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Supplements of an aqueous combination of Justicia adhatoda and Ocimum tenuiflorum boost antioxidative effects and impede hyperlipidemia

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Animal Models and Experimental Medicine 2020年第2期3卷 140-151页

作者： Ifrahim Iqbal Chowdhury MdAtiar Rahman Mohammad A.Hashem MMosharef Hossain Bhuiyan dina hajjar Walla Alelwani Arwa A.Makki Md.Areeful Haque Jitbanjong Tangpong M.Taher Bin Bakhtiar Department of Biochemistry and Molecular Biology University of ChittagongChittagongBangladesh Department of Biochemistry and Biotechnology University of Science and Technology ChittagongChittagongBangladesh Department of Chemistry University of ChittagongChittagongBangladesh Department of Biochemistry College of ScienceUniversity of JeddahJeddahSaudi Arabia Department of Pharmacy International Islamic University ChittagongChittagongBangladesh School of Allied Health Sciences Walailak UniversityNakhon Si ThammaratThailand Department of Pharmacy International Islamic University MalaysiaKuala LumpurMalaysia

Background: Justicia adhatoda and Ocimum tenuiflorum, locally known as bashok and tulsi, are two ethnomedicinally important herbs that have been using as dietary supplements for several therapeutic applications. This study evaluated the combined effect of both the herbs as an antioxidative and antihyperlipidemic ***: Antihyperlipidemic effect was assessed in a high-fat diet-induced hyperlipidemic model in Wistar albino rats. The rats were treated orally with extracts of bashok(J adhatoda, 200 mg/kg bw), tulshi(O tenuiflorum, 200 mg/kg bw), and a combination of bashok and tulshi(50:50), as well as with a reference drug, atorvastatin(10 mg/kg/day), with or without high-fat diet for 14 days. The antioxidative effect was studied using established in vitro models. The studies were supported by experimentally testing the effects of the extracts on membrane stabilization and inhibition of protein ***: The results showed that the serum lipid profile was significantly decreased in the different treatment groups, with bashok having the greatest effect. Body weights, total serum protein, LDH, and relative liver and adipose tissue weights were markedly restored towards baseline values, the lowest atherogenic index being achieved with the combined extract. The combination treatment significantly enhanced total phenolic content and antioxidative capacity and greatly potentiated membrane stabilization, but inhibition of protein denaturation was not significantly ***: The data demonstrate that a combination of Justicia adhatoda and Ocimum tenuiflorum could be developed as a food supplement with antioxidative and antihyperlipidemic benefits.

关键词： antihyperlipidemic antioxidative capacity high-fat fed diet-induced hyperlipidemia Justicia adhatoda membrane stabilization Ocimum tenuiflorum

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