diet and exposed to ***:The control group was sham operated,while groups 2-5 were ovariectomized and fed a high-fat *** 4 and 5 were exposed toγ-radiation(1 Gy/week for 5 weeks)after *** 3 and 5 were treated with 1 mL/250 g/day of Persea americana for one *** levels of estrogen,alanine aminotransferase,aspartate aminotransferase,cholesterol,triglycerides and lipoproteins were ***,hepatic oxidative stress,inflammatory and fibrogenic markers were ***:Persea americana treatment reduced the oxidative stress markers as well as the levels of triglyceride,total cholesterol,and low-density lipoprotein cholesterol,which in turn lowered hepatic fat ***,it suppressed hepatic inflammatory mediators(interleukin-6,tumor necrosis factor-α,and C-reactive protein)and downregulated pro-fibrogenic markers(transforming growth factor-βand tissue inhibitor of metalloproteinase-1).Conclusions:Persea americana provides protection against ovariectomy,and gamma radiation-mediated hepatic inflammation not only through its antioxidant,anti-inflammatory,lipid-lowering effect but also by modulating the fibrogenic markers.

关键词： Persea americana γ-Radiation Postmenopausal Oxidative stress Lipid Ovariectomy Hepatic inflammation Fibrogenic Rat

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Effective regulation of electronic structures and luminescence properties of LiGd_(9)(SiO_(4))6-x(GeO_(4))xO_(2):Dy^(3+)phosphors by tetrahedral substitution

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Journal of Rare Earths 2023年第5期41卷 673-681,I0002页

作者： Yuanyuan Zhang Lefu Mei Haikun Liu Sergey M.Aksenov dina V.Deyneko Deliang Chen School of Materials Sciences and Technology Dongguan University of TechnologyDongguan 523808China School of Materials Science and Engineering Xi'an Jiaotong UniversityXi'an 710049China Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes National Laboratory of Mineral MaterialsSchool of Materials Sciences and TechnologyChina University of GeosciencesBeijing 100083China Department of Energy and Chemical Engineering Dongguan University of TechnologyDongguan 523808China Laboratory of Arctic Mineralogy and Material Sciences Kola Science CentreRussian Academy of Sciences14 Fersman StrApatity184209Russia Laboratory of Nature-Inspired Technologies and Environmental Safety of the Arctic Kola Science CentreRussian Academy of SciencesApatity18420 Russia Department of Chemistry Lomonosov Moscow State UniversityMoscow119991Russia School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China

A series of Dy^(3+)-activated phosphors with the general formula LiGd_(9)(SiO_(4))6-x(GeO_(4))xO_(2):Dy^(3+)(0≤x≤3)characterized by an apatite-type structure were successfully synthesized via a simple solid-state technique involving a partial substitution of[SiO_(4)]^(4-)with[GeO_(4)]^(4-)*** effects of homovalent[GeO_(4)]^(4-)-[SiO_(4)]^(4-)substitution on the crystal structure,electronic structure,luminescence properties and thermal performance of LiGd_(9)(SiO_(4))6-x(GeO_(4))xO_(2):Dy^(3+)phosphors were studied in *** phases and microstructure were performed by using X-ray diffraction(XRD)Rietveld refinement method and scanning electron microscopy(SEM)*** substitution of smaller[SiO_(4)]^(4-)ions by larger[GeO_(4)]^(4-)ones makes their unit cell parameters increase gradually,and their band gaps *** photoluminescence spectra of LiGd_(9)(SiO_(4))6-x(GeO_(4))xO_(2):Dy^(3+)(0≤x≤3)exhibit obvious emission peaks located at 477,573 and 675 nm within a visible wavelength region,resulting in an excellent white ***,the I573nm/I477nm values of LiGd_(9)(SiO_(4))6-x(GeO_(4))xO_(2):Dy^(3+)(0≤x≤3)become larger with the partial substitution of[SiO_(4)]^(4-)by[GeO_(4)]^(4-),and their CIE chromaticity coordinates exhibit a yellow shift.

关键词： Apatite Structure substitution Electronic structure White emitting Rare earths

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Aryl Hydrocarbon Receptor is Involved in the Proinflammatory Cytokine Response to Cadmium

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Biomedical and Environmental Sciences 2021年第3期34卷 192-202页

作者： KULAS Jelena TUCOVIC dina ZELJKOVIC Milica POPOVIC Dusanka POPOV ALEKSANDROV Aleksandra KATARANOVSKI Milena MIRKOV Ivana Immunotoxicology Group Department of EcologyInstitute for Biological Research‘Sinisa Stankovic'-National Institute of Republic of SerbiaUniversity of Belgrade142 Bulevar despota StefanaBelgrade 11000Serbia

Objective To investigate involvement of the aryl hydrocarbon receptor(Ah R)in the immunomodulatory effects of cadmium(Cd).Methods The effect of Cd on Ah R activation(CYP1 A1 and CYP1 B1 m RNA expression)was examined in lung leukocytes of Cd-exposed rats(5 and 50 mg/L,30 d orally)and by in vitro leukocyte *** involvement of Ah R signaling in the effects of Cd on the interleukin(IL)-1β,IL-6,and tumor necrosis factor(TNF)lung leukocyte response was investigated in vitro using the receptor antagonist *** Cd increased CYP1 B1(in vivo and in vitro)and CYP1 A1(in vitro)m RNA,indicating Ah R involvement in the action of *** response to Cd,lung leukocytes increased IL-6 and decreased TNF at the gene expression and protein levels,but decreased IL-1βproduction due to reduced *** Ah R antagonist CH-223191 abrogated the observed effects of Cd on the cytokine *** absence of Ah R reactivity and cytokine response to Cd of leukocytes from the lungs of a rat strain that is less sensitive to Cd toxicity coincided with a high Ah R repressor m RNA *** Ah R signaling is involved in the lung leukocyte proinflammatory cytokine response to *** relevance of the Ah R to the cytokine response to Cd provides new insight into the mechanisms of Cd immunotoxicity.

关键词： Cadmium Lung leukocytes Aryl hydrocarbon receptor Cytokine(IL-6,TNF,IL-1β)response

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Current trends in acute pancreatitis:Diagnostic and therapeutic challenges

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World Journal of Gastroenterology 2023年第18期29卷 2747-2763页

作者： Enver Zerem Admir Kurtcehajic Suad Kunosić dina Zerem Malkočević Omar Zerem Department of Medical Sciences The Academy of Sciences and Arts of Bosnia and HerzegovinaSarajevo 71000Bosnia and Herzegovina Department of Gastroenterology and Hepatology Plava Medical GroupTuzla 75000Bosnia and Herzegovina Department of Physics Faculty of Natural Sciences and MathematicsUniversity of TuzlaTuzla 75000Bosnia and Herzegovina Department of Internal Medicine Cantonal Hospital“Safet Mujić”MostarMostar 88000Bosnia and Herzegovina

Acute pancreatitis(AP)is an inflammatory disease of the pancreas,which can progress to severe AP,with a high risk of *** is one of the most complicated and clinically challenging of all disorders affecting the *** main causes of AP are gallstone migration and alcohol *** causes are uncommon,controversial and insufficiently *** disease is primarily characterized by inappropriate activation of trypsinogen,infiltration of inflammatory cells,and destruction of secretory *** to the revised Atlanta classification,severity of the disease is categorized into three levels:Mild,moderately severe and severe,depending upon organ failure and local as well as systemic *** methods have been used for predicting the severity of AP and its outcome,such as clinical evaluation,imaging evaluation and testing of various biochemical ***,AP is a very complex disease and despite the fact that there are of several clinical,biochemical and imaging criteria for assessment of severity of AP,it is not an easy task to predict its subsequent ***,there are existing controversies regarding diagnostic and therapeutic modalities,their effectiveness and complications in the treatment of *** main reason being the fact,that the pathophysiologic mechanisms of AP have not been fully elucidated and need to be studied *** this editorial article,we discuss the efficacy of the existing diagnostic and therapeutic modalities,complications and treatment failure in the management of AP.

关键词： Pancreatitis Etiology and pathogenesis Diagnostic criteria Nutrition Antibiotics Management of complications

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Effect of iridium loading on HZSM-5 for isomerization of n-heptane

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Journal of Natural Gas Chemistry 2011年第5期20卷 477-482页

作者： Herma dina Setiabudi Sugeng Triwahyono Aishah Abdul Jalil Nur Hidayatul Nazirah Kamarudin Muhammad Arif Ab Aziz Department of Chemical Engineering Faculty of Chemical Engineering Universiti Teknologi Malaysia Ibnu Sina Institute for Fundamental Science Studies Faculty of Science Universiti Teknologi Malaysia

The effect of iridium loading on the properties and catalytic isomerization of n-heptane over Ir-HZSM-5 is studied. Ir-HZSM-5 was prepared by impregnation method and subjected to isomerization process in the presence of flowing hydrogen gas. XRD and BET studies show that the presence of iridium stabilizes the crystalline structure of HZSM-5, leading to more ordered framework structure and larger surface area. TGA and FTIR results substantiate that iridium species interacts with OH group on the surface of HZSM-5. Pyridine FT-IR study verifies the interaction between iridium and surface OH group slightly increased the Bro¨nsted and Lewis acid sites without changing the lattice structure of HZSM-5. The presence of iridium and the increase of strong Lewis acid sites on HZSM-5 were found to bring an increase about 4.1%, 33.2% and 11.8% in conversion, selectivity and yield of n-heptane isomerization, respectively.

关键词： Ir-HZSM-5 n-heptane isomerization Lewis acid sites protonic acid sites

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Development of Machine Learning Regression Models for Predicting the Performance of Nanofibrous Scaffolds for Skin Tissue Engineering

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生物组学研究杂志(英文) 2024年第3期7卷 97-104页

作者： Salem dina Ahmed Moharam Mohamed Hussein Hashem Esraa Mamdouh Computer Engineering Department Misr University for Science and Technology (MUST University)th of October Egypt Communication Engineering Department Misr University for Science and Technology (MUST University)th of October Egypt Biomedical Engineering Department Misr University for Science and Technology (MUST University)th of October Egypt

Tissue engineering is a branch of regenerative medicine that harnesses biomaterials and stem cells to utilize the body’s natural healing responses to regenerate tissue and organs. Skin components can be rebuilt by safeguarding their structure and function with the help of advanced scaffold manufacturing techniques. It is important to combine medical concerns with the vast explosion of artificial intelligence concepts to preserve human life and improve health. Currently, machine learning can make reliable contributions to critical decision-making in a wide range of applications. Regression machine learning models rely on correlations, associations, and other relationships between a dependent variable and a group of features. The main objective of this research was to study the effects of applying machine learning techniques on the performance of nanoscaffolds. A regression tree, a random forest, AdaBoost, and a gradient boosting algorithm were applied to the dataset and clustering data. By comparing our proposed models with the relevant studies to verify each machine learning model’s optimal performance, the AdaBoost technique was shown to have the highest accuracy (98.58%, 99.6%, 98.51%, and 98.85%), with a mean absolute percentage error of 1.41% and anR2 value of 0.999, which indicates a strong correlation between the predicted and actual values for the whole dataset and all subgroups.

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Mesenchymal stem cells transplantation attenuates experimentally induced brain injury after neonatal hypoxia by different two routes of administrations

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BIOCELL 2019年第1期43卷 21-28页

作者： Nesrine EBRAHIM Eman EHSAN Eman Abd EL GHANY dina SABRY Ashraf SHAMAA Histology and Cell Biology Department Faculty of MedicineBenha UniversityBenhaEgypt Pediatrics Department Faculty of MedicineCairo UniversityGizaEgypt Medical Biochemistry and molecular biology Department Faculty of MedicineCairo UniversityGizaEgypt Surgical and Radiology Department Faculty of Veterinary MedicineCairo UniversityGizaEgypt

The neonatal hypoxic-ischemic encephalopathy(HIE)is an important cause of neurological morbidity and mortality in *** therapy is considered a promising method for treating severe neurological disorders such as this *** cells have the capacity for self-renewal and differentiation into certain cell *** present study was aimed to find out the most beneficial route of bone marrow-derived mesenchymal stem cells(BMSCs)administration for the attenuation of experimentally induced HIE in neonatal *** neonatal rats were divided randomly into four *** 1:control *** 2:rats were exposed to bilateral ligation of cephalic *** 3:rats were exposed to bilateral ligation of cephalic arteries and then underwent intravenous(IV)BMSC *** 4:rats were exposed to bilateral ligation of cephalic arteries and then underwent intracerebroventricular(ICV)BMSC *** animals were evaluated by(a)neurobehavioral tests;(b)histopathology,i.e.,histological and immuno-histochemical studies;and(3)gene expression *** BMSC treated groups(3 and 4)showed improvement in neurobehavioral tests,histopathological studies,and gene expression,as compared to non-injected lesioned rats(Group 2)with better improvement in Group 4(ICV injections)than in Group 3(IV injections).

关键词： Cerebral cortex Neonatal hypoxic ischemia Stem cells

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Systematic framework for the efficient integration of wind technologies into buildings

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Frontiers of Architectural Research 2016年第1期5卷 1-14页

作者： Ashraf A. ELMokadem Naglaa A. Megahed dina S. Noaman Architecture and Urban Planning Department Faculty of Engineering Port-Said University Port SaidEgypt

The renewed interest that is being paid by architects, project developers and local governments to integrate wind turbines with buildings is mainly required a framework to unify much data, criteria and variables to ease the design process to many architects. Therefore, this paper introduces and elaborates the systematic framework towards the efficient integration of wind technologies into new building. Moreover, it evaluates the framework effectiveness by comparing the current status of wind technologies integration into a buitding with the suggested status if the framework is followed.

关键词： Building integratedwind technology Integration method Systematic framework

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Pathophysiology of chronic pancreatitis

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World Journal of Gastroenterology 2013年第42期19卷 7231-7240页

作者： Christina Brock Lecia Mφller Nielsen dina Lelic Asbjφrn Mohr Drewes Department of Gastroenterology and Hepatology Aalborg University HospitalDK-9000 AalborgDenmark Center for Sensory-Motor Interactions (SMI) Department of Health Science and TechnologyAalborg UniversityDK-9220 AalborgDenmark

Chronic pancreatitis(CP)is an inflammatory disease of the pancreas characterized by progressive fibrotic destruction of the pancreatic secretory *** the heterogeneity in pathogenesis and involved risk factors,processes such as necrosis/apoptosis,inflammation or duct obstruction are *** fibrosing process ultimately leads to progressive loss of the lobular morphology and structure of the pancreas,deformation of the large ducts and severe changes in the arrangement and composition of the *** conditions lead to irreversible morphological and structural changes resulting in impairment of both exocrine and endocrine *** prevalence of the disease is largely dependent on culture and *** etiological risk-factors associated with CP are multiple and involve both genetic and environmental *** this review the M-ANNHEIM classification system will be used,comprising a detailed description of risk factors such as:alcohol-consumption,nicotineconsumption,nutritional factors,hereditary factors,efferent duct factors,immunological factors and miscellaneous and rare metabolic *** knowledge of the different etiological factors may encourage the use of further advanced diagnostic tools,which potentially will help clinicians to diagnose CP at an earlier ***,in view of the multi factorial disease and the complex clinical picture,it is not surprising that treatment of patients with CP is challenging and often unsuccessful.

关键词： Chronic pancreatitis Pathogenesis Risk factors Etiology

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Complementary and alternative medications in hepatitis C infection

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World Journal of Hepatology 2014年第1期6卷 9-16页

作者： dina L Halegoua-De Marzio Jonathan M Fenkel Division of Gastroenterology and Hepatology Thomas Jefferson University Hospital

Chronic hepatitis C(CHC) infection affects almost 3% of the global population and can lead to cirrhosis, liver failure, and hepatocellular carcinoma in a significant number of those infected. Until recently, the only treatments available were pegylated interferon and ribavirin, which traditionally were not very effective and have considerable side effects. For this reason, interest in complementary and alternative medications(CAM) in the management of hepatitis C has been investigated. Some CAM has demonstrated therapeutic potential in chronic hepatitis C treatment. Unfortunately, some CAM has been shown to have the potential to cause drug-induced liver injury. This article will review and evaluate many of the natural molecules that interact with the hepatitis C virus(HCV) life cycle and discuss their potential use and safety in HCV therapy, as well as highlight some important interactions between medical and complementary treatments.

关键词： Hepatitis C infection Natural molecules Direct acting antivirals Hepatotoxicity Herbal treatments

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