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World Journal of Gastroenterology 2006年第26期12卷 4264-4266页

作者： dimitrios Siablis Zafiria G Papathanassiou dimitrios Karnabatidis Nikolaos Christeas Konstantinos Katsanos Constantine Vagianos Departments of Interventional Radiology and Surgery University Hospital of Patras RioGreece

Splenic arteriovenous fistula （SAVF） accounts for an unusual but well-documented treatable cause of portal hypertension. A case of a 50-year-old multiparous female who developed suddenly portal hypertension due to SAVF formation is presented. The patient suffered from repeated episodes of haematemesis and melaena during the past twelve days and thus was emergently admitted to hospital for management. Clinical and laboratory investigations established the diagnosis of portal hypertension in the absence of liver parenchymal disease. Endoscopy revealed multiple esophageal bleeding varices. Abdominal computed tomography （CT） and transfemoral celiac arteriography documented the presence of a tortuous and aneurysmatic splenic artery and premature filling of an enlarged splenic vein, findings highly suggestive of an SAVF. The aforementioned vascular abnormality was successfully treated with percutaneous transcatheter embolization. Neither recurrence nor other complications were observed.

关键词： Splenic artery aneurysm Splenic arteriovenous fistula Portal hypertension Transcatheter embolizaUon

Surgical dilemmas in the management of colorectal liver metastases: the role of timing

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World Journal of Gastroenterology 2016年第21期22卷 4963-4965页

作者： dimitrios Dimitroulis Gregory Kouraklis Second Department of Surgery University of Athens Medical SchoolAthens GreeceLaiko Hospital11527 AthensGreece

Colorectal cancer(CRC) is an emerging health problem in the Western World both for its raising tendency as well as for its metastatic potential. Almost half of the patients with CRC will develop liver metastases during the course of their disease. The liver surgeon dealing with colorectal liver metastases faces several surgical dilemmas especially in the setting of the timing of operation. Synchronous resectable metastases should be treated prior or after induction chemotherapy? Furthermore in the case of synchronous colorectal liver metastases which organ should we first deal with, the liver or the colon? All these questions are set in the editorial and impulse for further investigation is put focusing on multidisciplinary approach and individualization of treatment modalities.

关键词： Colorectal cancer Chemotherapy Timing of surgery Colorectal liver metastases Liver first procedure Multidisciplinary approach Individualized treatment strategies

Pseudopolyps in inflammatory bowel diseases: Have we learned enough?

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World Journal of Gastroenterology 2017年第9期23卷 1541-1551页

作者： dimitrios S Politis Konstantinos H Katsanos Epameinondas V Tsianos dimitrios K Christodoulou Department of Gastroenterology University Hospital of IoanninaFaculty of MedicineSchool of Health SciencesUniversity of Ioannina45110 IoanninaGreece

Pseudopolyps are a well described entity in the literature and even though the exact pathogenesis of their formation is not completely understood, they are considered non-neoplastic lesions originating from the mucosa after repeated periods of inflammation and ulceration associated with excessive healing processes. Their occurrence is less common in Crohn's disease than in ulcerative colitis, and their overall prevalence ranges from 4% to 74%; moreover, they are found more often in colon but have been detected in other parts of the gastrointestinal tract as well. When their size exceeds the arbitrary point of 1.5 cm, they are classified as giant pseudopolyps. Clinical evaluation should differentiate the pseudopolyps from other polypoid lesions, such as the dysplasiaassociated mass or lesion, but this situation represents an ongoing clinical challenge. Pseudopolyps can provoke complications such as bleeding or obstruction, and their management includes medical therapy, endoscopy and surgery; however, no consensus exists about the optimal treatment approach. Patients with pseudopolyps are considered at intermediate risk for colorectal cancer and regular endoscopic monitoring is recommended. Through a review of the literature, we provide here a proposed classification of the characteristics of pseudopolyps.

关键词： Pseudopolyps Inflammatory polyps Post-inflammatory polyps Giant pseudopolyps Ulcerative colitis Inflammatory bowel disease Crohn’s disease Classification Dysplasia-associated mass or lesion

GC-NICI-MS analysis of acetazolamide and other sulfonamide (R-SO2-NH2)drugs as pentafluorobenzyl derivatives [R-SO2-N(PFB)2] and quantification of pharmacological acetazolamide in human urine

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Journal of Pharmaceutical Analysis 2020年第1期10卷 49-59页

作者： Olga Begou Kathrin Drabert Georgios Theodoridis dimitrios Tsikas Institute of Toxicology Core Unit ProteomicsHannover Medical SchoolCarl-Neuberg-Strasse 1D-30625HannoverGermany Department of Chemistry Aristotle University of Thessaloniki54124ThessalonikiGreece BIOMIC_AUTh Center for Interdisciplinary Research and Innovation(CIRI-AUTH)Balkan Center10th Km Thessaloniki-Thermi RdP.O.Box 8318GR 57001ThessalonikiGreece

Acetazolamide(molecular mass(MM),222)belongs to the class of sulfonamides(R-SO2-NH2)and is one of the strongest pharmacological inhibitors of carbonic anhydrase *** is excreted unchanged in the ***,we report on the development,validation and biomedical application of a stable-isotope dilution GC-MS method for the reliable quantitative determination of acetazolamide in human *** method is based on evaporation to dryness of 50 mL urine aliquots,base-catalyzed derivatization of acetazolamide(d0-AZM)and its internal standard[acetylo-2H3]acetazolamide(d3-AZM)in 30 vol%pentafluorobenzyl(PFB)bromide in acetonitrile(60 min,30C),reconstitution in toluene(200 mL)and injection of 1-mL *** negative-ion chemical ionization(NICI)mass spectra(methane)of the PFB derivatives contained several intense ions including[M]‒at m/z 581 for d0-AZM and m/z 584 for d3-AZM,suggesting derivatization of their sulfonamide groups to form N,N-dipentafluorobenzyl derivatives(R-SO2-N(PFB)2),i.e.,d0-AZM-(PFB)2 and d3-AZM-(PFB)2,*** was performed by selected-ion monitoring of m/z 581 and 83 for d0-AZM-(PFB)2 and m/z 584 and 86 for d3-AZM-(PFB)*** limits of detection and quantitation of the method were determined to be 300 fmol(67 pg)and 1 mM of acetazolamide,***-and inter-assay precision and accuracy for acetazolamide in human urine samples in pharmacologically relevant concentration ranges were determined to be 0.3%e4.2%and 95.3%e109%,*** method was applied to measure urinary acetazolamide excretion after ingestion of a 250 mg acetazolamide-containing tablet(Acemit®)by a healthy *** other tested sulfonamide drugs,methazolamide(MM,236)was also found to form a N,N-dipentafluorobenzyl derivative,whereas dorzolamide(MM,324)was hardly *** GC-MS peaks were obtained from the PFB bromide derivatization of hydrochlorothiazide(MM,298),xipamide(MM,355),indapamide and metholazone(MM,366 each)or br

关键词： Acetazolamide Derivatization Quantification Sulfonamides Validation

Barring the gates to the battleground:DDR1 promotesimmune exclusion in solid tumors

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Signal Transduction and Targeted Therapy 2022年第2期7卷 339-340页

作者： dimitrios L.Wagner Enrico Klotzsch Berlin Center for Advanced Therapies(BeCAT)and BIH Center for Regenerative Therapies(BCRT) Charité-Universitätsmedizin BerlinAugustenburger Platz 113353BerlinGermany Institute for Biology Experimental Biophysics/MechanobiologyHumboldt University of BerlinBerlinGermany Laboratory of Applied Mechanobiology Department for Health Sciences and TechnologyETH ZurichZurichSwitzerland

In a recent article in Nature,Sun et al.1 identify a novel mechanism of how solid tumors prevent immune cell infiltration into cancer tissue by ***,they develop and test a new monoclonal antibody that may be used as a... 详细信息

关键词： tumors immune

Appetite for Natech Risk Information in Japan:Understanding Citizens'Communicative Behavior Towards Risk Information Disclosure Around Osaka Bay

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International Journal of Disaster Risk Science 2022年第3期13卷 372-390页

作者： dimitrios Tzioutzios Jeong-Nam Kim Ana Maria Cruz Department of Urban Management Graduate School of EngineeringKyoto UniversityKyoto615-8540Japan Gaylord College of Journalism and Mass Communication University of OklahomaNormanOK73019USA Disaster Prevention Research Institute Kyoto UniversityKyoto611-0011Japan

Effective risk communication is essential for disaster risk *** from empowering communities to make informed risk choices,risk information disclosure can also drastically enhance their disaster preparedness,especially concerning conjoint scenarios of technological and natural hazards(Natech).A fundamental precondition is the actual demand for such *** study ventures to assess whether residents around Osaka Bay have this demand,or"appetite,"for risk information disclosure,as well as to understand their communicative behavior and perceived challenges in the Japanese context through the prism of the Situational Theory of Problem *** test this framework under realistic conditions,data were collected through a household questionnaire survey from two urban areas near industrial complexes in Osaka *** results show that identifying Natech risk information deficiency as a problem was not a statistically significant predictor for individuals'motivation to ***,their motivation increased as their perceived personal involvement with the situation rose,while the perceived obstacles in doing something about it exerted a negative influence on their ***'motivation intensified their communicative actions to solve this *** segmentation underscored the elevated public perceptions concerning the issue of risk information deficiency in nearly nine out of ten *** findings indicate a strong community appetite for chemical and Natech risk information,which subsequently led to high situational motivation to engage in communicative action,particularly information *** management policy is suggested to focus on introducing chemical risk information disclosure regulatory initiatives to encourage citizen engagement.

关键词： Japan Natech risk information Participatory risk management Risk communication Situational Theory of Problem Solving(STOPS)

Indications,limitations and maneuvers to enable extended hepatectomy:Current trends

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World Journal of Gastroenterology 2014年第24期20卷 7887-7893页

作者： dimitrios Dimitroulis Petros Tsaparas Serena Valsami dimitrios Mantas Eleftherios Spartalis Charalampos Markakis Gregory Kouraklis Second Department of Propedeutic Surgery Athens University Medical School"Laiko" Hospital11527 AthensGreece Blood Transfusion Department Athens University Medical SchoolAreteion Hospital11527 AthensGreece

The liver is a solid organ with a wide variety of primary benign or malignant tumors as well as metastatic *** resection of these tumors remains the only curative *** limitations,however,do not allow the performance of these *** review evaluates the indications and limitations regarding these extended hepatic resections,as well as describing all the manipulations that increase the candidates for such operations.A thorough review of the literature was performed in order to define indications for extended hepatectomy,as well as to present all methods that contribute to increasing the volume of the future remnant *** role of portal vein ligation,portal vein embolization,two-stage hepatectomy,and in situ liver transection are evaluated in the setting of indications and *** hepatectomies are a necessity due to oncological *** methods developed in order to increase the volume of the remnant liver are safe and *** situ liver transection is a novel and revolutionary two-step procedure for extended hepatic *** clinical studies are required to estimate long-term results and the oncological basis of this technique.

关键词： Extended hepatectomy Portal vein ligation Remnant liver volume

SGLT-2 Inhibitor and GLP-1 Receptor Agonist Treatment for Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: Is Their Combination the Optimal Treatment Option?

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Journal of Clinical and Translational Hepatology 2022年第4期10卷 574-576页

作者： dimitrios Patoulias Theodoros Michailidis Second Propedeutic Department of Internal Medicine Aristotle University of ThessalonikiGeneral Hospital“Hippokration”ThessalonikiGreece Second Department of Internal Medicine Aristotle University of ThessalonikiGeneral Hospital“Hip-pokration”ThessalonikiGreece

Citation of this article:Patoulias D,Michailidis ***-2 Inhibitor and GLP-1 Receptor Agonist Treatment for Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabe-tes Mellitus:Is Their Combination the Optimal T... 详细信息

关键词： Patients Liver Receptor

Mucins in neoplasms of pancreas,ampulla of Vater and biliary system

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World Journal of Gastrointestinal Oncology 2016年第10期8卷 725-734页

作者： dimitrios Moschovis Giorgos Bamias Ioanna Delladetsima Department of Gastroenterology Agios Panteleimon General Hospital Academic Department of Gastroenterology Medical SchoolNational and Kapodistrian University of AthensLaikon Hospital First Department of Pathology Medical SchoolNational and Kapodistrian University of Athens

Tumors of the pancreas,the ampulla of Vater,and the extrahepatic and intrahepatic bile ducts have significant histological similarities due to the common embryonic origin of the pancreatobiliary *** obviates the need for discovery of biomarkers with diagnostic and prognostic value for these ***,especially MUC-1,-2,-4 and-5AC,are important candidates for developing into such reliable *** expression of MUC1 occurs in pancreatic ductal adenocarcinomas and is associated with increased degrees of dysplasia in pancreatic intraepithelial neoplasia(Pan IN).Positive expression of MUC2 in intraductal papillary mucinus neoplasms(IPMN) of the intestinal type indicates high potential progression to invasive carcinoma with de novo expression of MUC1,while absence of MUC2 expression in IPMNs of gastric type implies low potential to malignant *** novo MUC4 expression correlates to the severity of dysplasia in Pan IN and is associated with a poor prognosis in patients with pancreatic ductal *** biliary intraepithelial neoplasia(Bil IN),increased expression of MUC1 is associated with higher degrees of *** cholangiocarcinomas(ICC) are characterized by increased expression of all glycoforms of *** MUC2 expression in intraductal papillary neoplasm of the bile ducts(IPNB) of the intestinal type indicates high malignant potential with de novo expression of MUC1 in the invasive *** MUC2 expression in any degree of Bil IN may prove useful in differentiating them from *** novo expression of MUC4 is associated with poor prognosis in patients with ICC or carcinoma of the extrahepatic bile ducts(EHBDC).High de novo expression of MUC5 AC is found in all degrees of Bil IN and all types of IPNB and *** MUC5 AC is useful in the detection of neoplastic lesions of the bile duct at an early *** expression of mucin MUC1 in carcinoma of the ampulla of Vater associated with unfavorable b

关键词： Ampulla Vater neoplasms Biliary system neoplasms Mucins Pancreatic neoplasms

Beneficial effect of an antibody against interleukin-2 receptor (daclizumab) in an experimental model of hepatocyte xenotransplantation

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World Journal of Gastroenterology 2007年第9期13卷 1435-1437页

作者： dimitrios Papagoras Apostolos Papalois Alexandra Tsaroucha dimitrios Lytras John Kyriazanos Nikoletta Giannakou Prodromos Laftsidis Constantine Simopoulos 2~(nd) Department of Surgery Medical School "Democritus" University of Thrace AlexandroupolisGreece 2~(nd) Department of Surgery Medical School "Democritus" University of Thrace AlexandroupolisGreeceExperimental-Research Department Elpen Pharmaceuticals Athens Greece Department of Pathology "Aghia Olga" General Hospital AthensGreece

AIM: To investigate the use of Daclizumab (Dmab) as an immunosuppressive agent in an experimental model of hepatocyte xenotransplantation (XenoTx) in rats with fulminant hepatic failure (FHF). METHODS: Two white male New Zealand rabbits were used as donors and 68 Wistar rats as recipients. FHF was induced by intravenous application of dimethylnitrosamine (DMNA). The isolated hepatocytes of the rabbits were xenotransplanted into the spleen of the rats 24 h after FHF induction. Group A (n = 13): no treatment; Group B (n = 14): FHF and XenoTx; Group C (n = 14): FHF and XenoTx and cyclosporin (CsA); Group D (n = 14): FHF and XenoTx and Dmab; Group E (n = 13): FHF and XenoTx and CsA and Dmab. The rats were followed for 15 d. RESULTS: Statistical analysis showed better survival among groups D (92.86%) and E (76.92%) compared to group A (all rats died after 72 h), group B (28.57%) or group C (71.43%), although the differences were not statistically significant. Biochemical evaluation of the liver enzymes and histology confirmed satisfactory function and engraftment, respectively. CONCLUSION: This experimental model has shown the safe, effective and beneficial use of Dmab in a xenotransplantation model of rabbit hepatocytes in rats.

关键词： Transplantation Hepatocytes Daclizumab Cyclosporin