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An Updated Mini Review on Grapefruit: Interactions with Drugs, Obesity and Cardiovascular Risk Factors

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Food and Nutrition Sciences 2014年第4期5卷 376-381页

作者： dimitrios papandreou Andry Phily Department of Life and Health Science University of Nicosia Nicosia Cyprus. Department of Natural Science & Public Health Zayed University Abu Dhabi UAE

The paper examines the effects of grapefruit consumption in relation to drugs, obesity and cardiovascular risk factors. The review includes the most updated studies found in Pub-Med. The grapefruit effect refers to the ability of grapefruit juice and supplements to interact with a wide variety of pharmaceuticals, either enhancing or limiting their systemic availability. Due to altering the active dosage of the pharmaceutical, Grapefruit juice is commonly not allowed to be used alongside with many drugs. Naringin is the most important one, which can inhibit absorption of some drugs but more commonly 6’7’-dihydroxybergamottin, which inhibits CYP3A4. Lately, grapefruit has been found both in rats and adults to reduce body weight, blood pressure, improve lipid and hepatic profile and decrease platelet aggregation. These promising results must be followed by additional studies in order to add to the importance of the role and effects of grapefruit as part of our diet.

关键词： Grapefruit Drug Interactions Obesity Cardiovascular Risk Factors

The Role of Soluble, Insoluble Fibers and Their Bioactive Compounds in Cancer: A Mini Review

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Food and Nutrition Sciences 2015年第1期6卷 1-11页

作者： dimitrios papandreou Zujaja Tul Noor Maitha Rashed Department of Natural Sciences & Public Health CSSH Zayed University Abu Dhabi UAE

The cancer incidence has risen dramatically over the last decades. About 8 million people died globally according to latest reports, which represented almost 40% more than it was 20 years ago. Risk factors for the development of cancer have been found to include smoking, alcohol, drugs, obesity and diet. Fiber intake has shown to exhibit chemoprotective effects on cancer proliferation and metastasis that may seem to be very promising. This article will review the role of different types of fiber such as, cellulose, lignin, pectin and inulin in development and prevention of different types of cancers. This article would also discuss the effectiveness of both types of fiber in cancer prevention.

关键词： Fiber Cancer Insoluble Soluble Bioactive Compounds

Validation of a Food Frequency Questionnaire for Vitamin D and Calcium Intake in Healthy Female College Students

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Food and Nutrition Sciences 2014年第21期5卷 2048-2052页

作者： dimitrios papandreou Nikolaos Rachaniotis Maryam Lari Wafa Al Mussabi Department of Natural Sciences & Public Health College of Sustainability Sciences and Humanities (CSSH) Zayed University Abu Dhabi UAE

Objective: The objective of this study was to examine the reproducibility and validity of a Food Frequency Questionnaire (FFQ) and assess calcium and vitamin D intake in health female college students. Methods: Thirty-five healthy female students were conveniently selected to participate in the study. None of the subjects were taking any supplements. The FFQ was validated against intakes from a three-day diet food record report (FR). Results: Positive correlations were observed of daily vitamin D (r = 0.82, p –8, 9, p < 0.676 and 43 mg/d (95% CI: 20, 65, p < 0.01). Conclusions: The FFQ used in this study shows promising validation evidence to be used in the future for assessing vitamin D and calcium intakes in female students.

关键词： Vitamin D Calcium Food Frequency Questionnaire Osteoporosis Diabetes Type 2 Female Students

Bone and brain metastases from ampullary adenocarcinoma

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World Journal of Gastroenterology 2009年第21期15卷 2665-2668页

作者： Ioannis A Voutsadakis Stergios Doumas Konstantinos Tsapakidis Maria Papagianni Christos N papandreou Division of Medical Oncology University Hospital of Larissa

Ampullary carcinoma is the second most common cancer of the peri-ampullary area after pancreatic carcinoma and metastasizes mostly intra-abdominally and to the ***-abdominal metastases are less *** this report we describe the case of a patient with resected adenocarcinoma of the ampulla of Vater who developed skeletal metastases in the lower extremity and brain *** briefly discuss aspects of this comparatively rare gastrointestinal malignancy.

关键词： Adenocarcinoma Ampulla of Vater Peri-ampullary Metastases Prognosis

Colonic duplication in adults: Report of two cases presenting with rectal bleeding

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World Journal of Gastroenterology 2005年第32期11卷 5072-5074页

作者： C Fotiadis M Genetzakis I papandreou EP Misiakos E Agapitos GC Zografos 3rd Department of SurgeryUniversity of Athens School of MedicineAthensGreece 1st Department of Propedeutic SurgeryUniversity of Athens School of MedicineHippokration HospitalAthensGreece Department of PathologyUniversity of Athens School of MedicineAthensGreece

Gastrointestinal duplication is an uncommon congenital abnormality in two-thirds of cases manifesting before the age of 2 years. Ileal duplication is common while colonic duplication, either cystic or tubular, is a rather unusual clinical entity that remains asymptomatic and undiagnosed in most cases. Mostly occurring in pediatric patients,colonic duplication is encountered in adults only in a few cases. This study reports two cases of colonic duplication in adults. Both cases presented with rectal bleeding on admission. The study was focused on clinical, imaging,histological, and therapeutical aspects of the presenting cases. Gastrografin enema established the diagnosis in both cases. The cystic structure and the adjacent part of the colon were excised en-block. The study implies that colonic duplication, though uncommon, should be included in the differential diagnosis of rectal bleeding.

关键词： Colonic duplication Gastrointestinal bleeding

Sigmoid schwannoma: A rare case

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World Journal of Gastroenterology 2005年第32期11卷 5079-5081页

作者： Constantine I.Fotiadis Ilias A.Kouerinis Ioannis papandreou George C.Zografos George Agapitos Third Department of Propaudeutic SurgeryUniversity of Athens Sotiria HospitalAthens Greece First Department of Propaudeutic SurgeryUniversity of Athens Hippokration HospitalAthensGreece Third Department of Propaudeutic SurgeryUniversity of Athens Sotiria HospitalAthensGreece

Schwannomas are rare tumors derived from the cells of Schwann that form the neural sheath. When located in the gastrointestinal tract, they constitute together with leiomyoma, leiomyoblastoma, and leiomyosarcoma, the gastrointestinal stromal tumors (GIST). Peripheral nerve sheath tumors represent 2-6% GIST with most common location, the stomach and the small intestine. Schwannomas of the colon and rectum are extremely rare and radical excision with wide margins is mandatory, due to their tendency to recur locally and become malignant, if left untreated. In the present study, we report a rare case of a sigmoid schwannoma, which was successfully treated in our department and reviewed the literature.

关键词： Schwannoma Rectum GIST Tumor Prognosis Treatment

Complex knee injuries treated in acute phase: Long-term results using Ligament Augmentation and Reconstruction System artificial ligament

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World Journal of Orthopedics 2018年第3期9卷 24-34页

作者： John Gliatis Konstantinos Anagnostou Pantelis Tsoumpos Evdokia Billis Maria papandreou Spyridon Plessas Department of Orthopaedic University Hospital of Patras Department of Physical Therapy Technological Educational Institute of Western Greece Department of Physiotherapy Technological Educational Institute of Athens Department of Orthopaedic General Hospital of Nikaia "Snt.Panteleimon"

AIM To present the long-term results of complex knee injuries, treated early using the Ligament Augmentation and Reconstruction System(LARS) artificial ligament to reconstruct posterior cruciate ligament(PCL).METHODS From September 1997 to June 2010, thirty-eight complex knee injuries were treated, where early arthroscopic PCL reconstructions were undergone, using the LARS(Surgical Implants and Devices, Arc-sur-Tille, France) artificial ligament. Exclusion criteria were: Late(> 4 wk) reconstruction, open technique, isolated PCL reconstruction, knee degenerative disease, combinedfracture or vascular injury and use of allograft or autograft for PCL reconstruction. Clinical and functional outcomes were assessed with IKDC Subjective Knee Form, KOS-ADLS questionnaire, Lysholm scale and SF-12 Health Survey. Posterior displacement(PD) was measured with the Telos Stress Device. RESULTS Seven patients were excluded; two because of coexisting knee osteoarthritis and the remaining five because of failure to attend the final follow-up. The sample consisted of 31 patients with mean age at the time of reconstruction 33.2 ± 12.5 years(range 17-61). The postoperative follow-up was on average 9.27 ± 4.27 years(range 5-18). The mean average IKDC and KOS scores were 79.32 ± 17.1 and 88.1 ± 12.47% respectively. Average PD was 3.61 ± 2.15 mm compared to 0.91 ± 1.17 mm in the uninjured knees(one with grade 1+ and two with grade 2 +). Dial test was found positive in one patient, whereas the quadriceps active drawer test was positive in three patients. None was tested positive on the reverse-pivot shift test. The range of motion(ROM) was normal in thirty knees, in comparison with the contralateral one. There was no extension deficit. Osteoarthritic changes were found in three knees(9.6%).CONCLUSION Early treatment of complex knee injuries, using LARS artificial ligament for PCL reconstruction sufficiently reduces posterior tibia displacement and provides satisfactory long-term functional o

关键词： Complex knee injuries Posterior cruciate ligament Acute reconstruction Ligament Augmentation and Reconstruction System

Neuroendocrine differentiation and the ubiquitinproteasome system in cancer:Partners or enemies?

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World Journal of Experimental Medicine 2011年第1期1卷 7-9页

作者： Panagiotis J Vlachostergios Christos N papandreou Department of Medical Oncology University of Thessaly School of MedicineUniversity Hospital of LarissaBiopolis 41110LarissaGreece

Neuroendocrine(NE)differentiation of cancer and deregulation of the ubiquitin-proteasome system(UPS)are two processes that have been independently linked to the development of aggressive and treatment-resistant *** data suggest a plausible interconnection between these two mechanisms,based on indirect evidence of neuropeptide-induced effects on UPS,reversed by proteasome inhibition and deubiquitinaselike properties of NE *** the model of their exact interactions is one of the keys to targeting the NE malignant phenotype more effectively.

关键词： Neuroendocrine differentiation Ubiquitin Proteasome Cancer

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欧盟关于内幕交易和市场操纵的指令

公司法律评论 2005年第1期 147-158页

作者：井涛沈华勤宋筱琦 P.COX G.papandreou 不详

(2003/6号颁布于2003年1月28日) 欧洲议会和欧盟理事会,根据《建立欧洲共同体的条约》,特别是其中第95条,欧盟委员会的建议,欧盟经济和社会委员会的意见,到欧洲中央银行的意见,按照第251(4)条规定的程序,考虑到:(1)一个真正的金融服务... 详细信息

(2003/6号颁布于2003年1月28日) 欧洲议会和欧盟理事会,根据《建立欧洲共同体的条约》,特别是其中第95条,欧盟委员会的建议,欧盟经济和社会委员会的意见,到欧洲中央银行的意见,按照第251(4)条规定的程序,考虑到:(1)一个真正的金融服务的统一大市场对于欧共体的经济发展和促进就业至关重要。

关键词：经济指令市场意见社会规定理事会内幕委员会金融服务