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Effect of special types of bread with select herbal components on postprandial glucose levels in diabetic patients

World Journal of Diabetes 2024年第4期15卷 664-674页

作者： Drasko M Gostiljac Srdjan S Popovic Vesna dimitrijevic-Sreckovic Sasa M Ilic Jelena A Jevtovic Dragan M Nikolic Ivan A Soldatovic Clinic for Endocrinology Diabetes and Metabolic DiseasesUniversity Clinical Centre of SerbiaBelgrade 11000Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia Clinic for Gastroenterology and Hepatology University Clinical Centre of SerbiaBelgrade 11000Serbia Clinic for Endocrinology Diabetes and Metabolic Diseases-Laboratory for Human Pancreatic Islets CultureUniversity Clinical Centre of SerbiaBelgrade 11000Serbia

BACKGROUND Nutrition recommendations in patients with type 2 diabetes mellitus(T2DM)are to consume rye or integral bread instead of white bread.A positive effect on glucoregulation has been achieved by enriching food with various biologically active substances of herbal origin,so we formulated an herbal mixture that can be used as a supplement for a special type of bread(STB)to achieve better effects on postprandial glucose and insulin levels in patients with *** To compare organoleptic characteristics and effects of two types of bread on postprandial glucose and insulin levels in T2DM *** This trial included 97 patients with T2DM.A parallel group of 16 healthy subjects was also *** participants were given 50 g of rye bread and the same amount of a STB with an herbal mixture on 2 consecutive *** blood glucose and insulin levels were compared at the 30^(th),60^(th),90^(th) and 120th min.A questionnaire was used for subjective estimation of the organoleptic and satiety features of the two types of *** Compared to patients who consumed rye bread,significantly lower postprandial blood glucose and insulin concentrations were found in T2DM patients who consumed *** relevant differences were found among the healthy *** estimated organoleptic and satiety characteristics are better for STB than for rye *** STB have better effects than rye bread on postprandial glucoregulation in T2DM *** estimated organoleptic and satiety characteristics are better for STB than for rye ***,STB can be recommended for nutrition in T2DM patients.

关键词： Special types of bread Postprandial glucoregulation Insulin Nutrition Type 2 diabetes mellitus

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Crystal Structure and Chemical Composition of Ludwigite from Vranovac Ore Deposit (Boranja Mountain,Serbia)

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Acta Geologica Sinica(English Edition) 2012年第6期86卷 1524-1538页

作者： Pavle TANCIC Radovan dimitrijevic Maja POZNANOVIC Aleksandar PACEVSKI Slobodanka SUDAR Geological Institute of Serbia Faculty of Mining and Geology Department of Mineralogy and Crystallography

The crystal structure of ludwigite from Vranovac ore deposit （Boranja Mt., Serbia） was refined using the X-ray powder diffraction （XRPD） Rietveld method in the space group Pbam to a final RB=7.45% and RF=5.26%. It has the unit cell dimensions of： a=9.2515（2） A; b=12.3109（2） A; c=3.03712 （7） A; and V=345.91（1） A3. The calculated distances and angles are mostly in good agreement with the Mg2＋-Fe2＋ substitutions across the M（1） and M（3） sites, as well as with the Fe3＋-AI3＋ replacement in the M（4） site. However, the mean observed M（2）-O distance is considerably shorter than prescribed, due to a slight increase of the Fe3＋ content in the M（2） site. Such replacement was compensated by slight increase of the Fe2＋ content in the M（4） site, resulting in the （Mg1.4sFe2＋o.46Fe3＋***.o2）2.o1 （Fe3＋o.94Fe2＋0.04Al0.02）1.00B1.00Os composition. The formation temperature was estimated to be about 500- 600C. The influences of the various chemical compositions to the crystallographic parameters, M-O distances, M（3） and M（4） sites shift, distortion parameters and estimated valences, were also studied and compared with other reference samples.

关键词： ludwigite crystal structure chemical composition M-O distances distortion parameters,ions valences comparison formation temperature

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Enhanced wave and finite element method for wave propagation and forced response prediction in periodic piezoelectric structures

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Chinese Journal of Aeronautics 2017年第1期30卷 75-87页

作者： Fan Yu Manuel Collet Mohamed Ichchou Li Lin Olivier Bareille Zoran dimitrijevic Laboratory of Tribology and Systems Dynamic Ecole Centrale de Lyon Ecully 691304 France School of Energy and Power Engineering Beihang University Beijing 100083 China PSA Peugeot Citroen Paris F-78943 France

As a promising numerical tool of structural dynamics in mid- and high frequencies, the wave and finite element method（WFEM） is receiving increasingly attention and applications. In this paper, an enhanced WFEM has been developed with a reduced model and a new eigenvalue scheme. The reduced model is applicable for structures with piezoelectric shunts or local dampers;the new eigenvalue scheme can mitigate the ill-conditioning when the wave basis is calculated. The enhanced WFEM is applied to a thin-wall structure with periodically distributed piezoelectric materials（PZT）. Both free wave characteristics and forced response are analyzed and the influences of the suggested enhancements are presented. It is shown that if the control factors are properly chosen, these enhancements can improve the accuracy while accelerating the calculation. Resulting from the complexity of the application, these enhancements are not optional but imperative.

关键词： Eigenvalue scheme Periodic structure Piezoelectric shunt Reduced model Thin-wall structure Wave and finite element method

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Macroscopically-Zoned Grandite from the Garnetite Skarn of Meka Presedla(Kopaonik Mountain,Serbia)

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Acta Geologica Sinica(English Edition) 2012年第2期86卷 393-406页

作者： Pavle TANCIC Predrag VULIC Reinhard KAINDL Bernhard SARTORY Radovan dimitrijevic Geological Institute of Serbia BelgradeSerbia Department of Crystallography Faculty of Mining and GeologyUniversity of BelgradeBelgradeSerbia 3 Institute of Mineralogy and Petrography University of InnsbruckInnsbruckAustria

The macroscopically-zoned grandite from the garnetite skarn of Meka Presedla （Kopaonik Mountain, Serbia） was studied with optical microscopy, electron microprobe analysis （EMPA）, Fourier transform infra-red （FT-IR）, and Raman methods. The EMPA results indicate that the main core-rim compositional variations （Ca2.93-2.97Mn0.05-0.06Mg0.00-0.01AI1.14-L26 Fe0.72-0.83 Ti0.00-0.02Si2.97-3.02012） slightly differ along the zones, showing evidence for a quasi-cyclic alternation of the oscillatory zoning nature. Among this, considerable variation is observed only by the AI-Fe3＋ substitutions in the octahedral site. The EMPA also indicate that the grandite zones compositionally vary, mostly within ＋1 and ±2 mol% of the homogeneity level range, that is, Grs64±1Adra36±1SpS2 （A）, Grs62±1Adra38±1Sps2 （B）, Grs59±2Adr40±2Sps2 （C）, Grs58±2Adr41±2Sps2 （D）, and Grss±1Adr41±1Sps2 （E）. Therefore, the investigated garnet can be considered as relatively highly homogeneous. The majority of compositions lie within the narrow miscibility region of 0.58±2〈XGrs〈0.64±1, without gaps, and with only three outliers near the zone boundaries of approximately 0.38〈XGrs〈0.52. FT-IR and Raman bands are almost constant within the zones and adequate to the chemical compositions. All of the zones should be considered as anhydrous. From the results, formation temperatures between -600 and 720℃ and pressures 0f-2-3 kbars, are derived. Among five possible causes for the slightly optical anisotropy of grandite, three were reconsidered, and consequently rejected.

关键词： grandite anisotropy compositional variation zone homogeneities miscibility region

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Adenosquamous carcinoma arising within a retrorectal tailgut cyst: Report of a case

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World Journal of Gastroenterology 2005年第39期11卷 6225-6227页

作者： Zoran Krivokapic Ivan dimitrijevic Goran Barisic Velimir Markovic Miodrag Krstic Institute for Digestive Diseases Clinical Center of Serbia BelgradeSerbia and Montenegro

Retrorectal, developmental tail gut cysts, include dermoid cysts, rectal duplication cysts and retrorectal cyst-hamartomas. Retrorectal cyst-hamartomas （RCH） are derived from remnants of the tail gut, the most caudal part of the embryonic hincl gut, which normally involutes by the 8^th wk of embryonic development （3-8 mm stage）. They have specific radiological and histopathological features that distinguish them from other similar formations （dermoid cysts, enteric duplication cysts and teratomas）. We report a patient with adenosquamous carcinoma arising within RCH, who underwent complete resection of the cyst through anterior laparotomy, and reached complete （recurrencefree for 14 mo, so far） functional recovery. The cyst was incidentally discovered during hysterectomy 12 years ago. Diagnostic, therapeutic arid histopathological aspects of this rare case are discussed. The mentioned pedod between diagnosis and surgical treatment suggests that RCH, given enough time, can develop malignant degeneration, and should be resected at the time of diagnosis.

关键词： Tailgut cyst Malignant transformation

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Comethylation of p16 and MGMT genes in colorectal carcinoma:Correlation with clinicopathological features and prognostic value

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World Journal of Gastroenterology 2007年第8期13卷 1187-1194页

作者： Koviljka Krtolica Milena Krajnovic Slavica Usaj-Knezevic Dragan Babic Dusan Jovanovic Bogomir dimitrijevic Laboratory for Radiobiology and Molecular Genetics Institute of Nuclear Sciences "Vinca" P. O. BOX 522 Belgrade Serbia Institute of Oncology Sremska KamenicaSerbia Institute for Medical Statistics of Medical University BelgradeSerbia

AIM: To investigate the significance of p16 and O6- methylguanine-DNA methyltransferase (MGMT) genes promoter hypermethylation and K-ras mutations on colorectal tumorigenesis and progression. METHODS: p16 and MGMT methylation status was examined on 47 tumor samples, and K-ras mutational status was examined on 85 tumor samples. For methylation analysis, a methylation specific PCR (MS-PCR) method was used. RESULTS: p16 and MGMT promoter methylation was found in 51% (24/47) and 43% (20/47) of CRCs, respectively, and the K-ras mutation was found in 44% (37/85) of CRCs. Comethylation of p16 and MGMT genes was significantly associated with lower aggressiveness of the disease within a two-year period of observation. Only 27% of patients with simultaneous p 16 and MGMT methylation showed the detectible occurrence of metastasis and/or death, compared to 67% of patients without double methylation or with no methylation (3/11 vs 22/33, P < 0.05, χ2-test). In addition, p16 and MGMT comethylation showed a trend toward an association with longer survival in patients with CRCs (35.5 ± 6.0 mo vs 23.1 ± 3.2 mo, P = 0.072, Log-rank test). Progression of the disease within a two-year period was observed in 66% of patients carrying the K-ras mutation, compared to only 19% of patients with wild type K-ras (29/44 vs 7/37, P < 0.001, χ2-test). The presence of the K-ras mutation significantly correlated to shortened overall survival (20.0 ± 1.9 mo vs 37.0 ± 1.8 mo, P < 0.001, Log-rank test). The comethylation of p16 and MGMT genes was significantly associated with lower aggressiveness of the disease even when K-ras mutations were included in the analysis as an independent variable. CONCLUSION: Our data suggest that comethylation of promoters of p 16 and MGMT genes could have a prognostic value in patients with CRC. Specifically, concurrent methylation of both genes correlates with better prognosis.

关键词： Colorectal carcinoma DNA methylation p16 MGMT K-ras mutation

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Managing Health Risks during the Balkans Floods

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American Journal of Climate Change 2017年第4期6卷 597-606页

作者： Vladimir Kendrovski Franziska Matthies Goran Cerkez Maja Dragosavac Dragana dimitrijevic Milan Rancic Elizabet Paunovic Oliver Schmoll Bettina Menne WHO Regional Office for Europe European Centre for Environment and Health Bonn Germany Freelance Consultant Feldafing Germany Federal Ministry of Health Sarajevo Bosnia and Herzegovina Croatian Institute of Emergency Medicine Zagreb Croatia Institute of Public Health of Serbia Belgrade Serbia

Floods have always had and will continue to have significant consequences for society. In May 2014, there was widespread flooding in the Balkans affecting Bosnia and Herzegovina, Croatia and Serbia. The aim of this article is to show that resilient and proactive health systems that anticipate needs and challenges are more likely to reduce risks and respond effectively during emergencies, saving lives and alleviating human suffering. The method draws on multiple sources of information, including a Balkan case study questionnaire survey with public health professionals involved in response to floods (n = 18) from three affected countries, and focus group discussion results (n = 43) presented at the meeting on “Prevention, preparedness and response to reduce or avoid health effects of flood events”, held in Bonn, Germany, in October 2015. The proposed range of measures to protect population health, organized around flood prevention, preparedness, response and recovery listed issues and considerations largely corresponds to the identified needs by Member State requests, following the Balkan country experiences. The consideration of lessons for early warning, preparedness and response and the integration of research results would lead to improved preparedness measures to better prevent flooding risks. Experiences in the WHO European Region point to a need to shift the emphasis from disaster response to long-term risk management.

关键词： Managing Flooding Health Risks Resilient Health System Balkans Population Health

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The Influence of Solonetz Soil Limited Growth Conditions on Bread Wheat Yield

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Journal of Agricultural Science and Technology 2011年第2期5卷 194-201页

作者： M. dimitrijevic S. Petrovic M. Belic B. Banjac M. Vukosavljev N. Mladenov N. Hristov Faculty of Agriculture University of Novi Sad Sq. Dositeja Obradovica 8 21000 Serbia Institute of Field and Vegetable Crops St. Maksima Gorkog 30 21000 Novi Sad Serbia

The wheat yield variation on solonetz and chernozem soil in six environments was in study in order to obtain information for use of genetic variability and for building strategy in plant breeding for less productive and marginal environments. The sample of eight bread wheat varieties： Rcnesansa, Pobeda, Rapsodija, Dragana, Cipovka, Evropa 90, NSR-5 and Nevesinjka, which are characterized by tolerance to stressful growing conditions and broader adaptability, was selected for the study. The trial was established by Randomized Complete Block Design in three replications at two locations in the Pannonian Plain, Northern Serbia in two vegetation periods 2004/2005 and 2008/2009. Locations differed in a soil type, primarily. The tested locality was on solonetz, while control locality was on chernozem soil type. Additive Main and Multiplicative Interaction model （AMMI） grouped varieties that exhibited strong reaction to environmental improvement （Nevesinjka and Evropa 90）, varieties showing fairly small GE interaction （Renesansa, Cipovka and Pobeda） and varieties having the ability for maximum use of less productive soil in better meteorological conditions （Dragana, Rapsodija and NSR-5）. Meteorological conditions significantly influenced the effect of soil quality variation on grain yield in trial. Varieties have interacted differently with the environment, depending on their genetic background.

关键词： Wheat yield AMMI (Additive Main and Multiplicative Interaction model) interaction solonetz stress.

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听性稳态反应应用于婴幼儿听力评估的现状(英文)

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听力学及言语疾病杂志 2008年第1期16卷 2-15页

作者： Stapells DR Herdman A A Small S dimitrijevic a Hatton j 莫玲燕教授(编译) School of Audiology and Speech Sciences University of British Columbia Vancouver B.C. Canada Rotman Research Institute Baycrest Centre for Geriatric Care Toronto ON Canada 北京同仁医院

刺激速率为70～110Hz的听性稳态反应(auditory steady-state response,ASSR)(亦称为80Hz)最近倍受听力学工作者特别是小儿听力学工作者的关注,设备制造商也正在推销其产品。本文回顾了ASSR的技术、应用基础,并总结了其应用于婴幼儿听力... 详细信息

刺激速率为70～110Hz的听性稳态反应(auditory steady-state response,ASSR)(亦称为80Hz)最近倍受听力学工作者特别是小儿听力学工作者的关注,设备制造商也正在推销其产品。本文回顾了ASSR的技术、应用基础,并总结了其应用于婴幼儿听力评估的现状。文中斜体字为基本原则。详细的ASSR方法学、正常值以及一些ASSR研究结果请参阅Picton(2003)的综述。ASSR并不是一个新发现的听觉反应,1960年Geisler就从人类头颅上记录到了该反应;以后研究者又记录到了短声、正弦调制波以及方波调制波所诱发的反应。Galambos等在1981年发表的有关40Hz事件相关电位将ASSR引入听力领域。不同刺激速率的ASSR的产生部位是不同的,40Hz的ASSR产生于皮层和脑干,而80Hz的ASSR主要来源于脑干,而且很有可能它就是ABR的波Ⅴ,只是与ABR的刺激和记录方法不同而已。ASSR的重要特征之一就是在频域内分析的方法,通过计算位相相关性或刺激速率值处的信噪比,再根据统计学分析来判定反应的引出与否,这种客观性使ASSR显著优于ABR。ASSR的刺激信号最早是象ABR一样的短纯音信号,以后主要用调幅调制声,有时也加入10%～20%的调频调制,目前大多数设备都采用这一信号,最近一种新ASSR设备的缺省设置是5～8ms的短音。ASSR的另一个重要特征是能够同时记录多个刺激声信号所产生的反应,这种多频刺激的方法能够同时记录双耳八个频率(每耳四个频率)的反应。研究证明只要各个信号的频率相距一个倍频程以上,强度在75dBSPL以下,多个刺激声之间的干扰就很小或没有。不对称型的听力图、不同频率所产生的反应幅度的不同以及多频刺激方式所导致的各个频率反应幅度整体的下降延长了这种方法的测试时间,使其不如理想中的那么省时,但仍比单一刺激方式快2～3倍。80HzASSR通常采用的是正弦调幅调制纯音,因为其特有的频率特异性而被认为是优于短纯音ABR的一个方面,但是声信号的频率特异性只是其中的一方面,还应考虑到耳蜗基底膜的部位特异性以及神经反应的特异性。研究证明ASSR的频率特异性与短纯音ABR是非常接近的。ASSR技术以飞快的速度发展,十年前还没有商用的设备,五年前只有两家,而目前至少有六种不同的设备。随着设备的增加,各个设备之间标准化的问题突显出来。有些设备有很浑厚的研究背景,而有些则没有,使用者应该根据设备的性能及临床资料而加以选择。关于80HzASSR与行为听力测试相关性的研究很多,多为感音神经性聋成人或较大儿童,结果表明至少在该人群中ASSR的阈值能够很好地预测行为听力阈值。许多ABR与ASSR的比较研究声称ASSR比ABR能够更好地评估残余听力,也就是当受试者听力损失很重、ABR不能引出时,仍能够引出ASSR。尽管这一现象客观存在,但是还有一些其他需要考虑的影响因素,如:①所比较的信号在某一特定频率上的能量是不相等的,众所周知短声的能量分布频率范围很宽,其最大输出强度较ASSR信号小;②ASSR在高强度会有伪迹或非听性反应;③ASSR的长时强声刺激会导致耳蜗损害。因此需慎重对待这一问题。目前还没有关于传导性聋或混合性聋气导ASSR的研究,模拟传导性聋的研究表明气导ASSR阈值远高于行为听阈,而且ASSR骨气导差过大。骨导ASSR的研究显示听力正常婴幼儿各个频率的ASSR的阈值与成人显著不同。正常听力婴幼儿的短纯音ABR阈值以及诊断标准已经确立,而ASSR在这一方面的研究则显得不足,而且不同研究所采用的刺激(单频与多频)及记录(不同信噪比、噪声标准以及记录时间)方法不同,使这一形势更加恶化。综合不同调幅调制纯音ASSR的研究结果,正常听力婴幼儿在500、1000、2000及4000Hz的平均阈值分别为41、43、35和32dBHL,如果转换为dBSPL则与短纯音ABR非常相似。如果以均值的90%～95%为可信区间,取二倍标准差,则诊断标准在500Hz为60dBHL,1000、2000及4000Hz为50dBHL。关于感音神经性聋儿童ASSR的研究有很多,这种研究比较理想的方法应该将婴幼儿的ASSR阈值与行为听阈或短纯音ABR阈值相比较。遗憾的是多数研究都是短声ABR与ASSR的比较。总结以上工作发现,首先样本数量还很少,其次多数有方法学的缺陷,加之不同研究所采用的刺激和记录方法不同,临床资料就更加减少。最后还没有不同类型听力损失的婴幼儿ASSR的研究。总而言之,尽管ASSR在婴幼儿听力评估方面很有前途,但目前单独以此作为听力诊断的电生理方法还为时过早,还必须结合短纯音ABR,因为只有短纯音ABR才具有充足的基础、临床研究和明确的诊断标准,因而也是目前婴幼儿听力诊断电生理方法的金标准。根据上述回顾,ASSR在婴幼儿

关键词：听性稳态反应正常婴幼儿听力评估行为听力测试 40Hz事件相关电位感音神经性聋 ABR阈值频率特异性

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Content of Heavy Metals in Mulberry Fruits and Their Extracts-Correlation Analysis

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American Journal of Analytical Chemistry 2013年第11期4卷 674-682页

作者： Ruzica J.Micic Danica S.dimitrijevic Danijela A.Kostic Gordana S.Stojanovic Snezana S.Mitic Milan N.Mitic Aleksandra N.Pavlovic Sasa S.Randelovic Department of Chemistry Faculty of Natural Sciences and MathematicsUniversity of PristinaKosovska MitrovicaSerbia Department of Chemistry Faculty of Natural Sciences and MathematicsUniversity of NisNisSerbia

The aim of this research was the determination of heavy metals’ (iron, copper, zinc, manganese, cadmium, nickel and lead) contents of white, red and black mulberry fruit grown in southeast region of Serbia, and their extracts. The content of all metals was confirmed in the fruits. All of tree types of mulberry contained the highest content of iron in the fruit and the lowest content of Cd. The level of iron in all assayed fruits species was ranged between 23.06-57.38 mg?100g?1. The concentration range of cadmium for the tested fruits was found to be from 1.77 to 2.46 μg?100g?1 in fruit of Morus nigra L. and Morus alba L., respectively. The content of metals in the fruit of white mulberry decreases in the following order: Fe > Mn > Zn > Cu > Ni > Pb > Cd. The content of metals in the fruit of red mulberry by decreasing the value is: Fe > Zn > Mn > Cu > Ni > Pb > Cd and in the fruit of black mulberry decreases in the following order: Fe > Zn > Cu > Mn > Ni > Pb > Cd. In addition, an analysis of mulberries extracts showed a significant transfer of heavy metals during extraction procedure;therefore, the corresponding extraction coefficients reached values up to 73.09%. Those were especially high in the acetone-

关键词： Mulberry Extracts Heavy Metal Extraction Coefficient

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