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Application of neurotrophic and proangiogenic factors as therapy after peripheral nervous system injury

Neural Regeneration Research 2022年第6期17卷 1240-1247页

作者： Kamilla Faritovna Idrisova Alina Kazymovna Zeinalova Galina Andreevna Masgutova Alexey Andreevich Bogov Jr. Cinzia Allegrucci Valeriia Yurievna Syromiatnikova Ilnur Ildusovich Salafutdinov Ekaterna Evgenievna Garanina dina ivanovna andreeva Adilet Abdullaatovich Kadyrov Albert Anatolevich Rizvanov Ruslan Faridovich Masgutov Institute of Fundamental Medicine and Biology Kazan Federal UniversityKazanRussia Republican Clinical Hospital KazanRussia Biodiscovery Institute School of Veterinary Medicine and ScienceUniversity of NottinghamNottinghamUK Department of Traumatology and Orthopedics Kazan State Medical AcademyKazanRussia

The intrinsic ability of peripheral nerves to regenerate after injury is extremely limited,especially in case of severe injury.This often leads to poor motor function and permanent disability.Existing approaches for the treatment of injured nerves do not provide appropriate conditions to support survival and growth of nerve cells.This drawback can be compensated by the use of gene therapy and cell therapy-based drugs that locally provide an increase in the key regulators of nerve growth,including neurotrophic factors and extracellular matrix proteins.Each growth factor plays its own specific angiotrophic or neurotrophic role.Currently,growth factors are widely studied as accelerators of nerve regeneration.Particularly noteworthy is synergy between various growth factors,that is essential for both angiogenesis and neurogenesis.Fibroblast growth factor 2 and vascular endothelial growth factor are widely known for their proangiogenic effects.At the same time,fibroblast growth factor 2 and vascular endothelial growth factor stimulate neural cell growth and play an important role in neurodegenerative diseases of the peripheral nervous system.Taken together,their neurotrophic and angiogenic properties have positive effect on the regeneration process.In this review we provide an in-depth overview of the role of fibroblast growth factor 2 and vascular endothelial growth factor in the regeneration of peripheral nerves,thus demonstrating their neurotherapeutic efficacy in improving neuron survival in the peripheral nervous system.

关键词： fibroblast growth factor 2 growth factors nerve growth factor peripheral nerve injury peripheral nervous system vascular endothelial growth factor

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Physiological strategies in wild rodents:immune defenses of commensal rats

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Integrative Zoology 2024年第3期19卷 350-370页

作者： Ivana MIRKOV dina TUCOVIC Jelena KULAS Anastasija MALESEVIC Dragan KATARANOVSKI Milena KATARANOVSKI Aleksandra POPOV ALEKSANDROV Immunotoxicology Group Department of EcologyInstitute for Biological Research“Sinisa Stankovic”—National Institute of Republic of SerbiaUniversity of BelgradeBelgradeSerbia

The importance of issues associated with urban/commensal rats and mice(property damage,management costs,and health risks)press upon research on these animals.While the demography of commensal rodents is mostly studied,the need for understanding factors influencing their natural morbidity/mortality is also stressed.In this respect,more attention is expected to be paid to immunity,the physiological mechanism of defense against host survival threats(pathogens,parasites,diseases).Commensal rats and mice carry numerous pathogens that evoke diverse immune responses.The state of immunity in commensal house mice is studied in great detail,owing to the use of laboratory strains in biomedical research.Because commensal rats are,compared to mice,carriers of more zoonotic agents,rats’immunity is studied mainly in that context.Some of these zoonotic agents cause chronic,asymptomatic infections,which justified studies of immunological mechanisms of pathogen tolerance versus clearance regulation in rats.Occurrence of some infections in specific tissues/organs pressed upon analysis of local/regional immune responses and/or immunopathology.A survey of immunological activity/responses in commensal rats is given in this review,with mention of existing data in commensal mice.It should throw some light on the factors relevant to their morbidity and lifespan,supplementing the knowledge of commensal rodent ecology.

关键词： commensal rats and mice immunopathology infection inflammation tolerance

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Novel insights into D-Pinitol based therapies:a link between tau hyperphosphorylation and insulin resistance

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Neural Regeneration Research 2024年第2期19卷 289-295页

作者： dina Medina-Vera Antonio Jesús López-Gambero Juan Antonio Navarro Carlos Sanjuan Elena Baixeras Juan Decara Fernando Rodríguez de Fonseca Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND UGC Salud MentalMálagaSpain Facultad de Ciencias Universidad de MálagaMálagaSpain CIBER Enfermedades Cardiovasculares(CIBERCV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain University of Bordeaux INSERMNeurocentre MagendieBordeauxFrance Euronutra S.L.Calle Johannes Kepler MálagaSpain Departamento de Bioquímica y Biología Molecular Facultad de MedicinaUniversidad de MálagaMálagaSpain

Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s disease.The pathogenesis of Alzheimer’s disease is mainly mediated by the phosphorylation and aggregation of tau protein.Among the multiple causes of tau hyperphosphorylation,brain insulin resistance has generated much attention,and inositols as insulin sensitizers,are currently considered candidates for drug development.The present narrative review revises the interactions between these three elements:Alzheimer’s disease-tau-inositols,which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease.

关键词： Alzheimer’s disease cyclin-dependent kinase 5 diabetes D-Pinitol inositols insulin resistance kinases phosphorylation PI3K/Akt tau

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Surface Patterning of Metal Zinc Electrode with an In‑Region Zincophilic Interface for High‑Rate and Long‑Cycle‑Life Zinc Metal Anode

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Nano-Micro Letters 2024年第6期16卷 192-209页

作者： Tian Wang Qiao Xi Kai Yao Yuhang Liu Hao Fu Venkata Siva Kavarthapu Jun Kyu Lee Shaocong Tang dina Fattakhova‑Rohlfing Wei Ai Jae Su Yu Department of Electronics and Information Convergence Engineering Institute for Wearable Convergence ElectronicsKyung Hee UniversityYongin‑siGyeonggi‑do 17104Republic of Korea Frontiers Science Center for Flexible Electronics(FSCFE)and Shaanxi Institute of Flexible Electronics(SIFE) Northwestern Polytechnical University(NPU)127 West Youyi RoadXi’an 710072People’s Republic of China Institute of Energy and Climate Research:Materials Synthesis and Processing(IEK‑1) Forschungszentrum Julich GmbH52425 JulichGermany School of Chemical Engineering Sungkyunkwan University2066 Seobu‑RoJangan‑GuSuwon‑siGyeonggi‑doRepublic of Korea

The undesirable dendrite growth induced by non-planar zinc(Zn)deposition and low Coulombic efficiency resulting from severe side reactions have been long-standing challenges for metallic Zn anodes and substantially impede the practical application of rechargeable aqueous Zn metal batteries(ZMBs).Herein,we present a strategy for achieving a high-rate and long-cycle-life Zn metal anode by patterning Zn foil surfaces and endowing a Zn-Indium(Zn-In)interface in the microchannels.The accumulation of electrons in the microchannel and the zincophilicity of the Zn-In interface promote preferential heteroepitaxial Zn deposition in the microchannel region and enhance the tolerance of the electrode at high current densities.Meanwhile,electron aggregation accelerates the dissolution of non-(002)plane Zn atoms on the array surface,thereby directing the subsequent homoepitaxial Zn deposition on the array surface.Consequently,the planar dendrite-free Zn deposition and long-term cycling stability are achieved(5,050 h at 10.0 mA cm^(−2) and 27,000 cycles at 20.0 mA cm^(−2)).Furthermore,a Zn/I_(2) full cell assembled by pairing with such an anode can maintain good stability for 3,500 cycles at 5.0 C,demonstrating the application potential of the as-prepared ZnIn anode for high-performance aqueous ZMBs.

关键词： Zn metal anode Surface patterning Directional Zn deposition Aqueous Zn-I_(2)batteries

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Continuous ambulatory peritoneal dialysis telemonitoring and education:A scoping review

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Journal of Integrative Nursing 2024年第1期6卷 62-68页

作者： Muhammad Syamsul BAKHRI Yulian Wiji UTAMI dina Dewi Sartika Lestari ISMAIL Nursing Department Faculty of Health SciencesBrawijaya UniversityMalangIndonesia Dialysis Department RSUD Dr.Saiful AnwarMalangIndonesia

The risk of peritonitis complications in continuous ambulatory peritoneal dialysis(CAPD)can be prevented or reduced by providing proper education and continuous monitoring.Telemedicine and telemonitoring are methods that enable remote monitoring and patient care.This study aimed to determine the success and factors affecting telemonitoring in CAPD patient care.This study is a scoping review(ScR)using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-ScR method.Article searches were carried out on ProQuest,PubMed,and ScienceDirect with a time range of 2018-2023.Data extraction was performed regarding knowledge level,quality of life,clinical outcomes(peritonitis),and risk of hospitalization.Of the 12 articles and studies included,6 articles were related to the effect of telemonitoring on CAPD patient outcomes,and 6 articles were associated with the effect of education on CAPD patient outcomes.Education provided to patients can improve patient understanding of therapeutic modalities for renal disorders,reduce the potential for peritonitis and dialysis complications,and improve the quality of life of patients with CAPD.CAPD patients who received telemonitoring had a better quality of life,good clinical outcomes,and a lower risk of hospitalization than those who did not receive telemonitoring and had fewer health-care visits.In summary,the implementation of telemonitoring and education in chronic kidney disease patients with CAPD modality therapy has been proven effective in improving quality of life and reducing dialysis-related risks.

关键词： Clinical outcome continuous ambulatory peritoneal dialysis education peritonitis quality of life telemonitoring chronic kidney disease

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Wood anatomy chronologies of Scots pine in the foothills of the Western Sayan(Siberia)

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Journal of Forestry Research 2024年第3期35卷 13-27页

作者： Elena A.Babushkina Dmitry R.Dergunov Mikhail S.Zharkov Liliana V.Belokopytova dina F.Zhirnova Bao Yang Jingjing Liu Xiaomei Peng ·Eugene A.Vaganoy Khakass Technical Institute Siberian Federal UniversityAbakan 655017Russia Institute of Ecology and Geography Siberian Federal UniversityKrasnoyarsk 660036Russia Mathematical Methods and IT Department Siberian Federal UniversityKrasnoyarsk 660036Russia Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000People's Republic of China School of Geographic and Oceanographic Sciences Nanjing UniversityNanjing 210093People's Republic of China Department of Dendroecology V.N.Sukachev Institute of ForestSiberian Branch of the Russian Academy of ScienceKrasnoyarsk 660036Russia

Recent methodological advances in quantitative wood anatomy have provided new insights into the climatic responses of radial growth at the scale of cell structure of tree rings.This study considered long-term chronologies of tracheid measurements,indexed by a novel approach to separate their specific climatic responses from signal recorded in cell production(closely reflected in tree-ring width).To fll gaps in understanding the impact of climate on conifer xylem structure,Scots pine(Pinus sylvestris L.)trees>200 years old were selected within the forest-steppe zone in southern Siberia.Such habitats undergo mild moisture deficits and the resulting climatic regulation of growth processes.Mean and maximum values of cell radial diameter and cell wall thickness were recorded for each tree ring.Despite a low level of climatogenic stress,components of cell chronologies independent of cambial activity were separated to obtain significant climatic signals revealing the timing of the specific stages of tracheid differentiation.Cell expansion lasted from mid-April to July and was impacted similarly to tree-ring width(stimulated by precipitation and stressed by heat),maximum cell size formed late June.A switch in the climatic responses of mean anatomical traits indicated transition to latewood in mid-July.Secondary wall deposition lasted until mid-September,suppressed by end of season temperatures.Generally,anatomical climatic responses were modulated by a less dry May and September compared with summer months.

关键词： Quantitative wood anatomy Cell radial size Cell wall thickness Pinus sylvestris Climatic response

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主体教育视域下我国学科教育论课程的历史发展和现实逻辑

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湖南师范大学教育科学学报 2024年第3期23卷 34-45页

作者：裴娣娜北京师范大学教育学部北京100875

随着我国学校课程改革的深度推进,学科教育论课程的重构正在成为基础教育现代化发展的一个重要的研究议题。基于对历史的尊重和对未来的观照,探索主体教育视域下学科教育论课程建设及其教学实践范式的构建,是推进我国高品质教育实施的... 详细信息

随着我国学校课程改革的深度推进,学科教育论课程的重构正在成为基础教育现代化发展的一个重要的研究议题。基于对历史的尊重和对未来的观照,探索主体教育视域下学科教育论课程建设及其教学实践范式的构建,是推进我国高品质教育实施的重要内容。从时代转型分析和把握学科教育论在推进国家教育现代化发展中承担的责任,可以重新解读改革开放以来我国学科教育论课程发展的历史演进逻辑,揭示中国学科教育论课程体系基于主体教育视域实现研究转型的生成发展过程。通过全面梳理我国基础教育教学改革实践经验,沉淀出学科教育论课程实践中有待进一步完善的要素结构及其运作范式,继而通过学科教育论课程的重构,彰显主体教育视野下学科教育论的中国特色和当代形态。

关键词：学科教育学科教育论课程生成发展主体教育

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开源硬件获得成功

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科技纵览 2024年第4期 6-9页

作者： dina GENKINA 不详

在2024年2月,OpenTitan联盟发布了首款包含开源内置硬件安全功能的商用硅芯片.这一里程碑标志着开放硬件运动的发展又推进了一步.自2010年RISC-V开源指令集架构发布并广泛应用以来,开放硬件的普及和应用一直在拓展和加深.

关键词：硬件安全 Open 硅芯片 RISC 指令集架构开源硬件发布里程碑

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Correction: Surface Patterning of Metal ZincElectrode with an In-Region Zincophilic Interfacefor High-Rate and Long-Cycle-Life Zinc MetalAnode

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Nano-Micro Letters 2024年第7期16卷 456-457页

作者： Tian Wang Qiao Xi Kai Yao Yuhang Liu Hao Fu Venkata Siva Kavarthapu Jun Kyu Lee Shaocong Tang dina Fattakhova-Rohlfing Wei Ai Jae Su Yu Department of Electronics and Information Convergence Engineering Institute for Wearable Convergence ElectronicsKyung Hee UniversityYongin-siGyeonggi-do 17104Republic of Korea Frontiers Science Center for Flexible Electronics(FSCFE)and Shaanxi Institute of Flexible Electronics(SIFE) Northwestern Polytechnical University(NPU)127 West Youyi RoadXi’an 710072People’s Republic of China Institute of Energy and Climate Research:Materials Synthesis and Processing(IEK-1) Forschungszentrum Jülich GmbH52425 JülichGermany School of Chemical Engineering Sungkyunkwan University2066 Seobu-RoJangan-GuSuwon-siGyeonggi-doRepublic of Korea

Correction to:Nano-Micro Letters(2024)16:112 https://***/10.1007/s40820-024-01327-2 In the supplementary information the following corrections have been carried out:1.Institute of Energy and Climate Research,Materials Synthesis and Processing,Forschungszentrum Jülich GmbH,52425 Jülich,Germany.Corrected:Institute of Energy and Climate Research:Materials Synthesis and Processing(IEK-1),Forschungszentrum Jülich GmbH,52425 Jülich,Germany.

关键词： correction Zinc Electrode

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磁结能否为3D计算开辟新途径?

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科技纵览 2024年第3期 13-14页

作者： dina Genkina 不详

磁性材料中的结也许能够为下一代计算架构提供新的发展方向。为此,研究人员现在创造了一种新型磁结,它的外形像一个磁化的小肉桂螺旋粉。磁结嵌入磁性材料的方式有点像电子空穴嵌入半导体晶格,这种磁结可能会成为打破当今计算陷入2D平... 详细信息

磁性材料中的结也许能够为下一代计算架构提供新的发展方向。为此,研究人员现在创造了一种新型磁结,它的外形像一个磁化的小肉桂螺旋粉。磁结嵌入磁性材料的方式有点像电子空穴嵌入半导体晶格,这种磁结可能会成为打破当今计算陷入2D平面瓶颈的一大重要因素。在数学中,拓扑学研究的是形状和其中的空洞。例如,在拓扑学中,一个没有洞的篮球与足球等同,但与有一个洞的呼啦圈不同。拓扑的显著特性是稳健性。如果不对它施加暴力,我们就无法把足球变成呼啦圈。

关键词：拓扑学电子空穴呼啦圈磁性材料足球稳健性

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