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FSH/LH Ratio as a Predictor of the IVF Outcome in Young Women

Open Journal of Obstetrics and Gynecology 2018年第10期8卷 817-825页

作者： Eman Shaeer Ahmed M. Maged dina shaheen Hala Gomaa Obstetrics and Gynaecology Department Kasr Aini Hospital Cairo University Giza Egypt Centre of Fertility and Andrology Care (CFAC) Cairo Egypt Internal Medicine Department Kasr Aini Hospital Cairo University Giza Egypt New Life Fertility Center Mississauga Canada

In Vitro Fertilization (IVF) is the treatment for many causes of infertility. Many studies were done to investigate different factors that can affect the success rate. This study was conducted to evaluate if cycle day 3 (CD3) follicle-stimulating hormone (FSH)/luteinizing hormone (LH) ratio can be a predictor for the IVF outcome in young sub-fertile females ≤ 35 years with normal baseline FSH. This is a retrospective case control study conducted at the Centre of Fertility and Andrology Care (CFAC) in Egypt where 235 sub-fertile women underwent IVF. Patients were grouped based on CD3 FSH/LH ratio. Group A consisted of ≤35-year-old women with FSH/LH ratio ≤35-year-old women with FSH/LH ratio ≥ 2. The primary outcomes include the fertilization rate, implantation rate and the clinical pregnancy rate. The secondary outcomes include duration and the total dose of gonadotrophin used. We found that, there was no significant difference in the total dose of gonadotropin used during the IVF cycle. Also, there was no significant difference in the number of retrieved and fertilized oocytes and the number of good embryos. Clinical pregnancy rate was the same in both groups. In conclusion, in patients younger than 35 years, CD3 FSH/LH ratio is not a predictor for IVF outcome.

关键词： FSH/LH Ratio Ovarian Reserve IVF Pregnancy Rate

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Association of Hepatitis C Virus Infection and Type 2 Diabetes in Egypt: A Hospital-Based Study

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Journal of Diabetes Mellitus 2016年第1期6卷 77-89页

作者： Shaimaa B. Abdelaziz Yasmine S. Galal Amal S. Sedrak dina S. shaheen Department of Public Health Cairo University Cairo Egypt Department of Internal Medicine Cairo University Cairo Egypt

Background: The relation between hepatitis C virus (HCV) infection and the development of type 2 diabetes mellitus (T2DM) remains unknown. The aim of this study was to investigate the presence of an association between T2DM and HCV. Methods: A case control study was conducted at the outpatients’ clinics of Kasr El-Aini Hospital (KAH), from October 2013 till March 2014. In this study, 389 HCV patients were selected as cases and 389 healthy controls were also included. Demographic and clinical data were collected using a structured questionnaire. Laboratory investigations including liver function tests (LFT), blood glucose level and radioimmunoblot assay (ELISA) were performed. Results: Out of 389 HCV cases, 219 (56.3%) were diabetic, whereas 145 (37.3%) were diabetic among the healthy controls. Occurrence of diabetes among cirrhotic patients was 1.7 times higher than non-cirrhotic. Logistic regression showed that residence (P < 0.001, OR = 2.7), occupation (P = 0.03, OR = 1.8), and smoking (P = 0.04, OR = 2) were the predictive factors for occurrence of T2DM in HCV patients. Conclusions: In this study, we found a positive association between HCV infection and T2DM. Residence, occupation and smoking were the predictive factors for the association of T2DM in HCV patients, whereas hypertension and BMI were only adjunctive factors.

关键词： HCV Predictive Factors T2DM Cirrhosis

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