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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel E.Ocasio Rivera dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Assessing the lifetime performance index of weighted Lomax distribution based on progressive type-Ⅱ censoring scheme for bladder cancer

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International Journal of Biomathematics 2021年第4期14卷 49-66页

作者： dina A.Ramadan Department of Mathematics Faculty of Science Mansoura UniversityMansouraEgypt

In this paper,Health-related quality of life has not been adequately measured in bladder cancer.A recently developed reliable and disease-specific quality of life instrument(Bladder Cancer Index,RCI)was used to *** type Ⅱ censoring schemes have potential usefulness in practice where budget constraints in place or there is a necessity for the speedy *** test the process capability,the lifetime performance index Cl is widely recommended for evaluating the performance of the producfs lifetime and evaluating the lifetime performance index GL for the three-parameter Weighted-Lomax distribution(WLx)under progressive type-II censoring sample for a lower specification limit(L).The statistical inference concerning CL is conducted via obtaining the maximum likelihood of Cl on the base of progressive type-II *** asymptotic normal distribution of the MLE of CL and the confidence interval is ***,the hypothesis testing of CL for evaluating the lifetime performance of WLx data is ***,assuming the conjugate prior distribution and squared error loss function,this study constructs a Bayes estimator of *** Bayes estimator of CL is then utilized to develop a credible interval in the condition of known ***,we propose a Bayesian test to assess the lifetime performance of *** also propose a Bayesian test to assess the lifetime performance of ***,two examples are given,one of them is considering a real life data of the remission times of bladder cancer patients in endurance lifetime test and the other is a simulated example to illustrate the usage of the proposed procedure.

关键词： Lifetime performance index Weighted-Lomax distribution progressively type-II right censoring

Nucleon Form Factors and N-△ Transitions in a Hypercentral Constituent Quark Model with Meson Cloud

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Communications in Theoretical Physics 2007年第3期47卷 539-546页

作者： CHEN dina-Yong DONG Yu-Bing Institute of High Energy Physics the Chinese Academy of Sciences Beijing 100049 China Gradtuate School of the Chinese Academy of Sciences Beijing 100049 China

We study the nucleon form factors and the nucleon-△（1232） transitions in a framework of hypercentral constituent quark model. The pion meson cloud effect is taken into account explicitly. Our results show that the pion cloud contributes substantially to the nucleon form factors as well as to the helicity amplitudes of △（1232）, and it gives an improved agreement compared to the experimental.

关键词： electromagnetic form factor nucleon and △(1232) hypercentral constituent quark model meson cloud

E2F transcription factors and digestive system malignancies: How much do we know?

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World Journal of Gastroenterology 2013年第21期19卷 3189-3198页

作者： Athanasios Xanthoulis dina G Tiniakos Department of Surgery Section of Gastroenterological SurgeryLevanger HospitalNord-Tr ndelag Hospital Trust7600 LevangerNorway Laboratory of Histology-Embryology Medical SchoolNational and Kapodistrian University of Athens11527 AthensGreece

E2F family of transcription factors regulates various cellular functions related to cell cycle and apoptosis. Its individual members have traditionally been classified into activators and repressors, based on in vitro studies. However their contribution in human cancer is more complicated and difficult to predict. We review current knowledge on the expression of E2Fs in digestive system malignancies and its clinical implications for patient prognosis and treatment. E2F1, the most extensively studied member and the only one with prognostic value, exhibits a tumor-suppressing activity in esophageal, gastric and colorectal adenocarcinoma, and in hepatocellular carcinoma (HCC), whereas in pancreatic ductal adenocarcinoma and esophageal squamous cell carcinoma may function as a tumorpromoter. In the latter malignancies, E2F1 immunohistochemical expression has been correlated with higher tumor grade and worse patient survival, whereas in esophageal, gastric and colorectal adenocarcinomas is a marker of increased patient survival. E2F2 has only been studied in colorectal cancer, where its role is not considered significant. E2F4's role in colorectal, gastric and hepatic carcinogenesis is tumor-promoting. E2F8 is strongly upregulated in human HCC, thus possibly contributing to hepatocarcinogenesis. Adenoviral transfer of E2F as gene therapy to sensitize pancreatic cancer cells for chemotherapeutic agents has been used in experimental studies. Other therapeutic strategies are yet to be developed, but it appears that targeted approaches using E2F-agonists or antagonists should take into account the tissue-dependent function of each E2F member. Further understanding of E2Fs' contribution in cellular functions in vivo would help clarify their role in carcinogenesis.

关键词： E2F Colorectal cancer Gastric cancer Esophageal cancer Pancreatic cancer Hepatocellular carcinoma Digestive system malignancies

Warming induced changes in wood matter accumulation in tracheid walls of spruce

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Journal of Mountain Science 2020年第1期17卷 16-30页

作者： Elena BABUSHKINA dina ZHIRNOVA Liliana BELOKOPYTOVA Eugene VAGANOV Khakass Technical Institute Siberian Federal UniversityAbakan655017Russia Siberian Federal University Krasnoyarsk 660041Russia Sukachevlnstitute of Forest Siberian Branch of Russian Academy of SciencesKrasnoyarsk 660036Russia

The warming-driven increase of the vegetation season length impacts both net productivity and phenology of plants, changing an annual carbon cycle of terrestrial ecosystems. To evaluate this influence, tree growth along the temperature gradients can be investigated on various organization levels, beginning from detailed climatic records in xylem cells’ number and morphometric parameters. In this study, the Borus Ridge of the Western Sayan Mountains(South Siberia) was considered as a forest area under rapid climate change caused by massive Sayano-Shushenskoe reservoir. Several parameters of the xylem anatomical structure in Siberian spruce(Picea obovata Ledeb.)were derived from normalized tracheidograms of cell radial diameter and cell wall thickness and analyzed during 50 years across elevational gradient(at 520,960, and 1320 m a.s.l.). On the regional scale, the main warming by 0.42°C per decade occurs during cold period(November–March). Construction of the reservoir accelerated local warming substantially since 1980, when abrupt shift of the cold season temperature by 2.6°C occurred. It led to the vegetation season beginning 3-6 days earlier and ending 4-10 day later with more stable summer heat supply. Two spatial patterns were found in climatic response of maximal cell wall thickness:(1)temperature has maximal impact during 21-day period, and its seasonality shifts with elevation in tune with temperature gradient;(2) response to the date of temperature passing +9.5°C threshold is observed at two higher sites. Climate change yielded significantly bigger early wood spruce tracheids at all sites, but its impact on cell wall deposition process had elevational gradient: maximal wall thickness increased by 7.9% at the treeline, by 18.2% mid-range,and decreased by 4.9% at the lower boundary of spruce growth;normalized total cell wall area increased by 6.2%-6.8% at two higher sites but remained stable at the lowest one. We believe that these patterns are caused by two m

关键词： Climate change Sayano-Shushenskoe Reservoir Elevational gradient Picea obovata Quantitative wood anatomy Climate–growth relationship

Constrained Fractional Variational Problems of Variable Order

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IEEE/CAA Journal of Automatica Sinica 2017年第1期4卷 80-88页

作者： dina Tavares Ricardo Almeida Delfim F.M.Torres Department of Mathematics Polytechnic Institute of Leiria Department of Mathematics University of Aveiro

Isoperimetric problems consist in minimizing or maximizing a cost functional subject to an integral *** this work, we present two fractional isoperimetric problems where the Lagrangian depends on a combined Caputo derivative of variable fractional order and we present a new variational problem subject to a holonomic constraint. We establish necessary optimality conditions in order to determine the minimizers of the fractional problems. The terminal point in the cost integral,as well as the terminal state, are considered to be free, and we obtain corresponding natural boundary conditions.

关键词： Fractional calculus fractional calculus of variations holonomic constraints isoperimetric constraints optimization variable fractional order

Responses of soil fauna community under changing environmental conditions

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Journal of Arid Land 2023年第5期15卷 620-636页

作者： KUDURETI Ayijiamali ZHAO Shuai dina ZHAKYP TIAN Changyan State Key Laboratory of Desert and Oasis Ecology Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Saken Seifullin Kazakh Agrotechnical University Astana 010000Kazakhstan

Soil faunas account for 23%of known animal species and play a crucial role in ecosystem processes such as mineralizing nutrients,regulating microbial community composition,forming soil aggregates,and enhancing primary ***,due to global climate change,population density,community composition,and distribution patterns of soil fauna *** the responses of soil fauna to major environmental change facilitate the conservation of ***,a review work of recent researches for analysing the effects of key environmental factors on soil fauna,such as warming,drought,food quality,and soil physical-chemical properties was *** most species,warming may exert a positive effect on their abundance and population development,however,it can inhibit the survival and reproduction of hibernating *** leads to low soil porosity and water holding capacity,which reduces soil fauna population and changes their community *** also can reduce the coverage of flora and alter microclimate of the soil surface,which in turn indirectly reduces fauna *** warming and elevated atmospheric carbon dioxide can reduce litter quality,which will force soil fauna to change their dietary choices(from higher-quality foods to poor quality foods)and reduce reproduction for ***,it is still predicted that enhanced species richness of plant(or litter)mixtures will positively affect soil fauna *** loss caused by the deterioration of soil physical-chemical property is primary factor affecting soil *** mainly discuss the threats of increased salinity(a major factor in arid land)to soil fauna and their potential responses to anthropogenic disturbance in saline *** increase in soil salinity can override other factors that favour habitat specialists,leading to negative effects on soil ***,we find that more studies are needed to explore the responses of soil fauna in saline soils to

关键词： biodiversity habitat soil fauna species distribution stress factors

The latest development of Sc-strengthened aluminum alloys by laser powder bed fusion

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Journal of Materials Science & Technology 2023年第18期149卷 1-17页

作者： dina Bayoumy Wenhao Kan Xinhua Wu Yuman Zhu Aijun Huang Monash Centre for Additive Manufacturing 15-17 Normanby RoadNotting HillVIC 3168Australia Department of Materials Science and Engineering Monash UniversityClaytonVIC 3800Australia

Laser powder bed fusion(LPBF)is one of the typical additive manufacturing techniques that enables the fabrication of complex-shaped structures with great freedom of *** to the challenges encoun-tered in LPBF processing of Al alloys,most studies have focused on AlSi alloys which are much easier to process but are not inherently designed for high-strength *** recent years,however,signif-icant progress has been made to develop Sc-containing Al alloys that are designed specifically for LPBF *** alloys display excellent processability and superior mechanical properties that open up a range of possible applications in industries that require high specific strength,good thermal stability,and increased *** such,this paper reviews the available literature on how Sc additions in-fluence the microstructure and properties of Al alloys when processed via LPBF and thus,aims to shed light on the considerations that have been made to achieve remarkable material consolidation alongside excellent mechanical properties,with the latter achieved through a high degree of Sc supersaturation and a great potential for nanoprecipitation.

关键词： Aluminum alloys Scandium Additive manufacturing Laser powder bed fusion Mechanical property Microstructure

Parasites of the Nile rat in rural and urban regions of Sudan

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Integrative Zoology 2009年第2期4卷 179-187页

作者： dina M.FAGIR El-Amin EL-RAYAH Department of Zoology University of KhartoumKhartoumSudan

In this investigation on endoparasites(helminths)and ectoparasites of the Nile rat(Arvicanthis niloticus Desmarest,1822),a total of 220 Nile rats were trapped from different regions of Sudan during the period January 2003–January *** of different tissues,identification of parasites,effect of these parasites on the organs,the preva-lence and intensity of infestation of the parasites and their relation to the habitat of the host,and sex-related infestations were *** showed that the variation among helminth species was wide,especially in those that are transferred by *** protozoan parasites or distortion in the infected tissues were *** examination for Toxoplasma gondii was carried *** species of cestodes(Hymenolepis nana,Hymenolepis diminuta),two genera(Raillietina sp.I,Raillietina ***)and one unidentified Hymenolepididae were *** most prevalent species of cestodes was Raillietina *** for nematodes only one species and one genus were recovered(Monanema nilotica and Streptopharagus sp.).Investigation of skin revealed that 83.8%of rats were infested with one or more of ectoparasites;namely,insects and *** survey also revealed that fleas and lice were the most common ectoparasites that infested the Nile *** rodents,particularly those living in close association with man,play a significant role in human health,welfare and *** has to be stressed that their arthropod ectoparasites are important vectors of pathogenic microorganisms and they can also be important reservoirs for parasitic zoonoses,like trichinellosis and *** doubt,the increase in rodent populations could be followed by an increase in zoonotic diseases(Stojcevic et al.2004,Durden et al.2000).Rats and mice(commensal and wild)play an important role in public health,being carriers or reservoirs for infectious diseases that can be transmitted to humans(zoonoses).Xenopsylla cheopis is the most important vector

关键词： Arvicanthis fleas lice mites Nile rat Sudan ticks.