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Parasites of the Nile rat in rural and urban regions of Sudan

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Integrative Zoology 2009年第2期4卷 179-187页

作者： dina M.FAGIR el-Amin el-RAYAH Department of Zoology University of KhartoumKhartoumSudan

In this investigation on endoparasites(helminths)and ectoparasites of the Nile rat(Arvicanthis niloticus Desmarest,1822),a total of 220 Nile rats were trapped from different regions of Sudan during the period January 2003–January *** of different tissues,identification of parasites,effect of these parasites on the organs,the preva-lence and intensity of infestation of the parasites and their relation to the habitat of the host,and sex-related infestations were *** showed that the variation among helminth species was wide,especially in those that are transferred by *** protozoan parasites or distortion in the infected tissues were *** examination for Toxoplasma gondii was carried *** species of cestodes(Hymenolepis nana,Hymenolepis diminuta),two genera(Raillietina sp.I,Raillietina ***)and one unidentified Hymenolepididae were *** most prevalent species of cestodes was Raillietina *** for nematodes only one species and one genus were recovered(Monanema nilotica and Streptopharagus sp.).Investigation of skin revealed that 83.8%of rats were infested with one or more of ectoparasites;namely,insects and *** survey also revealed that fleas and lice were the most common ectoparasites that infested the Nile *** rodents,particularly those living in close association with man,play a significant role in human health,welfare and *** has to be stressed that their arthropod ectoparasites are important vectors of pathogenic microorganisms and they can also be important reservoirs for parasitic zoonoses,like trichinellosis and *** doubt,the increase in rodent populations could be followed by an increase in zoonotic diseases(Stojcevic et al.2004,Durden et al.2000).Rats and mice(commensal and wild)play an important role in public health,being carriers or reservoirs for infectious diseases that can be transmitted to humans(zoonoses).Xenopsylla cheopis is the most important vector

关键词： Arvicanthis fleas lice mites Nile rat Sudan ticks.

Radiolabeling, docking studies, in silico ADME and biological evaluation of serotonin with 125I for 5-HTRs imaging

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Nuclear Science and Techniques 2020年第8期31卷 64-71页

作者： dina M.el-Sharawy Marwa S.el Refaye H.Hussien Asmaa M.AboulMagd Labeled Compounds Department Hot Lab.CenterEgyptian Atomic Energy Authority(EAEA)P.O.Box 13759CairoEgypt Radioactive Isotopes and Generators Department Hot Lab.CenterEgyptian Atomic Energy Authority(EAEA)P.O.Box 13759CairoEgypt Cyclotron Project Nuclear Research CenterCairoEgypt Pharmaceutical Chemistry Department Faculty of PharmacyNahda UniversityBeni SuefEgypt Pharmaceutics and Clinical Pharmacy Department Faculty of PharmacyNahda UniversityBeni SuefEgypt

Serotonin is one of the significant signaling molecules used by several neural systems in the gut and brain. This study aimed to develop a novel and potent tracer for targeting, detecting, and imaging serotonin receptors(5-HTRs), which is a promising tool in the determination of the receptor’s function and relationship with the diseases related to serotonin and its receptor dysfunction. Serotonin was effectively labeled via a direct electrophilic substitutional reaction using an oxidizing agent such as iodogen with 125I in a neutral medium, and 125I-serotonin was achieved with a maximum labeling yield of 91 ± 0.63% with in vitro stability up to 24 h. Molecular modeling was conducted to signify 125I-serotonin structure and confirm that the radiolabeling process did not affect serotonin binding ability to its receptors. Biodistribution studies show that the maximum gastro intestinal tract uptake of 125I-serotonin was 17.8 ± 0.93% ID/organ after 30 min postinjection and the tracer’s ability to pass the blood–brain barrier. Thus, 125I-serotonin is a promising single photon emission computed tomography tracer in the detection of 5 HTRs.

关键词： Serotonin electrophilic substitution Molecular modeling 5HTRs

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel E.Ocasio Rivera dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Synthesis of an eco-friendly nanocomposite fertilizer for common bean based on carbon nanoparticles from agricultural waste biochar

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Pedosphere 2021年第6期31卷 923-933页

作者： dina M.SALAMA Mahmoud E.ABD el-AZIZ Mehrez E.el-NAGGAR Essam A.SHAABAN Mohamed S.ABD el-WAHED Vegetable Research Department National Research Centre33 El Bohouth StreetDokkiGiza 12622(Egypt) Polymers&Pigments Department National Research Centre33 El Bohouth StreetDokkiGiza 12622(Egypt) Textile Research Division National Research Centre33 El Bohouth StreetDokkiGiza 12622(Egypt) Pomology Department National Research Centre33 El Bohouth StreetDokkiGiza 12622(Egypt) Botany Department National Research Centre33 El Bohouth StreetDokkiGiza 12622(Egypt)

The burning of agricultural waste is a major cause of environmental *** this study,we sought to prepare biochar from agricultural waste as a source material for the preparation of carbon nanoparticles(CNPs).Surface morphology,hydrodynamic particle size,and purity and crystallinity of CNPs were extensively investigated using transmission electron microscopy(TEM),zeta sizing,and X-ray diffraction(XRD)spectroscopy,*** CNPs were subsequently immersed in a solution of potassium nitrate(KNO_(3))to prepare a CNPs/NK nanocomposite(CNPs loaded with nitrogen(N)and potassium(K))as a nanocomposite fertilizer for common bean(Phaseolus vulgaris L.).The CNPs/NK nanocomposite was sprayed as a foliar fertilizer at 0,10,20,30,and 40 mg L^(-1) on common bean plants 25 d after sowing on a farm in Shebin el-Kom,el-Monifia,*** growth,yield,and quality of common bean were investigated during two successive growing seasons(2017 and 2018).The highest seed yields of 2.04 and 2.01 t ha^(-1) and the highest values of growth parameters including plant height of 61.5 and 59.2 cm,number of leaves per plant of 35 and 35,number of flowers per plant of 83.3 and 82.7,and plant fresh weight of 148.7 and 152.8 g plant^(-1) were obtained when using the CNPs/NK nanocomposite at a concentration of 20 mg L^(-1) during the 2017 and 2018 growing seasons,respectively.

关键词： foliar fertilizer N and K-loaded nanosized carbon particles Phaseolus vulgaris L. plant growth yield

Mesenchymal stem cells transplantation attenuates experimentally induced brain injury after neonatal hypoxia by different two routes of administrations

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BIOCelL 2019年第1期43卷 21-28页

作者： Nesrine EBRAHIM Eman EHSAN Eman Abd el GHANY dina SABRY Ashraf SHAMAA Histology and Cell Biology Department Faculty of MedicineBenha UniversityBenhaEgypt Pediatrics Department Faculty of MedicineCairo UniversityGizaEgypt Medical Biochemistry and molecular biology Department Faculty of MedicineCairo UniversityGizaEgypt Surgical and Radiology Department Faculty of Veterinary MedicineCairo UniversityGizaEgypt

The neonatal hypoxic-ischemic encephalopathy(HIE)is an important cause of neurological morbidity and mortality in *** therapy is considered a promising method for treating severe neurological disorders such as this *** cells have the capacity for self-renewal and differentiation into certain cell *** present study was aimed to find out the most beneficial route of bone marrow-derived mesenchymal stem cells(BMSCs)administration for the attenuation of experimentally induced HIE in neonatal *** neonatal rats were divided randomly into four *** 1:control *** 2:rats were exposed to bilateral ligation of cephalic *** 3:rats were exposed to bilateral ligation of cephalic arteries and then underwent intravenous(IV)BMSC *** 4:rats were exposed to bilateral ligation of cephalic arteries and then underwent intracerebroventricular(ICV)BMSC *** animals were evaluated by(a)neurobehavioral tests;(b)histopathology,i.e.,histological and immuno-histochemical studies;and(3)gene expression *** BMSC treated groups(3 and 4)showed improvement in neurobehavioral tests,histopathological studies,and gene expression,as compared to non-injected lesioned rats(Group 2)with better improvement in Group 4(ICV injections)than in Group 3(IV injections).

关键词： Cerebral cortex Neonatal hypoxic ischemia Stem cells

Serum ferritin in neonatal cholestasis: A specific and active molecule or a non-specific bystander marker?

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Hepatobiliary & Pancreatic Diseases International 2019年第2期18卷 173-180页

作者： Behairy el-Sayed Behairy Hatem Abd-Alsattar Konswa Hanaa Talaat Ahmed dina Shehata el-Azab Nermin Mohamed Adawy Ahmad Mohamed Sira Department of Pediatric Hepatology Gastroenterology and Nutrition National Liver Institute Menofiya University Department of Pathology National Liver Institute Menofiya University

Background: Serum ferritin(SF) and consequently hepatic iron have long been considered important in liver fibrosis progression. They have been studied in different liver diseases with no previous reports in neonatal cholestasis(NC). This study aimed to measure SF in different etiologies of NC and investigate its relation to hepatic iron and fibrosis. Methods: SF was measured in 75 infants, including 50 with NC and 25 with sepsis. SF was compared between these two groups. Biochemical parameters, hepatic iron grades, and liver fibrosis and other histopathological characteristics and correlated with SF were assessed in NC group. Finally, a comparison between intrahepatic cholestasis and obstructive etiology was performed. Results: SF was elevated in NC(1598 ± 2405 ng/mL) with no significant difference from those with sepsis( P = 0.445). NC and sepsis constituted augmenting factors leading to more elevation of SF(2589 ± 3511 ng/mL). SF was significantly correlated with hepatic iron grades( r = 0.536, P ell transformation( P = 0.009) and hepatocyte swelling( P = 0.023) than those with obstructive etiology(672 ± 566 ng/mL) and their prevalent pathological findings of ductular proliferation( P = 0.003) and bile plugs( P = 0.002). SF was unrelated to the grade of liver fibrosis( P = 0.058). Conclusions: SF is non-specifically elevated in NC, with positive correlation to hepatic iron grades. SF ≥ 803.5 ng/mL can predict higher grades( ≥ grade 3) of hepatic iron. However, an active role of increased SF and hepatic iron in disease progression remains questionable.

关键词： Biliary atresia Liver fibrosis Hepatic iron grade Intrahepatic cholestasis Iron

Gastrointestinal and hepatic diseases during the COVID-19 pandemic:Manifestations,mechanism and management

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World Journal of Gastroenterology 2021年第28期27卷 4504-4535页

作者： dina Zakaria Mohamed Mai el-Sayed Ghoneim Sally el-Sayed Abu-Risha Ramy Ahmed Abdelsalam Mohamed Abdelhalem Farag Department of Pharmacology and Toxicology Faculty of PharmacyTanta UniversityTanta 31511Egypt Department of Pharmacology and Toxicology Faculty of PharmacyUniversity of Sadat CityMenoufia 32632Egypt Department of Pathology Faculty of MedicineMansoura UniversityMansoura 35511Egypt Department of Pediatrics Nebru General HospitalNebru 35511Egypt

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is considered the causative pathogen of coronavirus disease 2019(COVID-19)and has become an international danger to human *** respiratory transmission and symptoms are still the essential manifestations of COVID-19,the digestive system could be an unconventional or supplementary route for COVID-19 to be transmitted and manifested,most likely due to the presence of angiotensin-converting enzyme 2(ACE2)in the gastrointestinal *** addition,SARS-CoV-2 can trigger hepatic injury via direct binding to the ACE2 receptor in cholangiocytes,antibodydependent enhancement of infection,systemic inflammatory response syndrome,inflammatory cytokine storms,ischemia/reperfusion injury,and adverse events of treatment *** symptoms,including anorexia,nausea,vomiting,and diarrhea,which are unusual in patients with COVID-19,and some digestive signs may occur without other respiratory ***,SARS-CoV-2 can be found in infected patients’stool,demonstrating the likelihood of transmission through the fecal-oral *** addition,liver function should be monitored during COVID-19,particularly in more severe *** review summarizes the evidence for extra-pulmonary manifestations,mechanisms,and management of COVID-19,particularly those related to the gastrointestinal tract and liver.

关键词： COVID-19 Angiotensin-converting enzyme 2 Gastrointestinal Inflammatory bowel disease Liver Management

Is toxoplasmosis a potential risk factor for liver cirrhosis?

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Asian Pacific Journal of Tropical Medicine 2015年第10期8卷 768-775页

作者： Abeer Abd el-Rehim el-Henawy Ahmed Abdel-Razik Sahar Zakaria dina elhammady Niveen Saudy Manar Sobh Azab Department of Medical Parasitology Faculty of MedicineMansoura University Department of Tropical Medicine Faculty of MedicineMansoura University Department of Clinical Pathology Faculty of MedicineMansoura University

Objective:To document Toxoplasma gondii(***) antibody status in patients with liver disease,blood samples were taken from 180 hepatic patients and 180 healthy ***:Toxoplasma IgG antibody was detected using enzyme-linked immunosorbent assay and histopathological assessment of liver biopsy METAVIR score was ***:*** IgG antibodies were found in 32.8%of patients and in 22.2%of controls(P=0.02).Toxoplasma seropositivity was significantly associated with lymphadenopathy,history of blood transfusion and reflex impairment in *** hepatitis C virus(HCV)and chronic HCV-related cirrhosis groups compared to chronic HBV and chronic HBV-related cirrhosis groups expressed significantly higher prevalence of *** seropositivity(odds ratio(OR) =4;95%confidence interval(CI):1.3-12.6;P=0.013,OR=4.8;95%CI:1.5-14.9;P=0.006,respectively).Within the chronic HCV group,*** seropositivity significantly associated disease evolution as regards to METAVIR histopathological system for fibrosis and inflammation(OR=19.4;95%CI:2.3-165.2;P=0.0008,OR=0.29;95%CI:0.1-0.8;P=0.01,respectively).Albumin,international normalized ratio(INR) and platelets count were the laboratory parameters significantly altered in Toxoplasma-positrvc chronic HCV patients(P=0.00 l,0.03,0.04,respectively).Child-Pugh scoring for cirrhosis in chronic HCV group placed the majority of seropositive patient in class C with significant statistical difference compared to Child A reference group(OR= 0.08;95%67:0.01-0.5;P=0.003).Conclusions:Toxoplasma seropositivity was high in patients with cirrhosis and associated higher grades of inflammation and necrosis signifying disease evolution,suggesting that cirrhotic patients may thus form a risk group for toxoplasmosis.

关键词： Toxoplasma gondii HBV HCV Liver cirrhosis METAVIR

The Glenn Shunt Revisited, A Single Center Registry in Ain Shams University Cardiology Department

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Congenital Heart Disease 2022年第1期17卷 71-85页

作者： Mina Tewfik Maiy el-Sayed Alaa Roushdy Soha Romeih dina Ezzeldin Hebatalla Attia Cardiology Department Ain Shams UniversityCairoEgypt Prof.Magdy Yacoub Aswan Heart Centre AswanEgypt Cardiology Department Tanta UniversityTantaEgypt

Background:Bidirectional Glenn shunts have long been available as palliative procedures for patients with single ventricle physiology that is,patients unsuitable for biventricular *** our country they are performed at an older age than that recommended by the ***,we aim to assess post bidirectional Glenn shunt patients to detect the presence of any complications and to evaluate their functional ***:This was a descriptive study that included all patients who underwent a bidirectional Glenn shunt and were referred for follow up in Ain shams university *** taking including NYHA class and physical activity,clinical examination,six-minutes-walk test,laboratory investigations,full echocardiographic assessment were done for all *** patients needed invasive cardiac ***:Our registry included 178 patients who underwent bidirectional Glenn procedure referred for follow up in Ain Shams university hospital from January 2019 till July *** mean age of the registry was 18.7±8.26 years(range between 5 and 37 years),85 males(48%)and 93 females(52%).Regarding the basic anatomy,double outlet right ventricle with hypoplastic left ventricle was the ***,our descriptive study confirmed many characteristic similarities between our patients and patients in developing *** patients underwent bidirectional Glenn shunt at a median age of 6 years which is considered a relatively old age but similar to other studies that have been made in developing countries like Pakistan,India and *** is a significant delay in the operation in Egyptian patients due to lack of patients’awareness,few numbers of primary health care facilities and high economic ***:Although the presence of slight systemic desaturation,our study demonstrated a satisfactory functional capacity among our patients;thus,bidirectional Glenn can be considered an acceptable definite univentricular repair in patients

关键词： Bidirectional Glenn shunt single ventricle univentricular repair