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Open Journal of Obstetrics and Gynecology 2017年第3期7卷 326-333页

作者： Henny Anna Rie Klomp Johannes Maria Gulielmus Cobben Paul Jan Quirien van der linden Department of Obstetrics and Gynecology Deventer Ziekenhuis Deventer The Netherlands Department of Anesthesiology Deventer Ziekenhuis Deventer The Netherlands

Objective: To study whether there is a relation between the application of corticosteroids and occurrence of postmenopausal bleeding. Also we want to determine whether corticosteroids can cause an irregularity in a previously regular menstruation cycle. Design and Setting: Prospective cohort study in the department of anesthesiology. Patients: 209 women who received a single dosage of corticosteroids as treatment for pain. Interventions: None, observational cohort study;all women received standard care. Main outcome measures: Postmenopausal blood loss or disruption of menstruation cycle. Result: Postmenopausal blood loss or disruption of menstruation cycle were both more common 6 weeks after administration of corticosteroids, but were sometimes also reported 2 weeks after administration of corticosteroids. Conclusion: After administration of corticosteroids in a postmenopausal woman an episode of menstruation like bleeding can be expected. This is probably due to a transient drop of androstenedione. In premenopausal women a transient change in menstruation cycle can be observed.

关键词： Postmenopausal Bleeding Corticosteroids Bleeding Patterns

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实现小批量工件的自动化生产

现代制造 2013年第44期 44-45页

作者： JAN van der linden

位于Dtilmen的Lidu公司是一家家族企业，几十年来为钥匙制造行业提供高质量个性化的产品。该公司在设备先进的计算机数字化控制机床（CNC）车间进行加工作业。最近，Lidu公司从荷兰的设备和系统生产厂家Auto—Cell公司购置了一套特殊的... 详细信息

位于Dtilmen的Lidu公司是一家家族企业，几十年来为钥匙制造行业提供高质量个性化的产品。该公司在设备先进的计算机数字化控制机床（CNC）车间进行加工作业。最近，Lidu公司从荷兰的设备和系统生产厂家Auto—Cell公司购置了一套特殊的车削加工单元，即Auto—Cell 24／7，该车削单元配置了一台机器人来自动更换转台上的刀具夹板和刀具（图1）。

关键词：自动化生产小批量工件加工单元 Cell 数字化控制家族企业制造行业

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实现小批量工件的自动化生产

现代制造 2014年第12期 42-43页

作者： JAN van der linden

为了提高小批量工件加工生产的灵活性，机械加工生产厂家Lienenbrugger公司（简称Lidu）新近投资设计了一个新的生产单元。在该生产单元中有两台车床同步投人使用，由机器人装置予以技术支持，使得该生产单元的工件加工系统几乎达到了... 详细信息

为了提高小批量工件加工生产的灵活性，机械加工生产厂家Lienenbrugger公司（简称Lidu）新近投资设计了一个新的生产单元。在该生产单元中有两台车床同步投人使用，由机器人装置予以技术支持，使得该生产单元的工件加工系统几乎达到了无人操作的水准。

关键词：工件加工小批量自动化生产生产单元加工生产生产厂家机械加工技术支持

Evaluation of Real-Time PCR and Culturing for the Detection of Leptospires in Canine Samples

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Advances in Microbiology 2012年第2期2卷 162-170页

作者： Ahmed Ahmed Henricus L. B. M. Klaasen Mark van der Veen Hans van der linden Marga G. A. Goris Rudy A. Hartskeerl MSD Animal Health Department Microbiological Research and Development Boxmeer The Netherlands WHO/FAO/OIE and National Collaborating Centre for Reference and Research on Leptospirosis Department of Biomedical Research Royal Tropical Institute Amsterdam The Netherlands WHO/FAO/OIE and National Collaborating Centre for Reference and Research on Leptospirosis Department of Biomedical Research Royal Tropical Institute Amsterdam The Netherlands

Validated real-time PCRs detecting leptospires for veterinary purposes are not readily available. This paper describes the prospective evaluation of a SYBR Green-based real-time PCR on serum samples collected from experimentally infected dogs. Compared to culturing, the assay had a diagnostic sensitivity and specificity of 91.7% and 90.0%, respectively. Culturing for part is complementary to PCR and preferably both should be applied for diagnosis and vaccine challenge experiments. In a subsequent prospective study on the dynamics of experimental infections with serovars Canicola and Copenhageni and serovar complex Bananal-Liangguang in young and adult dogs, the PCR was applied on serum samples in conjunction with culturing on blood, urine and kidney samples with the following results: 1) Leptospires persisted longer in the blood of young dogs than of adult ones;2) Numbers of viable leptospires in the blood are rapidly reduced but DNA remains occasionally detectable up to 7 days post infection;3) Appearance of viable leptospires in the urine follows a biphasic dynamics;4) EDTA hampers effective culturing from blood samples;5) Serovar Canicola persists longer in the blood of dogs than Copenhageni and Bananal-Liangguang. Together with a markedly higher recovery rate from kidney samples (71% compared to respectively 33% and 0% in young dogs), this probably reflects the adaptation power of Canicola to its canine maintenance host. Appearance of leptospires in the urine samples indicates that experimental infections have been successful. PCR presents a valuable adjunct to the diagnosis of veterinary leptospirosis and the follow-up in vaccine protection experiments.

关键词： Leptospirosis Diagnosis PCR Evaluation Canine Experimental Infection Challenge Infection Kinetics

Foley Balloon Catheter versus Oral Misoprostol for Induction of Labour after Prelabour Rupture of Membranes: A Retrospective Data Analysis

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Open Journal of Obstetrics and Gynecology 2022年第7期12卷 579-589页

作者： Anna Bouwknegt Sjuul Jongen Kim Kamphorst Maria G. van Pampus Paul J. Q. van der linden Joost J. Zwart Department of Obstetrics and Gynaecology Deventer Hospital Deventer The Netherlands Department of Obstetrics and Gynaecology OLVG Hospital Amsterdam The Netherlands

Objectives: The Foley balloon catheter (FC) is a viable method for cervical ripening, but concerns about infection risk restrict its use in cases of prolonged prelabour rupture of membranes (PROM). This study aims to evaluate the efficacy and safety of the FC compared to oral misoprostol for cervical ripening after PROM. Study Design: A retrospective data-analysis of 128 pregnant women was conducted. Of these, 49 underwent cervical ripening with an FC and 79 with oral misoprostol. We included all women with a vital singleton pregnancy at 37 - 42 weeks of gestation who underwent cervical ripening after ≥ 24 hours of PROM in specific time frames in two Dutchsecondary care and teaching hospitals. The primary outcome was the incidence of intrapartum infection, a composite of maternal and neonatal infection. In addition, we evaluated the mode of delivery, duration of priming and priming-to-delivery interval. Secondary endpoints included uterine hyperstimulation, umbilical cord prolapse, birth weight, Apgar scores, length of admission to the neonatal low dependency unit, admission to the (neonatal) Intensive Care Unit (ICU) and mortality. Statistical analyses included bivariate and multivariate techniques. Results: Cervical ripening with FC, compared with oral misoprostol, showed a higher incidence of intrapartum infection, respectively 32.7% (n = 16) vs. 12.7% (n = 10) (p = 0.006). However, after adjusting for epidural anaesthesia and pregestational BMI, the association was no longer significant. No difference was found in mode of delivery and total priming-to-delivery interval (median 21.3 hours vs. 22.0, p = 0.897). Furthermore, FC, compared with oral misoprostol, showed a longer duration of cervical ripening and hence a shorter duration of active labour (p 0.001). Apart from the 1-min Apgar score, secondary maternal and neonatal outcomes did not differ between the groups. Conclusion: In women who require cervical ripening after prolonged PROM at term, the FC and oral

关键词： Prelabour Rupture of Membranes (PROM) Balloon Catheter Misoprostol Cervical Ripening Labour Induction Chorioamnionitis

The Inter- and Intraindividual Anatomical Relationship of the Femoral Anteversion and Distal Femoral Rotation. A Cadaveric Study on the Femoral Anteversion Angle, Posterior and Inferior Condylar Angle Using Computed Tomography

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Advances in Computed Tomography 2015年第1期4卷 9-18页

作者： H. M. J. van der linden-van der Zwaag L. C. D. Konijn T. J. van der Steenhoven H. J. L. van der Heide M. C. de Ruiter R. G. H. H. Nelissen Department of Orthopaedic Surgery Leiden University Medical Center Leiden The Netherlands Department of Anatomy Leiden University Medical Center Leiden The Netherlands

Malrotation following Total Knee Arthroplasty (TKA) is directly related to poor outcome. Knowledge of the rotational axes (torsion) and angles is therefore important. The aim of the study was to determine whether an association existed between the Femoral Anteversion Angle (FAA) Posterior Condylar Angle (PCA) and the Inferior Condylar Angle (ICA) in individuals. A CT scan of 50 (25 paired) cadaver femora was made. The FAA, PCA and ICA were measured. Statistical analysis of comparative relationships between these different angles was examined by calculating Pearson correlation coefficients and a paired t-test. The mean FAA, PCA and ICA for the whole group were respectively 11.7° (range 0 - 32, SD 8.2), 5.18° (range 0 - 12, SD 2.4) and 4.4° (range 0 - 10, SD 2.1). A correlation of 0.82 (p = 0.01) of the FAA was found between left versus right. For the overall group a correlation coefficient between the PCA of the left and right femur was r = 0.59, p = 0.01. The Pearson correlation between the FAA and PCA in the whole group was r = 0.27, p = 0.06. In females this was r = 0.54 (p = 0.03). Although the difference of the mean ICA and PCA was very small (0.7°), there was no correlation between these angles (r = 0.14, p = 0.23). In conclusion, one should be aware that, considering the weak correlation of the FAA and PCA, an individual rotational variation exists. Furthermore, no correlation was found between the PCA and ICA. Therefore, for now, this angle cannot be assumed to be helpful in TKA. A more individual approach in total knee arthroplasty seems essential for future TKA.

关键词： Knee Femoral Anteversion Angle Posterior Condylar Angle Inferior Condylar Angle Computed Tomography

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外科医生手术量与腹股沟疝修补术后复发风险关系：全国登记资料研究

作者： (美)彼得·范德林登(Peter van der linden)

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英国医学杂志中文版 2008年第4期11卷 215-218页

作者： Par Nordin Willem van der linden 秦宏(译) Department of Surgery Osterstmd Hospital S83183 Ostersund Sweden 不详

目的探讨存在于外科医生大型手术量与手术结果之间的某种关联是否同样存在于小型手术。设计汇总分析在瑞典进行的疝修补术的术后结果。地点瑞典疝登记处备案注册的外科单位，2004年大约完成全瑞典疝修补术总例数的95％。参与者自199... 详细信息

目的探讨存在于外科医生大型手术量与手术结果之间的某种关联是否同样存在于小型手术。设计汇总分析在瑞典进行的疝修补术的术后结果。地点瑞典疝登记处备案注册的外科单位，2004年大约完成全瑞典疝修补术总例数的95％。参与者自1996年至2004年，在参研外科单位中共有86409例15岁以上患者入选，实施单侧或双侧腹股沟疝修补术96601例（94077例腹股沟疝加2524例股疝）。主要结局评估指标复发后再次手术。结果与每年疝修补术例数较多的外科医生相比，每年只完成1～5例疝修补术的外科医生进行再次手术的比率显著增高。手术结果与进一步提高外科医生手术量之间无关联。尽管在瑞典大约有半数外科医生完成的疝修补术例数都很低，但只占所有疝修补术总例数的8．4％。结论在瑞典，有许多疝外科医生的手术量都很低，但只占总手术例数中的很小一部分，所以尽管其手术结果不佳，但对全国再次手术率的影响极其微小。外科医生手术量只是大概提示了一名外科医生每年应该完成的疝修补术例数的最小数值，但是对于手术量超过该数值的外科医生，手术量并不能提示其手术熟练程度。

关键词：腹股沟疝修补术外科医生手术量复发风险登记资料修补术后手术结果再次手术

左西孟旦对左室功能低下的心脏手术患者的作用

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麻醉与镇痛 2008年第2期4卷 14-22页

作者： Stefan G. De Hert Suraphong Lorsomradee, MD Stefanie Cromheecke, MD Philippe J. van der linden 翁莹琪(译) 郭曲练(校) Department of Anesthesiology University of Antwerp University Hospital Antwerp Belgium Department of Anesthesiology CHU Brugmann HUDERF Brussels Belgium 不详

背景左室功能低下的患者体外循环手术后常需要立即给予正性肌力药支持。左西孟旦能改善心功能，其作用机制不同于现有药物。我们推测，对心室功能严重受损的患者，使用左西孟旦比使用增加心肌耗氧的正性肌力药，更有助于手术后心功能的... 详细信息

背景左室功能低下的患者体外循环手术后常需要立即给予正性肌力药支持。左西孟旦能改善心功能，其作用机制不同于现有药物。我们推测，对心室功能严重受损的患者，使用左西孟旦比使用增加心肌耗氧的正性肌力药，更有助于手术后心功能的恢复。方法30例手术前射血分数≤30％，拟行择期体外循环心脏手术的患者，随机分配到两个药物实验组：开放主动脉后立即分别给予米力农0．5mg·kg^-1·min^-1或左西孟旦0．1mg·kg^-1·min^-1.观察者不清楚患者用药种类。所有患者均给予多巴酚丁胺5mg·kg^-1·min^-1。结果手术后两组最初每搏输出量相似。但12小时后，尽管两组充盈压接近，米力农组每搏输出量下降，而左西孟旦组无下降（组间P〈0．05）。左西孟旦组正性肌力药。息剂量、用药持续时间和去甲肾上腺素的用量均少于米力农组（P〈0．05），且气管插管持续时间也较短（P=0008）。手术后30天内，米力农组有3例患者死亡，而左西孟旦组无一例死亡。结论对于手术前射血分数低下的心脏手术患者，手术后合用多巴酚丁胺与左西孟旦比合用多巴酚丁胺与米力农，能更好地维持心搏出量。

关键词：体外循环心脏手术左室功能低下左西孟旦正性肌力药多巴酚丁胺每搏输出量去甲肾上腺素射血分数

Single-port laparoscopic cholecystectomy vs standard laparoscopic cholecystectomy:A non-randomized,agematched single center trial

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World Journal of Gastrointestinal Surgery 2015年第8期7卷 145-151页

作者： Yoen TK van der linden Koop Bosscha Hubert A Prins Daniel J Lips Department of Surgery Jeroen Bosch Hospital

AIM: To compare the safety of single-port laparoscopic cholecystectomies with standard four-port ***: Between January 2011 and December 2012 datas were gathered from 100 consecutive patients who received a single-port cholecystectomy. Patient baseline characteristics of all 100 single-port cholecystectomies were collected(body mass index, age, etc.) in a database. This group was compared with 100 age-matched patients who underwent a conventional laparoscopic cholecystectomy in the same period. Retrospectively, per- and postoperative data were added. The two groups were compared to each other using independent t-tests and χ2-tests, P values below 0.05 were considered significantly ***: No differences were found between both groups regarding baseline characteristics. Operating time was significantly shorter in the total single-port group(42 min vs 62 min, P < 0.05); in procedures performed by surgeons the same trend was seen(45 min vs 59 min, P < 0.05). Peroperative complications between both groups were equal(3 in the single-port group vs 5 in the multiport group; P = 0.42). Although not significant less postoperative complications were seen in the single-port group compared with the multiport group(3 vs 9; P = 0.07). No statistically significant differences were found between both groupswith regard to length of hospital stay, readmissions and mortality. CONCLUSION: Single-port laparoscopic cholecystectomy has the potential to be a safe technique with a low complication rate, short in-hospital stay and comparable operating time. Single-port cholecystectomy provides the patient an almost non-visible scar while preserving optimal quality of surgery. Further prospective studies are needed to prove the safety of the single-port technique.

关键词： Single-port Minimal invasive Laparoscopy Safety Fe