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Histone deacetylase inhibitors as a novel therapeutic approach for pheochromocytomas and paragangliomas

Oncology Research 2022年第5期30卷 211-219页

作者： ASPASIA MANTA SPYRIDON KAZANAS STEFANOS KARAMAROUDIS HELEN GOGAS dimitrios C.ZIOGAS Endocrine Unit Second Department of Internal Medicine Propaedeutic&Research InstituteMedical SchoolNational and Kapodistrian University of AthensAttikon University HospitalAthens12461Greece First Department of Internal Medicine Medical SchoolNational and Kapodistrian University of AthensLaikon General HospitalAthens11527Greece Department of Obstetrics&Gynecology General Hospital of Elefsina ThriassioElefsina19600Greece

Epigenetic mechanisms,such as DNA methylation and histone modiﬁcations(e.g.,acetylation and deacetylation),are strongly implicated in the carcinogenesis of various *** transcription,the expression and functionality of coding gene products are altered following the histone acetylation and *** processes are regulated by histone acetyltransferases(HATs)and histone deacetylases(HDACs),*** inhibitors(HDACis)have been developed as promising therapeutic agents,to limit exposure to traditional and toxic chemotherapies and offer more alternatives for some speciﬁc malignant diseases with limited ***,these agents affect many intracellular pathways,including cell cycle arrest,apoptosis and differentiation,and their mechanism of action mainly depends on the type of ***,ﬁve HDACis have been approved for the treatment of several hematological malignancies(e.g.,T-cell lymphoma subtypes and multiple myeloma);while,many of them are tested for further therapeutic indications in solid tumors(e.g.,colorectal,thyroid,breast,lung and pancreatic cancer).Herein,we review the literature and gather all available evidence,from in vitro and in vivo data to clinical trial results,that recognizes the antitumor activity of HDACis on pheochromocytomas and paragangliomas;and supports their clinical implementation in the treatment of these rare neuroendocrine tumors at metastatic setting.

关键词： HDACis HDAC inhibitors Neuroendocrine tumors Epigenetics Histone deacetylation Cancer

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Long noncoding RNAs in mesenchymal stromal/stem cells osteogenic differentiation:Implications in osteoarthritis pathogenesis

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World Journal of Stem Cells 2022年第6期14卷 429-434页

作者： Daniel Quintero Hugo C Rodriguez Anish G Potty dimitrios Kouroupis Ashim Gupta Department of Orthopaedics Division of Sports MedicineUniversity of MiamiMiller School of MedicineMiamiFL 33136United States Holy Cross Orthopedic Institute:Fort Lauderdale Practice Oakland ParkFL 33334United States South Texas Orthopedic Research Institute LaredoTX 78045 United States Diabetes Research Institute Cell Transplant CenterUniversity of MiamiMiller School of MedicineMiamiFL 33136United States BioIntegrate LawrencevilleGA 30043United States Future Biologics LawrencevilleGA 30043United States

This letter focuses on a recently published article that provided an exceptional description of the effect of epigenetic modifications on gene expression patterns related to skeletal system ***,it discusses a novel modality of epigenetic regulation,the long noncoding RNAs(lncRNAs),and provides evidence of their involvement in mesenchymal stromal/stem cells osteo-/adipogenic differentiation *** focus on lncRNAs,there is an emerging cross talk between lncRNAs and miRNAs interaction as a novel mechanism in the regulation of the function of the musculoskeletal system,by controlling bone homeostasis and bone regeneration,as well as the osteogenic differentiation of stem ***,we touched on some examples to demonstrate this *** addition,we believe there is still much to discover from the effects of lncRNAs on progenitor and non-progenitor cell *** incorporated data from other published articles to review lncRNAs in normal progenitor cell osteogenic differentiation,determined lncRNAs involved in osteoarthritis pathogenesis in progenitor cells,and provided a review of lncRNAs in non-progenitor cells that are differentially regulated in *** conclusion,we really enjoyed reading this article and with this information we hope to further our understanding of lncRNAs and mesenchymal stromal/stem cells regulation.

关键词： Long noncoding RNAs Epigenetics Mesenchymal stromal/stem cells Degenerative bone diseases Osteoarthritis Osteoporosis

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钢筋混凝土结构的耐久性和服役寿命预测（英文）

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硅酸盐学报 2015年第10期43卷 1408-1419页

作者： Luping TANG Peter UTGENANNT dimitrios BOUBITSAS Chalmers University of Technology SE-412 96 Gothenburg Sweden CBI Swedish Cement and Concrete Research Institute SE-100 44 Stockholm Sweden

介绍了钢筋混凝土结构在氯离子渗透、碳化和冻融侵蚀作用下的耐久性和服役寿命预测模型。过去几年有关组织或国际学术委员会提出了大量的混凝土结构耐久性设计模型。为了在混凝土结构耐久性设计过程中，能够安全地使用此类模型，需要通... 详细信息

介绍了钢筋混凝土结构在氯离子渗透、碳化和冻融侵蚀作用下的耐久性和服役寿命预测模型。过去几年有关组织或国际学术委员会提出了大量的混凝土结构耐久性设计模型。为了在混凝土结构耐久性设计过程中，能够安全地使用此类模型，需要通过分析和比较长期暴露在不同气候条件下的混凝土劣化现场数据，对预测模型的可用性进行验证。在本文中，对混凝土抗氯离子渗透、碳化和冻融侵蚀的各种模型进行了简要阐述。通过暴露时间超过20年的露天场数据，以及约使用了30年的公路桥的现场数据，对包括简单ERFC模型、DuraCrete模型和ClinConc模型在内的3种氯离子渗透模型进行了评估。同时，使用暴露11年的露天场所的现场数据和7～13年的现有建筑的有限数据对一种预测混凝土碳化深度的物理化学模型进行了评价。针对冻融侵蚀的模型，讨论了临界饱和度测量和实际的饱和度测量中的一些问题。根据对结果的比较，可以发现在大多数情况下，简单ERFC模型在大多数情况下对氯离子渗透的预测值高于实际值，而DuraCrete模型的预测值偏低。另外，ClinConc模型对短期f1年）和长期（21年）暴露条件下的预测更合理，预测效果更好。与在挪威获得的暴露级别为XC3现场数据比较，发现Papadakis碳化模型可以较好地预测碳化深度；但是，与暴露级别为XC4级的现场数据比较发现，该模型低估了碳化深度。

关键词：混凝土耐久性模型服役寿命验证

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Addressing Frequency Control Challenges in Future Low-Inertia Power Systems:A Great Britain Perspective

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Engineering 2021年第8期7卷 1057-1063页

作者： Qiteng Hong Md Asif Uddin Khan Callum Henderson AgustíEgea-Àlvarez dimitrios Tzelepis Campbell Booth Department of Electronic and Electrical Engineering University of StrathclydeGlasgow G11XWUK

The ambitious global targets on decarbonization present the need for massive integration of renewable generation in power systems,resulting in a significant decrease in the system *** addition to the reduction in system inertia,the transmission system in Great Britain(GB)faces some unique challenges owing to its relatively small capacity,while being decoupled from other transmission systems and with the renewable resources largely non-uniformly distributed across the *** paper presents opinions and insights on the challenges associated with frequency control in a low-inertia system and the potential solutions from a GB *** this paper,we focus on three main techniques that act over different time scales:synchronous condensers,inertia emulation,and fast frequency *** evaluate their relative advantages and limitations with learnings from recent research and development projects in GB,along with the opinions on their roles in addressing the frequency control challenges in future low-inertia systems.

关键词： Fast frequency control Inertia emulation Synchronous compensation Low-inertia systems

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An advanced discrete‐time RNN for handling discrete time‐varying matrix inversion:Form model design to disturbance‐suppression analysis

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CAAI Transactions on Intelligence Technology 2023年第3期8卷 607-621页

作者： Yang Shi Qiaowen Shi Xinwei Cao Bin Li Xiaobing Sun dimitrios K.Gerontitis School of Information Engineering Yangzhou UniversityYangzhouChina Jiangsu Province Engineering Research Center of Knowledge Management and Intelligent Service Yangzhou UniversityYangzhouChina School of Business Jiangnan UniversityWuxiChina Department of Information and Electronic Engineering International Hellenic UniversityThessalonikiGreece

Time‐varying matrix inversion is an important field of matrix research,and lots of research achievements have been *** the process of solving time‐varying matrix inversion,disturbances inevitably exist,thus,a model that can suppress disturbance while solving the problem is *** this paper,an advanced continuous‐time recurrent neural network(RNN)model based on a double integral RNN design formula is pro-posed for solving continuous time‐varying matrix inversion,which has incomparable disturbance‐suppression *** digital hardware applications,the corresponding advanced discrete‐time RNN model is proposed based on the discretisation *** a result of theoretical analysis,it is demonstrated that the advanced continuous‐time RNN model and the corresponding advanced discrete‐time RNN model have global and exponential convergence performance,and they are excellent for suppressing different ***,inspiring experiments,including two numerical experiments and a practical experiment,are presented to demonstrate the effectiveness and superiority of the advanced discrete‐time RNN model for solving discrete time‐varying matrix inversion with disturbance‐suppression.

关键词： neural control neural network real‐time systems

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Omeprazole maintenance therapy prevents recurrent ulcer bleeding after surgery for duodenal ulcer

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World Journal of Gastroenterology 2006年第5期12卷 791-795页

作者： Konstantinos Demertzis dimitrios Polymeros Theodoros Emmanuel Konstantinos Triantafyllou Pericles Tassios Spiros D Ladas Hepatogastroenterology Unit2~(nd) Department of Internal Medicine"Attikon"University General Hospital11528 AthensGreece

AIM： To evaluate the omeprazole maintenance therapy in patients with recurrent ulcer bleeding after surgery for duodenal ulcer. METHODS： We studied 15 consecutive patients with recurrent ulcer bleeding after surgery for duodenal ulcer. Omeprazole （20 mg/d） maintenance therapy was given after ulcer healing. In addition to clinical follow-up, ambulatory 24-h gastric pH assay was performed before and during omeprazole therapy in those patients and controls with previous duodenal ulcer surgery but no ulcer recurrence. RESULTS： All the 15 ulcers were healed after being treated with omeprazole （40 mg/d） for 2 too. Eleven patients with two （1-9） episodes of recurrent ulcer bleeding completed the follow-up （43, 12-72 too）. None of them had a bleeding episode while on omeprazole. One patient discontinued the therapy and had recurrent bleeding. The median 24-h fraction time of gastric pH 〈4 in patients was 80, 46-95%, and was reduced to 32, 13-70% by omeprazole （P= 0.002）. CONCLUSION： Long-term maintenance therapy with omeprazole （20 rag/day） is effective in preventing recurrent ulcer bleeding.

关键词： Duodenal ulcer Gastrectomy Vagotomy Omeprazole

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Humanin and diabetes mellitus: A review of in vitro and in vivo studies

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World Journal of Diabetes 2022年第3期13卷 213-223页

作者： Chrysoula Boutari Panagiotis D Pappas Theodoros D Theodoridis dimitrios Vavilis Second Propedeutic Department of Internal Medicine Hippocration HospitalAristotle University of ThessalonikiThessaloniki 54642Greece First Department of Obstetrics and Gynaecology Papageorgiou HospitalAristotle University of ThessalonikiThessaloniki 56429Greece Medical School University of CyprusNicosiaCyprus 205371678Cyprus

Humanin(HN)is a 24-amino acid mitochondrial-derived polypeptide with cytoprotective and anti-apoptotic effects that regulates the mitochondrial functions under stress *** evidence suggests the role of HN against age-related diseases,such as Alzheimer’s *** decline in insulin action is a metabolic feature of aging and thus,type 2 diabetes mellitus is considered an agerelated disease,as *** has been suggested that HN increases insulin sensitivity,improves the survival of pancreatic beta cells,and delays the onset of diabetes,actions that could be deployed in the treatment of *** aim of this review is to present the in vitro and in vivo studies that examined the role of HN in insulin resistance and diabetes and to discuss its newly emerging role as a therapeutic option against those conditions.

关键词： Diabetes mellitus Insulin resistance Humanin Aging Apoptosis Oxidative stress

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Diffusion-weighted MR imaging of normal and abnorma scrotum： preliminary results

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Asian Journal of Andrology 2012年第4期14卷 649-654页

作者： Athina C Tsili Maria I Argyropoulou dimitrios Giannakis Stavros Tsampalas Nikolaos Sofikitis Konstantinos Tsampoulas Department of Clinical Radiology University Hospital of Ioannina Ioannina 45500 Greece Department of Urology University Hospital of Ioannina Ioannina 45500 Greece

Magnetic resonance （MR） imaging of the scrotum represents an important supplemental diagnostic tool in the evaluation of scrotal diseases. Diffusion-weighted （DW） MR imaging is a developing technique, proved to improve tissue characterization. We evaluated the feasibility and diagnostic performance of DW MR imaging in the detection and characterization of scrotal lesions. We retrospectively evaluated 31 scrotal lesions （23 intratesticular and 8 extratesticular） in 26 men. All MR examinations were performed on a 1.5-T unit, using a pelvic-phased array coil. DW sequences were obtained using a single shot, multislice spin echo planar diffusion pulse sequence and a b factor of 0 and 900 s mm-2. The DW MR characteristics and the apparent diffusion coefficient （ADC） values of normal scrotal contents and scrotal diseases were evaluated. Comparison between the ADC values of normal scrotum, benign lesions and scrotal malignancies was performed. The accuracy of conventional sequences, DW images alone and DW imaging combined with conventional images in differentiating benign from malignant scmtal lesions was calculated. The ADC values of testicular malignancies were different from those of normal testis and benign intratesticular lesions, and the ADC values of benign extratesticular lesions from those of normal epididymis （P〈0.05）. The overall accuracy of conventional imaging, DW imaging alone and DW MR combined with conventional sequences in the characterization of intratesticular lesions was 91%, 87% and 100%, respectively. Our findings suggest that DW MR imaging and ADC values may provide valuable information in the diagnosis and characterization of scrotal diseases.

关键词： diagnosis epididymis male genital neoplasms scrotum testicular neoplasms testis

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Unusual site of recurrent musculoskeletal hydatid cyst: Case report and brief review of the literature

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World Journal of Gastroenterology 2006年第34期12卷 5577-5578页

作者： Panagiotis G Drimousis Konstantinos M Stamou Athanasios Koutras dimitrios Konstantinos Tsekouras George Zografos 1~(st) Department of Propeudeutic Surgery Hippocrateion Hospital Athens Medical School Athens 11527 Greece

A case of a large multiplex recurrent hydatid cyst involving the left gluteal muscle and the left iliopsoas, accompanied with degeneration of the musculature of the left upper leg is presented along with a review of the relevant literature. Very few such cases have been reported worldwide. The presented case is also distinguished by the involvement of muscles of distant anatomic areas.

关键词： Echinococcosis Hydatid disease Musculoskeletal hydatid

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Solitary colonic neurofibroma in a patient with transient segmental colitis: Case report

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World Journal of Gastroenterology 2005年第35期11卷 5573-5576页

作者： Vasilios Panteris Thivi Vassilakaki Nikos Vaitsis Ioannis Elemenoglou Irini Mylonakou dimitrios Georgios Karamanolis Department of Gastroenterology "Tzaneion" General Hospital Zanni and Afentouli 1 Piraeus 18536 Greece Department of Pathology "Tzaneion" General Hospital Zanni and Afentouli 1 Piraeus 18536 Greece Department of Pathology"Tzaneion" General Hospital Zanni and Afentouli 1 Piraeus 18536 Greece

Neurofibromas of the large bowel are very rare and usually are part of the colonic involvement in neurofibromatosis type 1 （Nf1, yon Recklinghausen＇s disease）. Solitary neurofibromas of the colon are extremely rare. We describe a case of an isolated neurofibroma that was found in the large bowel of a patient who suffered from segmental colitis and presented with bloody diarrhea. A review of the literature is also included, concerning the disclosure of isolated neurofibromas in the gut and other body parts and the type of gastrointestinal involvement in von Recklinghausen＇s disease.

关键词： Solitary neurofibroma Isolated neurofibroma,Neurofibromatosis Intestinal neurofibromatosis von Recklinghausen's disease

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