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How can ecosystem engineer plants boost productivity in east Mediterranean drylands

Ecological Processes 2023年第1期12卷 425-437页

作者： Elena Constantinou dimitrios Sarris Magda Psichoudaki Javier Cabello Ioannis N.Vogiatzakis Faculty of Pure&Applied Sciences Open University of Cyprus2252 NicosiaCyprus KES Research Centre 1055 NicosiaCyprus KES College 1055 NicosiaCyprus Nireas-International Water Research Center University of CyprusP.O.Box 205371678 NicosiaCyprus Andalusian Center for the Assessment and Monitoring of Global Change University of Almería04120 AlmeríaSpain Department of Biology and Geology University of Almería04120 AlmeríaSpain.

Background Water availability is the key limiting factor for plant productivity in drylands covering ca.40%of Earth’s land *** such ecosystems to retain productivity and biodiversity under climatic change,it would be valu-able to identify/promote keystone plant species that(i)have developed strategies to more efficiently utilize moisture resources not easily accessible and(ii)improve moisture conditions for neighboring *** very deep-rooted Ziziphus lotus,considered an ecosystem engineer,is one such ***,it is not known which biotic traits:(a)canopy interception of moisture/rainfall,(b)hydraulic redistribution of deep ground moisture by roots,or non-biotic factors:(c)soil’s volume,and(d)organic matter content,*** activates/modulates to play such a ***,thus,selected dryland ecosystems where the plant dominates and measured for potential effects on the less deep-rooted Thymbra *** assessing impacts on ecosystem productivity,we measured the spatial aggregation of ca.3600 *** *** a proxy for soil moisture availability and its spatial variability,we conducted a 7-year-long study using thymes’nighttime *** extended up to 15 m away from *** The density of *** plants growing up to 5 m around *** *** growing 10-15 m away was found significantly increased(2.5-4.5 times),while their stem/leaf moisture was ca.10%higher at predawn compared to nightfall during the dry *** suggests that ecosystem productivity is driven by a greater soil moisture avail-ability around *** permitting more thyme daytime transpiration,in contrast to thymes growing further *** phenomenon appeared only under dry topsoil(during the dry season;becoming stronger during dry years).Morning dew/rainfall interception from the canopy or soil depth/organic matter did not show significant effects,leaving only the hydraulic lift properties of *** as the most likely driver for soil moisture avail

关键词： Plant–plant interaction Desertification Mediterranean Dryland Moisture content Deep root Ziziphus lotus Stress-gradient

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Modified TiO_(2) based photocatalysts for improved air and health quality

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Journal of Materiomics 2017年第1期3卷 3-16页

作者： Vassilios Binas Danae Venieri dimitrios Kotzias George Kiriakidis Institute of Electronic Structure and Laser Foundation for Research and Technology HellasP.O.Box 152771110 HeraklionGreece Crete Center for Quantum Complexity and Nanotechnology Department of PhysicsUniversity of CreteP.O.Box 220871003 HeraklionGreece School of Environmental Engineering Technical University of CreteGR-73100 ChaniaGreece Joint Research Centre Institute for Health and Consumer ProtectionVia Germania 29Ispra21027 VAItaly

Photocatalysis with modified titania is a promising approach to improve both air and health *** titania with novel photocatalytic properties under indoor light irradiation leads to smart coatings,which are benchmark materials suitable for their indoor *** is generally accepted that the photocatalytic activity is affected by the light absorption,charge creation/recombination rate and surface *** this contribution we focus on modified TiO_(2) as catalyst in heterogeneous photocatalytic processes and address the efficiency of TiO_(2)-based building and construction materials on the removal of environmental pollutants indoors and *** also present data on the presence of eventually formed,toxicologically relevant and harmful by-products as the result of the photo-induced degradation of pollutants in an effort for better evaluation of induced risks for human health from the application of TiO_(2) modified ***,we present recent results on the disinfection performance of these material and the inactivation of severe pathogens contained in water and indoor air environments.

关键词： Photocatalysis Indoor air quality Visible light photocatalyst Disinfection

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Risk of colorectal neoplasm in patients with acromegaly: A meta-analysis

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World Journal of Gastroenterology 2008年第22期14卷 3484-3489页

作者： Theodoros Rokkas dimitrios Pistiolas Panos Sechopoulos Georgios Margantinis Georgios Koukoulis Gastroenterology Clinic Henry Dunant Hospital 107 Messogion Ave. Athens 11526 Greece

AIM: To examine the risk of colorectal neoplasm in acromegalic patients by meta-analyzing all relevant controlled studies. METHODS: Extensive English language medical literature searches for human studies, up to December 2007, were performed using suitable keywords. Pooled estimates [odds ratio (OR) with 95% confidence intervals (CI)] were obtained using either the fixed or random-effects model as appropriate. Heterogeneity between studies was evaluated with the Cochran Q test whereas the likelihood of publication bias was assessed by constructing funnel plots. Their symmetry was estimated by the adjusted rank correlation test. RESULTS: For hyperplastic polyps the pooled ORs with 95% CI were 3.557 (2.587-4.891) by fixed effects model and 3.703 (2.565-5.347) by random effects model. The Z test values for overall effect were 7.81 and 6.984, respectively (P < 0.0001). For colon adenomas the pooled ORs with 95% CI were 2.486 (1.908-3.238) (fixed effects model) and 2.537 (1.914-3.364) (random effects model). The Z test values were 6.747 and 6.472, respectively (P < 0.0001). For colon cancer the pooled OR with 95% CI was identical for both fixed and random effects model (OR, 4.351; 95% CI, 1.533-12.354; Z = 2.762, P = 0.006]. There was no significant heterogeneity and no publication bias in all the above meta-analyses. CONCLUSION: Acromegaly is associated with an increased risk of colorectal neoplasm.

关键词： Acromegaly Colon cancer Colon polyps Colon neoplasia Meta-analysis

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Short benign ileocolonic anastomotic strictures-management with bi-flanged metal stents:Six case reports and review of literature

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World Journal of Clinical Cases 2022年第28期10卷 10162-10171页

作者： Panagiotis Kasapidis Georgios Mavrogenis dimitrios Mandrekas Fateh Bazerbachi Department of Gastroenterology and Endoscopy Unit Central Clinic of AthensAthens 10680Greece Department of Gastroenterology Mediterraneo HospitalGlyfadaAthens 16685Greece Department of Surgery National and Kapodistrian University of AthensAthens 11527Greece Department of Surgery Attendant of Central Clinic of AthensAthens 10680Greece CentraCare Interventional Endoscopy ProgramSt Cloud HospitalSt CloudMN 56301United States

BACKGROUND The endoscopic management of benign short post-anastomotic ileocolonic stricture(PAICS) that is refractory to primary and secondary treatment modalities remains *** lumen-apposing metal stent(LAMS) is a novel device recently developed for therapeutic gastrointestinal *** have demonstrated significantly better results with regard to stent migration than fully covered self-expandable metal stents(FCSEMSs).CASE SUMMARY This article presents six cases of symptomatic PAICS successfully treated with a LAMS and a review of the relevant *** report a life-saving technique not previously documented and the use of technology to improve patient *** six patients(median age,75 years) suffered from vomiting,constipation and recurrent abdominal pain,with symptoms starting 23-25 wk *** median stricture length was 1.83 *** six patients underwent successful and uneventful bi-flanged metal stent(BFMS)-LAMS placement for benign *** patients remained asymptomatic during the three months of stent indwelling and up to a median of 7 mo after stent *** to the literature,the application of LAMS for PAICS is associated with a < 10% risk of migration and a < 5% risk of ***,FCSEMS has a high migration rate(15%-50%).CONCLUSION The evolving role of interventional endoscopy and the availability of LAMSs provide patients with minimally invasive treatment options,allowing them to avoid more invasive surgical *** BFMS(NAGI stent) is longer and larger than the prototype AXIOS-LAMS,which should be considered in the management of short ileocolonic post-anastomotic strictures longer than 10 mm and shorter than 30 mm.

关键词： Bi-flanged metal stent Lumen-apposing metal stent Anastomotic ileocolonic stricture Selfexpanding metal stent Endoscopic innovation Case report

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Concept of histone deacetylases in cancer:Reflections on esophageal carcinogenesis and treatment

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World Journal of Gastroenterology 2018年第41期24卷 4635-4642页

作者： dimitrios Schizas Aikaterini Mastoraki Leon Naar Eleftherios Spartalis Diamantis I Tsilimigras Georgia-Sofia Karachaliou George Bagias dimitrios Moris 1^st Department of Surgery Laikon General HospitalNational and Kapodistrian University of AthensAthens 11527Greece 4^th Department of Surgery Attikon University HospitalNational and Kapodistrian University of AthensAthens 12462Greece Laboratory of Experimental Surgery and Surgical Research National and Kapodistrian University of AthensAthens 11527Greece Department of General Visceral and Transplant SurgeryUniversity Hospital EssenEssen 45141Germany Department of Surgery Duke University Medical CenterDurhamNC 27710United States

Esophageal cancer (EC) presents a high mortality rate, mainly due to its aggressive nature. Squamous cell carcinoma is the most common histological type world-wide, though, a continuous increase in esophageal adenocarcinomas has been noted in the past decades. Common risk factors associated with EC include smoking, alcohol consumption, gastroesophageal reflux disease, Barrett's esophagus and obesity. In an effort to overcome chemotherapy resistance in oncology, it was discovered that histone acetylation/deacetylation equilibrium is altered in carcinogenesis, leading to changes in chromatin structure and altering expression of genes important in the cell cycle, differentiation and apoptosis. Based on this knowledge, histone acetylation was addressed as a potential novel chemotherapy drug target to repress cancer cell proliferation. There are four classes of histone deacetylases (HDACs) inhibitors with a variety of different mechanisms of actions that render them possible anticancer drugs. They arrest the cell cycle, inhibit differentiation and angiogenesis and induce apoptosis. They do not necessarily act on histone proteins, since they can also exert indirect anti-cancer effects, by modifying various cellular *** addition,HDACs have also been associated with increased chemotherapy *** on the literature,HDACs have been associated with EC,with surveys revealing that increased expression of certain HDACs correlates with advanced TNM stages,tumor grade,metastatic potential and decreased 5-year overall and disease-free *** aim of this survey is to elucidate the molecular identity and mechanism of action of HDAC inhibitors as well as verify their potential utility as anti-cancer agents in esophageal cancer.

关键词： Esophageal cancer Histone deacatylases Inhibitors Drugs

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Clock genes:Their role in colorectal cancer

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World Journal of Gastroenterology 2014年第8期20卷 1986-1992页

作者： Theodoros Karantanos George Theodoropoulos dimitrios Pektasides Maria Gazouli First Department of Propaedeutic Surgery School of MedicineUniversity of Athens11725 AthensGreece Second Pathology Department School of MedicineUniversity of Athens11725 AthensGreece Department of Basic Medical Science Laboratory of BiologySchool of MedicineUniversity of Athens11725 AthensGreece

Clock genes create a complicated molecular time-keeping system consisting of multiple positive and negative feedback loops at transcriptional and translational levels. This circadian system coordinates and regulates multiple cellular procedures implicated in cancer development such as metabolism, cell cycle and DNA damage response. Recent data support that molecules such as CLOCK1, BMAL1 and PER and CRY proteins have various effects on c-Myc/p21 and Wnt/β-catenin pathways and influence multiple steps of DNA damage response playing a critical role in the preservation of genomic integrity in normal and cancer cells. Notably, all these events have already been related to the development and progression of colorectal cancer (CRC). Recent data highlight critical correlations between clock genes’ expression and pathogenesis, progression, aggressiveness and prognosis of CRC. Increased expression of positive regulators of this circadian system such as BMAL1 has been related to decrease overall survival while decreased expression of negative regulators such as PER2 and PER3 is connected with poorer differentiation, increased aggressiveness and worse prognosis. The implications of these molecules in DNA repair systems explain their involvement in the development of CRC but at the same time provide us with novel targets for modern therapeutic approaches for patients with advanced CRC.

关键词： Clock genes Colorectal cancer Development Prognosis

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Graft choices for anterolateral ligament knee reconstruction surgery: Current concepts

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World Journal of Clinical Cases 2022年第24期10卷 8463-8473页

作者： Byron Chalidis Charalampos Pitsilos dimitrios Kitridis Panagiotis Givissis 1^(st)Orthopaedic Department Aristotle University of ThessalonikiSchool of MedicineThessaloniki 57010Greece 2^(nd)Orthopaedic Department Aristotle University of ThessalonikiSchool of MedicineThessaloniki 54635Greece

The anterolateral ligament(ALL)is a primary structure of the anterolateral complex of the knee that contributes to internal rotational stability of the *** of the ALL is commonly associated with rupture of the anterior cruciate *** left untreated,ALL lesions may lead to residual anterolateral rotational instability of the knee after anterior cruciate ligament reconstruction,which is a common cause of anterior cruciate ligament graft *** function of the ALL can be restored by lateral extraarticular tenodesis or anterolateral ligament reconstruction(ALLR).In the lateral extraarticular tenodesis procedure,a strip of the iliotibial band is placed in a non-anatomical position to restrain the internal rotation of the tibia,while in ALLR,a free graft is fixed at the insertion points of the native *** and semitendinosus grafts have mainly been utilized for ALLR,but other autografts have also been ***,allografts and synthetic grafts have been applied to minimize donor-site morbidity and maximize the size and strength of the ***,there has been no strong evidence to fully support one method over another thus *** present review presents a detailed description of the graft choices for ALLR and the current literature available in regard to the effectiveness and outcomes of published surgical techniques.

关键词： Anterolateral ligament Reconstruction Lateral extraarticular tenodesis Anterior cruciate ligament Hamstrings Gracilis Semitendinosus

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Dispersive Shallow Water Wave *** I:Model Derivation on a Globally Flat Space

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Communications in Computational Physics 2018年第1期23卷 1-29页

作者： Gayaz Khakimzyanov Denys Dutykh Zinaida Fedotova dimitrios Mitsotakis Institute of Computational Technologies Siberian Branch of the Russian Academy of SciencesNovosibirsk 630090Russia LAMA UMR 5127 CNRSUniversitéSavoie Mont BlancCampus Scientifique73376 Le Bourget-du-Lac CedexFrance Victoria University of Wellington School of MathematicsStatistics and Operations ResearchPO Box 600Wellington 6140New Zealand

In this paperwe reviewthe history and current state-of-the-art in modelling of long nonlinear dispersive *** the sake of conciseness of this review we omit the unidirectional models and focus especially on some classical and improved BOUSSINESQ-type and SERRE-GREEN-NAGHDI ***,we propose also a unified modelling framework which incorporates several well-known and some less known dispersive wave *** present manuscript is the first part of a series of two *** second part will be devoted to the numerical discretization of a practically important model on moving adaptive grids.

关键词： Long wave approximation nonlinear dispersive waves shallow water equations solitary waves

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Autoimmune liver serology:Current diagnostic and clinical challenges

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World Journal of Gastroenterology 2008年第21期14卷 3374-3387页

作者： dimitrios P Bogdanos Diego Vergani Pietro Invernizzi Ian R Mackay Institute of Liver Studies King's College London School of Medicine at King's College HospitalDenmark Hill CampusLondon SE5 9RSUnited Kingdom Institute of Liver Studies King’s College London School of Medicine at King’s College HospitalDenmark Hill CampusLondon SE5 9RSUnited Kingdom Division of Internal Medicine and Liver Unit San Paolo Hospital School of MedicineUniversity of Mi-lanMilan 20142Italy Department of Biochemistry and Molecular Bi-ology Monash UniversityClaytonVictoria 3800Australia

Liver-related autoantibodies are crucial for the correct diagnosis and classification of autoimmune liver diseas-es(AiLD),namely autoimmune hepatitis types 1 and 2(AIH-1 and 2),primary biliary cirrhosis(PBC),and the sclerosing cholangitis variants in adults and ***-1 is specified by anti-nuclear antibody(ANA) and smooth muscle antibody(SMA).AIH-2 is specified by antibody to liver kidney microsomal antigen type-1(anti-LKM1) and anti-liver cytosol type 1(anti-LC1).SMA,ANA and anti-LKM antibodies can be present in de-novo AIH following liver *** is specified by antimitochondrial antibodies(AMA) react-ing with enzymes of the 2-oxo-acid dehydrogenase complexes(chiefly pyruvate dehydrogenase complex E2 subunit) and disease-specific ANA mainly react-ing with nuclear pore gp210 and nuclear body *** cholangitis presents as at least two variants,first the classical primary sclerosing cholangitis(PSC) mostly affecting adult men wherein the only(and non-specific) reactivity is an atypical perinuclear antineutro-phil cytoplasmic antibody(p-ANCA),also termed peri-nuclear anti-neutrophil nuclear antibodies(p-ANNA) and second the childhood disease called autoimmune sclerosing cholangitis(ASC) with serological features resembling those of type 1 *** diagnostic serol-ogy is a fast-expanding area of investigation as new purified and recombinant autoantigens,and automatedtechnologies such as ELISAs and bead assays,become available to complement(or even compete with) tradi-tional immunofluorescence *** survey for the first time global trends in quality assurance impact-ing as it does on(1) manufacturers/purveyors of kits and reagents,(2) diagnostic service laboratories that fulfill clinicians' requirements,and(3) the end-user,the physician providing patient care,who must properly interpret test results in the overall clinical context.

关键词： Autoantigen Autoimmune hepatitis Auto-antibody Primary biliary cirrhosis Primary sclerosing cholangitis Liver disease

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Low rectal cancer:Sphincter preserving techniques-selection of patients,techniques and outcomes

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World Journal of Gastrointestinal Oncology 2015年第7期7卷 55-70页

作者： Nikoletta Dimitriou Othon Michail dimitrios Moris John Griniatsos 1st Department of Surgery University of AthensMedical SchoolLaiko Hospital

Low rectal cancer is traditionally treated by abdominoperineal resection. In recent years, several new techniques for the treatment of very low rectal cancer patients aiming to preserve the gastrointestinal continuity and to improve both the oncological as well as the functional outcomes, have been emerged. Literature suggest that when the intersphincteric resection is applied in T1-3 tumors located within 30-35 mm from the anal verge, is technically feasible, safe, with equal oncological outcomes compared to conventional surgery and acceptable quality of life. The Anterior Perineal Plan E for Ultra-low Anterior Resection technique, is not disrupting the sphincters, but carries a high complication rate, while the reports on the oncological and functional outcomes are limited. Transanal Endoscopic Micro Surgery(TEM) and Trans Anal Minimally Invasive Surgery(TAMIS) should represent the treatment of choice for T1 rectal tumors, with specific criteria according to the NCCN guidelines and favorable pathologic features. Alternatively to the standard conventional surgery, neoadjuvant chemo-radiotherapy followed by TEM or TAMIS seems promising for tumors of a local stage T1sm2-3 or T2. Transanal Total Mesorectal Excision should be performed only when a board approved protocol is available by colorectal surgeons with extensive experience in minimally invasive and transanal endoscopic surgery.

关键词： Low rectal cancer Sphincter preservingsurgery Intersphincteric resection Anterior PerinealPlanE for Ultra-low Anterior Resection of the Rectum Total mesorectal excision TransAnal Minimally InvasiveSurgery Transanal Total Mesorectal Excision Quality oflife Oncological outcome Functional outcome

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