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Complementary and alternative medications in hepatitis C infection

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World Journal of Hepatology 2014年第1期6卷 9-16页

作者： dina L Halegoua-De Marzio Jonathan M Fenkel Division of Gastroenterology and Hepatology Thomas Jefferson University Hospital

Chronic hepatitis C(CHC) infection affects almost 3% of the global population and can lead to cirrhosis, liver failure, and hepatocellular carcinoma in a significant number of those infected. Until recently, the only treatments available were pegylated interferon and ribavirin, which traditionally were not very effective and have considerable side effects. For this reason, interest in complementary and alternative medications(CAM) in the management of hepatitis C has been investigated. Some CAM has demonstrated therapeutic potential in chronic hepatitis C treatment. Unfortunately, some CAM has been shown to have the potential to cause drug-induced liver injury. This article will review and evaluate many of the natural molecules that interact with the hepatitis C virus(HCV) life cycle and discuss their potential use and safety in HCV therapy, as well as highlight some important interactions between medical and complementary treatments.

关键词： Hepatitis C infection Natural molecules Direct acting antivirals Hepatotoxicity Herbal treatments

A new algorithm for the diagnosis of celiac disease

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Cellular & Molecular Immunology 2011年第2期8卷 146-149页

作者： Orit Rozenberg Aaron Lerner Avi Pacht Maya Grinberg dina Reginashvili Clara Henig Mira Barak Central Laboratory of Haifa and Western Galilee Clalit Health Services and Pediatric GastroenterologyHaifaIsrael Nutrition Unit Carmel Medical CenterHaifaIsrael Technion-Israel Institute of Technology HaifaIsrael

Celiac disease(CD)affects at least 1%of the Western population but remains largely *** our laboratory,we utilize a novel algorithm to diagnose pediatric CD that offers both high sensitivity and high specificity for diagnosis in an outpatient *** aim of the present study was to challenge this algorithm and to test its performance in children and adults suspected of having *** a three-assay algorithm,screening with the most sensitive tissue transglutaminase(tTG)complexed with deamidated gliadin peptide neoepitope immunoglobulin A(IgA)1IgG assay and confirming with the two specific tTG IgA and tTG IgA1IgG assays,we examined the serological results from 112 children aged 0–17 years old and 60 adults in comparison to their respective biopsy *** algorithm performance was calculated by statistical *** use of the new algorithm enabled us to diagnose CD with 98%sensitivity,93%specificity and 95%accuracy in the pediatric group and 94%sensitivity,92%specificity and 93%accuracy in the total population *** false-negative cases in the adult group were attributed to previous adherence to a gluten-free diet,and the single false-negative result in a young child became a true positive after 6 *** have also monitored three celiac patients before and after diagnosis and found that the algorithm may be suitable for disease *** newly proposed three-assay algorithm for celiac detection is very reliable in both children and *** to the high performance of this assay,the further need for confirmatory intestinal biopsies will be reassessed.

关键词： celiac disease diagnosis intestinal histopathology sensitivity specificity tissue transglutaminase

The Two Cultures of Science: Implications for University-Industry Relationships in the U.S. Agriculture Biotechnology

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Journal of Integrative Agriculture 2014年第2期13卷 455-466页

作者： William B Lacy Leland L Glenna dina Biscotti Rick Welsh Kate Clancy University of California State College Pennsylvania State University Syracuse University Johns Hopkins University

Partnerships between U.S. universities and industries have existed for several decades and in recent years have become generally more varied, wider in scope, more aggressive and experimental and higher in public visibility. In addition, in the last few decades, public and private interests have advocated for government policies and laws to globally promote the commercialization of university science. This paper examines the persistence or convergence of the two cultures of science and the implications of this commercialization for university-industry relationships in agriculture biotechnology. The perceptions and values of over 200 U.S. university and industry scientists, managers and administrators who participate in or oversee research collaborations in agricultural biotechnology were analyzed. The findings revealed that the participants in these research relationships continue to perceive very distinct cultures of science and identify a wide range of concerns and disadvantages of these partnerships. Several actions were discussed to ensure that the two cultures serve complementary roles and that they maximize the public benefits from these increasing collaborations.

关键词： two cultures of science agricultural biotechnology university-industry relationships

Variant signaling topology at the cancer cell–T-cell interface induced by a two-component T-cell engager

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Cellular & Molecular Immunology 2021年第6期18卷 1568-1570页

作者： dina Kouhestani Maria Geis Saed Alsouri Thomas GPBumm Hermann Einsele Markus Sauer Gernot Stuhler Department of Internal Medicine II Hematology and OncologyUniversity Clinic WürzburgWürzburgGermany Department of Biotechnology and Biophysics University WürzburgWürzburgGermany

Bispecific T-cell-engaging antibodies(BiTEs)convey antigenic information from cancer to the T-lymphocyte-associated CD3 complex,thus redirecting immune effector cells to induce target cell *** antigenic information from transformed tissues is rarely unambiguous,we recently introduced novel T-cell-engaging antibody fragments called hemibodies for the combinatorial,ultraprecise targeting of cancer.1 Here,we report the unprecedented enhancement of the plasticity of immunological synapse(IS)formation and variant signaling topology at the cancer cell–T-cell interface induced by hemibodies compared to that induced by BiTEs.

关键词： cancer interface topology

The Glenn Shunt Revisited, A Single Center Registry in Ain Shams University Cardiology Department

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Congenital Heart Disease 2022年第1期17卷 71-85页

作者： Mina Tewfik Maiy El-Sayed Alaa Roushdy Soha Romeih dina Ezzeldin Hebatalla Attia Cardiology Department Ain Shams UniversityCairoEgypt Prof.Magdy Yacoub Aswan Heart Centre AswanEgypt Cardiology Department Tanta UniversityTantaEgypt

Background:Bidirectional Glenn shunts have long been available as palliative procedures for patients with single ventricle physiology that is,patients unsuitable for biventricular *** our country they are performed at an older age than that recommended by the ***,we aim to assess post bidirectional Glenn shunt patients to detect the presence of any complications and to evaluate their functional ***:This was a descriptive study that included all patients who underwent a bidirectional Glenn shunt and were referred for follow up in Ain shams university *** taking including NYHA class and physical activity,clinical examination,six-minutes-walk test,laboratory investigations,full echocardiographic assessment were done for all *** patients needed invasive cardiac ***:Our registry included 178 patients who underwent bidirectional Glenn procedure referred for follow up in Ain Shams university hospital from January 2019 till July *** mean age of the registry was 18.7±8.26 years(range between 5 and 37 years),85 males(48%)and 93 females(52%).Regarding the basic anatomy,double outlet right ventricle with hypoplastic left ventricle was the ***,our descriptive study confirmed many characteristic similarities between our patients and patients in developing *** patients underwent bidirectional Glenn shunt at a median age of 6 years which is considered a relatively old age but similar to other studies that have been made in developing countries like Pakistan,India and *** is a significant delay in the operation in Egyptian patients due to lack of patients’awareness,few numbers of primary health care facilities and high economic ***:Although the presence of slight systemic desaturation,our study demonstrated a satisfactory functional capacity among our patients;thus,bidirectional Glenn can be considered an acceptable definite univentricular repair in patients

关键词： Bidirectional Glenn shunt single ventricle univentricular repair

MAFLD Not NAFLD is Associated with Impairment of Health-related Quality of Life

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Journal of Clinical and Translational Hepatology 2022年第1期10卷 4-5页

作者： dina Attia Nadia Abdel Aty Ahmed Shawket Ebada Said Yasser Fouad Department of Gastroenterology Hepatology and Endemic MedicineFaculty of MedicineBeni-Suef UniversityEgypt Department of Gastroenterology Hepatology and Endemic MedicineFaculty of MedicineAin Shams UniversityEgypt Department of Gastroenterology Hepatology and Endemic MedicineFaculty of MedicineAssiut UniversityEgypt Depart-ment of Gastroenterology Hepatology and Endemic MedicineFaculty of MedicineBenha UniversityEgypt Department of Gastroenterology Hepatology and Endemic MedicineFaculty of MedicineMinia UniversityEgypt

Citation of this article:Attia D,Aty NA,Shawket A,Said E,Fouad *** Not NAFLD is Associated with Impairment of Health-related Quality of Life.J Clin Transl Hepatol 2022;10(1):***:10.14218/*** the Editor,We read with great interest the article by Yu et al.1 who reported that the metabolic dysfunction-associated fatty liver disease(MAFLD)criteria are more practical and im-prove the identification of high-risk patients with fatty liver disease compared with the previous nonalcoholic fatty liver disease(NAFLD)criteria.

关键词： NAFLD Quality MAF

Radiolabeling, docking studies, in silico ADME and biological evaluation of serotonin with 125I for 5-HTRs imaging

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Nuclear Science and Techniques 2020年第8期31卷 64-71页

作者： dina M.El-Sharawy Marwa S.El Refaye H.Hussien Asmaa M.AboulMagd Labeled Compounds Department Hot Lab.CenterEgyptian Atomic Energy Authority(EAEA)P.O.Box 13759CairoEgypt Radioactive Isotopes and Generators Department Hot Lab.CenterEgyptian Atomic Energy Authority(EAEA)P.O.Box 13759CairoEgypt Cyclotron Project Nuclear Research CenterCairoEgypt Pharmaceutical Chemistry Department Faculty of PharmacyNahda UniversityBeni SuefEgypt Pharmaceutics and Clinical Pharmacy Department Faculty of PharmacyNahda UniversityBeni SuefEgypt

Serotonin is one of the significant signaling molecules used by several neural systems in the gut and brain. This study aimed to develop a novel and potent tracer for targeting, detecting, and imaging serotonin receptors(5-HTRs), which is a promising tool in the determination of the receptor’s function and relationship with the diseases related to serotonin and its receptor dysfunction. Serotonin was effectively labeled via a direct electrophilic substitutional reaction using an oxidizing agent such as iodogen with 125I in a neutral medium, and 125I-serotonin was achieved with a maximum labeling yield of 91 ± 0.63% with in vitro stability up to 24 h. Molecular modeling was conducted to signify 125I-serotonin structure and confirm that the radiolabeling process did not affect serotonin binding ability to its receptors. Biodistribution studies show that the maximum gastro intestinal tract uptake of 125I-serotonin was 17.8 ± 0.93% ID/organ after 30 min postinjection and the tracer’s ability to pass the blood–brain barrier. Thus, 125I-serotonin is a promising single photon emission computed tomography tracer in the detection of 5 HTRs.

关键词： Serotonin Electrophilic substitution Molecular modeling 5HTRs

氢氧化钠对地质聚合物制备及高温力学性能影响

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环境科学与技术 2024年第5期47卷 46-54页

作者：李洁伊元荣刘伟李春辉迪娜·加阿拜佳素然·阿比利米提亚夏尔新疆大学生态与环境学院新疆乌鲁木齐830046 新疆绿洲生态教育部重点实验室新疆乌鲁木齐830046 新疆精河温带荒漠生态系统教育部野外科学观测研究站新疆乌鲁木齐830046

该研究旨在探索锂辉石尾矿与精炼渣的资源化利用新途径。通过单因素实验和正交实验,分析了氢氧化钠添加量、水玻璃添加量和锂辉石尾矿与精炼渣掺量比对地质聚合物力学性能的影响。在此基础上,重点分析了氢氧化钠添加量对锂辉石尾矿-精... 详细信息

该研究旨在探索锂辉石尾矿与精炼渣的资源化利用新途径。通过单因素实验和正交实验,分析了氢氧化钠添加量、水玻璃添加量和锂辉石尾矿与精炼渣掺量比对地质聚合物力学性能的影响。在此基础上,重点分析了氢氧化钠添加量对锂辉石尾矿-精炼渣基地质聚合物制备力学性能的影响,采用XRD、SEM、FT-IR等表征手段分析了氢氧化钠对地质聚合物微观结构的影响。研究结果表明,锂辉石尾矿与精炼渣掺比量为7∶3、水玻璃添加量为15 mL、氢氧化钠添加量为2 g的条件下,制备地质聚合物28 d抗压强度可达26.78 MPa。氢氧化钠添加量对地质聚合物制备的影响最为显著,当锂辉石尾矿的碱度过高时,会减缓或抑制硅氧四面体和铝氧四面体的溶出,从而影响了C-S-H凝胶和N-A-S-H凝胶的合成。XRD和SEM分析显示,随着氢氧化钠含量的增加,生成的凝胶先增多后减少,同时与蓝晶石等物质结合,提高了地质聚合物的致密程度。此外,在800℃下,锂辉石尾矿-精炼渣基地质聚合物的抗压强度损失较小,表明其具有良好的耐高温性能。

关键词：锂辉石尾矿精炼渣氢氧化钠添加量凝胶物质地质聚合物

Staging of portal hypertension and portosystemic shunts using dynamic nuclear medicine investigations

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World Journal of Gastroenterology 2008年第24期14卷 3841-3848页

作者： Mircea Dragoteanu Ioan A Balea Liliana A dina Cecilia D Piglesan Ioana Grigorescu Stefan Tamas Sabin O Cotul Department of Nuclear Medicine "ProfessorDr. Octavian Fodor" Clinical Emergency Hospital Resident doctor in nuclear medicine "ProfessorDr. Octavian Fodor" Clinical Emergency Hospital Department of Internal Medicine "ProfessorDr. Octavian Fodor" Clinical Emergency Hospital

AIM： To explore portal hypertension and portosystemic shunts and to stage chronic liver disease （CLD） based on the pathophysiology of portal hemodynamics. METHODS： Per-rectal portal scintigraphy （PRPS） was performed on 312 patients with CLD and liver angioscintigraphy （LAS） on 231 of them. The control group included 25 healthy subjects. We developed a new model of PRPS interpretation by introducing two new parameters, the liver transit time （LTT） and the circu-lation time between right heart and liver （RHLT）. LTT for each lobe was used to evaluate the early portal hypertension. RHLT is useful in cirrhosis to detect liver areas missing portal inflow. We calculated the classical per-rectal portal shunt index （PRSI） at PRPS and the hepatic perfusion index （HPI） at LAS. RESULTS： The normal LTT value was 24 ± 1 s. Abnormal LTT had PPV = 100% for CLD. Twenty-seven noncirrhotic patients had LTT increased up to 35 s （median 27 s）. RHLT （42 ± 1 s） was not related to liver disease. Cirrhosis could be excluded in all patients with PRSI 〈 5% （P 〈 0.01）. PRSI 〉 30% had PPV = 100% for cirrhosis. Based on PRPS and LAS we propose the classification of CLD in 5 hemodynamic stages. Stage 0 is normal （LTT = 24 s, PRSI 〈 5%）. In stage 1, LTT is increased, while PRSI remains normal. In stage 2, LTT is decreased between 16 s and 23 s, whereas PRSI is increased between 5% and 10%. In stage 3, PRSI is increased to 10%-30%, and LTT becomes undetectable by PRPS due to the portosystemic shunts. Stage 4 includes the patients with PRSI 〉 30%. RHLT and HPI were used to subtype stage 4. In our study stage 0 had NPV = 100% for CLD, stage 1 had PPV = 100% for non-cirrhotic CLD, stages 2 and 3 represented the transition from chronic hepatitis to cirrhosis, stage 4 had PPV = 100% for cirrhosis. CONCLUSION： LTT allows the detection of early portal hypertension and of opening of transhepatic shunts. PRSI is useful in CLD with extrahepatic portosystemic shunts. Our hemodynamic model stages the evolution

关键词： Chronic liver disease Portal hypertension Portosystemic shunts Per-rectal portal scintigraphy Angioscintigraphy