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Microproteinuria in patients with inflammatory bowel disease:Is it associated with the disease activity or the treatment with 5-aminosalicylic acid?

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World Journal of Gastroenterology 2006年第5期12卷 739-746页

作者： Androniki c Poulou Konstantinos E Goumas dimitrios c Dandakis Ioannis Tyrmpas Maria Panagiotaki Androniki Georgouli dimitrios c soutos Athanasios Archimandritis Gastroenterology Department of Red cross Hospital of Athens Athanasaki 111521 AthensGreece 2~(nd) Department of Internal Medicine University of Athens Medical School"Hippokratio"General Hospital11521 AthensGreece

AIM： To investigate whether microproteinuria in patients with inflammatory bowel disease （IBD） is associated with the disease activity or the treatment with 5-aminosalicylic acid （5-ASA）. METHODS： We prospectively studied microproteinuria in 86 consecutive patients with IBD, 61 with ulcerative colitis （Uc） and 25 with crohn＇s disease （cD）, before as well as 2 and 6 months after their inclusion in the study. Forty-six patients received 5-ASA for a period of 28.8 months （range 1-168 too）. Microalbuminuria （mALB） and urine levels of the renal tubular proteins β2-microglobulin （β2mGLB） and β-N-acetyI-D-glucosamidase （β-NAG） as well as the creatinine clearance were determined in a 12-h overnight urine collection. Tumor necrosis factor-α （TNF-α） serum levels were also measured. RESULTS： A total of 277 measurements （194 in Uc patients and 83 in cD patients） were performed. The prevalence of abnormal microoproteinuria in Uc and cD patients was 12.9% and 6.0% for mALB, 22.7% and 27.7% for B2mGLB, and 11.3% and 8.4% for β-NAG, respectively, mALB was not associated with IBD activity. β2mGLB and B-NAG urine levels were correlated to Uc activity （UcAI： P〈0.01; UcEI： P〈0.005）. mALB in Uc patients and β-NAG urine levels in cD patients were related to TNF-α serum levels. An association was noticed between microproteinuria and smoking habit. Treatment with 5-ASA was not correlated to the severity of microproteinuria or to the changes of creatinine clearance.cONcLUSION： Microproteinuria is mainly associated with Uc and its activity but not affected by 5-ASA.

关键词： Inflammatory bowel disease Microproteinuria 5-aminosalicylic acid

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